Projects per year
Personal profile
Biography
Professor Phil Darcy is currently a NHMRC Senior Research Fellow and Group Leader at the Peter MacCallum Cancer Centre. His laboratory focuses on developing novel T cell based immunotherapy approaches for cancer in preclinical mouse models and translating this into patients. Specifically, he is focused on the development of gene modified mouse and human T cells expressing chimeric antigen receptors (CARs) that can effectively target and eradicate cancer in mice. A Phase I clinical trial leading from this work was recently completed at the Peter MacCallum Cancer Centre in patients with acute myeloid leukaemia which represented a first in Australia using this approach and another trial using this approach in non-small cell lung carcinoma patients is underway. His laboratory is also focused on development of combined immune based therapies for cancer.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Cancer immunology
- T-cell
- Clinical translation
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Projects
- 2 Active
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Developing novel CAR T cell therapy approaches to treat prostate cancer
Taylor, R., Porter, L., Trapani, J., Darcy, P., Neeson, P., Risbridger, G., Risbridger, G., Solomon, B. J., Azad, A. & Furic, L.
1/01/22 → 31/12/25
Project: Research
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Targeting Immune Checkpoints In Obesity-Driven HCC
Wiede, F., Tiganis, T., Darcy, P., Johnstone, R. W., McLean, C. & Febbraio, M.
1/07/21 → 30/06/23
Project: Research
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CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy
Giuffrida, L., Sek, K., Henderson, M. A., Lai, J., Chen, A. X. Y., Meyran, D., Todd, K. L., Petley, E. V., Mardiana, S., Mølck, C., Stewart, G. D., Solomon, B. J., Parish, I. A., Neeson, P. J., Harrison, S. J., Kats, L. M., House, I. G., Darcy, P. K. & Beavis, P. A., Dec 2021, In: Nature Communications. 12, 1, 18 p., 3236.Research output: Contribution to journal › Article › Research › peer-review
Open Access20 Citations (Scopus) -
PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours
Wiede, F., Lu, K-H., Du, X., Liang, S., Hochheiser, K., Dodd, G. T., Goh, P. K., Kearney, C., Meyran, D., Beavis, P. A., Henderson, M. A., Park, S. L., Waithman, J., Zhang, S., Zhang, Z. Y., Oliaro, J., Gebhardt, T., Darcy, P. K. & Tiganis, T., 15 Jan 2020, In: The EMBO Journal. 39, 2, 26 p., e103637.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile33 Citations (Scopus) -
Targeting adenosine receptor signaling in cancer immunotherapy
Sek, K., Mølck, C., Stewart, G. D., Kats, L., Darcy, P. K. & Beavis, P. A., 1 Dec 2018, In: International Journal of Molecular Sciences. 19, 12, 23 p., 3837.Research output: Contribution to journal › Review Article › Research › peer-review
Open AccessFile91 Citations (Scopus) -
A multifunctional role for adjuvant anti-4-1BB therapy in augmenting antitumor response by chimeric antigen receptor T cells
Mardiana, S., John, L. B., Henderson, M. A., Slaney, C. Y., von Scheidt, B., Giuffrida, L., Davenport, A. J., Trapani, J. A., Neeson, P. J., Loi, S., Haynes, N. M., Kershaw, M. H., Beavis, P. A. & Darcy, P. K., 15 Mar 2017, In: Cancer Research. 77, 6, p. 1296-1309 14 p.Research output: Contribution to journal › Article › Research › peer-review
48 Citations (Scopus) -
A Novel Target Antigen for the Treatment of Acute Myeloid Leukemia by CAR T Cells
Beavis, P. A., Sek, K. & Darcy, P. K., Sep 2017, In: Molecular Therapy. 25, 9, p. 1997-1998 2 p.Research output: Contribution to journal › Short Survey › Other › peer-review
2 Citations (Scopus)