20102021

Research output per year

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Personal profile

Biography

Dr Qi Zhang has a longstanding interest in the structure and function of epigenetic modifiers. She is a postdoctoral researcher in the Davidovich Lab at Monash University since 2016. Her current research focus is to understand fundamental mechanisms governing the regulation of epigenetic modifiers in gene silencing, with a particular interest in the histone methyltransferase Polycomb repressive complex 2 (PRC2). Before that, she was a postdoctoral fellow at the Structure Genomics Consortium, University of Toronto, studying the structure and function of ubiquitination complexes involved in stress response and gene regulation. She completed her PhD in 2013, at China Agricultural University, investigating the molecular mechanism of the regulation of a histone demethylase.

Dr Zhang currently holds an ARC DECRA Fellowship (2018-2020) and is a recipient of the NHMRC EL1 Investigator Grant (2021-2025).

Community service

Biomedicine Discovery Institute Early Career Researchers Committee (2019 - 2020)

  • Chair, career development workshop sub-committee (2020)

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Projects

  • 2 Not started

Research Output

Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X

Paudel, P., Zhang, Q., Leung, C., Greenberg, H. C., Guo, Y., Chern, Y. H., Dong, A., Li, Y., Vedadi, M., Zhuang, Z. & Tong, Y., 9 Apr 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 15, p. 7288-7297 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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8 Citations (Scopus)

RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2

Zhang, Q., McKenzie, N. J., Warneford-Thomson, R., Gail, E. H., Flanigan, S. F., Owen, B. M., Lauman, R., Levina, V., Garcia, B. A., Schittenhelm, R. B., Bonasio, R. & Davidovich, C., 4 Mar 2019, In : Nature Structural & Molecular Biology. 26, 3, p. 237-247 11 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation

Gao, Y., Zhang, Q., Lang, Y., Liu, Y., Dong, X., Chen, Z., Tian, W., Tang, J., Wu, W., Tong, Y. & Chen, Z., Jun 2017, In : Journal of Molecular Cell Biology. 9, 3, p. 220-230 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

The substrate binding domains of human SIAH E3 ubiquitin ligases are now crystal clear

Zhang, Q., Wang, Z., Hou, M-F., Harding, R., Huang, X., Dong, A., Walker, J. R. & Tong, Y., Jan 2017, In : Biochimica et Biophysica Acta - General Subjects. 1861, 1, p. 3095-3105 11 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Family-wide characterization of histone binding abilities of human CW domain-containing proteins

Liu, Y., Tempel, W., Zhang, Q., Liang, X., Loppnau, P., Qin, S. & Min, J., 22 Apr 2016, In : The Journal of Biological Chemistry. 291, 17, p. 9000-9013 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
20 Citations (Scopus)