Projects per year
Personal profile
Biography
Dr Pierre-Antoine Dugué is a Senior Research Fellow in the Precision Medicine team, School of Clinical Sciences at Monash Health, since 2019. His research focuses on investigating associations between genetic/epigenetic/lifestyle factors and risk of and survival from cancer.
Pierre completed undergraduate studies in Mathematics and Physics, and a MSc in Statistics in France, after which he worked as a biostatistician at the French National Institute for Health and Medical Research (Paris) analysing data from clinical trials of colorectal cancer patients. He obtained in 2014 a PhD in Health and Medical Sciences from the Department of Public Health, University of Copenhagen, Denmark, studying cervical cancer epidemiology and prevention through screening. Late 2014, he moved to Australia where he took up a position as Research Fellow at the Cancer Epidemiology Division, Cancer Council Victoria, and conducted epidemiological studies of the associations between DNA methylation, lifestyle factors and the risk of cancer.
Dr Dugué's goal is to contribute to a better understanding, prediction and prevention of cancer risk and mortality through the use of sound study designs and the integration of lifestyle, administrative, clinical and -omic data.
Supervision interests
Opportunities are available for PhD or Master's research projects. See more at the links below, and feel free to contact me should you be interested or have any questions.
Research interests
Selected publications
Epigenome-wide association studies
Dugué PA, Wilson R, Lehne B, et al. Alcohol consumption is associated with widespread changes in blood DNA methylation: analysis of cross-sectional and longitudinal data. Addiction Biol. 2019
Dugué PA, Jung C-H, Joo JE, et al. Smoking and blood DNA methylation: an epigenome-wide association study and assessment of reversibility. Epigenetics, 2019
Li S*, Dugué PA*[co-first], Baglietto L, et al. Genome-wide association study of peripheral blood DNA methylation and conventional mammographic density measures, Int J Cancer, 2019
Chamberlain JA*, Dugué PA*[co-first], Bassett JK, et al. Dietary intake of one-carbon metabolism nutrients and DNA methylation in peripheral blood, Am J Clin Nutr, 2018
Geurts YM*, Dugué PA*[co-first], Joo JE, et al. Novel associations between blood DNA methylation and body mass index in middle-aged and older adults, Int J Obesity, 2017
Blood DNA methylation and cancer risk
Dugué PA, Hodge AM, Wong EM, et al. Methylation marks of prenatal exposure to maternal smoking and risk of cancer in adulthood, Int J Epidemiol, 2020
Gagliardi A, Dugué PA*[co-first], Nøst TH, et al. Stochastic Epigenetic Mutations Are Associated with Risk of Breast Cancer, Lung Cancer, and Mature B-cell Neoplasms, CEBP, 2020
Chamberlain JA, Dugué PA*[co-first], Bassett JK, et al. DNA methylation in peripheral blood and risk of gastric cancer: a prospective nested case-control study, Cancer Prev Res, 2020
Bodelon C, Ambatipudi S, Dugué PA*[co-first], et al. Blood DNA methylation and breast cancer risk: a meta-analysis of four prospective cohort studies, Breast Cancer Res, 2019
Dugué PA, Dowty JG, Joo JE et al., Heritable methylation marks associated with breast and prostate cancer risk, Prostate, 2018
Dugué PA, Milne RL, Hopper JL, DNA methylation‐based biological aging and cancer risk and survival: Pooled analysis of seven prospective studies, Int J Cancer, 2017
Dugué PA, Bassett JK, Joo JE et al. Association of DNA Methylation-Based Biological Age with Health Risk Factors, and Overall and Cause-Specific Mortality, Am J Epidemiol, 2017
Dugué PA* [co-first], Brinkman MT*, Milne RL, et al., Genome-wide measures of DNA methylation in peripheral blood and the risk of urothelial cell carcinoma: a nested prospective case-control study, Br J Cancer, 2016
Cancer screening
Dugué PA, Rebolj M, Hallas J, Garred P, Lynge E. Risk of cervical cancer in women with autoimmune diseases, in relation with their use of immunosuppressants and screening: Population-based cohort study. Int J Cancer, 2015, 136(6):E711-9
Dugué PA, Lynge E, Rebolj M. Mortality of non-participants in cervical screening: Register-based cohort study, Int J Cancer, 2014, 134(11):2674-82
Lifestyle and cancer
Wu Z, […], Dugué PA. Social connectedness and mortality after prostate cancer diagnosis: a prospective cohort study, Int J Cancer, 2019
Dugué PA, Bassett JK, Brinkman MT, et al. Dietary intake of nutrients involved in one-carbon metabolism and risk of gastric cancer: a prospective study, Nutr Cancer, 2019
Dugué PA, Brinkman MT, Hodge AM et al., Dietary intake of nutrients involved in one-carbon metabolism and risk of urothelial cell carcinoma: a prospective cohort study, Int J Cancer, 2018
Seviiri M, […], Dugué PA. Resting heart rate, temporal changes in resting heart rate, and overall and cause-specific mortality, Heart, 2017
Yang Y, […], Dugué PA. Blood pressure and risk of breast cancer, overall and by subtypes: a prospective cohort study, J Hypertens, 2017
Dugué PA, Hodge AM, Brinkman MT et al. Association between selected dietary scores and the risk of urothelial cell carcinoma: A prospective cohort study. Int J Cancer 2016
Letters (replication analyses)
Dugué PA* [co-first], Chamberlain JA, Overall lack of replication of associations between dietary intake of folate and vitamin B-12 and DNA methylation in peripheral blood, Am J Clin Nutr, 2019
Dugué PA, Lynge E, Rebolj, M. Increased risk of high-grade squamous intraepithelial lesions in systemic lupus erythematosus: Additional data from Denmark. Autoimmun Rev, 2014, 13(12):1241-2. Letter
Dugué PA, Milne RL, Southey MC. A prospective study of peripheral blood DNA methylation at RPTOR, MGRN1 and RAPSN and risk of breast cancer, Breast Cancer Res Treat, 2017
Book chapters
Dugué PA, DNA methylation-based measures of biological aging, Chapter 3, Epigenetics in Human Disease, Second Edition, 2018
Li S, Dugué PA, Milne RL, Hopper JL, Epigenetic prospects in epidemiology and public heatlh, Chapter 32, Epigenetics in Human Disease, Second Edition, 2018
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Health and Medical Sciences, PhD
Statistics, MSc
External positions
Honorary Senior Research Associate, Cancer Council Victoria
Jan 2019 → …
Honorary Research Fellow, University of Melbourne
Jan 2015 → …
Research area keywords
- Cancer
- Epidemiology
- Epigenetics
- Genetics
- Genomics
- Biostatistics
- Lifestyle
- Screening
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Prostate cancer subtyping and prediction of outcomes using genome-wide tumour DNA methylation data
1/09/22 → 31/08/23
Project: Research
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Integrating genetic and epigenetic data for prediction of prostate cancer aggressiveness and outcomes
Dugue, P., Southey, M., Azad, A., Giles, G., Maclnnis, R., Barlee, A. & Cavill, S.
1/01/24 → 31/12/27
Project: Research
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Evidence-based translation of epigenetic testing to increase the precision of prostate cancer risk and prognosis prediction.
Southey, M., Giles, G. G., Dowty, J. G., Milne, R., MacInnis, R. J. & Dugue, P.
Prostate Cancer Foundation of Australia
1/10/19 → 30/09/22
Project: Research
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Improved and automated measures of breast cancer risk based on digital mammography and family history data collected by BreastScreen that will enable tailored screening for breast cancer
Hopper, J. L., Schmidt, D., Nickson, C. A., Makalic, E., Nguyen, L., Mann, G. B., Frazer, H., Dugue, P., Dite, G. S. & Evans, J.
1/01/19 → 31/12/21
Project: Research
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Epigenome-wide meta-analysis of BMI in nine cohorts: Examining the utility of epigenetically predicted BMI
Do, W. L., Sun, D., Meeks, K., Dugué, P. A., Demerath, E., Guan, W., Li, S., Chen, W., Milne, R., Adeyemo, A., Agyemang, C., Nassir, R., Manson, J. A. E., Shadyab, A. H., Hou, L., Horvath, S., Assimes, T. L., Bhatti, P., Jordahl, K. M., Baccarelli, A. A., & 6 others, 2 Feb 2023, In: American Journal of Human Genetics. 110, 2, p. 273-283 11 p.Research output: Contribution to journal › Article › Research › peer-review
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Heritable methylation marks associated with prostate cancer risk
Dowty, J. G., Yu, C., Hosseinpour, M., Joo, J. E., Wong, E. M., Nguyen-Dumont, T., Rosenbluh, J., Giles, G. G., Milne, R. L., MacInnis, R. J., Dugué, P. A. & Southey, M. C., 2023, (Accepted/In press) In: Familial Cancer. 5 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Sleep characteristics of middle-aged adults with non-alcoholic fatty liver disease: findings from the Shahrekord PERSIAN cohort study
Zarean, E., Looha, M. A., Amini, P., Ahmadi, A. & Dugué, P. A., Dec 2023, In: BMC Public Health. 23, 1, 11 p., 312.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Association of Markers of Inflammation, the Kynurenine Pathway and B Vitamins with Age and Mortality, and a Signature of Inflammaging
Dugue, P. A., Hodge, A. M., Ulvik, A., Ueland, P. M., Midttun, O., Rinaldi, S., MacInnis, R. J., Li, S. X., Meyer, K., Navionis, A. S., Flicker, L., Severi, G., English, D. R., Vineis, P., Tell, G. S., Southey, M. C., Milne, R. L. & Giles, G. G., Apr 2022, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 77, 4, p. 826-836 11 p.Research output: Contribution to journal › Article › Research › peer-review
9 Citations (Scopus) -
Does genetic predisposition modify the effect of lifestyle-related factors on DNA methylation?
Yu, C., Hodge, A. M., Wong, E. M., Joo, J. E., Makalic, E., Schmidt, D. F., Buchanan, D. D., Severi, G., Hopper, J. L., English, D. R., Giles, G. G., Milne, R. L., Southey, M. C. & Dugué, P-A., Dec 2022, In: Epigenetics. 17, 12, p. 1838-1847 10 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus)