Projects per year
Personal profile
Research interests
To understand the interplay between genetic, fibrotic and inflammatory factors in diabetes that contribute to diabetic complications.
Research goals
Our research is focused on understanding the role of various cytokines and growth factors that drive the development of diabetic complications and in particular end stage kidney disease and atherosclerosis. Our laboratory has demonstrated that several cytokines and growth factors are elevated in diabetes and this results in dysregulation of certain microRNA, which are important regulators of fibrotic and inflammatory pathways in the kidney and the aorta. Targeting of these factors and microRNA directly has remained difficult due to their normal physiological roles.
More recently, we have made an exciting discovery in that a family of small endogenous molecules known as “resolvins” are able to attenuate the pathological signaling in diabetes by dampening both inflammatory and fibrotic pathways in tissues where complications occur. We are currently testing various analogues as novel treatments for dealing with multiple complications.
Another aspect of our work focusses on the identification of genetic markers in biological fluids by the use of RNA-seq in order to establish a biomarker profile that is predictive of the development of diabetic complications.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Molecular Biology, PhD, Molecular Biology of Rotaviruses, University of Melbourne
Award Date: 1 Dec 1993
Virology, BSc (Hons), Gene Coding assignments of the Rotavirus, University of Melbourne
Award Date: 1 Dec 1983
Research area keywords
- Diabetes
- diabetic complications
- nephropathy
- atherosclerosis
- microRNA
- Fibrosis
Collaborations and top research areas from the last five years
Projects
- 1 Finished
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A novel endogenous inhibitor for the treatment of diabetic nephropathy
Cooper, M. (Primary Chief Investigator (PCI)) & Kantharidis, P. (Chief Investigator (CI))
1/01/17 → 31/12/19
Project: Research
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Does the expression of glucagon-like peptide-1 receptor on bone marrow derived cells influence the onset and progression of diabetic kidney disease?
Sourris, K. C., Bertuzzo Veiga, C., Kantharidis, P., Rosado, C., Bose, M., Dimitropoulos, A., Xu, Y., Coughlan, M. T., Aziz, M., Morgan, P., Drucker, D. J., Murphy, A. J., Jandeleit-Dahm, K. A. M. & Cooper, M. E., Sept 2024, In: Diabetologia. 67, S1, p. S106 1 p., OP198.Research output: Contribution to journal › Meeting Abstract › peer-review
Open AccessFile -
Glucagon-like peptide-1 receptor signaling modifies the extent of diabetic kidney disease through dampening the receptor for advanced glycation end products–induced inflammation
Sourris, K. C., Ding, Y., Maxwell, S. S., Al-Sharea, A., Kantharidis, P., Mohan, M., Rosado, C., Penfold, S., Haase, C. G., Xu, Y., Forbes, J. M., Crawford, S. A., Ramm, G., Harcourt, B. E., Jandeleit-Dahm, K. A. M., Advani, A., Murphy, A. J., Timmermann, D. B., Karihaloo, A. & Knudsen, L. B. & 4 others, , Jan 2024, In: Kidney International. 105, 1, p. 132-149 18 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access56 Citations (Scopus) -
Potential of Modulating Aldosterone Signaling and Mineralocorticoid Receptor with microRNAs to Attenuate Diabetic Kidney Disease
Hagiwara, S., Gohda, T., Kantharidis, P., Okabe, J., Murakoshi, M. & Suzuki, Y., Jan 2024, In: International Journal of Molecular Sciences. 25, 2, 14 p., 869.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access3 Citations (Scopus) -
YB-1: the Jekyll and Hyde of kidney disease?
Kantharidis, P. & Cooper, M. E., Jan 2024, In: Kidney International. 105, 1, p. 18-20 3 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
1 Citation (Scopus) -
Ameliorating diabetes-associated atherosclerosis and diabetic nephropathy through modulation of soluble guanylate cyclase
Sharma, A., Choi, J., Sim, L., Dey, A., Mohan, M., Kantharidis, P., Dietz, L., Sandner, P. & de Haan, J. B., 2023, In: Frontiers in Cardiovascular Medicine. 10, 15 p., 1220095.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus)