19972019
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Research Output 1997 2019

2019

Amphiphilic surface chemistry of fullerenols is necessary for inhibiting the amyloid aggregation of alpha-synuclein NACore

Sun, Y., Kakinen, A., Zhang, C., Yang, Y., Faridi, A., Davis, T. P., Cao, W., Ke, P. C. & Ding, F., 28 Jun 2019, In : Nanoscale. 11, 24, p. 11933-11945 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Amyloid Self-Assembly of hIAPP8-20 via the Accumulation of Helical Oligomers, α-Helix to β-Sheet Transition, and Formation of β-Barrel Intermediates

Sun, Y., Kakinen, A., Xing, Y., Faridi, P., Nandakumar, A., Purcell, A. W., Davis, T. P., Ke, P. C. & Ding, F., May 2019, In : Small. 15, 18, 10 p., 1805166.

Research output: Contribution to journalArticleResearchpeer-review

Mitigation of Amyloidosis with Nanomaterials

Ke, P. C., Pilkington, E. H., Sun, Y., Javed, I., Kakinen, A., Peng, G., Ding, F. & Davis, T. P., 11 Jun 2019, (Accepted/In press) In : Advanced Materials. 7 p., 1901690.

Research output: Contribution to journalReview ArticleResearchpeer-review

Nucleation of β-rich oligomers and β-barrels in the early aggregation of human islet amyloid polypeptide

Sun, Y., Kakinen, A., Xing, Y., Pilkington, E. H., Davis, T. P., Ke, P. C. & Ding, F., 1 Feb 2019, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1865, 2, p. 434-444 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Physical and toxicological profiles of human IAPP amyloids and plaques

Kakinen, A., Sun, Y., Javed, I., Faridi, A., Pilkington, E. H., Faridi, P., Purcell, A. W., Zhou, R., Ding, F., Lin, S., Ke, P. C. & Davis, T. P., 15 Jan 2019, In : Science Bulletin. 64, 1, p. 26-35 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Probing the Aggregation and Immune Response of Human Islet Amyloid Polypeptides with Ligand-Stabilized Gold Nanoparticles

Javed, I., He, J., Kakinen, A., Faridi, A., Yang, W., Davis, T. P., Ke, P. C. & Chen, P., 20 Mar 2019, In : ACS Applied Materials and Interfaces. 11, 11, 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and identification of novel pryidazinylpyrazolone based diazo compounds as inhibitors of human islet amyloid polypeptide aggregation

Bin Farrukh, S. U., Javed, I., Ather, A. Q., Emwas, A-H., Alazmi, M., Gao, X., Chotana, G. A., Davis, T. P., Ke, P. C. & Saleem, R. S. Z., Mar 2019, In : Bioorganic Chemistry. 84, p. 339-346 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Graphene quantum dots against human IAPP aggregation and toxicity in vivo

Wang, M., Sun, Y., Cao, X., Peng, G., Javed, I., Kakinen, A., Davis, T. P., Lin, S., Liu, J., Ding, F. & Ke, P. C., 14 Nov 2018, In : Nanoscale. 10, 42, p. 19995-20006 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Human plasma proteome association and cytotoxicity of nano-graphene oxide grafted with stealth polyethylene glycol and poly(2-ethyl-2-oxazoline)

Wang, M., Gustafsson, O. J. R., Siddiqui, G., Javed, I., Kelly, H. G., Blin, T., Yin, H., Kent, S. J., Creek, D. J., Kempe, K., Ke, P. C. & Davis, T. P., 21 Jun 2018, In : Nanoscale. 10, 23, p. 10863-10875 13 p.

Research output: Contribution to journalArticleResearchpeer-review

In Vivo Mitigation of Amyloidogenesis through Functional-Pathogenic Double-Protein Coronae

Javed, I., Yu, T., Peng, G., Sánchez-Ferrer, A., Faridi, A., Kakinen, A., Zhao, M., Mezzenga, R., Davis, T. P., Lin, S. & Ke, P. C., 12 Sep 2018, In : Nano Letters. 18, 9, p. 5797-5804 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Mitigating Human IAPP Amyloidogenesis In Vivo with Chiral Silica Nanoribbons

Faridi, A., Sun, Y., Okazaki, Y., Peng, G., Gao, J., Kakinen, A., Faridi, P., Zhao, M., Javed, I., Purcell, A. W., Davis, T. P., Lin, S., Oda, R., Ding, F. & Ke, P. C., 22 Nov 2018, In : Small. 14, 47, 13 p., 1802825.

Research output: Contribution to journalArticleResearchpeer-review

Nanoparticle-Proteome In Vitro and In Vivo

Wang, M., Gustafsson, O. J. R., Pilkington, E. H., Kakinen, A., Javed, I., Faridi, A., Davis, T. P. & Ke, P. C., 1 Jan 2018, In : Journal of Materials Chemistry B. 6, 38, p. 6026-6041 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Nanoscale inhibition of polymorphic and ambidextrous IAPP amyloid aggregation with small molecules

Kakinen, A., Adamcik, J., Wang, B., Ge, X., Mezzenga, R., Davis, T. P., Ding, F. & Ke, P. C., Jul 2018, In : Nano Research. 11, 7, p. 3636-3647 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Profiling the Serum Protein Corona of Fibrillar Human Islet Amyloid Polypeptide

Pilkington, E. H., Gustafsson, O. J. R., Xing, Y., Hernandez-Fernaud, J., Zampronio, C., Kakinen, A., Faridi, A., Ding, F., Wilson, P., Ke, P. C. & Davis, T. P., 26 Jun 2018, In : ACS Nano. 12, 6, p. 6066-6078 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Serum albumin impedes the amyloid aggregation and hemolysis of human islet amyloid polypeptide and alpha synuclein

Kakinen, A., Javed, I., Faridi, A., Davis, T. P. & Ke, P. C., Sep 2018, In : Biochimica et Biophysica Acta - Biomembranes. 1860, 9, p. 1803-1809 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Understanding Effects of PAMAM Dendrimer Size and Surface Chemistry on Serum Protein Binding with Discrete Molecular Dynamics Simulations

Wang, B., Sun, Y., Davis, T. P., Ke, P. C., Wu, Y. & Ding, F., 4 Sep 2018, In : ACS Sustainable Chemistry & Engineering. 6, 9, p. 11704-11715 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Uptake and transcytosis of functionalized superparamagnetic iron oxide nanoparticles in an: In vitro blood brain barrier model

Ivask, A., Pilkington, E. H., Blin, T., Käkinen, A., Vija, H., Visnapuu, M., Quinn, J. F., Whittaker, M. R., Qiao, R., Davis, T. P., Ke, P. C. & Voelcker, N. H., 1 Feb 2018, In : Biomaterials Science. 6, 2, p. 314-323 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

A Decade of the Protein Corona

Ke, P. C., Lin, S., Parak, W. J., Davis, T. P. & Caruso, F., 26 Dec 2017, In : ACS Nano. 11, 12, p. 11773-11776 4 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Brushed Polyethylene Glycol and Phosphorylcholine as Promising Grafting Agents against Protein Binding

Wang, B., Blin, T., Kakinen, A., Ge, X., Pilkington, E. H., Quinn, J., Whittaker, M. R., Davis, T. P., Ke, P. C. & Ding, F., 3 Feb 2017, In : Biophysical Journal. 112, 3

Research output: Contribution to journalLetterOtherpeer-review

Cofibrillization of Pathogenic and Functional Amyloid Proteins with Gold Nanoparticles against Amyloidogenesis

Javed, I., Sun, Y., Adamcik, J., Wang, B., Kakinen, A., Pilkington, E. H., Ding, F., Mezzenga, R., Davis, T. P. & Ke, P. C., 11 Dec 2017, In : Biomacromolecules. 18, 12, p. 4316-4322 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Differential effects of silver and iron oxide nanoparticles on IAPP amyloid aggregation

Wang, M., Kakinen, A., Pilkington, E. H., Davis, T. P. & Ke, P-C., 1 Mar 2017, In : Biomaterials Science. 5, 3, p. 485-493 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of protein corona on IAPP amyloid aggregation, fibril remodelling, and cytotoxicity

Pilkington, E. H., Xing, Y., Wang, B., Kakinen, A., Wang, M., Davis, T. P., Ding, F. & Ke, P-C., 1 Dec 2017, In : Scientific Reports. 7, 1, 13 p., 2455.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Implications of peptide assemblies in amyloid diseases

Ke, P. C., Sani, M. A., Ding, F., Kakinen, A., Javed, I., Separovic, F., Davis, T. P. & Mezzenga, R., 7 Nov 2017, In : Chemical Society Reviews. 46, 21, p. 6492-6531 40 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Lysophosphatidylcholine modulates the aggregation of human islet amyloid polypeptide

Xing, Y., Pilkington, E. H., Wang, M., Nowell, C. J., Kakinen, A., Sun, Y., Wang, B., Davis, T. P., Ding, F. & Ke, P. C., 7 Dec 2017, In : Physical Chemistry Chemical Physics. 19, 45, p. 30627-30635 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Modulating protein amyloid aggregation with nanomaterials

Wang, B., Pilkington, E. H., Sun, Y., Davis, T. P. T., Ke, P. C. & Ding, F., 1 Sep 2017, In : Environmental Science: Nano. 4, 9, p. 1772-1783 12 p.

Research output: Contribution to journalArticleResearchpeer-review

NanoEHS beyond toxicity-focusing on biocorona

Lin, S., Mortimer, M., Chen, R., Kakinen, A., Riviere, J. E., Davis, T. P., Ding, F. & Ke, P-C., 2017, In : Environmental Science: Nano. 4, 7, p. 1433-1454 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Plasma Proteome Association and Catalytic Activity of Stealth Polymer-Grafted Iron Oxide Nanoparticles

Wang, M., Siddiqui, G., Gustafsson, O. J. R., Käkinen, A., Javed, I., Voelcker, N. H., Creek, D. J., Ke, P. C. & Davis, T. P., 27 Sep 2017, In : Small. 13, 36, 1701528.

Research output: Contribution to journalArticleResearchpeer-review

Poly(2-oxazoline)-based micro- and nanoparticles: a review

Wilson, P., Ke, P. C., Davis, T. P. & Kempe, K., 1 Mar 2017, In : European Polymer Journal. 88, p. 486-515 30 p.

Research output: Contribution to journalArticleResearchpeer-review

Star Polymers Reduce Islet Amyloid Polypeptide Toxicity via Accelerated Amyloid Aggregation

Pilkington, E. H., Lai, M., Ge, X., Stanley, W. J., Wang, B., Wang, M., Kakinen, A., Sani, M-A., Whittaker, M. R., Gurzov, E. N., Ding, F., Quinn, J., Davis, T. P. & Ke, P. C., 11 Dec 2017, In : Biomacromolecules. 18, 12, p. 4249-4260 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Zinc-coordination and C-peptide complexation: A potential mechanism for the endogenous inhibition of IAPP aggregation

Ge, X., Kakinen, A., Gurzov, E. N., Yang, W., Pang, L., Pilkington, E. H., Nedumpully-Govindan, P., Chen, P., Separovic, F., Davis, T. P., Ke, P. C. & Ding, F., 2017, In : Chemical Communications. 53, 68, p. 9394-9397 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Brushed polyethylene glycol and phosphorylcholine for grafting nanoparticles against protein binding

Wang, B., Blin, T., Kakinen, A., Ge, X., Pilkington, E. H., Quinn, J. F., Whittaker, M. R., Davis, T. P., Ke, P. C. & Ding, F., 7 Dec 2016, In : Polymer Chemistry. 7, 45, p. 6875-6879 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Determining the size exclusion for nanoparticles in citrus leaves

Etxeberria, E., Gonzalez, P., Bhattacharya, P., Sharma, P. & Ke, P-C., 1 Jun 2016, In : HortScience. 51, 6, p. 732-737 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Fate, Behavior, and Biophysical Modeling of Nanoparticles in Living Systems

Salonen, E., Ding, F. & Ke, P. C., 19 Sep 2016, Engineered Nanoparticles and the Environment: Biophysicochemical Processes and Toxicity. Xing, B., C. D. V. & Senesi, N. (eds.). Hoboken NJ USA: John Wiley & Sons, p. 295-313 19 p. (Series in Biophysico-Chemical Processes in Environmental Systems).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Open Access
File

Graphene oxide inhibits hIAPP amyloid fibrillation and toxicity in insulin-producing NIT-1 cells

Nedumpully-Govindan, P., Gurzov, E., Chen, P., Pilkington, E. H., Stanley, W. J., Litwak, S. A., Davis, T. P., Ke, P. C. & Ding, F., 2016, In : Physical Chemistry Chemical Physics. 18, 1, p. 94-100 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of hIAPP amyloid aggregation and pancreatic β-cell toxicity by OH-terminated PAMAM dendrimer

Gurzov, E., Wang, B., Pilkington, E. H., Chen, P., Kakinen, A., Stanley, W. J., Litwak, S. A., Hanssen, E. G., Davis, T. P., Ding, F. & Ke, P. C., 23 Mar 2016, In : Small. 12, 12, p. 1615-1626 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Pancreatic β-cell membrane fluidity and toxicity induced by human islet amyloid polypeptide species

Pilkington, E. H., Gurzov, E., Kakinen, A., Litwak, S. A., Stanley, W. J., Davis, T. P. & Ke, P. C., 2016, In : Scientific Reports. 6, p. 1-10 10 p., 21274.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Stabilizing off-pathway oligomers by polyphenol nanoassemblies for IAPP aggregation inhibition

Nedumpully-Govindan, P., Kakinen, A., Pilkington, E. H., Davis, T. P., Ke, P. C. & Ding, F., 2016, In : Scientific Reports. 6, p. 1-12 12 p., 19463.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Synthesis and in vitro properties of iron oxide nanoparticles grafted with brushed phosphorylcholine and polyethylene glycol

Blin, T., Kakinen, A., Pilkington, E. H., Ivask, A., Ding, F., Quinn, J., Whittaker, M. R., Ke, P. C. & Davis, T. P., 2016, In : Polymer Chemistry. 7, 10, p. 1931-1944 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

A thermodynamics model for the emergence of a stripe-like binary SAM on a nanoparticle surface

Ge, X., Ke, P. C., Davis, T. P. & Ding, F., 2015, In : Small. 11, 37, p. 4894-4899 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Contrasting effects of nanoparticle-protein attraction on amyloid aggregation

Radic, S., Davis, T. P., Ke, P. C. & Ding, F., 2015, In : RSC Advances. 5, 127, p. 105489-105498 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Deviation from the unimolecular micelle paradigm of PAMAM dendrimers induced by strong interligand interactions

Wang, B., Geitner, N. K., Davis, T. P., Ke, P. C., Ladner, D. A. & Ding, F., 2015, In : Journal of Physical Chemistry C. 119, 33, p. 19475-19484 10 p.

Research output: Contribution to journalArticleResearchpeer-review

DNA melting and genotoxicity induced by silver nanoparticles and graphene

Ivask, A., Voelcker, N., Seabrook, S. A., Hor, M., Kirby, J. K., Fenech, M. F., Davis, T. P. & Ke, P. C., 2015, In : Chemical Research in Toxicology. 28, 5, p. 1023-1035 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Formation of a protein corona on silver nanoparticles mediates cellular toxicity via scavenger receptors

Shannahan, J. H., Podila, R., Aldossari, A. A., Emerson, H. P., Powell, B. A., Ke, P. C., Rao, A. M. & Brown, J. M., 1 Jan 2015, In : Toxicological Sciences. 143, 1, p. 136-146 11 p.

Research output: Contribution to journalArticleResearchpeer-review

PAMAM dendrimers and graphene: materials for removing aromatic contaminants from water

DeFever, R. S., Geitner, N. K., Bhattacharya, P., Ding, F., Ke, P. C. & Sarupria, S., 2015, In : Environmental Science and Technology. 49, 7, p. 4490-4497 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Reducing the cytotoxicity of ZnO nanoparticles by a pre-formed protein corona in a supplemented cell culture medium

Yin, H., Chen, R., Casey, P. S., Ke, P. C., Davis, T. P. & Chen, C., 2015, In : RSC Advances. 5, 90, p. 73963-73973 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Thermostability and reversibility of silver nanoparticle-protein binding

Wang, B., Seabrook, S. A., Nedumpully-Govindan, P., Chen, P., Yin, H., Waddington, L. J., Epa, V. C., Winkler, D. A., Kirby, J. K., Ding, F. & Ke, P. C., 2015, In : Physical Chemistry Chemical Physics. 17, 3, p. 1728-1739 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Contrasting effects of nanoparticle binding on protein denaturation

Chen, P., Seabrook, S. A., Epa, V. C., Kurabayashi, K., Barnard, A. S., Winkler, D. A., Kirby, J. K. & Ke, P. C., 2014, In : Journal of Physical Chemistry C. 118, 38, p. 22069 - 22078 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of fullerenol surface chemistry on nanoparticle binding-induced protein misfolding

Radic, S., Nedumpully-Govindan, P., Chen, R., Salonen, E., Brown, J. M., Ke, P. C. & Ding, F., 21 Jul 2014, In : Nanoscale. 6, 14, p. 8340-8349 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure-function relationship of PAMAM dendrimers as robust oil dispersants

Geitner, N. K., Wang, B., Andorfer, R. E., Ladner, D. A., Ke, P. C. & Ding, F., 4 Nov 2014, In : Environmental Science and Technology. 48, 21, p. 12868-12875 8 p.

Research output: Contribution to journalArticleResearchpeer-review