Pierre-Antoine Dugue

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Pierre-Antoine Dugue

Assoc Professor

 https://orcid.org/0000-0003-2736-3023

  • 246 Clayton Road, TRF Building 7.22., Monash Medical Centre

    3168 Clayton

    Australia

Accepting PhD Students

PhD projects

<a href="https://www.monash.edu/medicine/research/supervisorconnect" onclick="target='_blank';">https://www.monash.edu/medicine/research/supervisorconnect</a>

20072024

Research activity per year

Personal profile

Biography

Pierre-Antoine Dugué is an Associate Professor in the School of Clinical Sciences at Monash Health. He heads the Molecular Epidemiology team (Precision Medicine), which uses statistical / machine learning methods coupled with molecular data to address key epidemiological and clinical questions.

A/Prof Dugué completed undergraduate studies in Mathematics and Physics and a MSc in Statistics in France, after which he worked as a biostatistician at the French National Institute for Health and Medical Research (Paris), analysing clinical trial data. He completed in 2014 a PhD in the Department of Public Health, University of Copenhagen, Denmark, studying cervical cancer epidemiology and prevention through screening. Late 2014, he moved to Australia where he took up a position as Research Fellow at the Cancer Epidemiology Division, Cancer Council Victoria, and conducted epidemiological studies exploring the interplay of DNA methylation, lifestyle factors and the risk of cancer.

A/Prof Dugué's goal is to contribute to a better understanding, prediction and prevention of cancer risk and mortality through the use of sound study designs and the integration of lifestyle, administrative, clinical and -omic data. His research has been supported by funding from the NHMRC and mid-career fellowships from PCFA and VCA.

 

Supervision interests

Opportunities are available for PhD or Master's research projects. See more at the links below, and feel free to contact me should you be interested or have any questions.

https://supervisorconnect.med.monash.edu/projects/enhancing-prediction-cancer-risk-using-dna-methylation-data

https://supervisorconnect.med.monash.edu/projects/inflammation-epigenetics-and-their-role-healthy-aging-and-cancer

 

Research interests

Selected publications

Epigenome-wide association studies

Dugué PA, Wilson R, Lehne B, et al. Alcohol consumption is associated with widespread changes in blood DNA methylation: analysis of cross-sectional and longitudinal data. Addiction Biol. 2019

Dugué PA, Jung C-H, Joo JE, et al. Smoking and blood DNA methylation: an epigenome-wide association study and assessment of reversibility. Epigenetics, 2019

Li S*, Dugué PA*[co-first], Baglietto L, et al. Genome-wide association study of peripheral blood DNA methylation and conventional mammographic density measures, Int J Cancer, 2019

Chamberlain JA*, Dugué PA*[co-first], Bassett JK, et al. Dietary intake of one-carbon metabolism nutrients and DNA methylation in peripheral blood, Am J Clin Nutr, 2018

Geurts YM*, Dugué PA*[co-first], Joo JE, et al. Novel associations between blood DNA methylation and body mass index in middle-aged and older adults, Int J Obesity, 2017

Blood DNA methylation and cancer risk

Dugué PA, Hodge AM, Wong EM, et al. Methylation marks of prenatal exposure to maternal smoking and risk of cancer in adulthood, Int J Epidemiol, 2020

Gagliardi A, Dugué PA*[co-first], Nøst TH, et al. Stochastic Epigenetic Mutations Are Associated with Risk of Breast Cancer, Lung Cancer, and Mature B-cell Neoplasms, CEBP, 2020

Chamberlain JA, Dugué PA*[co-first], Bassett JK, et al. DNA methylation in peripheral blood and risk of gastric cancer: a prospective nested case-control study, Cancer Prev Res, 2020

Bodelon C, Ambatipudi S, Dugué PA*[co-first], et al. Blood DNA methylation and breast cancer risk: a meta-analysis of four prospective cohort studies, Breast Cancer Res, 2019

Dugué PA, Dowty JG, Joo JE et al., Heritable methylation marks associated with breast and prostate cancer risk, Prostate, 2018

Dugué PA, Milne RL, Hopper JL, DNA methylation‐based biological aging and cancer risk and survival: Pooled analysis of seven prospective studies, Int J Cancer, 2017

Dugué PA, Bassett JK, Joo JE et al. Association of DNA Methylation-Based Biological Age with Health Risk Factors, and Overall and Cause-Specific Mortality, Am J Epidemiol, 2017

Dugué PA* [co-first], Brinkman MT*, Milne RL, et al., Genome-wide measures of DNA methylation in peripheral blood and the risk of urothelial cell carcinoma: a nested prospective case-control study, Br J Cancer, 2016

Cancer screening

Dugué PA, Rebolj M, Hallas J, Garred P, Lynge E. Risk of cervical cancer in women with autoimmune diseases, in relation with their use of immunosuppressants and screening: Population-based cohort study. Int J Cancer, 2015, 136(6):E711-9

Dugué PA, Lynge E, Rebolj M. Mortality of non-participants in cervical screening: Register-based cohort study, Int J Cancer, 2014, 134(11):2674-82

Lifestyle and cancer

Wu Z, […], Dugué PA. Social connectedness and mortality after prostate cancer diagnosis: a prospective cohort study, Int J Cancer, 2019

Dugué PA, Bassett JK, Brinkman MT, et al. Dietary intake of nutrients involved in one-carbon metabolism and risk of gastric cancer: a prospective study, Nutr Cancer, 2019

Dugué PA, Brinkman MT, Hodge AM et al., Dietary intake of nutrients involved in one-carbon metabolism and risk of urothelial cell carcinoma: a prospective cohort study, Int J Cancer, 2018

Seviiri M, […], Dugué PA. Resting heart rate, temporal changes in resting heart rate, and overall and cause-specific mortality, Heart, 2017

Yang Y, […], Dugué PA. Blood pressure and risk of breast cancer, overall and by subtypes: a prospective cohort study, J Hypertens, 2017

Dugué PA, Hodge AM, Brinkman MT et al. Association between selected dietary scores and the risk of urothelial cell carcinoma: A prospective cohort study. Int J Cancer 2016

Letters (replication analyses)

Dugué PA* [co-first], Chamberlain JA, Overall lack of replication of associations between dietary intake of folate and vitamin B-12 and DNA methylation in peripheral blood, Am J Clin Nutr, 2019

Dugué PA, Lynge E, Rebolj, M. Increased risk of high-grade squamous intraepithelial lesions in systemic lupus erythematosus: Additional data from Denmark. Autoimmun Rev, 2014, 13(12):1241-2. Letter

Dugué PA, Milne RL, Southey MC. A prospective study of peripheral blood DNA methylation at RPTOR, MGRN1 and RAPSN and risk of breast cancer, Breast Cancer Res Treat, 2017

Book chapters

Dugué PA, DNA methylation-based measures of biological aging, Chapter 3, Epigenetics in Human Disease, Second Edition, 2018

Li S, Dugué PA, Milne RL, Hopper JL, Epigenetic prospects in epidemiology and public heatlh, Chapter 32, Epigenetics in Human Disease, Second Edition, 2018

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Health and Medical Sciences, PhD, Aspects of cervical cancer screening and epidemiology

Statistics, MSc

External positions

Honorary Senior Research Associate, Cancer Council Victoria

Jan 2019 → …

Honorary Research Fellow, University of Melbourne

Jan 2015 → …

Research area keywords

  • Cancer
  • Epidemiology
  • Epigenetics
  • Genetics
  • Genomics
  • Biostatistics
  • Lifestyle
  • Screening

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Explore network further

  • Epigenetics, epidemiology, and public health

    Li, S., Dugué, P. A., Milne, R. L. & Hopper, J. L., 2024, Epigenetics in Human Disease. Tollefsbol, T. (ed.). 3rd ed. London UK: Elsevier, p. 1249-1274 26 p.

    Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

  • New WHO classification of genetic variants causing G6PD deficiency

    Luzzatto, L., Bancone, G., Dugué, P. A., Jiang, W., Minucci, A., Nannelli, C., Pfeffer, D., Prchal, J., Sirdah, M., Sodeinde, O., Vulliamy, T., Wanachiwanawin, W., Cunningham, J. & Bosman, A., 1 Aug 2024, In: Bulletin of the World Health Organization. 102, 8, p. 615-617 3 p.

    Research output: Contribution to journal › Comment / Debate › Other › peer-review

    Open Access
    7 Citations (Scopus)

  • Sustained Hypothetical Interventions on Midlife Alcohol Consumption in Relation to All-Cause and Cancer Mortality: The Australian Longitudinal Study on Women's Health

    Yang, Y., Hodge, A. M., Lynch, B. M., Dugué, P. A., Williamson, E. J., Jayasekara, H., Mishra, G. & English, D. R., 1 Jan 2024, In: American Journal of Epidemiology. 193, 1, p. 75-86 12 p.

    Research output: Contribution to journal › Article › Research › peer-review

    Open Access
    1 Citation (Scopus)

  • Adiposity and plasma concentrations of kynurenine pathway metabolites and traditional markers of inflammation

    Wang, M. E., Hodge, A. M., Li, S. X., Southey, M. C., Giles, G. G. & Dugué, P. A., May 2023, In: Obesity Research and Clinical Practice. 17, 3, p. 203-209 7 p.

    Research output: Contribution to journal › Article › Research › peer-review

    1 Citation (Scopus)

  • A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry

    Middha, P., Wang, X., Behrens, S., Bolla, M. K., Wang, Q., Dennis, J., Michailidou, K., Ahearn, T. U., Andrulis, I. L., Anton-Culver, H., Arndt, V., Aronson, K. J., Auer, P. L., Augustinsson, A., Baert, T., Freeman, L. E. B., Becher, H., Beckmann, M. W., Benitez, J., Bojesen, S. E., & 115 othersBrauch, H., Brenner, H., Brooks-Wilson, A., Campa, D., Canzian, F., Carracedo, A., Castelao, J. E., Chanock, S. J., Chenevix-Trench, G., Cordina-Duverger, E., Couch, F. J., Cox, A., Cross, S. S., Czene, K., Dossus, L., Dugué, P. A., Eliassen, A. H., Eriksson, M., Evans, D. G., Fasching, P. A., Figueroa, J. D., Fletcher, O., Flyger, H., Gabrielson, M., Gago-Dominguez, M., Giles, G. G., González-Neira, A., Grassmann, F., Grundy, A., Guénel, P., Haiman, C. A., Håkansson, N., Hall, P., Hamann, U., Hankinson, S. E., Harkness, E. F., Holleczek, B., Hoppe, R., Hopper, J. L., Houlston, R. S., Howell, A., Hunter, D. J., Ingvar, C., Isaksson, K., Jernström, H., John, E. M., Jones, M. E., Kaaks, R., Keeman, R., Kitahara, C. M., Ko, Y. D., Koutros, S., Kurian, A. W., Lacey, J. V., Lambrechts, D., Larson, N. L., Larsson, S., Le Marchand, L., Lejbkowicz, F., Li, S., Linet, M., Lissowska, J., Martinez, M. E., Maurer, T., Mulligan, A. M., Mulot, C., Murphy, R. A., Newman, W. G., Nielsen, S. F., Nordestgaard, B. G., Norman, A., O'Brien, K. M., Olson, J. E., Patel, A. V., Prentice, R., Rees-Punia, E., Rennert, G., Rhenius, V., Ruddy, K. J., Sandler, D. P., Scott, C. G., Shah, M., Shu, X. O., Smeets, A., Southey, M. C., Stone, J., Tamimi, R. M., Taylor, J. A., Teras, L. R., Tomczyk, K., Troester, M. A., Truong, T., Vachon, C. M., Wang, S. S., Weinberg, C. R., Wildiers, H., Willett, W., Winham, S. J., Wolk, A., Yang, X. R., Zamora, M. P., Zheng, W., Ziogas, A., Dunning, A. M., Pharoah, P. D. P., García-Closas, M., Schmidt, M. K., Kraft, P., Milne, R. L., Lindström, S., Easton, D. F., Chang-Claude, J., CTS Consortium, ABCTB Investigators & kConFab Investigators, 9 Aug 2023, In: Breast Cancer Research. 25, 1, 13 p., 93.

    Research output: Contribution to journal › Article › Research › peer-review

    Open Access
    4 Citations (Scopus)
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