Projects per year
Personal profile
Biography
Dr Qi Zhang has a longstanding interest in the structure and function of epigenetic modifiers. She is a postdoctoral researcher in the Davidovich Lab at Monash University since 2016. Her current research focus is to understand fundamental mechanisms governing the regulation of epigenetic modifiers in gene silencing, with a particular interest in the histone methyltransferase Polycomb repressive complex 2 (PRC2). Before that, she was a postdoctoral fellow at the Structural Genomics Consortium, University of Toronto, studying the structure and function of ubiquitination complexes involved in stress response and gene regulation. She completed her PhD in 2013, at China Agricultural University, investigating the molecular mechanism of the regulation of a histone demethylase.
Dr Zhang currently holds an ARC DECRA Fellowship (2018-2020) and is a recipient of the NHMRC EL1 Investigator Grant (2021-2025).
Community service
Biomedicine Discovery Institute Early Career Researchers Committee (2019 - 2020)
- Chair, career development workshop sub-committee (2020)
Network
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Parallel Extended HDX system (Trajan Scientific and Medical)
Schittenhelm, R., Davidovich, C., Purcell, A., Ellisdon, A., Li, J., Aguilar, M., Cryle, M., Stone, M., Lithgow, T. & Zhang, Q.
1/10/21 → 31/12/22
Project: Research
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Allosteric regulation of histone lysine methyltransferases: From context-specific regulation to selective drugs
Davidovich, C. & Zhang, Q., Apr 2021, In: Biochemical Society Transactions. 49, 2, p. 591-607 17 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access3 Citations (Scopus) -
PALI1 facilitates DNA and nucleosome binding by PRC2 and triggers an allosteric activation of catalysis
Zhang, Q., Agius, S. C., Flanigan, S. F., Uckelmann, M., Levina, V., Owen, B. M. & Davidovich, C., Dec 2021, In: Nature Communications. 12, 1, 18 p., 4592.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Structural and functional characterization of ubiquitin variant inhibitors for the JAMM-family deubiquitinases STAMBP and STAMBPL1
Guo, Y., Liu, Q., Mallette, E., Caba, C., Hou, F., Fux, J., LaPlante, G., Dong, A., Zhang, Q., Zheng, H., Tong, Y. & Zhang, W., Oct 2021, In: Journal of Biological Chemistry. 297, 4, 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X
Paudel, P., Zhang, Q., Leung, C., Greenberg, H. C., Guo, Y., Chern, Y. H., Dong, A., Li, Y., Vedadi, M., Zhuang, Z. & Tong, Y., 9 Apr 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 15, p. 7288-7297 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile22 Citations (Scopus) -
RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2
Zhang, Q., McKenzie, N. J., Warneford-Thomson, R., Gail, E. H., Flanigan, S. F., Owen, B. M., Lauman, R., Levina, V., Garcia, B. A., Schittenhelm, R. B., Bonasio, R. & Davidovich, C., 4 Mar 2019, In: Nature Structural & Molecular Biology. 26, 3, p. 237-247 11 p.Research output: Contribution to journal › Article › Research › peer-review
53 Citations (Scopus)