Rachel Lee

Dr

20102019
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Research Output 2010 2019

2019

Characterization of the ERG-regulated Kinome in Prostate Cancer Identifies TNIK as a Potential Therapeutic Target

Lee, R. S., Zhang, L., Berger, A., Lawrence, M. G., Song, J., Niranjan, B., Davies, R. G., Lister, N. L., Sandhu, S. K., Rubin, M. A., Risbridger, G. P., Taylor, R. A., Rickman, D. S., Horvath, L. G. & Daly, R. J., 1 Apr 2019, In : Neoplasia (United States). 21, 4, p. 389-400 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation

Ma, X., Zhang, L., Song, J., Nguyen, E., Lee, R. S., Rodgers, S. J., Li, F., Huang, C., Schittenhelm, R. B., Chan, H., Chheang, C., Wu, J., Brown, K. K., Mitchell, C. A., Simpson, K. J. & Daly, R. J., 17 Jan 2019, In : Nature Communications. 10, 1, 16 p., 296.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2018

Impact of the anticancer drug nt157 on tyrosine kinase signaling networks

Su, S-P., Flashner-Abramson, E., Klein, S., Gal, M., Lee, R. S., Wu, J., Levitzki, A. & Daly, R. J., 1 May 2018, In : Molecular Cancer Therapeutics. 17, 5, p. 931-942 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Cell cycle and growth stimuli regulate different steps of RNA polymerase I transcription

Hung, S., Lesmana, A., Peck, A., Lee, R., Tchoubrieva, E., Hannan, K. M., Lin, J. I., Sheppard, K. E., Jastrzebski, K., Quinn, L. M., Rothblum, L. I., Pearson, R. B., Hannan, R. D. & Sanij, E., 15 May 2017, In : Gene. 612, p. 36-48 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Homo- and heterotypic association regulates signaling by the SgK269/PEAK1 and SgK223 pseudokinases

Liu, L., Phua, Y. W., Lee, R. S., Ma, X., Jenkins, Y., Novy, K., Humphrey, E. S., Chan, H., Shearer, R., Ong, P. C., Dai, W., Saunders, D. N., Lucet, I. S. & Daly, R. J., 7 Oct 2016, In : Journal of Biological Chemistry. 291, 41, p. 21571-21583 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy

Astle, M., Hannan, K., Ng, P., Lee, R., George, A., Hsu, A., Haupt, Y., Hannan, R. & Pearson, R., 2012, In : Oncogene. 31, 15, p. 1949 - 1962 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer

Chan, J., Hannan, K. M., Riddell, K., Ng, P. Y., Peck, A., Lee, R. S., Hung, S., Astle, M. V., Bywater, M., Wall, M., Poortinga, G., Jastrzebski, K., Sheppard, K. E., Hemmings, B. A., Hall, M. N., Johnstone, R. W., McArthur, G. A., Hannan, R. D. & Pearson, R. B., 2011, In : Science Signaling. 4, 188 (Art. No: ra56), p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Relative expression levels rather than specific activity plays the major role in determining in vivo AKT isoform substrate specificity

Lee, R. S., House, C. M., Cristiano, B., Hannan, R., Pearson, R. B. & Hannan, K., 2011, In : Enzyme Research. 2011, 720985, p. 1 - 18 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2010

Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation

Jabbour, A., Daunt, C. P., Green, B. D., Vogel, S., Gordon, L., Lee, R. S-H., Silke, N., Pearson, R. B., Vandenberg, C. J., Kelly, P., Nutt, S. L., Strasser, A., Borner, C. & Ekert, P. G., 2010, In : Blood. 115, 2, p. 344 - 352 9 p.

Research output: Contribution to journalArticleResearchpeer-review