Projects per year
Personal profile
Biography
Ralf studied Biochemistry at the University of Bayreuth, Germany, and received his PhD from the University of Zurich, Switzerland, in 2009 for his work on cell cycle regulation and the composition of centromeres and kinetochores in Drosophila melanogaster.
After his PhD, he joined the group of Prof. Dr. Ernst Hafen at the Swiss Federal Institute of Technology (ETH) in Zurich, Switzerland. In close collaboration with the group of Prof. Dr. Ruedi Aebersold, he identified and validated novel components of the insulin receptor / target of rapamycin (InR/TOR) pathway using mass spectrometric approaches in combination with biochemical assays.
In 2012, Ralf was awarded a Swiss National Foundation (SNF) Fellowship for Prospective Researchers and joined the group of Prof. Dr. Anthony Purcell at Monash University in Melbourne, Australia. During that time, he utilized high-resolution mass spectrometry to study the onset and progression of a variety of clinically relevant diseases known as spondyloarthropathies. Because of his work, Ralf was awarded with a SFGBM (Swiss Foundation for Grants in Biology and Medicine) Fellowship for Advanced Researchers in 2013.
In 2016, Ralf was appointed as the Director of the Monash Biomedical Proteomics Platform to provide mass spectrometric expertise to researchers and the broader community.
Network
Projects
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Developing high throughput single cell proteomics
de Marco, A., Neild, A. & Schittenhelm, R.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/21 → 31/12/24
Project: Research
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IMP: A National Scale Data Asset to Integrate Molecular Imaging with Bio-analytics
Goscinski, W., Whisstock, J., de Marco, A. & Schittenhelm, R.
31/12/20 → 31/12/22
Project: Research
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Exploiting network vulnerabilities to devise effective combination therapies against breast cancer
Nguyen, L., Abud, H., Schittenhelm, R. & Daly, R.
1/10/20 → 30/11/22
Project: Research
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Mechanisms of Ligand-Selective Signalling by Chemokine Receptors
Stone, M., Canals, M., Lane, R. & Schittenhelm, R.
1/01/18 → 31/12/20
Project: Research
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Mapping pathways of human Z-antitrypsin turnover in transgenic zebrafish
Bird, P., Bryson-Richardson, R., Ramialison, M. & Schittenhelm, R.
1/07/16 → 30/06/18
Project: Research
Research output
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A Chemoenzymatic Approach to the Synthesis of Glycopeptide Antibiotic Analogues
Tailhades, J., Zhao, Y., Ho, Y. T. C., Greule, A., Ahmed, I., Schoppet, M., Kulkarni, K., Goode, R. J. A., Schittenhelm, R. B., De Voss, J. J. & Cryle, M. J., 15 Apr 2020, (Accepted/In press) In : Angewandte Chemie - International Edition. 6 p.Research output: Contribution to journal › Article › Research › peer-review
5 Citations (Scopus) -
A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver TRM Cell-Mediated Immunity against Malaria in Mice
Valencia-Hernandez, A. M., Ng, W. Y., Ghazanfari, N., Ghilas, S., de Menezes, M. N., Holz, L. E., Huang, C., English, K., Naung, M., Tan, P. S., Tullett, K. M., Steiner, T. M., Enders, M. H., Beattie, L., Chua, Y. C., Jones, C. M., Cozijnsen, A., Mollard, V., Cai, Y., Bowen, D. G. & 15 others, , 10 Jun 2020, In : Cell Host & Microbe. 27, 6, p. 950-962 13 p.Research output: Contribution to journal › Article › Research › peer-review
8 Citations (Scopus) -
Cellular and structural basis of synthesis of the unique intermediate dehydro-F420-0 in mycobacteria
Grinter, R., Ney, B., Brammananth, R., Barlow, C. K., Cordero, P. R. F., Gillett, D. L., Izoré, T., Cryle, M. J., Harold, L. K., Cook, G. M., Taiaroa, G., Williamson, D. A., Warden, A. C., Oakeshott, J. G., Taylor, M. C., Crellin, P. K., Jackson, C. J., Schittenhelm, R. B., Coppel, R. L. & Greening, C., Jun 2020, In : mSystems. 5, 3, 14 p., e00389-20.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile -
Exploring modular reengineering strategies to redesign the teicoplanin non-ribosomal peptide synthetase
Kaniusaite, M., Goode, R. J. A., Tailhades, J., Schittenhelm, R. B. & Cryle, M. J., 21 Sep 2020, In : Chemical Science. 11, 35, p. 9443-9458 16 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile -
Exploring the Tetracyclization of Teicoplanin Precursor Peptides through Chemoenzymatic Synthesis
Zhao, Y., Goode, R. J. A., Schittenhelm, R. B., Tailhades, J. & Cryle, M. J., 7 Feb 2020, In : The Journal of Organic Chemistry. 85, 3, p. 1537-1547 11 p.Research output: Contribution to journal › Article › Research › peer-review
6 Citations (Scopus)