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Research Output 2010 2019

2019

A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity

Ooi, J. D., Jiang, J-H., Eggenhuizen, P. J., Chua, L. L., van Timmeren, M., Loh, K. L., O’Sullivan, K. M., Gan, P. Y., Zhong, Y., Tsyganov, K., Shochet, L. R., Ryan, J., Stegeman, C. A., Fugger, L., Reid, H. H., Rossjohn, J., Heeringa, P., Holdsworth, S. R., Peleg, A. Y. & Kitching, A. R., 29 Jul 2019, In : Nature Communications. 10, 1, 14 p., 3392.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Natural killer cell function predicts severe infection in kidney transplant recipients

Dendle, C., Gan, P. Y., Polkinghorne, K. R., Ngui, J., Stuart, R. L., Kanellis, J., Thursky, K., Mulley, W. R. & Holdsworth, S., 1 Jan 2019, In : American Journal of Transplantation. 19, 1, p. 166-177 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

C5a receptor 1 promotes autoimmunity, neutrophil dysfunction and injury in experimental anti-myeloperoxidase glomerulonephritis

Dick, J., Gan, P. Y., Ford, S. L., Odobasic, D., Alikhan, M. A., Loosen, S. H., Hall, P., Westhorpe, C. L., Li, A., Ooi, J. D., Woodruff, T. M., Mackay, C. R., Kitching, A. R., Hickey, M. J. & Holdsworth, S. R., 1 Mar 2018, In : Kidney International. 93, 3, p. 615-625 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Measurement of Humoral Immune Competence and the Risk of Sinopulmonary Infection in a Cohort of Kidney Transplant Recipients

Dendle, C., Stuart, R. L., Mulley, W. R., Polkinghorne, K. R., Gan, P. Y., Kanellis, J., Ngui, J., Laurie, K., Thursky, K., Leung, V. K. & Holdsworth, S. R., 1 Dec 2018, In : Transplantation Proceedings. 50, 10, p. 3367-3370 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Seroresponses and safety of 13-valent pneumococcal conjugate vaccination in kidney transplant recipients

Dendle, C., Stuart, R. L., Polkinghorne, K. R., Balloch, A., Kanellis, J., Ling, J., Kummrow, M., Moore, C., Thursky, K., Buttery, J., Mulholland, K., Gan, P. Y., Holdsworth, S. & Mulley, W. R., 1 Apr 2018, In : Transplant Infectious Disease. 20, 2, 9 p., e12866.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2017

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells

Ooi, J. D., Petersen, J., Tan, Y. H., Huynh, M., Willett, Z. J., Ramarathinam, S. H., Eggenhuizen, P. J., Loh, K. L., Watson, K. A., Gan, P. Y., Alikhan, M. A., Dudek, N. L., Handel, A., Hudson, B. G., Fugger, L., Power, D. A., Holt, S. G., Coates, P. T., Gregersen, J. W., Purcell, A. W. & 5 others, Holdsworth, S. R., La Gruta, N. L., Reid, H. H., Rossjohn, J. & Kitching, A. R., 11 May 2017, In : Nature. 545, 7653, p. 243-247 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Pathogenic role for γδ T cells in autoimmune anti-myeloperoxidase glomerulonephritis

Gan, P. Y., Fujita, T., Ooi, J. D., Alikhan, M. A., Dick, J., Shim, R., Odobasic, D., O'Sullivan, K. M., Kitching, A. R. & Holdsworth, S. R., 1 Nov 2017, In : Journal of Immunology. 199, 9, p. 3042-3050 9 p.

Research output: Contribution to journalArticleResearchpeer-review

T cell receptor assessment in autoimmune disease requires access to the most adjacent immunologically active organ

Oftedal, B. E., Ardesjö Lundgren, B., Hamm, D., Gan, P. Y., Holdsworth, S. R., Hahn, C. N., Schreiber, A. W. & Scott, H. S., 1 Jul 2017, In : Journal of Autoimmunity. 81, p. 24-33 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2016

Biologics for the treatment of autoimmune renal diseases

Holdsworth, S. R., Gan, P. Y. & Kitching, A. R., 1 Apr 2016, In : Nature Reviews Nephrology. 12, 4, p. 217-231 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Endogenous toll-like receptor 9 regulates AKI by promoting regulatory T cell recruitment

Alikhan, M., Summers, S. A., Gan, P. Y., Chan, A., Khouri, M., Ooi, J., Ghali, J., Odobasic, D., Hickey, M. J., Kitching, A. R. & Holdsworth, S. R., 2016, In : Journal of the American Society of Nephrology. 27, 3, p. 706 - 714 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Mast cell stabilization ameliorates autoimmune anti-myeloperoxidase glomerulonephritis

Gan, P-Y., O'Sullivan, K. M., Ooi, J. D., Alikhan, M. A., Odobasic, D., Summers, S. A., Kitching, A. R. & Holdsworth, S. R., 1 May 2016, In : Journal of the American Society of Nephrology. 27, 5, p. 1321 - 1333 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Myeloperoxidase peptide-based nasal tolerance in experimental ANCA-associated GN

Gan, P. Y., Tan, D. S. Y., Ooi, J., Alikhan, M., Kitching, A. R. & Holdsworth, S. R., 2016, In : Journal of the American Society of Nephrology. 27, 2, p. 385 - 391 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Cytokines: Names and numbers you should care about

Holdsworth, S. R. & Gan, P. Y., 2015, In : Clinical Journal of the American Society of Nephrology. 10, 12, p. 2243 - 2254 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Local IL-17 production exerts a protective role in murine experimental glomerulonephritis

Hamour, S., Gan, P. Y., Pepper, R., Florez-Barros, F., Wang, H-H., O'Sullivan, K., Iwakura, Y., Cook, T., Pusey, C., Holdsworth, S. R. & Salama, A., 2015, In : PLoS ONE. 10, 8, 16 p., e0136238.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Mouse models of anti-neutrophil cytoplasmic antibody-associated vasculitis

Gan, P. Y., Ooi, J., Kitching, A. R. & Holdsworth, S. R., 2015, In : Current Pharmaceutical Design. 21, 18, p. 2380 - 2390 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Renal participation of myeloperoxidase in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis

O'Sullivan, K., Lo, C. Y-W., Summers, S. A., Elgass, K., McMillan, P., Longano, A., Ford, S. L., Gan, P. Y., Kerr, P. G., Kitching, A. R. & Holdsworth, S. R., 2015, In : Kidney International. 88, 5, p. 1030 - 1046 17 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Absence of the lysosomal protein Limp-2 attenuates renal injury in crescentic glomerulonephritis

Lee, D. H. K., Gan, P. Y., Katerelos, M., Fraser, S. A., Gleich, K., Holdsworth, S. R. & Power, D. A., 2014, In : Immunology and Cell Biology. 92, 5, p. 400 - 408 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Fc(gamma)RIIB regulates T-cell autoreactivity, ANCA production, and neutrophil activation to suppress anti-myeloperoxidase glomerulonephritis

Ooi, J., Gan, P. Y., Chen, T., Eggenhuizen, P. J., Chang, J., Alikhan, M., Odobasic, D., Holdsworth, S. R. & Kitching, A. R., 2014, In : Kidney International. 86, 6, p. 1140 - 1149 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Innate IL-17A-producing leukocytes promote acute kidney injury via inflammasome and Toll-like receptor activation

Chan, A., Alikhan, M., Odobasic, D., Gan, P. Y., Khouri, M., Steinmetz, O., Mansell, A. S., Kitching, A. R., Holdsworth, S. R. & Summers, S. A., 2014, In : American Journal of Pathology. 184, 5, p. 1411 - 1418 8 p.

Research output: Contribution to journalArticleResearchpeer-review

T cell mediated autoimmune glomerular disease in mice

Ooi, J., Gan, P. Y., Odobasic, D., Holdsworth, S. R. & Kitching, A. R., 2014, In : Current Protocols in Immunology. 107, p. 1 - 19 19 p.

Research output: Contribution to journalArticleOther

Thymic deletion and regulatory T cells prevent antimyeloperoxidase GN

Tan, D. S. Y., Gan, P. Y., O'Sullivan, K., Hammett, M. V., Summers, S. A., Ooi, J., Lundgren, B. A., Boyd, R. L., Scott, H. S., Kitching, A. R., Chidgey, A. P. & Holdsworth, S. R., 2013, In : Journal of the American Society of Nephrology. 24, 4, p. 573 - 585 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Mast cell activation and degranulation promotes renal fibrosis in experimental unilateral ureteric obstruction

Summers, S. A., Gan, P-Y., Dewage, L. T., Ma, F., Ooi, J., O'Sullivan, K., Nikolic-Paterson, D. J., Kitching, A. R. & Holdsworth, S. R., 2012, In : Kidney International. 82, 6, p. 676 - 685 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Mast cells contribute to peripheral tolerance and attenuate autoimmune vasculitis

Gan, P. Y., Summers, S. A., Ooi, J., O'Sullivan, K., Tan, D. S. Y., Muljadi, R. C. M., Odobasic, D., Kitching, A. R. & Holdsworth, S. R., 2012, In : Journal of the American Society of Nephrology. 23, 12, p. 1955 - 1966 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Interleukin-17A promotes early but attenuates established disease in crescentic glomerulonephritis in mice

Odobasic, D., Gan, P-Y., Summers, S. A., Semple, T., Muljadi, R., Iwakura, Y., Kitching, A. & Holdsworth, S., 2011, In : American Journal of Pathology. 179, 3, p. 1188 - 1198 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Mast cells mediate acute kidney injury through the production of TNF

Summers, S. A., Chan, J., Gan, P-Y., Dewage, L., Nozaki, Y., Steinmetz, O., Nikolic-Paterson, D., Kitching, A. & Holdsworth, S., 2011, In : Journal of the American Society of Nephrology. 22, 12, p. 2226 - 2236 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The Th17-defining transcription factor RORgammat promotes glomerulonephritis

Steinmetz, O., Summers, S. A., Gan, P-Y., Semple, T., Holdsworth, S. & Kitching, A., 2011, In : Journal of the American Society of Nephrology. 22, 3, p. 472 - 483 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Toll-like receptor 2 induces Th17 myeloperoxidase autoimmunity while Toll-like receptor 9 drives Th1 autoimmunity in murine vasculitis

Summers, S. A., Steinmetz, O., Gan, P-Y., Ooi, J., Odobasic, D., Kitching, A. & Holdsworth, S., 2011, In : Arthritis and Rheumatism. 63, 4, p. 1124 - 1135 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis

Summers, S. A., van der Veen, B. S., O'Sullivan, K., Gan, P-Y., Ooi, J., Heeringa, P., Satchell, S. C., Mathieson, P. W., Saleem, M. A., Visvanathan, K., Holdsworth, S. R. & Kitching, A. R., 2010, In : Kidney International. 78, 12, p. 1263 - 1274 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Th17 cells promote autoimmune anti-myeloperoxidase glomerulonephritis

Gan, P-Y., Steinmetz, O., Tan, D. S. Y., O'Sullivan, K., Ooi, J., Iwakura, Y., Kitching, A. R. & Holdsworth, S. R., 2010, In : Journal of the American Society of Nephrology. 21, 6, p. 925 - 931 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Toll-like receptor 9 enhances nephritogenic immunity and glomerular leukocyte recruitment, exacerbating experimental crescentic glomerulonephritis

Summers, S. A., Steinmetz, O., Ooi, J., Gan, P-Y., O'Sullivan, K., Visvanathan, K., Akira, S., Kitching, A. R. & Holdsworth, S. R., 2010, In : American Journal of Pathology. 177, 5, p. 2234 - 2244 11 p.

Research output: Contribution to journalArticleResearchpeer-review