Projects per year
Personal profile
Biography
I obtained my PhD in Medical Microbiology from University of Malaya. My PhD thesis focused on studying the temporal dynamics of the gut microbiome and metabolome in preterm neonates. Along the way, I also characterised multidrug-resistant bacteria isolated from these neonates using microbial genomic methods.
In 2021, I joined Monash University Malaysia on a postdoctoral fellowship to investigate the One Health genomic transmission dynamics of multidrug-resistant Gram-negative bacteria. I work on isolates from clinical, water, soil samples, healthy Malaysians, and the indigenous (Orang Asli) population. This has enabled me to adopt a multidisciplinary approach, integrating microbiology, microbial genomics, microbiomes, health, and dietary data to explore complex interactions between environmental and human health factors, particularly how diet and exposure to different ecosystems influence bacterial transmission and antimicrobial resistance patterns.
Since 2022, I have also served as the point of contact and principal investigator for an international partnership focused on enhancing capacity building to strengthen viral infection surveillance in low- and middle-income countries (LMICs) through portable sequencing technologies. This initiative aims to improve the rapid detection and monitoring of viral pathogens, fostering collaboration and skill development across LMICs.
Research interests
Since my PhD work revealed early-life carriage of multidrug-resistant bacteria among preterm neonates, characterised by significant gut microbial changes, my research has focused on infectious diseases and the human microbiome. Recognising the critical need for enhanced pandemic preparedness, especially in Southeast Asia—a hotspot for emerging infectious diseases (EID) and antimicrobial resistance (AMR) - I have placed particular emphasis on enhancing rapid detection and surveillance of emerging pathogens using sequencing-based techniques, with an aim to guide better stewardship and interventions. Additionally, I am committed to enhancing local research capacity through international collaborations and effective skills transfer.
Research Interest and Area of Expertise
- Medical Microbiology – NGS of clinically important pathogens; Antimicrobial Resistance; Molecular Genomics; Molecular Epidemiology
- Urban and Rural Health – Gut microbiome; One Health; Neglected tropical diseases
- Omics Technologies – Metagenomics and Metabolomics
- Natural products – Drug discovery; Reversal of antimicrobial resistance and mechanism
Community service
Beyond research, I am passionate about science policy, science communication and science leadership. I am actively involved in the Young Scientists Network-Academy of Sciences Malaysia (YSN-ASM), particularly the Science Leadership working group, where I'm excited to nurture the new generation of young scientists, inspiring them to contribute to society. I am also a Lesson Leader of One Health Lessons, taking on a mission to get every child on the planet caring about One Health.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medical Microbiology, PhD, Universiti Malaya (University of Malaya)
Research area keywords
- Microbial genomics
- Infectious disease genomics
- Metagenomics
- Oxford Nanopore Sequencing
- Gut microbiome
- Multidrug-Resistant Pathogens
- Antimicrobial Resistance
- Metabolomics
- One Health
Collaborations and top research areas from the last five years
Projects
- 2 Finished
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Deployment of a Highly Multiplexed Sequencing Based Human Disease Panel for Novel Pathogen Detection - Phase II
Yap, P., SyedHassan, S., Fang, N. C. & Dhanoa, A.
1/10/23 → 10/09/24
Project: Research
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Deployment of a Highly Multiplexed Sequencing Based Human Disease Panel for Novel Pathogen Detection
Yap, P., SyedHassan, S., Fang, N. C. & Dhanoa, A.
30/07/22 → 14/07/23
Project: Research
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A Landscape View of the Female Genital Tract Microbiome in Healthy Controls and Women With Reproductive Health Conditions Associated With Ectopic Pregnancy
Teh, H. E., Pung, C. K., Arasoo, V. J. T. & Yap, P. S. X., 12 Jan 2024, In: British Journal of Biomedical Science. 80, 23 p., 12098.Research output: Contribution to journal › Review Article › Research › peer-review
Open AccessFile1 Citation (Scopus) -
A multicentre study to determine the in vitro efficacy of flomoxef against extended-spectrum beta-lactamase producing Escherichia coli in Malaysia
Yap, P. S. X., Chong, C. W., Ponnampalavanar, S., Ramli, R., Harun, A., Jamaluddin, T. Z. M. T., Khan, A. A., Ngoi, S. T., Lee, Y. Q., Lau, M. Y., Tan, S. C., Kong, Z. X., Woon, J. J., Mak, S. T., Jabar, K. A., Karunakaran, R., Ismail, Z., Salleh, S. A., Noor, S. S. M., Masri, S. N., & 7 others , 28 Nov 2023, In: PeerJ. 11, 18 p., e16393.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile1 Citation (Scopus) -
Microbial Genomics: Innovative Targets and Mechanisms
Alkatheri, A. H., Yap, P. S. X., Abushelaibi, A., Lai, K. S., Cheng, W. H. & Erin Lim, S. H., Feb 2023, In: Antibiotics. 12, 2, 24 p., 190.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access4 Citations (Scopus) -
Anti- and pro-oxidant properties of essential oils against antimicrobial resistance
Kong, A. S-Y., Maran, S., Yap, P. S-X., Lim, S-H. E., Yang, S-K., Cheng, W-H., Tan, Y-H. & Lai, K-S., Sept 2022, In: Antioxidants. 11, 9, 12 p., 1819.Research output: Contribution to journal › Review Article › Research › peer-review
Open AccessFile14 Citations (Scopus) -
Host–bacterial interactions: Outcomes of antimicrobial peptide applications
Alkatheri, A. H., Yap, P. S-X., Abushelaibi, A., Lai, K-S., Cheng, W-H. & Lim, S-H. E., Jul 2022, In: Membranes. 12, 7, 21 p., 715.Research output: Contribution to journal › Review Article › Research › peer-review
Open AccessFile4 Citations (Scopus)
Prizes
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Best Oral Presenter - 2nd runner up
Yap, Polly (Recipient), 2022
Prize: Prize (including medals and awards)
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Young Scientist Network-Academy of Sciences Malaysia (YSN-ASM)
Yap, Polly (Recipient), 2023
Prize: Election to learned society
Activities
- 2 Peer review responsibility
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Scientific Reports (Journal)
Polly Yap (Peer reviewer)
2022 → 2023Activity: Publication peer-review and editorial work types › Peer review responsibility
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PLoS ONE (Journal)
Polly Yap (Peer reviewer)
2022Activity: Publication peer-review and editorial work types › Peer review responsibility