20102021

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2019

Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X

Paudel, P., Zhang, Q., Leung, C., Greenberg, H. C., Guo, Y., Chern, Y. H., Dong, A., Li, Y., Vedadi, M., Zhuang, Z. & Tong, Y., 9 Apr 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 15, p. 7288-7297 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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8 Citations (Scopus)

RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2

Zhang, Q., McKenzie, N. J., Warneford-Thomson, R., Gail, E. H., Flanigan, S. F., Owen, B. M., Lauman, R., Levina, V., Garcia, B. A., Schittenhelm, R. B., Bonasio, R. & Davidovich, C., 4 Mar 2019, In : Nature Structural & Molecular Biology. 26, 3, p. 237-247 11 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)
2017

Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation

Gao, Y., Zhang, Q., Lang, Y., Liu, Y., Dong, X., Chen, Z., Tian, W., Tang, J., Wu, W., Tong, Y. & Chen, Z., Jun 2017, In : Journal of Molecular Cell Biology. 9, 3, p. 220-230 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

The substrate binding domains of human SIAH E3 ubiquitin ligases are now crystal clear

Zhang, Q., Wang, Z., Hou, M-F., Harding, R., Huang, X., Dong, A., Walker, J. R. & Tong, Y., Jan 2017, In : Biochimica et Biophysica Acta - General Subjects. 1861, 1, p. 3095-3105 11 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)
2016

Family-wide characterization of histone binding abilities of human CW domain-containing proteins

Liu, Y., Tempel, W., Zhang, Q., Liang, X., Loppnau, P., Qin, S. & Min, J., 22 Apr 2016, In : The Journal of Biological Chemistry. 291, 17, p. 9000-9013 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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23 Citations (Scopus)

Structural basis of the recruitment of ubiquitin-specific protease USP15 by spliceosome recycling factor SART3

Zhang, Q., Harding, R., Hou, F., Dong, A., Walker, J. R., Bteich, J. & Tong, Y., 12 Aug 2016, In : The Journal of Biological Chemistry. 291, 33, p. 17283-17292 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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12 Citations (Scopus)
2015

Mechanistic insights into metal ion activation and operator recognition by the ferric uptake regulator

Deng, Z., Wang, Q., Liu, Z., Zhang, M., Machado, A. C. D., Chiu, T. P., Feng, C., Zhang, Q., Yu, L., Qi, L., Zheng, J., Wang, X., Huo, X. M., Qi, X., Li, X., Wu, W., Rohs, R., Li, Y. & Chen, Z., 2 Jul 2015, In : Nature Communications. 6, 12 p., 7642.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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48 Citations (Scopus)

New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins

Zhang, Q., Fan, L., Hou, F., Dong, A., Wang, Y. X. & Tong, Y., 22 Oct 2015, In : Scientific Reports. 5, 13 p., 15660.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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16 Citations (Scopus)

Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation

Zheng, J., Lang, Y., Zhang, Q., Cui, D., Sun, H., Jiang, L., Chen, Z., Zhang, R., Gao, Y., Tian, W., Wu, W., Tang, J. & Chen, Z., 2015, In : Genes & Development. 29, 14, p. 1524-1534 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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35 Citations (Scopus)
2014

Crystal structures of the human RNA demethylase alkbh5 reveal basis for substrate recognition

Feng, C., Liu, Y., Wang, G., Deng, Z., Zhang, Q., Wu, W., Tong, Y., Cheng, C. & Chen, Z., 25 Apr 2014, In : The Journal of Biological Chemistry. 289, 17, p. 11571-11583 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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59 Citations (Scopus)

Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase

Deng, Z., Lehmann, K. C., Li, X., Feng, C., Wang, G., Zhang, Q., Qi, X., Yu, L., Zhang, X., Feng, W., Wu, W., Gong, P., Tao, Y., Posthuma, C. C., Snijder, E. J., Gorbalenya, A. E. & Chen, Z., 1 Mar 2014, In : Nucleic Acids Research. 42, 5, p. 3464-3477 14 p., gkt1310.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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19 Citations (Scopus)
2013

Crystallization and initial X-ray data of abscisic acid receptor PYL3 in the presence of (-)-ABA

Zhang, X., Zhang, Q. & Wang, G., May 2013, In : Acta Crystallographica. Section F: Structural Biology Communications. 69, 5, p. 540-543 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural Insights into the Abscisic Acid Stereospecificity by the ABA Receptors PYR/PYL/RCAR

Zhang, X., Jiang, L., Wang, G., Yu, L., Zhang, Q., Xin, Q., Wu, W., Gong, Z. & Chen, Z., 2 Jul 2013, In : PLoS ONE. 8, 7, 10 p., e67477.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
32 Citations (Scopus)

Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b

Zhang, Q., Qi, S., Xu, M., Yu, L., Tao, Y., Deng, Z., Wu, W., Li, J., Chen, Z. & Wong, J., Feb 2013, In : Cell Research. 23, 2, p. 225-241 17 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)
2012

Complex structures of the abscisic acid receptor PYL3/RCAR13 reveal a unique regulatory mechanism

Zhang, X., Zhang, Q., Xin, Q., Yu, L., Wang, Z., Wu, W., Jiang, L., Wang, G., Tian, W., Deng, Z., Wang, Y., Liu, Z., Long, J., Gong, Z. & Chen, Z., 9 May 2012, In : Structure. 20, 5, p. 780-790 11 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)
2010

Structural insights into a novel histone demethylase PHF8

Yu, L., Wang, Y., Huang, S., Wang, J., Deng, Z., Zhang, Q., Wu, W., Zhang, X., Liu, Z., Gong, W. & Chen, Z., Feb 2010, In : Cell Research. 20, 2, p. 166-173 8 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)