Raffi Gugasyan

Dr

20002018

Research output per year

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Research Output

2018

Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner

O'Reilly, L. A., Putoczki, T. L., Mielke, L. A., Low, J. T., Lin, A., Preaudet, A., Herold, M. J., Yaprianto, K., Tai, L., Kueh, A., Pacini, G., Ferrero, R. L., Gugasyan, R., Hu, Y., Christie, M., Wilcox, S., Grumont, R., Griffin, M. D. W., O'Connor, L., Smyth, G. K. & 4 others, Ernst, M., Waring, P., Gerondakis, S. & Strasser, A., 20 Mar 2018, In : Immunity. 48, 3, p. 570-583 14 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)
2017

Vaginal lactic acid elicits an anti-inflammatory response from human cervicovaginal epithelial cells and inhibits production of pro-inflammatory mediators associated with HIV acquisition

Hearps, A. C., Tyssen, D., Srbinovski, D., Bayigga, L., Diaz, D. J. D., Aldunate, M., Cone, R. A., Gugasyan, R., Anderson, D. J. & Tachedjian, G., 1 Nov 2017, In : Mucosal Immunology. 10, 6, p. 1480-1490 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
46 Citations (Scopus)
2016

Correction: Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics (Cancer Cell (2016) 30(3) (499–500) (S1535610816000350) (10.1016/j.ccell.2016.01.006))

Lalaoui, N., Hänggi, K., Brumatti, G., Chau, D., Nguyen, N. Y. N., Vasilikos, L., Spilgies, L. M., Heckmann, D. A., Ma, C., Ghisi, M., Salmon, J. M., Matthews, G. M., de Valle, E., Moujalled, D. M., Menon, M. B., Spall, S. K., Glaser, S. P., Richmond, J., Lock, R. B., Condon, S. M. & 10 others, Gugasyan, R., Gaestel, M., Guthridge, M., Johnstone, R. W., Munoz, L., Wei, A., Ekert, P. G., Vaux, D. L., Wong, W. W. L. & Silke, J., 12 Sep 2016, In : Cancer Cell. 30, 3, p. 499-500 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

10 Citations (Scopus)

NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells

de Valle, E., Grigoriadis, G., O'Rielly, L. A., Willis, S. N., Maxwell, M. J., Corcoran, L. M., Tsantikos, E., Cornish, J. K. S., Fairfax, K. A., Vasanthakumar, A., Febbraio, M. A., Hibbs, M. L., Pellegrini, M., Banerjee, A., Hodgkin, P. D., Kallies, A., Mackay, F., Strasser, A., Gerondakis, S. & Gugasyan, R., 4 Apr 2016, In : Journal of Experimental Medicine. 213, 4, p. 621-641 21 p., PMC4821646.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics

Lalaoui, N., Hanggi, K., Brumatti, G., Chau, D., Nguyen, N-Y. N., Vasilikos, L., Spilgies, L. M., Heckmann, D. A., Ma, C., Ghisi, M., Salmon, J. M., Matthews, G. M., de Valle, E., Moujalled, D. M., Menon, M. B., Spall, S. K., Glaser, S. P., Richmond, J., Lock, R. B., Condon, S. M. & 10 others, Gugasyan, R., Gaestel, M., Guthridge, M., Johnstone, R. W., Munoz, L., Wei, A., Ekert, P. G., Vaux, D. L., Wong, W. W-L. & Silke, J., 2016, In : Cancer Cell. 29, 2, p. 145 - 158 14 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

Brumatti, G., Ma, C., Lalaoui, N., Nguyen, N. Y., Navarro, M., Tanzer, M. C., Richmond, J., Ghisi, M., Salmon, J. M., Silke, N., Pomilio, G., Glaser, S. P., de Valle, E., Gugasyan, R., Gurthridge, M. A., Condon, S. M., Johnstone, R. W., Lock, R., Salvesen, G. S., Wei, A. & 3 others, Vaux, D. L., Ekert, P. G. & Silke, J., 18 May 2016, In : Science Translational Medicine. 8, 339, 339ra69.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)

The NF-κB transcription factor RelA is required for the tolerogenic function of Foxp3+ regulatory T cells

Messina, N., Fulford, T., O'Reilly, L., Loh, W. X., Motyer, J. M., Ellis, D., McLean, C., Naeem, H., Lin, A., Gugasyan, R., Slattery, R. M., Grumont, R. J. & Gerondakis, S., Jun 2016, In : Journal of Autoimmunity. 70, p. 52-62 11 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)
2015

Antimicrobial and immune modulatory effects of lactic acid and short chain fatty acids produced by vaginal microbiota associated with eubiosis and bacterial vaginosis

Aldunate, M. C., Srbinovski, D., Hearps, A. C., Latham, C. F., Ramsland, P. A., Gugasyan, R., Cone, R. A. & Tachedjian, G., 2015, In : Frontiers in Physiology. 6, 23 p., 164.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
85 Citations (Scopus)
2014

Lactic Acid, a Vaginal Microbiota Metabolite, Elicits an Anti-inflammatory Response from Vaginal and Cervical Epithelial Cells

Hearps, A. C., Batista, F. (ed.), Gugasyan, R., Srbinovski, D., Tyssen, D. P., Aldunate, M. C., Anderson, D. J., Cone, R. & Tachedjian, G., 2014, p. 238 - 239. 2 p.

Research output: Contribution to conferenceAbstract

2012

NF-k(kappa)B subunit specificity in hemopoiesis.

Gerondakis, S. D., Banerjee, A., Grigoriadis, G., Vasanthakumar, A., Gugasyan, R., Sidwell, T. & Grumont, R. J., 2012, In : Immunological Reviews. 246, 1, p. 272 - 285 14 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

The NF-[kappa]B1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties

Gugasyan, R., Horat, E., Kinkel, S., Ross, F., Grigoriadis, G., Gray, D., O'Keeffe, M., Berzins, S., Belz, G., Grumont, R., Banerjee, A., Strasser, A., Godfrey, D., Tsichlis, P. & Gerondakis, S., 2012, In : The EMBO Journal. 31, 3, p. 692 - 706 15 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)
2011

Distinct roles in NKT cell maturation and function for the different transcription factors in the classical NF-I?B pathway

Stankovic, S., Gugasyan, R., Kyparissoudis, K., Grumont, R., Banerjee, A., Tsichlis, P., Gerondakis, S. & Godfrey, D., 2011, In : Immunology and Cell Biology. 89, 2, p. 294 - 303 10 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)
2010

c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells (The Journal of Experimental Medicine (December 21, 2009) 206, 13 (3001-3014))

Isomura, I., Palmer, S., Grumont, R. J., Bunting, K., Hoyne, G. F., Wilkinson, N., Banerjee, A., Proietto, A. I., Gugasyan, R., Wu, L., McNally, A., Steptoe, R. J., Thomas, R., Shannon, M. F. & Gerondakis, S., 12 Apr 2010, In : Journal of Experimental Medicine. 207, 4, p. 899 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

1 Citation (Scopus)
2009

c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells

Isomura, I., Palmer, S., Grumont, R. J., Bunting, K., Hoyne, G. F., Wilkinson, N., Banerjee, A., Proietto, A. I., Gugasyan, R., Wu, L., McNally, A., Steptoe, R. J., Thomas, R., Shannon, M. F. & Gerondakis, S. D., 2009, In : Journal of Experimental Medicine. 206, 13, p. 3001 - 3014 14 p.

Research output: Contribution to journalArticleResearchpeer-review

157 Citations (Scopus)

Fatal Hepatitis Mediated by Tumor Necrosis Factor TNFα Requires Caspase-8 and Involves the BH3-Only Proteins Bid and Bim

Kaufmann, T., Jost, P. J., Pellegrini, M., Puthalakath, H., Gugasyan, R., Gerondakis, S., Cretney, E., Smyth, M. J., Silke, J., Hakem, R., Bouillet, P., Mak, T. W., Dixit, V. M. & Strasser, A., 16 Jan 2009, In : Immunity. 30, 1, p. 56-66 11 p.

Research output: Contribution to journalArticleResearchpeer-review

97 Citations (Scopus)
2008

NF-kappaB1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms

Banerjee, A., Grumont, R. J., Gugasyan, R., White, C. L., Strasser, A. & Gerondakis, S. D., 2008, In : Blood. 112, 13, p. 5063 - 5073 11 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)
2007

Loss of the BH3-only protein Bid does not rescue RelA-deficient embryos from TNF-R1-mediated fatal hepatocyte destruction [2]

Kaufmann, T., Gugasyan, R., Gerondakis, S., Dixit, V. M. & Strasser, A., 1 Mar 2007, In : Cell Death and Differentiation. 14, 3, p. 637-639 3 p.

Research output: Contribution to journalLetterOtherpeer-review

4 Citations (Scopus)
2006

Bcl-2 transgene expression fails to prevent fatal hepatocyte apoptosis induced by endogenous TNFα in mice lacking RelA [1]

Gugasyan, R., Christou, A., O'Reilly, L. A., Strasser, A. & Gerondakis, S., 1 Jul 2006, In : Cell Death and Differentiation. 13, 7, p. 1235-1237 3 p.

Research output: Contribution to journalLetterOtherpeer-review

5 Citations (Scopus)
116 Citations (Scopus)

Unravelling the complexities of the NF-κB signalling pathway using mouse knockout and transgenic models

Gerondakis, S., Grumont, R., Gugasyan, R., Wong, L., Isomura, I., Ho, W. & Banerjee, A., 30 Oct 2006, In : Oncogene. 25, 51, p. 6781-6799 19 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

203 Citations (Scopus)
2005

Distinct roles for the NF-κB1 and c-Rel transcription factors in the differentiation and survival of plasmacytoid and conventional dendritic cells activated by TLR-9 signals

O'Keeffe, M., Grumont, R. J., Hochrein, H., Fuchsberger, M., Gugasyan, R., Vremec, D., Shortman, K. & Gerondakis, S., 15 Nov 2005, In : Blood. 106, 10, p. 3457-3464 8 p.

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)
2004

The transcription factors c-rel and RelA control epidermal development and homeostasis in embryonic and adult skin via distinct mechanisms

Gugasyan, R., Voss, A. K., Varigos, G., Thomas, T., Grumont, R. J., Kaur, P., Grigoriadis, G. & Gerondakis, S. D., 2004, In : Molecular and Cellular Biology. 24, 13, p. 5733 - 5745 13 p.

Research output: Contribution to journalArticleResearchpeer-review

66 Citations (Scopus)
2002

The combined absence of NF-κB1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells

Pohl, T., Gugasyan, R., Grumont, R. J., Strasser, A., Metcalf, D., Tarlinton, D., Sha, W., Baltimore, D. & Gerondakis, S., 2 Apr 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 7, p. 4514-4519 6 p.

Research output: Contribution to journalArticleResearchpeer-review

86 Citations (Scopus)
2001

c-Rel regulates interleukin 12 p70 expression in CD8+ dendritic cells by specifically inducing p35 gene transcription

Grumont, R., Hochrein, H., O'Keeffe, M., Gugasyan, R., White, C., Caminschi, I., Cook, W. & Gerondakis, S., 15 Oct 2001, In : Journal of Experimental Medicine. 194, 8, p. 1021-1031 11 p.

Research output: Contribution to journalArticleResearchpeer-review

144 Citations (Scopus)
2000

Rel/NF-κB transcription factors: Key mediators of B-cell activation

Gugasyan, R., Grumont, R., Grossmann, M., Nakamura, Y., Pohl, T., Nesic, D. & Gerondakis, S., 1 Jan 2000, In : Immunological Reviews. 176, p. 134-140 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

95 Citations (Scopus)

The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression

Grossmann, M., O'Reilly, L. A., Gugasyan, R., Strasser, A., Adams, J. M. & Gerondakis, S., 1 Dec 2000, In : The EMBO Journal. 19, 23, p. 6351-6360 10 p.

Research output: Contribution to journalArticleResearchpeer-review

183 Citations (Scopus)

The role of the Rel transcription factor in B cells

Gerondakis, S., Grossmann, M., Nakamura, Y., Pohl, T., Gugasyan, R. & Grumont, R., 1 Jan 2000, In : Immunologist. 8, 1-2, p. 14-15 2 p.

Research output: Contribution to journalArticleResearchpeer-review