Projects per year
Personal profile
Biography
Dr Ram Bhusal is an NHMRC Investigator Fellow in the Biomedicine Discovery Institute (BDI) of Monash University. Dr Bhusal research focuses on a comprehensive understanding of how the tick salivary proteins (evasins) inhibits human chemokines. This is of direct significance for the development of anti-inflammatory therapeutics. Additionally, Dr Bhusal research explores the evolutionary landscape of evasins to unfurl how they gain new functional properties. This is of broad significance to understand the sequence-structure-function relationships of various proteins.
Dr Ram Bhusal received his PhD at the University of Auckland, New Zealand under the joint supervision of Prof Jonathan Sperry and Dr Ivanhoe Leung. The most notable achievement during his graduate work was that he was part of the team that solved the first structure of Mycobacterium tuberculosis (Mtb) isocitrate lyase 2 and provided the molecular mechanism of how this enzyme helps Mtb to switch between different carbon sources.
Dr Bhusal completed bachelor’s degree in pharmaceutical sciences from Pokhara University (Nepal) and master’s degree in Medicinal chemistry from Wonkwang University (South Korea).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Chemical Biology, PhD, Biochemical and structural studies of Mycobacterium tuberculosis isocitrate lyase , University of Auckland
1 Oct 2014 → 29 Oct 2018
Award Date: 1 May 2019
Collaborations and top research areas from the last five years
Projects
- 2 Active
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Suppression of Treg Recruitment in Cancer Immunotherapy: Tick Evasins as Chemokine-targeted Therapeutics
Stone, M. (Primary Chief Investigator (PCI)), Robert, R. (Chief Investigator (CI)), Bhusal, R. (Associate Investigator (AI)), Taylor, R. (Associate Investigator (AI)), Payne, R. J. (Associate Investigator (AI)) & Ascher, D. B. (Associate Investigator (AI))
1/01/25 → 31/12/28
Project: Research
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Harnessing ticks' tricks to develop therapies for inflammatory diseases
1/01/24 → 31/12/28
Project: Research
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Structural basis of chemokine recognition by the class A3 tick evasin EVA-ACA1001
Devkota, S. R., Aryal, P., Wilce, M. C. J., Payne, R. J., Stone, M. J. & Bhusal, R. P., Jun 2024, In: Protein Science. 33, 6, 11 p., e4999.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
The effect of probiotic strains on the proteolytic activity and peptide profiles of lupin oat-based yoghurt
Dhakal, D., Younas, T., Bhusal, R. P., Devkota, L., Li, L., Zhang, B. & Dhital, S., Apr 2024, In: Food Hydrocolloids. 149, 15 p., 109570.Research output: Contribution to journal › Article › Research › peer-review
Open Access16 Citations (Scopus) -
Tyrosine Sulfation Modulates the Binding Affinity of Chemokine-Targeting Nanobodies
Dilly, J. J., Morgan, A. L., Bedding, M. J., Low, J. K. K., Mackay, J. P., Conibear, A. C., Bhusal, R. P., Stone, M. J., Franck, C. & Payne, R. J., 19 Jul 2024, In: ACS Chemical Biology. 19, 7, p. 1426−1432 7 p.Research output: Contribution to journal › Article › Research › peer-review
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Design rules of plant-based yoghurt-mimic: Formulation, functionality, sensory profile and nutritional value
Dhakal, D., Younas, T., Bhusal, R. P., Devkota, L., Henry, C. J. & Dhital, S., Sept 2023, In: Food Hydrocolloids. 142, 21 p., 108786.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access43 Citations (Scopus) -
Editorial: Bacteriophages to treat infections with multidrug resistant pathogens
Subedi, D., Fang, T., Bhusal, R. P. & Willcox, M., 2023, In: Frontiers in Medicine. 10, 3 p., 1348463.Research output: Contribution to journal › Editorial › Other › peer-review
Open Access
Prizes
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Australian Peptide Conference 2022 - Travel Award
Bhusal, Ram (Recipient), 2022
Prize: Prize (including medals and awards)
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File
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Biomedicine Discovery Institute Travel Grant.
Bhusal, R. (Recipient), 2021
Prize: Prize (including medals and awards)
File -
Diversity Equity and Inclusion Travel Award-The Protein Society Annual Symposium
Bhusal, Ram (Recipient), 2022
Prize: Prize (including medals and awards)
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Faculty Bridging Postdoctoral Fellowship
Bhusal, R. (Recipient), Jul 2019
Prize: Competitive Fellowships