Projects per year
Personal profile
Biography
Ralf studied Biochemistry at the University of Bayreuth, Germany, and received his PhD from the University of Zurich, Switzerland, in 2009 for his work on cell cycle regulation and the composition of centromeres and kinetochores in Drosophila melanogaster.
After his PhD, he joined the group of Prof. Dr. Ernst Hafen at the Swiss Federal Institute of Technology (ETH) in Zurich, Switzerland. In close collaboration with the group of Prof. Dr. Ruedi Aebersold, he identified and validated novel components of the insulin receptor / target of rapamycin (InR/TOR) pathway using mass spectrometric approaches in combination with biochemical assays.
In 2012, Ralf was awarded a Swiss National Foundation (SNF) Fellowship for Prospective Researchers and joined the group of Prof. Dr. Anthony Purcell at Monash University in Melbourne, Australia. During that time, he utilized high-resolution mass spectrometry to study the onset and progression of a variety of clinically relevant diseases known as spondyloarthropathies. Because of his work, Ralf was awarded with a SFGBM (Swiss Foundation for Grants in Biology and Medicine) Fellowship for Advanced Researchers in 2013.
In 2016, Ralf was appointed as the Director of the Monash Biomedical Proteomics Platform to provide mass spectrometric expertise to researchers and the broader community.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Network
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High-Precision Mass Spectrometry Imaging Facility
Voelcker, N., Tuck, K., McConville, M., Li, J., Loessner, D., Pigram, P. J., van Oppen, M. J. H., Winkler, D., Hartland, E., Velkov, T., Stewart, A., Schittenhelm, R., Williamson, N. A., Rudd, D. & Baybrook, C.
Australian Research Council (ARC)
17/03/23 → 16/03/24
Project: Research
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Uncovering novel mechanisms of treatment resistance in lethal colorectal cancers
Abud, H., Engel, R., McMurrick, P., Schittenhelm, R., Lum, C. D. R. & Archer, S.
1/01/23 → 31/12/25
Project: Research
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Characterization of the Germline Regulatory Landscape
Pocock, R., Cao, W., Fan, Q., Hutt, K., Gopal, S., Schittenhelm, R., Hobbs, R., Archer, S. & Coutts, S.
1/01/23 → 31/12/27
Project: Research
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Preventing a nephron deficit in premature offspring
Bertram, J., Cullen-McEwen, L., Charlton, J., Simpson, S. J., Solon-Biet, S., Rose, A., Schittenhelm, R., Barlow, C., Combes, A., Tan, K., Johnstone, L., Wlodek, M. & Stanford, K.
1/01/23 → 31/12/26
Project: Research
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Discovery of new molecular targets for stroke-associated pneumonia to improve recovery
Wong, C., Wen, S. W., Ma, H., Schittenhelm, R., Bedo, J. & Phan, T.
1/06/22 → 31/12/24
Project: Research
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Exploring the Flexibility of the Glycopeptide Antibiotic Crosslinking Cascade for Extended Peptide Backbones
Ho, Y. T. C., Schittenhelm, R. B., Iftime, D., Stegmann, E., Tailhades, J. & Cryle, M. J., 14 Mar 2023, In: ChemBioChem. 24, 6, 9 p., e202200686.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Expression of the Z Variant of α1-Antitrypsin Suppresses Hepatic Cholesterol Biosynthesis in Transgenic Zebrafish
Fung, C., Wilding, B., Schittenhelm, R. B., Bryson-Richardson, R. J. & Bird, P. I., 27 Jan 2023, In: International Journal of Molecular Sciences. 24, 3, 23 p., 2475.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
The pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive oncogenic signalling in triple-negative breast cancer
Yang, X., Cruz, M. I., Nguyen, E. V., Huang, C., Schittenhelm, R. B., Luu, J., Cowley, K. J., Shin, S-Y., Nguyen, L. K., Lim Kam Sian, T. C. C., Clark, K. C., Simpson, K. J., Ma, X. & Daly, R. J., 10 Mar 2023, In: Oncogene. 42, 11, p. 833–847 15 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Adaptation of the periplasm to maintain spatial constraints essential for cell envelope processes and cell viability
Mandela, E., Stubenrauch, C. J., Ryoo, D., Hwang, H., Cohen, E. J., Torres, V. L., Deo, P., Webb, C. T., Huang, C., Schittenhelm, R. B., Beeby, M., Gumbart, J. C., Lithgow, T. & Hay, I. D., Jan 2022, In: eLife. 11, 21 p., e73516.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
Altered Blood–Brain Barrier Dynamics in the C9orf72 Hexanucleotide Repeat Expansion Mouse Model of Amyotrophic Lateral Sclerosis
Pan, Y., Kagawa, Y., Sun, J., Turner, B. J., Huang, C., Shah, A. D., Schittenhelm, R. B. & Nicolazzo, J. A., Dec 2022, In: Pharmaceutics. 14, 12, 17 p., 2803.Research output: Contribution to journal › Article › Research › peer-review
Open Access
Press/Media
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Faculty of Opinions recommendation
Jennifer Payne, Max Cryle, Julien Tailhades, Alex Fulcher, Felix Ellett, Daniel Irima, Xenia Kostoulias, Ryan Leung, Steph Louch, Amy Tran, Severin Weber, Ralf Schittenhelm, Graham Lieschke, Chengxue Helena Qin, Anton Peleg & Ting Fu
3/12/21
1 item of Media coverage
Press/Media: Article/Feature
Equipment
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Monash Proteomics & Metabolomics Facility
Ralf Schittenhelm (Manager)
Faculty of Medicine Nursing and Health Sciences Research PlatformsFacility/equipment: Facility