Projects per year
Personal profile
Biography
I obtained my PhD in Medical Microbiology from University of Malaya. My PhD thesis focused on studying the temporal dynamics of the gut microbiome and metabolome in preterm neonates. Along the way, I also characterised multidrug-resistant bacteria isolated from these neonates using microbial genomic methods.
In 2021, I joined Monash University Malaysia on a postdoctoral fellowship to investigate the One Health genomic transmission dynamics of multidrug-resistant Gram-negative bacteria. I work on isolates from clinical, water, soil samples, healthy Malaysians, and the indigenous (Orang Asli) population. This has enabled me to adopt a multidisciplinary approach, integrating microbiology, microbial genomics, microbiomes, health, and dietary data to explore complex interactions between environmental and human health factors, particularly identifying bacterial and antimicrobial resistance (AMR) transmission patterns for targeted intervention.
Since 2022, I have also served as the point of contact and principal investigator for an international partnership focused on enhancing capacity building to strengthen viral infection surveillance in low- and middle-income countries (LMICs) through portable Oxford Nanopore sequencing technologies. This initiative aims to improve local deployment of advanced sequencing techniques for monitoring emerging viral pathogens, fostering collaboration and skills development across LMICs in pandemic preparedness.
Research interests
Trained as a medical microbiologist, I combine culture-based methods with advanced sequencing approaches to strengthen pathogen detection and surveillance - critical foundations for preventing the next pandemic and slowing ongoing ones such as AMR. I apply both agnostic and semi-agnostic sequencing techniques to generate viral and bacterial sequencing data that aimed for targeted interventions and better antimicrobial stewardship. In addition, I am committed to building sustainable local research capacity through international collaborations and effective skills transfer.
Research Interest and Area of Expertise
- Medical Microbiology – NGS of clinically important pathogens; Antimicrobial Resistance; Molecular Genomics; Molecular Epidemiology
- Urban and Rural Health – Gut microbiome; One Health; Neglected tropical diseases
- Omics Technologies – Metagenomics and Metabolomics
Community service
Beyond research, I am passionate about evidence-based policy, where I believe scientific knowledge can help improving policy and decision-making. I am actively involved in the Young Scientists Network-Academy of Sciences Malaysia (YSN-ASM), where we aim to increase the involvement of young scientists in STIE (Science, Technology, Innovation, and Economy) policies. I am also a Lesson Leader of One Health Lessons, taking on a mission to get every child on the planet caring about One Health.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medical Microbiology, PhD, Universiti Malaya (University of Malaya)
Research area keywords
- Microbial genomics
- Infectious disease genomics
- Metagenomics
- Oxford Nanopore Sequencing
- Gut microbiome
- Multidrug-Resistant Pathogens
- Antimicrobial Resistance
- Metabolomics
- One Health
Collaborations and top research areas from the last five years
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Assessment of Antimicrobial Resistance Genes in Malaysian Wastewater Treatment Plants: Prevalence, Removal Efficiency, and Transmission Risks.
Hock Siew, T. (Primary Chief Investigator (PCI)), Yap, P. (Chief Investigator (CI)) & Ayub, Q. (Chief Investigator (CI))
1/08/25 → 31/07/26
Project: Research
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Comparison of Faecal Microbial Composition and Microbial Activities After Protein and/or Probiotics Supplementation in an ex vivo fermentation model
Chun Wie, C. (Primary Chief Investigator (PCI)), Asnawi, S. (Chief Investigator (CI)), Yap, P. (Chief Investigator (CI)), Cheen, S. (Chief Investigator (CI)) & Lim, W. M. (Chief Investigator (CI))
15/04/25 → 14/04/26
Project: Research
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Effect of Alcohol Consumption on the Gut Microbiota and the Potential Protective Effects of Probiotics on Alcohol: An Ex Vivo Experiment
Chun Wie, C. (Primary Chief Investigator (PCI)), Yap, P. (Chief Investigator (CI)) & Cheen, S. (Chief Investigator (CI))
1/04/25 → 30/04/26
Project: Research
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Deployment of a Highly Multiplexed Sequencing Based Human Disease Panel for Novel Pathogen Detection - Phase II
Yap, P. (Primary Chief Investigator (PCI)), SyedHassan, S. (Chief Investigator (CI)), Fang, N. C. (Chief Investigator (CI)) & Dhanoa, A. (Chief Investigator (CI))
1/10/23 → 10/12/24
Project: Research
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Deployment of a Highly Multiplexed Sequencing Based Human Disease Panel for Novel Pathogen Detection
Yap, P. (Primary Chief Investigator (PCI)), SyedHassan, S. (Chief Investigator (CI)), Fang, N. C. (Chief Investigator (CI)) & Dhanoa, A. (Chief Investigator (CI))
30/07/22 → 14/07/23
Project: Research
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A Landscape View of the Female Genital Tract Microbiome in Healthy Controls and Women With Reproductive Health Conditions Associated With Ectopic Pregnancy
Teh, H. E., Pung, C. K., Arasoo, V. J. T. & Yap, P. S. X., 12 Jan 2024, In: British Journal of Biomedical Science. 80, 23 p., 12098.Research output: Contribution to journal › Review Article › Research › peer-review
Open AccessFile6 Citations (Scopus) -
Plasmid-Mediated Co-Occurrence of mcr-1.1 in Extended-Spectrum β-Lactamase (ESBL)-Producing Escherichia coli Isolated From the Indigenous Seminomadic Community in Malaysia
Yap, P. S. X., Yeo, L. F., Teh, C. S. J., Dhanoa, A. & Phipps, M. E., 9 Oct 2024, In: Transboundary and Emerging Diseases. 2024, 1, 11 p., 9223696.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
A multicentre study to determine the in vitro efficacy of flomoxef against extended-spectrum beta-lactamase producing Escherichia coli in Malaysia
Yap, P. S. X., Chong, C. W., Ponnampalavanar, S., Ramli, R., Harun, A., Jamaluddin, T. Z. M. T., Khan, A. A., Ngoi, S. T., Lee, Y. Q., Lau, M. Y., Tan, S. C., Kong, Z. X., Woon, J. J., Mak, S. T., Jabar, K. A., Karunakaran, R., Ismail, Z., Salleh, S. A., Noor, S. S. M. & Masri, S. N. & 7 others, , 28 Nov 2023, In: PeerJ. 11, 18 p., e16393.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile1 Citation (Scopus) -
Microbial Genomics: Innovative Targets and Mechanisms
Alkatheri, A. H., Yap, P. S. X., Abushelaibi, A., Lai, K. S., Cheng, W. H. & Erin Lim, S. H., Feb 2023, In: Antibiotics. 12, 2, 24 p., 190.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access18 Citations (Scopus) -
Anti- and pro-oxidant properties of essential oils against antimicrobial resistance
Kong, A.S.-Y., Maran, S., Yap, P.S.-X., Lim, S.-H. E., Yang, S.-K., Cheng, W.-H., Tan, Y.-H. & Lai, K.-S., Sept 2022, In: Antioxidants. 11, 9, 12 p., 1819.Research output: Contribution to journal › Review Article › Research › peer-review
Open AccessFile31 Citations (Scopus)
Prizes
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Affiliate (Young Scientist Network-Academy of Sciences Malaysia)
Yap, P. (Recipient), 2023
Prize: Election to learned society
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Best e-poster presentation entitled Enhancing Medical Students’ Understanding of Basic Immunology through Innovative Approaches
SyedHassan, S. (Recipient), Radhakrishnan, A. (Recipient), Pillai, B. S. B. (Recipient), Pallath, V. (Recipient), Balasubramaniam, V. (Recipient), Naidu, R. (Recipient), Yap, P. (Recipient), Ming, L. W. (Recipient) & Abdul Kadar, N. (Recipient), 2024
Prize: Prize (including medals and awards)
File -
Best Oral Presenter - 2nd runner up
Yap, P. (Recipient), 2022
Prize: Prize (including medals and awards)
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Best Poster Award at 15th Ministry of Health (MOH)-Academy of Medicine Malaysia (AMM) Scientific Meeting 2024
Yap, P. (Recipient), Fang, N. C. (Recipient), Dhanoa, A. (Recipient) & SyedHassan, S. (Recipient), 22 Aug 2024
Prize: Prize (including medals and awards)
File -
Member (Young Scientists Network - Academy of Sciences Malaysia)
Yap, P. (Recipient), 2025
Prize: Election to learned society
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Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene
Yap, P. (Speaker) & Yap, P. (Session chair)
13 Nov 2024 → 17 Nov 2024Activity: Participating in or organising an event types › Contribution to conference
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British Journal of Biomedical Science (Journal)
Yap, P. (Guest editor)
14 Jul 2023 → 15 Mar 2024Activity: Publication peer-review and editorial work types › Editorial responsibility
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PLoS ONE (Journal)
Yap, P. (Peer reviewer)
2022Activity: Publication peer-review and editorial work types › Peer review responsibility
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Scientific Reports (Journal)
Yap, P. (Peer reviewer)
2022 → 2023Activity: Publication peer-review and editorial work types › Peer review responsibility