Projects per year
Personal profile
Biography
Raelene Pickering is an experienced molecular and cell biologist. She obtained her PhD in Immunology at Monash University investigating the modulation of the immune response to a plant-made vaccine. During her PhD she gained a broad range of skills in molecular biology, immunology as well as experience with animal studies in mice and baboons. After completion of her PhD she changed fields accepting a post-doc position in Merlin Thomas’ laboratory at BakerIDI to begin research into Diabetic Complications. Here she gained experience with RAAS signalling and diabetic mouse models. For the past 8 years, most of her research has been focused on Angiotensin II signalling through the Angiotensin II type 1 receptor and Receptor for Advanced Glycation End products (RAGE) in atherosclerosis. Her recent work has described a new Angiotensin II signalling mechanism. Here she was able to demonstrate that the RAGE and the angiotensin II type 1 receptors are co-located, that the RAGE tail is transactivated leading to inflammation and that this signalling can be blocked. She is also interested in the role of this signalling pathway and RAGE in other diseases.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Molecular biology
- Immunology
- Diabetic Complications
- RAAS signalling
- Angiotensin II
- Receptor for Advanced Glycation End (RAGE) products
Network
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Inhaled oligonucleotides to generate a decoy receptor for the SARS Coronarvirus-2
Thomas, M., Wilton, S., McAuley, J. & Pickering, R.
1/06/20 → 28/02/21
Project: Research
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Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice
Pymm, P., Adair, A., Chan, L. J., Cooney, J. P., Mordant, F. L., Allison, C. C., Lopez, E., Haycroft, E. R., O'Neill, M. T., Tan, L. L., Dietrich, M. H., Drew, D., Doerflinger, M., Dengler, M. A., Scott, N. E., Wheatley, A. K., Gherardin, N. A., Venugopal, H., Cromer, D., Davenport, M. P. & 9 others, , 11 May 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 19, 12 p., e2101918118.Research output: Contribution to journal › Article › Research › peer-review
Open Access39 Citations (Scopus) -
Oxidative stress and inflammation in cardiovascular diseases
Pickering, R. J., Feb 2021, In: Antioxidants. 10, 2, 2 p., 171.Research output: Contribution to journal › Editorial › Other › peer-review
Open Access4 Citations (Scopus) -
Transient Intermittent Hyperglycemia Accelerates Atherosclerosis by Promoting Myelopoiesis
Flynn, M. C., Kraakman, M. J., Tikellis, C., Lee, M. K., Hanssen, N., Kammoun, H. L., Pickering, R., Dragoljevic, D., Al-Sharea, A., Barrett, T. J., Hortle, F., Byrne, F. L., Olzomer, E., McCarthy, D. A., Schalkwijk, C. G., Forbes, J. M., Hoehn, K., Makowski, L., Lancaster, G. I., El-Osta, A. & 6 others, , 11 Sep 2020, In: Circulation Research. 127, 7, p. 877-892 16 p.Research output: Contribution to journal › Article › Research › peer-review
34 Citations (Scopus) -
Transactivation of RAGE mediates angiotensin-induced inflammation and atherogenesis
Pickering, R. J., Tikellis, C., Rosado, C. J., Tsorotes, D., Dimitropoulos, A., Smith, M., Huet, O., Seeber, R. M., Abhayawardana, R., Johnstone, E. K. M., Golledge, J., Wang, Y., Jandeleit-Dahm, K. A., Cooper, M. E., Pfleger, K. D. G. & Thomas, M. C., 2 Jan 2019, In: Journal of Clinical Investigation. 129, 1, p. 406-421 16 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile39 Citations (Scopus) -
A novel synthetic small molecule DMFO targets Nrf2 in modulating proinflammatory/antioxidant mediators to ameliorate inflammation
Mathew, G., Sharma, A., Pickering, R. J., Rosado, C. J., Lemarie, J., Mudgal, J., Thambi, M., Sebastian, S., Jandeleit-Dahm, K. A., de Haan, J. B. & Unnikrishnan, M. K., 3 Oct 2018, In: Free Radical Research. 52, 10, p. 1140-1157 18 p.Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus)