Projects per year
Personal profile
Biography
Dr. Rakesh Naidu is an Associate Professor in Biomedical Science at the Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia. He was a lecturer in International Medical University and Department of Molecular Medicine, Faculty of Medicine, University of Malaya prior to his appointment at Monash University. He is involved in the teaching of biochemistry, genetics, and cancer. His current research focuses on the molecular biology of cancer, cancer therapeutics, and cancer venomics. He has been successful in securing several internal and external research grants in the research areas of molecular oncology and cancer therapeutics. He has published peer-reviewed research papers in several international and national journals and book chapters in cancer. He has supervised and currently supervising several graduate students including PhD and Masters over the years.
Research interests
Dr Rakesh Naidu is actively involved in cancer research. One of the research interests is to understand the molecular alterations that lead to cancer development with particular focus on breast, prostate and colon cancers. Genomics and proteomics analysis were performed on human cancer samples to determine and identify several genetics alteration that could potentially be used as biomarkers and to understand mechanisms underlying cancer development. Some of the genetic alterations noted were distinct than that reported by other investigators perhaps of different demographics and ethnic population. Currently, his research group focuses on identification and understanding the underlying molecular mechanisms of synthetic compounds and analogues derived from natural compounds as well as natural components from venoms that contribute to anti-cancer activities in human cancer cells such as cervical, prostate, colon, breast and lung. Several ‘omics’ platform technologies such as transcriptomics and proteomics are used to identify specific target mRNAs, miRNAs and proteins as well as relevant biological pathways modulated by these potential anticancer compounds. High-density microarrays, sequencing and mass spectrometry are used to achieve these outcomes which contribute to the understanding of targeted anti-cancer therapy by these compounds that may lead to future development of novel anti-cancer drugs.
Monash teaching commitment
- Student Project Cases
- Problem Based Learning
- Biochemistry
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Molecular Oncology, MSc, Universiti Malaya (University of Malaya)
Molecular Oncology, PhD, Universiti Malaya (University of Malaya)
BSc(Ed), Universiti Sains Malaysia (University of Science Malaysia)
Research area keywords
- Biomedical Science
- Cancer Therapeutics
- Molecular Oncology
- Genomics
- Transcriptomics
- Proteomics
- Cancer Venomics
- Cancer Biology
Network
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Fabry disease: Understanding the requirements for genetic complementation of the defect by modifying alpha-galactosidase A and globotriaosylceramide levels
Narayanan, K., Naidu, R. & Joon Ching, J.
1/09/19 → 31/05/23
Project: Research
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Induction of Apoptosis and Identification of Molecular Pathways and Molecular Targets in Human Lung Cancer Cells Treated by a Selected Synthetic Diarylpentanoid
Naidu, R., Abas, F., Kia Fatt, Q. & Othman, I.
1/11/20 → 31/10/22
Project: Research
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Investigating the underlying cause of downregulation of semaphorin 5A and the loss of its tumor suppressor function in human glioblastomas
Lee, A. Y. W. & Naidu, R.
1/09/19 → 30/11/22
Project: Research
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Cellular and molecular events leading to paraquat-induced apoptosis: mechanistic insights into Parkinson’s disease pathophysiology
See, W. Z. C., Naidu, R. & Tang, K. S., Jun 2022, In: Molecular Neurobiology. 59, 6, p. 3353-3369 17 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile1 Citation (Scopus) -
Curcumin as an enhancer of therapeutic efficiency of chemotherapy drugs in breast cancer
Farghadani, R. & Naidu, R., 2 Feb 2022, In: International Journal of Molecular Sciences. 23, 4, 19 p., 2144.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile11 Citations (Scopus) -
G protein-coupled estrogen receptor-1: homology modeling approaches and application in screening new GPER-1 modulators
Khan, S. U., Ahemad, N., Chuah, L. H., Naidu, R. & Htar, T. T., 2022, In: Journal of Biomolecular Structure and Dynamics. 40, 7, p. 3325-3335 11 p.Research output: Contribution to journal › Review Article › Research › peer-review
1 Citation (Scopus) -
miRNA: A promising therapeutic target in cancer
Menon, A., Abd-Aziz, N., Khalid, K., Poh, C. L. & Naidu, R., Oct 2022, In: International Journal of Molecular Sciences. 23, 19, 29 p., 11502.Research output: Contribution to journal › Review Article › Research › peer-review
Open AccessFile3 Citations (Scopus) -
Natural bioactive compounds as a new source of promising G protein-coupled estrogen receptor (GPER) modulators: comprehensive in silico approach
Khan, S. U., Ahemad, N., Chuah, L. H., Naidu, R. & Htar, T. T., 2022, In: Journal of Biomolecular Structure and Dynamics. 40, 4, p. 1617-1628 12 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus)