Phillip Kantharidis


Accepting PhD Students

PhD projects

1. Pro-resolution strategies to target inflammatory genes and pathways as a novel treatment for diabetic kidney disease.
2. Lipoxin A4 as a novel treatment against the development and progression of diabetes associated atherosclerosis.

1983 …2022

Research activity per year

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Personal profile

Research interests

To understand the interplay between genetic, fibrotic and inflammatory factors in diabetes that contribute to diabetic complications.

Research goals

Our research is focused on understanding the role of various cytokines and growth factors that drive the development of diabetic complications and in particular end stage kidney disease and atherosclerosis. Our laboratory has demonstrated that several cytokines and growth factors are elevated in diabetes and this results in dysregulation of certain microRNA, which are important regulators of fibrotic and inflammatory pathways in the kidney and the aorta. Targeting of these factors and microRNA directly has remained difficult due to their normal physiological roles.

More recently, we have made an exciting discovery in that a family of small endogenous molecules known as “resolvins” are able to attenuate the pathological signaling in diabetes by dampening both inflammatory and fibrotic pathways in tissues where complications occur. We are currently testing various analogues as novel treatments for dealing with multiple complications.

Another aspect of our work focusses on the identification of genetic markers in biological fluids by the use of RNA-seq in order to establish a biomarker profile that is predictive of the development of diabetic complications.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Molecular Biology, PhD, Molecular Biology of Rotaviruses, University of Melbourne

Award Date: 1 Dec 1993

Virology, BSc (Hons), Gene Coding assignments of the Rotavirus, University of Melbourne

Award Date: 1 Dec 1983

Research area keywords

  • Diabetes
  • diabetic complications
  • nephropathy
  • atherosclerosis
  • microRNA
  • Fibrosis

Collaborations and top research areas from the last five years

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