Piero Perucca

Assoc Professor

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Personal profile


Piero Perucca, MD, PhD, FRACP is an Associate Professor at the Department of Neuroscience, Central Clinical School, Monash University. He is a Consultant Neurologist and Epileptologist at The Royal Melbourne Hospital, where he heads the First Seizure Clinic and the Epilepsy Assessment Clinic, and at Alfred Health. He is also an Honorary Senior Fellow at the Melbourne Medical School, The University of Melbourne.

A/Prof Perucca received his MD and specialist-in-neurology degrees from the University of Pavia, Italy. He undertook higher training in epilepsy at Columbia University, USA; the Montreal Neurological Institute, McGill University, Canada; and The Royal Melbourne Hospital. He obtained his PhD from The University of Melbourne, with a thesis focused on the role of genetic factors in the aetiology of focal epilepsies and in the outcomes of epilepsy therapy.

His main research interests include epilepsy genetics, electroencephalography, the pharmacological and surgical treatment of epilepsy, and genomic and electrophysiological biomarkers of epilepsy outcomes.


  • Neurology
  • Epilepsy
  • Genetics
  • EEG
  • Antiepileptic drugs
  • Epilepsy surgery
  • Focal epilepsy

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Projects 2018 2022

Perampanel in glioma associated seizures - efficacy and safety: a pilot phase II randomsied controlled trial.(PEGASUS)

O'Brien, T. J., Neal, A., Kwan, K. L. P., Drummond, K., Morokoff, A., Desmond, P. M., Moffat, B. M., Perucca, P. C., Gonen, O., Yuen, T. I., Murphy, M., Bulluss, K. J. & Cher, L.


Project: Research

Research Output 2006 2019

Electrophysiological biomarkers of epileptogenicity after traumatic brain injury

Perucca, P., Smith, G., Santana-Gomez, C., Bragin, A. & Staba, R., Mar 2019, In : Neurobiology of Disease. 123, p. 69-74 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Sleep-disordered breathing among patients admitted for inpatient video-EEG monitoring

Sivathamboo, S., Farrand, S., Chen, Z., White, E. J., Pattichis, A. A., Hollis, C., Carino, J., Roberts, C. J., Minogue, T., Jones, N. C., Yerra, R., French, C., Perucca, P., Kwan, P., Velakoulis, D., O'Brien, T. J. & Goldin, J., 15 Jan 2019, In : Neurology. 92, 3, p. e194-e204 11 p.

Research output: Contribution to journalArticleResearchpeer-review


Devinsky, O., Vezzani, A., O'Brien, T. J., Jette, N., Scheffer, I. E., De Curtis, M. & Perucca, P., 3 May 2018, In : Nature Reviews Disease Primers. 4, 24 p., 18024.

Research output: Contribution to journalReview ArticleOtherpeer-review

Generalized polyspike train: An EEG biomarker of drug-resistant idiopathic generalized epilepsy

Sun, Y., Seneviratne, U. K., Perucca, P. C., Chen, Z., Tan, M., O'Brien, T. J., D'souza, W. & Kwan, K. L. P., 6 Nov 2018, In : Neurology. 91, 19, p. e1822-e1830 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Genetics of focal epilepsies: What do we know and where are we heading?

Perucca, P., 1 Nov 2018, In : Epilepsy Currents. 18, 6, p. 356-362 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access