Projects per year
Personal profile
Biography
Dr Qi Zhang has a longstanding interest in the structure and function of epigenetic modifiers. She is a postdoctoral researcher in the Davidovich Lab at Monash University since 2016. Her current research focus is to understand fundamental mechanisms governing the regulation of epigenetic modifiers in gene silencing, with a particular interest in the histone methyltransferase Polycomb repressive complex 2 (PRC2). Before that, she was a postdoctoral fellow at the Structural Genomics Consortium, University of Toronto, studying the structure and function of ubiquitination complexes involved in stress response and gene regulation. She completed her PhD in 2013, at China Agricultural University, investigating the molecular mechanism of the regulation of a histone demethylase.
Dr Zhang currently holds an ARC DECRA Fellowship (2018-2020) and is a recipient of the NHMRC EL1 Investigator Grant (2021-2025).
Community service
Biomedicine Discovery Institute Early Career Researchers Committee (2019 - 2020)
- Chair, career development workshop sub-committee (2020)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Network
-
A universal platform for affinity purification of RNA
Zhang, Q., Davidovich, C., Knott, G. & Illing, P.
21/10/22 → 30/11/25
Project: Research
-
Rewriting the dogma of chromatin compaction: a new pathway for polycomb-mediated gene repression in development and disease
Davidovich, C., Uckelmann, M., Zhang, Q., de Marco, A. & Das, P.
1/01/22 → 31/12/24
Project: Research
-
Parallel Extended HDX system (Trajan Scientific and Medical)
Schittenhelm, R., Davidovich, C., Purcell, A., Ellisdon, A., Li, J., Aguilar, M., Cryle, M., Stone, M., Lithgow, T. & Zhang, Q.
1/10/21 → 31/12/22
Project: Research
-
Allosteric regulation of histone lysine methyltransferases: From context-specific regulation to selective drugs
Davidovich, C. & Zhang, Q., Apr 2021, In: Biochemical Society Transactions. 49, 2, p. 591-607 17 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access4 Citations (Scopus) -
PALI1 facilitates DNA and nucleosome binding by PRC2 and triggers an allosteric activation of catalysis
Zhang, Q., Agius, S. C., Flanigan, S. F., Uckelmann, M., Levina, V., Owen, B. M. & Davidovich, C., Dec 2021, In: Nature Communications. 12, 1, 18 p., 4592.Research output: Contribution to journal › Article › Research › peer-review
Open Access10 Citations (Scopus) -
Structural and functional characterization of ubiquitin variant inhibitors for the JAMM-family deubiquitinases STAMBP and STAMBPL1
Guo, Y., Liu, Q., Mallette, E., Caba, C., Hou, F., Fux, J., LaPlante, G., Dong, A., Zhang, Q., Zheng, H., Tong, Y. & Zhang, W., Oct 2021, In: Journal of Biological Chemistry. 297, 4, 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Citations (Scopus) -
Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X
Paudel, P., Zhang, Q., Leung, C., Greenberg, H. C., Guo, Y., Chern, Y. H., Dong, A., Li, Y., Vedadi, M., Zhuang, Z. & Tong, Y., 9 Apr 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 15, p. 7288-7297 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile30 Citations (Scopus) -
RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2
Zhang, Q., McKenzie, N. J., Warneford-Thomson, R., Gail, E. H., Flanigan, S. F., Owen, B. M., Lauman, R., Levina, V., Garcia, B. A., Schittenhelm, R. B., Bonasio, R. & Davidovich, C., 4 Mar 2019, In: Nature Structural & Molecular Biology. 26, 3, p. 237-247 11 p.Research output: Contribution to journal › Article › Research › peer-review
61 Citations (Scopus)