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Personal profile


Piero Perucca, MD, PhD, FRACP is a Consultant Neurologist and Epileptologist at The Royal Melbourne Hospital, where he heads the First Seizure Clinic and the Epilepsy Assessment Clinic, and at Alfred Health. He is a Senior Research Fellow at the Department of Neuroscience, Central Clinical School, Monash University. He is also an Honorary Senior Fellow at the Melbourne Medical School, The University of Melbourne.

Dr Perucca received his MD and specialist-in-neurology degrees from the University of Pavia, Italy. He undertook higher training in epilepsy at Columbia University, USA; the Montreal Neurological Institute, Canada; and The Royal Melbourne Hospital. He obtained his PhD from The University of Melbourne, with a thesis focused on the role of genetic factors in the aetiology of focal epilepsies and in the outcomes of epilepsy therapy.

His main research interests include epilepsy genetics, electroencephalography, the pharmacological and surgical treatment of epilepsy, and genomic and electrophysiological biomarkers of epilepsy outcomes.


  • Neurology
  • Epilepsy
  • Genetics
  • EEG
  • Antiepileptic drugs
  • Epilepsy surgery
  • Focal epilepsy

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Projects 2018 2022

Perampanel in glioma associated seizures - efficacy and safety: a pilot phase II randomsied controlled trial.(PEGASUS)

O'Brien, T. J., Neal, A., Kwan, K. L. P., Drummond, K., Morokoff, A., Desmond, P. M., Moffat, B. M., Perucca, P. C., Gonen, O., Yuen, T. I., Murphy, M., Bulluss, K. J. & Cher, L.


Project: Research

Research Output 2006 2018

Electrophysiological biomarkers of epileptogenicity after traumatic brain injury

Perucca, P., Smith, G., Santana-Gomez, C., Bragin, A. & Staba, R., 1 Jan 2018, (Accepted/In press) In : Neurobiology of Disease. 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review


Devinsky, O., Vezzani, A., O'Brien, T. J., Jette, N., Scheffer, I. E., De Curtis, M. & Perucca, P., 3 May 2018, In : Nature Reviews Disease Primers. 4, 24 p., 18024.

Research output: Contribution to journalReview ArticleOtherpeer-review

Generalized polyspike train: An EEG biomarker of drug-resistant idiopathic generalized epilepsy

Sun, Y., Seneviratne, U. K., Perucca, P. C., Chen, Z., Tan, M., O'Brien, T. J., D'souza, W. & Kwan, K. L. P., 6 Nov 2018, In : Neurology. 91, 19, p. e1822-e1830 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Heart rate variability measurement in epilepsy: How can we move from research to clinical practice?

Myers, K. A., Sivathamboo, S. & Perucca, P., Dec 2018, In : Epilepsia. 59, 12, p. 2169-2178 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Removing high-frequency oscillations: A prospective multicenter study on seizure outcome

Jacobs, J., Wu, J. Y., Perucca, P. C., Zelmann, R., Mader, M., Dubeau, F., Mathern, G. W., Schulze-Bonhage, A. & Gotman, J., 11 Sep 2018, In : Neurology. 91, 11, p. e1040-e1052 13 p.

Research output: Contribution to journalArticleResearchpeer-review