20102020

Research output per year

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Personal profile

Biography

Dr. Bhusal is a Postdoctoral Research Fellow in the Department of Biochemistry and Molecular Biology and Biomedicine Discovery Institute (BDI) at Monash University. He completed Bachelor in pharmacy from Pokhara University (Nepal). After completion of his Bachelor's degree, he worked in a pharmaceutical company in Nepal for more than a year then secured a scholarship to pursue his Master’s degree in Pharmaceutical chemistry at Wonkwang University (South Korea). After his Master’s degree, He worked as a lecturer, undergraduate research supervisor and research coordinator in a college affiliated to Pokhara University for more than three years (Nepal). During that period, he co-founded a small pharmaceutical manufacturing (generics) company, demonstrating his entrepreneurial prowess. Ram earned his Ph.D. at The University of Auckland (New Zealand) in the discipline of chemical biology under the auspices of the competitive University of Auckland Doctoral Scholarship.

Dr. Bhusal is experienced in chemical synthesis, molecular biology techniques, the production and purification of recombinant proteins, the binding and kinetic assays of proteins using various biophysical techniques, and the crystallization of proteins and structure determination.

Currently, Dr. Bhusal’s project involves characterizing a novel family of tick proteins (evasins) that target chemokines to suppress inflammation. His long-term career interest centers on investigating biochemical mechanisms in the context of infectious disease and the host immune response.

Education/Academic qualification

Chemical Biology, PhD, University of Auckland

1 Oct 201429 Oct 2018

Award Date: 1 May 2019

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Research Output

Discovery of Potent Cyclic Sulfopeptide Chemokine Inhibitors via Reprogrammed Genetic Code mRNA Display

Johansen-Leete, J., Passioura, T., Foster, S. R., Bhusal, R. P., Ford, D. J., Liu, M., Jongkees, S. A. K., Suga, H., Stone, M. J. & Payne, R. J., 20 May 2020, In : Journal of the American Chemical Society. 142, 20, p. 9141-9146 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Evasins: Tick Salivary Proteins that Inhibit Mammalian Chemokines

Bhusal, R. P., Eaton, J. R. O., Chowdhury, S. T., Power, C. A., Proudfoot, A. E. I., Stone, M. J. & Bhattacharya, S., Feb 2020, In : Trends in Biochemical Sciences. 45, 2, p. 108-122 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

Semisynthesis of an evasin from tick saliva reveals a critical role of tyrosine sulfation for chemokine binding and inhibition

Franck, C., Foster, S. R., Johansen-Leete, J., Chowdhury, S., Cielesh, M., Bhusal, R. P., Mackay, J. P., Larance, M., Stone, M. J. & Payne, R. J., 9 Jun 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 23, p. 12657-12664 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural basis of chemokine and receptor interactions: Key regulators of leukocyte recruitment in inflammatory responses

Bhusal, R. P., Foster, S. R. & Stone, M. J., Feb 2020, In : Protein Science. 29, 2, p. 420-432 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

3 Citations (Scopus)

Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2

Bhusal, R. P., Jiao, W., Kwai, B. X. C., Reynisson, J., Collins, A. J., Sperry, J., Bashiri, G. & Leung, I. K. H., 11 Oct 2019, In : Nature Communications. 10, 1, 7 p., 4639.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Prizes

Faculty Bridging Postdoctoral Fellow

Bhusal, Ram (Recipient), Jul 2019

Prize: Competitive Fellowships