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Personal profile

Biography

Ralf studied Biochemistry at the University of Bayreuth, Germany, and received his PhD from the University of Zurich, Switzerland, in 2009 for his work on cell cycle regulation and the composition of centromeres and kinetochores in Drosophila melanogaster.

After his PhD, he joined the group of Prof. Dr. Ernst Hafen at the Swiss Federal Institute of Technology (ETH) in Zurich, Switzerland. In close collaboration with the group of Prof. Dr. Ruedi Aebersold, he identified and validated novel components of the insulin receptor / target of rapamycin (InR/TOR) pathway using mass spectrometric approaches in combination with biochemical assays.

In 2012, Ralf was awarded a Swiss National Foundation (SNF) Fellowship for Prospective Researchers and joined the group of Prof. Dr. Anthony Purcell at Monash University in Melbourne, Australia. During that time, he utilized high-resolution mass spectrometry to study the onset and progression of a variety of clinically relevant diseases known as spondyloarthropathies. Because of his work, Ralf was awarded with a SFGBM (Swiss Foundation for Grants in Biology and Medicine) Fellowship for Advanced Researchers in 2013.

In 2016, Ralf was appointed as the Director of the Monash Biomedical Proteomics Platform to provide mass spectrometric expertise to researchers and the broader community.

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Projects 2016 2020

Research Output 2005 2018

AgRP Neurons Require Carnitine Acetyltransferase to Regulate Metabolic Flexibility and Peripheral Nutrient Partitioning

Reichenbach, A., Stark, R., Mequinion, M., Denis, R. R. G., Goularte, J. F., Clarke, R. E., Lockie, S. H., Lemus, M. B., Kowalski, G. M., Bruce, C. R., Huang, C., Schittenhelm, R. B., Mynatt, R. L., Oldfield, B. J., Watt, M. J., Luquet, S. & Andrews, Z. B., 13 Feb 2018, In : Cell Reports. 22, 7, p. 1745-1759 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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A Metabolic Checkpoint for the Yeast-to-Hyphae Developmental Switch Regulated by Endogenous Nitric Oxide Signaling

Koch, B., Barugahare, A. A., Lo, T. L., Huang, C., Schittenhelm, R. B., Powell, D. R., Beilharz, T. H. & Traven, A., 20 Nov 2018, In : Cell Reports. 25, 8, p. 2244-2258 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Biodosimetric transcriptional and proteomic changes are conserved in irradiated human tissue

Keam, S. P., Gulati, T., Gamell, C., Caramia, F., Arnau, G. M., Huang, C., Schittenhelm, R. B., Kleifeld, O., Neeson, P. J., Williams, S. G. & Haupt, Y., 30 May 2018, (Accepted/In press) In : Radiation and Environmental Biophysics. 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Determination of the small RNA GcvB regulon in the gram-negative bacterial pathogen Pasteurella multocida and identification of the GcvB seed binding region

Gulliver, E. L., Wright, A., Deveson, D., Megroz, M., Kleifeld, O., Schittenhelm, R. B., Powell, D. R., Seemann, T., Bulitta, J. B., Harper, M. & Boyce, J. D., 12 Feb 2018, In : Rna-A Publication of the Rna Society. 24, p. 704-720 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Exploring the oncoproteomic response of human prostate cancer to therapeutic radiation using data-independent acquisition (DIA) mass spectrometry

Keam, S. P., Gulati, T., Gamell, C., Caramia, F., Huang, C., Schittenhelm, R. B., Kleifeld, O., Neeson, P. J., Haupt, Y. & Williams, S. G., 1 Jun 2018, In : Prostate. 78, 8, p. 563-575 13 p.

Research output: Contribution to journalArticleResearchpeer-review