Phillip Nagley

Emeritus Prof

1988 …2019
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Research Output 1988 2019

2019

Inhibition of bioenergetics provides novel insights into recruitment of PINK1-dependent neuronal mitophagy

Shin, Y. S., Ryall, J. G., Britto, J. M., Lau, C. L., Devenish, R. J., Nagley, P. & Beart, P. M., Apr 2019, In : Journal of Neurochemistry. 149, 2, p. 269-283 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Mitochondrial research in Australia: a major player in worldwide trends

Nagley, P., St John, J. C., Gabriel, K. & McKenzie, M., 2014, In : Biochimica et Biophysica Acta. General Subjects. 1840, 4, p. 1225 - 1226 2 p.

Research output: Contribution to journalLetterOther

Mutant SOD1 inhibits ER-Golgi transport in amyotrophic lateral sclerosis

Atkin, J., Farg, M. A., Soo, K-Y., Walker, A. K., Halloran, M., Turner, B. J., Nagley, P. & Horne, M. K., 2014, In : Journal of Neurochemistry. 129, 1, p. 190 - 204 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

Mitochondria: an unexpected force in innate immunity

Khoo, J., Nagley, P. & Mansell, A. S., 2013, In : Australian Biochemist. 44, 1, p. 17 - 20 4 p.

Research output: Contribution to journalArticleOther

Mitochondria: organelles with many roles

Nagley, P., 2013, In : Australian Biochemist. 44, 1, p. 4 - 4 1 p.

Research output: Contribution to journalArticleOther

Mitochondrially localised MUL1 is a novel modulator of antiviral signaling

Jenkins, K. A., Khoo, J. J., Sadler, A. J., Piganis, R. A. R., Wang, D., Borg, N., Hjerrild, K., Gould, J. A., Thomas, B., Nagley, P., Hertzog, P. J. & Mansell, A. S., 2013, In : Immunology and Cell Biology. 91, 4, p. 321 - 330 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Apoptosis, Necrosis and Much More - Is oxidative stress getting on your nerves?

Higgins, G., Beart, P. & Nagley, P., Apr 2012, In : Australian Biochemist. 43, 1, p. 16-20 5 p.

Research output: Contribution to journalArticleOther

Application of flow cytometry to determine differential redistribution of cytochrome c and Smac/DIABLO from mitochondria during cell death signaling

Ng, H., Smith, D. J. & Nagley, P., 2012, In : PLoS ONE. 7, 7, 10 p., e42298.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Bim links ER stress and apoptosis in cells expressing mutant SOD1 associated with amyotrophic lateral sclerosis

Soo, K-Y., Atkin, J. D., Farg, M. A., Walker, A. K., Horne, M. K. & Nagley, P., 2012, In : PLoS ONE. 7, 4, 11 p., e35413.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Identification of a novel gene product that promotes survival of mycobacterium smegmatis in macrophages

Pelosi, A., Smith, D. J., Brammananth, R., Topolska, A. E., Billman-Jacobe, H., Nagley, P., Crellin, P. K. & Coppel, R. L., 2012, In : PLoS ONE. 7, 2, 11 p., e31788.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Mitochondrial contributions to neuronal programmed cell death: evidence for involvement of autophagy

Shin, Y. S., Mercer, L. D., Higgins, G. C., Nagley, P. M. & Beart, P., 2012, p. 67-68. 2 p.

Research output: Contribution to conferencePosterOtherpeer-review

Open Access

Transitory phases of autophagic death and programmed necrosis during superoxide-induced neuronal cell death

Higgins, G. C., Devenish, R. J., Beart, P. M. & Nagley, P., 2012, In : Free Radical Biology and Medicine. 53, 10, p. 1960 - 1967 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Autophagic activity in cortical neurons under acute oxidative stress directly contributes to cell death

Higgins, G. C., Devenish, R. J., Beart, P. M. & Nagley, P., 2011, In : Cellular and Molecular Life Sciences. 68, 22, p. 3725 - 3740 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Department of Biochemistry & Molecular Biology, Monash University - 50th Anniversary Celebrations

Nagley, P., 2011, In : Australian Biochemist. 42, 2, p. 43 - 43 1 p.

Research output: Contribution to journalArticleOther

History of Biochemistry and Molecular Biology at Monash University: Part 2 (1992-2011)

Nagley, P., 2011, In : Australian Biochemist. 42, 2, p. 36 - 42 7 p.

Research output: Contribution to journalArticleOther

Human neuroblastoma SH-SY5Y cells show increased resistance to hyperthermic stress after differentiation, associated with elevated levels of Hsp72

Cheng, L., Smith, D., Anderson, R. L. & Nagley, P., 2011, In : International Journal of Hyperthermia. 27, 5, p. 415 - 426 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Modulation of cellular Hsp72 levels in undifferentiated and neuron-like SH-SY5Y cells determines resistance to staurosporine-induced apoptosis

Cheng, L., Smith, D., Anderson, R. & Nagley, P., 2011, In : PLoS ONE. 6, 9, 9 p., e24473.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2010

Multifaceted deaths orchestrated by mitochondria in neurones

Nagley, P., Higgins, G. C., Atkin, J. D. & Beart, P. M., 2010, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1802, p. 167 - 185 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Oxidative Stress: Emerging Mitochondrial and Cellular Themes and Variations in Neuronal Injury

Higgins, G. C., Beart, P. M., Shin, Y. S., Chen, M. J., Sang Cheung, N. & Nagley, P., 2010, In : Journal of Alzheimer's Disease. 20, Suppl 2, p. 453 - 473 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Sensitive and specific detection of alpha-synuclein in human plasma

Tinsley, R., Kotschet, K., Modesto, D., Ng, H., Wang, Y., Nagley, P., Shaw, G. & Horne, M. K., 2010, In : Journal of Neuroscience Research. 88, 12, p. 2693 - 2700 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Age-related decline in stress responses of human myocardium may not be explained by changes in mtDNA

Miller, F. J., Nagley, P., Mariani, J., Ou, R., Liu, V. W. S., Zhang, C., Linnane, A. W., Pepe, S. & Rosenfeldt, F. L., 2009, In : Mechanisms of Ageing and Development. 130, 11-12, p. 742 - 747 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Differential insult-dependent recruitment of the intrinsic mitochondrial pathway during neuronal programmed cell death

Diwakarla, S., Nagley, P., Hughes, M. L. R., Chen, B. & Beart, P. M., 2009, In : Cellular and Molecular Life Sciences. 66, 1, p. 156 - 172 17 p.

Research output: Contribution to journalArticleResearchpeer-review

GABAergic striatal neurons exhibit caspase-independent, mitochondrially mediated programmed cell death

Diwakarla, S., Mercer, L. D., Kardashsyan, L., Chu, P. W. Y., Shin, Y. S., Lau, C. L., Hughes, M. L. R., Nagley, P. & Beart, P. M., 2009, In : Journal of Neurochemistry. 109, Suppl 1, p. 198 - 206 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Oxidative and excitotoxic insults exert differential effects on spinal motoneurons and astrocytic glutamate transporters: Implications for the role of astrogliosis in amyotrophic lateral sclerosis

Zagami, C. J., Beart, P. M., Wallis, N., Nagley, P. & O'Shea, R., 2009, In : GLIA. 57, 2, p. 119 - 135 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Oxidative stress triggers neuronal caspase-independent death: Endonuclease G involvement in programmed cell death-type III

Higgins, G. C., Beart, P. M. & Nagley, P., 2009, In : Cellular and Molecular Life Sciences. 66, 16, p. 2773 - 2787 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Recruitment of mitochondria into apoptotic signaling correlates with the presence of inclusions formed by amyotrophic lateral sclerosis-associated SOD1 mutations

Soo, K. Y., Atkin, J. D., Horne, M. K. & Nagley, P., 2009, In : Journal of Neurochemistry. 108, p. 578 - 590 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Lack of correlation between MYCN expression and the Warburg effect in neuroblastoma cell lines

Smith, D. J., Cossins, L. R., Hatzinisiriou, I., Haber, M. & Nagley, P., 2008, In : BMC Cancer. 8, 8, p. 1 - 8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Student project cases: a learner-centred team activity broadly integrated across the undergraduate medical curriculum

Macaulay, J. O. & Nagley, P., 2008, In : Medical Teacher. 30, 1, p. e23 - e33 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The mitochondrial gateway to cell death

Smith, D. J., Ng, H., Kluck, R. M. & Nagley, P., 2008, In : IUBMB Life. 60, 6, p. 383 - 389 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

Hierarchical recruitment by AMPA but not staurosporine of pro-apoptotic mitochondrial signaling in cultured cortical neurons: evidence for caspase-dependent/independent cross-talk

Beart, P. M., Lim, M. L. R., Chen, B., Diwakarla, S., Mercer, L., Cheung, N. S. & Nagley, P., 2007, In : Journal of Neurochemistry. 103, 6, p. 2408 - 2427 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Rotenone and MPP+ preferentially redistribute apoptosis-inducing factor in apoptotic dopamine neurons

Lim, M. L. R., Mercer, L., Nagley, P. & Beart, P. M., 2007, In : NeuroReport. 18, 4, p. 307 - 312 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1

Atkin, J. D., Farg, M. A., Turner, B. J., Tomas, D., Lysaght, J. A., Nunan, J., Rembach, A., Nagley, P., Beart, P. M., Cheema, S. S. & Horne, M. K., 2006, In : Journal of Biological Chemistry. 281, 40, p. 30152 - 30165 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Microsatellite instability in mitochondrial genome of common female cancers

Wang, Y., Liu, V. W. S., Tsang, P. CK., Chiu, P. M., Cheung, A. N. Y., Khoo, U. S., Nagley, P. & Ngan, H. Y. S., 2006, In : International Journal of Gynecological Cancer. 16, Supplement 1, p. 259 - 266 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Relative timing of redistribution of cytochrome c and Smac/DIABLO from mitochondria during apoptosis assessed by double immunocytochemistry on mammalian cells

Lim, M. L. R., Chen, B., Beart, P. M. & Nagley, P., 2006, In : Experimental Cell Research. 312, 7, p. 1174 - 1184 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Smac/DIABLO is not released from mitochondria during apoptotic signalling in cells deficient in cytochrome c

Hansen, T. M., Smith, D. J. & Nagley, P., 2006, In : Cell Death and Differentiation. 13, 7, p. 1181 - 1190 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2005

Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue

Rosenfeldt, F. L., Marasco, S., Lyon, W., Wowk, M., Sheeran, F. L., Bailey, M. J., Esmore, D. S., Davis, B., Pick, A., Rabinov, M., Smith, J. A., Nagley, P. & Pepe, S., 2005, In : Journal of Thoracic and Cardiovascular Surgery. 129, 1, p. 25 - 32 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Frequent occurrence of mitochondrial microsatellite instability in the D-loop region of human cancers

Wang, Y., Liu, V. W. S., Ngan, H. Y. & Nagley, P., 2005, In : Annals of the New York Academy of Sciences. 1042, p. 123 - 129 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2004

Response of the senescent heart to stress. Clinical therapeutic strategies and quest for mitochondrial predictors of biological age

Rosenfeldt, F. L., Miller, F., Nagley, P., Hadj, A., Marasco, S., Quick, D., Sheeran, F., Wowk, M. & Pepe, S., 2004, In : Annals of the New York Academy of Sciences. 1019, p. 78 - 84 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2003

AIF: a multifunctional cog in the life and death machine

Hansen, T. M. & Nagley, P., 2003, In : Science Signaling. 29th July, p. 1 - 4 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Each yeast mitochondrial F1F0-ATP synthase complex contains a single copy of subunit 8

Stephens, A. N., Nagley, P. & Devenish, R. J., 2003, In : Biochimica et Biophysica Acta - Bioenergetics. 1607, 2-3, p. 181 - 189 9 p.

Research output: Contribution to journalArticleResearchpeer-review

High frequency of mitochondrial genome instability in human endometrial carcinomas

Liu, V. W. S., Yang, H. J., Wang, Y., Tsang, P. C. K., Cheung, A. N. Y., Chiu, P. M., Ng, T. Y., Wong, L. C., Nagley, P. & Ngan, H. Y. S., 2003, In : British Journal of Cancer. 89, 4, p. 697 - 701 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Mitochondrial DNA variant 16189T>C is associated with susceptibility to endometrial cancer

Liu, V. W. S., Wang, Y., Yang, H-J., Tsang, P. C. K., Ng, T-Y., Wong, L-C., Nagley, P. & Ngan, H. Y. S., 2003, In : Human Mutation. 22, 2, p. 173 - 174 2 p.

Research output: Contribution to journalArticleResearchpeer-review

Precise determination of mitochondrial DNA copy number in human skeletal and cardiac muscle by a PCR-based assay: lack of change of copy number with age

Miller, F. J., Rosenfeldt, F. L., Zhang, C., Linnane, A. W. & Nagley, P., 2003, In : Nucleic Acids Research. 31, 11, p. e61 - e67 7 p.

Research output: Contribution to journalArticleResearchpeer-review

The molecular neighbourhood of subunit 8 of yeast mitochondrial F1F0-ATP synthase probed by cysteine scanning mutagenesis and chemical modification

Stephens, A. N., Khan, M. A., Roucou, X., Nagley, P. & Devenish, R. J., 2003, In : Journal of Biological Chemistry. 278, 20, p. 17867 - 17875 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Two phases of signalling between mitochondria during apoptosis leading to early depolarisation and delayed cytochrome c release

Lum, M-G. & Nagley, P., 2003, In : Journal of Cell Science. 116, 8, p. 1437 - 1447 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2002

Coenzyme Q10 protects the ageing heart against stress

Rosenfeldt, F. L., Pepe, S., Linnane, A. W., Nagley, P., Rowland, M. A., Ou, R., Marasco, S., Lyon, W. & Esmore, D. S., 2002, In : Annals of the New York Academy of Sciences. 959, 1, p. 355 - 359 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Microscopic photosensitization: A new tool to investigate the role of mitochondria in cell death

Lum, M-G., Minamikawa, T. & Nagley, P., 2002, In : The Scientific World Journal. 2, p. 1198 - 1208 11 p.

Research output: Contribution to journalArticleResearchpeer-review

On release of Cytochome c from mitochondria during cell death signaling

Lim, M. L. R., Lum, M-G., Hansen, T. M., Roucou, X. & Nagley, P., 2002, In : Journal of Biomedical Science. 9, 6, p. 488 - 506 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Subunit fusion are functionally incorporated into mitochondrial F1F0 synthase arguing against a rigid cap structure at the top of F1

Prescott, M., Nowakowski, S., Gavin, P., Nagley, P., Whisstock, J. C. & Devenish, R. J., 2002, In : Journal of Biological Chemistry. 278, 1, p. 251 - 256 6 p.

Research output: Contribution to journalArticleResearchpeer-review

The effects of ageing on the response to cardiac surgery: protective strategiess for the ageing myocardium

Rosenfeldt, F. L., Pepe, S., Linnane, A. W., Nagley, P., Rowland, M. A., Ou, R., Marasco, S. & Lyon, W., 2002, In : Biogerontology. 3, 12, p. 37 - 40 4 p.

Research output: Contribution to journalArticleResearchpeer-review