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Personal profile

Research interests

To understand the interplay between genetic, fibrotic and inflammatory factors in diabetes that contribute to diabetic complications.

Research goals

Our research is focused on understanding the role of various cytokines and growth factors that drive the development of diabetic complications and in particular end stage kidney disease and atherosclerosis. Our laboratory has demonstrated that several cytokines and growth factors are elevated in diabetes and this results in dysregulation of certain microRNA, which are important regulators of fibrotic and inflammatory pathways in the kidney and the aorta. Targeting of these factors and microRNA directly has remained difficult due to their normal physiological roles.

More recently, we have made an exciting discovery in that a family of small endogenous molecules known as “resolvins” are able to attenuate the pathological signaling in diabetes by dampening both inflammatory and fibrotic pathways in tissues where complications occur. We are currently testing various analogues as novel treatments for dealing with multiple complications.

Another aspect of our work focusses on the identification of genetic markers in biological fluids by the use of RNA-seq in order to establish a biomarker profile that is predictive of the development of diabetic complications.

Keywords

  • Diabetes
  • diabetic complications
  • nephropathy
  • atherosclerosis
  • microRNA
  • Fibrosis

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Projects 2019 2022

Research Output 1983 2018

Lipoxins protect against inflammation in diabetes-associated atherosclerosis

Brennan, E. P., Mohan, M., McClelland, A., De Gaetano, M., Tikellis, C., Marai, M., Crean, D., Dai, A., Beuscart, O., Derouiche, S., Gray, S. P., Pickering, R., Tan, S. M., Godson-Treacy, M., Sheehan, S., Dowdall, J. F., Barry, M., Belton, O., Ali-Shah, S. T., Guiry, P. J. & 4 othersJandeleit-Dahm, K., Cooper, M. E., Godson, C. & Kantharidis, P., 1 Dec 2018, In : Diabetes. 67, 12, p. 2657-2667 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Lipoxins regulate the early growth response-1 network and reverse diabetic kidney disease

Brennan, E. P., Mohan, M., McClelland, A., Tikellis, C., Ziemann, M., Kaspi, A., Gray, S. P., Pickering, R., Tan, S. M., Tasadaque Ali-Shah, S., Guiry, P. J., El-Osta, A., Jandeleit-Dahm, K., Cooper, M. E., Godson, C. & Kantharidis, P., 1 May 2018, In : Journal of the American Society of Nephrology. 29, 5, p. 1437-1448 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Perinatal exposure to high dietary advanced glycation end products in transgenic NOD8.3 mice leads to pancreatic beta cell dysfunction

Borg, D. J., Yap, F. Y. T., Keshvari, S., Simmons, D. G., Gallo, L. A., Fotheringham, A. K., Zhuang, A., Slattery, R. M., Hasnain, S. Z., Coughlan, M. T., Kantharidis, P. & Forbes, J. M., 2 Jan 2018, In : Islets. 10, 1, p. 10-24 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

RAGE deletion confers renoprotection by reducing responsiveness to transforming growth factor-β and increasing resistance to apoptosis

Hagiwara, S., Sourris, K., Ziemann, M., Tieqiao, W., Mohan, M., McClelland, A. D., Brennan, E., Forbes, J., Coughlan, M., Harcourt, B., Penfold, S., Wang, B., Higgins, G., Pickering, R., El-Osta, A., Thomas, M. C., Cooper, M. E. & Kantharidis, P., 1 May 2018, In : Diabetes. 67, 5, p. 960-973 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Increased liver AGEs induce hepatic injury mediated through an OST48 pathway

Zhuang, A., Yap, F. Y., Bruce, C., Leung, C., Plan, M. R., Sullivan, M. A., Herath, C. B., McCarthy, D., Sourris, K. C., Kantharidis, P., Coughlan, M. T., Febbraio, M. A., Hodson, M. P., Watt, M. J., Angus, P., Schulz, B. L. & Forbes, J. M., 1 Dec 2017, In : Scientific Reports. 7, 1, 12292.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File