• 23 Innovation Walk, Building 77

    3800 Clayton

    Australia

1980 …2020

Research output per year

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Research Output

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2020

Detection of Active Granzyme A in NK92 Cells with Fluorescent Activity-Based Probe

Kołt, S., Janiszewski, T., Kaiserman, D., Modrzycka, S., Snipas, S. J., Salvesen, G., Dra¸g, M., Bird, P. I. & Kasperkiewicz, P., 26 Mar 2020, In : Journal of Medicinal Chemistry. 63, 6, p. 3359-3369 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Extracellular Granzyme A Promotes Colorectal Cancer Development by Enhancing Gut Inflammation

Santiago, L., Castro, M., Sanz-Pamplona, R., Garzón, M., Ramirez-Labrada, A., Tapia, E., Moreno, V., Layunta, E., Gil-Gómez, G., Garrido, M., Peña, R., Lanuza, P. M., Comas, L., Jaime-Sanchez, P., Uranga-Murillo, I., del Campo, R., Pelegrín, P., Camerer, E., Martínez-Lostao, L., Muñoz, G. & 8 others, Uranga, J. A., Alcalde, A., Galvez, E. M., Ferrandez, A., Bird, P. I., Metkar, S., Arias, M. A. & Pardo, J., 7 Jul 2020, In : Cell Reports. 32, 1, 16 p., 107847.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Granzyme A in Chikungunya and Other Arboviral Infections

Schanoski, A. S., Le, T. T., Kaiserman, D., Rowe, C., Prow, N. A., Barboza, D. D., Santos, C. A., Zanotto, P. M. A., Magalhães, K. G., Aurelio, L., Muller, D., Young, P., Zhao, P., Bird, P. I. & Suhrbier, A., 14 Jan 2020, In : Frontiers in Immunology. 10, 14 p., 3083.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Noninvasive optical detection of granzyme B from natural killer cells with enzyme-activated fluorogenic probes

Janiszewski, T., Kołt, S., Kaiserman, D., Snipas, S. J., Li, S., Kulbacka, J., Saczko, J., Bovenschen, N., Salvesen, G., Drąg, M., Bird, P. I. & Kasperkiewicz, P., 10 Jul 2020, In : The Journal of Biological Chemistry. 295, 28, p. 9567-9582 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2019

A transgenic zebrafish model of hepatocyte function in human Z α1-antitrypsin deficiency

Yip, E., Giousoh, A., Fung, C., Wilding, B., Prakash, M. D., Williams, C., Verkade, H., Bryson-Richardson, R. J. & Bird, P. I., 12 Jun 2019, In : Biological Chemistry. 400, 12, p. 1603-1616 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Cathepsin G inhibition by Serpinb1 and Serpinb6 prevents programmed necrosis in neutrophils and monocytes and reduces GSDMD-driven inflammation

Burgener, S. S., Leborgne, N. G. F., Snipas, S. J., Salvesen, G. S., Bird, P. I. & Benarafa, C., 18 Jun 2019, In : Cell Reports. 27, 12, p. 3646-3656 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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16 Citations (Scopus)

Granzyme K expressed by classically activated macrophages contributes to inflammation and impaired remodeling

Turner, C. T., Zeglinski, M. R., Richardson, K. C., Zhao, H., Shen, Y., Papp, A., Bird, P. I. & Granville, D. J., 1 Apr 2019, In : Journal of Investigative Dermatology. 139, 4, p. 930-939 10 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

SerpinB1 controls encephalitogenic T helper cells in neuroinflammation

Hou, L., Rao, D. A., Yuki, K., Cooley, J., Henderson, L. A., Jonsson, A. H., Kaiserman, D., Gorman, M. P., Nigrovic, P. A., Bird, P. I., Becher, B. & Remold-O’Donnell, E., 8 Oct 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 41, p. 20635-20643 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1

Pang, S. S., Bayly-Jones, C., Radjainia, M., Spicer, B. A., Law, R. H. P., Hodel, A. W., Parsons, E. S., Ekkel, S. M., Conroy, P. J., Ramm, G., Venugopal, H., Bird, P. I., Hoogenboom, B. W., Voskoboinik, I., Gambin, Y., Sierecki, E., Dunstone, M. A. & Whisstock, J. C., 19 Sep 2019, In : Nature Communications. 10, 1, 9 p., 4288.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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8 Citations (Scopus)
2017

A pro-survival role for the intracellular granzyme B inhibitor Serpinb9 in natural killer cells during poxvirus infection

Mangan, M. S., Melo-Silva, C. R., Luu, J., Bird, C. H., Koskinen, A., Rizzitelli, A., Prakash, M., Scarff, K. L., Müllbacher, A., Regner, M. & Bird, P. I., 1 Nov 2017, In : Immunology and Cell Biology. 95, 10, p. 884-894 11 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization

Brasacchio, D., Alsop, A. E., Noori, T., Lufti, M., Iyer, S., Simpson, K. J., Bird, P. I., Kluck, R. M., Johnstone, R. W. & Trapani, J. A., 2017, In : Cell Death and Differentiation. 24, p. 961-970 10 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Granzyme a deficiency breaks immune tolerance and promotes autoimmune diabetes through a Type i interferon-dependent pathway

Mollah, Z. U. A., Quah, H. S., Graham, K. L., Jhala, G., Krishnamurthy, B., Dharma, J. F. M., Chee, J., Trivedi, P. M., Pappas, E. G., Mackin, L., Chu, E. P. F., Akazawa, S., Fynch, S., Hodson, C., Deans, A. J., Trapani, J. A., Chong, M. M. W., Bird, P. I., Brodnicki, T. C., Thomas, H. E. & 1 others, Kay, T. W. H., 1 Dec 2017, In : Diabetes. 66, 12, p. 3041-3050 10 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Granzyme K-deficient mice show no evidence of impaired antiviral immunity

Joeckel, L. T., Allison, C. C., Pellegrini, M., Bird, C. H. & Bird, P. I., 1 Sep 2017, In : Immunology and Cell Biology. 95, 8, p. 676-683 8 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Neurodevelopmental MACPFs: The vertebrate astrotactins and BRINPs

Berkowicz, S. R., Giousoh, A. & Bird, P. I., Dec 2017, In : Seminars in Cell and Developmental Biology. 72, p. 171-181 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Reply to: "Differential expression of serpins may selectively license distinct granzyme B functions including antigen cross-presentation"

Mangan, M. S., Vega-Ramos, J., Joeckel, L. T., Mitchell, A. J., Rizzitelli, A., Roediger, B., Kaiserman, D., Weninger, W. W., Villadangos, J. A. & Bird, P. I., Jul 2017, In : Molecular Immunology. 87, 2 p.

Research output: Contribution to journalArticleOtherpeer-review

RNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammation

Wilson, J. A. C., Prow, N. A., Schroder, W. A., Ellis, J. J., Cumming, H. E., Gearing, L. J., Poo, Y. S., Taylor, A., Hertzog, P. J., Di Giallonardo, F., Hueston, L., Le Grand, R., Tang, B., Le, T. T., Gardner, J., Mahalingam, S., Roques, P., Bird, P. I. & Suhrbier, A., 16 Feb 2017, In : PLoS Pathogens. 13, 2, 32 p., e1006155.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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33 Citations (Scopus)

Serpinb9 is a marker of antigen cross-presenting dendritic cells

Mangan, M. S., Vega-Ramos, J., Joeckel, L. T., Mitchell, A. J., Rizzitelli, A., Roediger, B., Kaiserman, D., Weninger, W. W., Villadangos, J. A. & Bird, P. I., Feb 2017, In : Molecular Immunology. 82, p. 50-56 7 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)
2016

A novel serpin regulatory mechanism: SERPINB9 is reversibly inhibited by vicinal disulfide bond formation in the reactive center loop

Mangan, M. S. J., Bird, C. H., Kaiserman, D., Matthews, A. Y., Hitchen, C., Steer, D. L., Thompson, P. E. & Bird, P. I., 12 Feb 2016, In : The Journal of Biological Chemistry. 291, 7, p. 3626-3638 13 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Brinp1-/- mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density

Berkowicz, S. R., Featherby, T. J., Qu, Z., Giousoh, A., Borg, N. A., Heng, J. I., Whisstock, J. C. & Bird, P. I., 31 Mar 2016, In : Molecular Autism. 7, 22, 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
16 Citations (Scopus)

Characterization of Lgr5+ progenitor cell transcriptomes in the apical and basal turns of the mouse cochlea

Waqas, M., Guo, L., Zhang, S., Chen, Y., Zhang, X., Wang, L., Tang, M., Shi, H., Bird, P. I., Li, H. & Chai, R., 7 Apr 2016, In : Oncotarget. 7, 27, p. 41123-41141 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
22 Citations (Scopus)

Mice lacking Brinp2 or Brinp3, or both, exhibit behaviors consistent with neurodevelopmental disorders

Berkowicz, S. R., Featherby, T. J., Whisstock, J. C. & Bird, P. I., 25 Oct 2016, In : Frontiers in Behavioral Neuroscience. 10, 15 p., 196.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)
2015

Analysis of perforin assembly by quartz crystal microbalance reveals a role for cholesterol and calcium-independent membrane binding

Stewart, S. E., Bird, C. H., Tabor, R. F., D'Angelo, M., Piantavigna, S., Whisstock, J. C., Trapani, J. A., Martin, L. L. & Bird, P. I., 2015, In : The Journal of Biological Chemistry. 290, 52, p. 31101 - 31112 12 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Assembly of streptolysin O pores assessed by quartz crystal microbalance and atomic force microscopy provides evidence for the formation of anchored but incomplete oligomers

Stewart, S. E., D'Angelo, M. E., Piantavigna, S., Tabor, R. F., Martin, L. L. & Bird, P. I., 2015, In : Biochimica et Biophysica Acta - Biomembranes. 1848, 1 (Part A), p. 115 - 126 12 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Bone morphogenetic protein/retinoic acid inducible neural-specific protein (brinp) expression during danio rerio development

Giousoh, A., Rodrigues Vaz, R., Bryson-Richardson, R. J., Whisstock, J. C., Verkade, H. M. & Bird, P. I., 2015, In : Gene Expression Patterns. 18, 1-2, p. 37 - 43 7 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Zebrafish models for nemaline myopathy reveal a spectrum of nemaline bodies contributing to reduced muscle function

Sztal, T. E., Zhao, M., Williams, C., Oorschot, V., Parslow, A. C., Giousoh, A., Yuen, M., Hall, T. E., Costin, A., Ramm, G., Bird, P. I., Busch-Nentwich, E. M., Stemple, D. L., Currie, P. D., Cooper, S. T., Laing, N. G., Nowak, K. J. & Bryson-Richardson, R. J., 2015, In : Acta Neuropathologica. 130, 3, p. 389-406 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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21 Citations (Scopus)
2014

A functional genomics screen identifies PCAF and ADA3 as regulators of human granzyme B-mediated apoptosis and Bid cleavage

Brasacchio, D., Noori, T., House, C. M., Brennan, A. J., Simpson, K. J., Susanto, O., Bird, P. I., Johnstone, R. W. & Trapani, J. A., 2014, In : Cell Death and Differentiation. 21, 5, p. 748 - 760 13 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Analysis of the evolution of granule associated serine proteases of immune defence (GASPIDs) suggests a revised nomenclature

Ahmad, J., Bird, P. I. & Kaiserman, D., 1 Oct 2014, In : Biological Chemistry. 395, 10, p. 1253-1262 10 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

A natural genetic variant of granzyme B confers lethality to a common viral infection

Andoniou, C. E., Sutton, V. R., Wikstrom, M. E., Fleming, P., Thia, K. Y. T., Matthews, A. Y., Kaiserman, D., Schuster, I. S., Coudert, J. D., Eldi, P., Chaudhri, G., Karupiah, G., Bird, P. I., Trapani, J. A. & Degli-Esposti, M. A., 2014, In : PLoS Pathogens. 10, 12, 13 p., e1004526.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
9 Citations (Scopus)

Are all granzymes cytotoxic in vivo?

Joeckel, L. & Bird, P. I., 2014, In : Biological Chemistry. 395, 2, p. 181 - 202 22 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Blessing or curse? Proteomics in granzyme research

Joeckel, L. & Bird, P. I., 2014, In : Proteomics - Clinical Applications. 8, 5-6, p. 351 - 381 31 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Granzyme B promotes cytotoxic lymphocyte transmigration via basement membrane remodeling

Prakash, M. D., Munoz, M., Jain, R., Tong, P. L., Koskinen, A. M. L., Regner, M., Kleifeld, O., Ho, B. K-C., Olson, M. R., Turner, S. J., Mrass, P., Weninger, W. & Bird, P. I., 2014, In : Immunity. 41, 6, p. 960 - 972 13 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Identification of Serpinb6b as a species-specific mouse granzyme A inhibitor suggests functional divergence between human and mouse granzyme A

Kaiserman, D., Stewart, S. E., Plasman, K., Gevaert, K., Van Damme, P. & Bird, P. I., 2014, In : The Journal of Biological Chemistry. 289, 13, p. 9408 - 9417 10 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Maspin is not required for embryonic development or tumour suppression

Teoh, S. S. Y., Vieusseux, J. L., Prakash, M. D., Berkowicz, S. R., Luu, J., Bird, C. H., Law, R. H. P., Rosado, C. J., Price, J. T., Whisstock, J. C. & Bird, P. I., 2014, In : Nature Communications. 5, (Art. No.: 3164), p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
25 Citations (Scopus)

NK cell intrinsic regulation of MIP-1alpha by granzyme M

Baschuk, N., Wang, N., Watt, S. V., Halse, H. M., House, C. M., Bird, P. I., Strugnell, R. A., Trapani, J. A., Smyth, M. & Andrews, D. M., 2014, In : Cell Death and Disease. 5, 3 (Art. No.: e1115), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
12 Citations (Scopus)

Substrate specificities of the granzyme tryptases A and K

Plasman, K., Demol, H., Bird, P. I., Gevaert, K. & Van Damme, P., 2014, In : Journal of Proteome Research. 13, 12, p. 6067 - 6077 11 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

The granzyme B-Serpinb9 axis controls the fate of lymphocytes after lysosomal stress

Bird, C. H., Christensen, M. E., Mangan, M., Prakash, M. D., Sedelies, K. A., Smyth, M., Harper, I. S., Waterhouse, N. J. & Bird, P. I., 2014, In : Cell Death and Differentiation. 21, 6, p. 876 - 887 12 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

The perforin pore facilitates the delivery of cationic cargos

Stewart, S. E., Kondos, S., Matthews, A. Y., D'Angelo, M., Dunstone, M. A., Whisstock, J., Trapani, J. A. & Bird, P. I., 2014, In : The Journal of Biological Chemistry. 289, 13, p. 9172 - 9181 10 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)
2013

Absence of SERPINB6A causes sensorineural hearing loss with multiple histopathologies in the mouse inner ear

Tan, J., Prakash, M. D., Kaiserman, D. & Bird, P. I., 2013, In : American Journal of Pathology. 183, 1, p. 49 - 59 11 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Cloning and characterising an unusual perforin from chicken (Gallus gallus)

D'Angelo, M., Arjomand, A., Trapani, J. A. & Bird, P. I., 2013, In : Developmental and Comparative Immunology. 41, 2, p. 105 - 109 5 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Conservation of the extended substrate specificity profiles among homologous granzymes across species

Plasman, K., Maurer-Stroh, S., Ahmad, J., Hao, H., Kaiserman, D., Sirota, F. L., Jonckheere, V., Bird, P. I., Gevaert, K. & Van Damme, P., 2013, In : Molecular & Cellular Proteomics. 12, 10, p. 2921 - 2934 14 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis

Susanto, O., Stewart, S. E., Voskoboinik, I., Brasacchio, D., Hagn, M., Ellis, S. L., Asquith, S., Sedelies, K. A., Bird, P. I., Waterhouse, N. J. & Trapani, J. A., 2013, In : Cell Death and Differentiation. 20, 9, p. 1183 - 1193 11 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack

Lopez, J., Susanto, O., Jenkins, M., Lukoyanova, N., Sutton, V. R., Law, R. H. P., Johnston, A., Bird, C. H., Bird, P. I., Whisstock, J., Trapani, J. A., Saibil, H. & Voskoboinik, I., 2013, In : Blood. 121, 14, p. 2659 - 2668 10 p.

Research output: Contribution to journalArticleResearchpeer-review

102 Citations (Scopus)
2012

A versatile monoclonal antibody specific to human SERPINB5

Teoh, S. SY., Wang, H., Risbridger, G. P., Whisstock, J. C. & Bird, P. I., 2012, In : Hybridoma. 31, 5, p. 333 - 339 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737

Sutton, V. R., Sedelies, K. A., Dewson, G., Christensen, M. E., Bird, P. I., Kluck, R. M., Trapani, J. A. & Waterhouse, N. J., 2012, In : Cell Death and Disease. 3, 7 (Art. ID: e344), p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
10 Citations (Scopus)

Intercellular communication via the endo-lysosomal system: Translocation of granzymes through membrane barriers

Stewart, S., D'Angelo, M. & Bird, P., 2012, In : BBA Proteins and Proteomics. 1824, 1, p. 59 - 67 9 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi

D'Angelo, M., Dunstone, M. A., Whisstock, J. C., Trapani, J. & Bird, P. I., 2012, In : BMC Evolutionary Biology. 12, Art. ID: 59, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
26 Citations (Scopus)

Serpinb9 (Spi6)-deficient mice are impaired in dendritic cell-mediated antigen cross-presentation

Rizzitelli, A., Meuter, S., Vega Ramos, J., Bird, C. H., Mintern, J. D., Mangan, M. MJ., Villadangos, J. A. & Bird, P. I., 2012, In : Immunology and Cell Biology. 90, 9, p. 841 - 851 11 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)
2011

Probing the efficiency of proteolytic events by positional proteomics

Plasman, K., Van Damme, P., Kaiserman, D., Impens, F., Demeyer, K., Helsens, K., Goethals, M., Bird, P. I., Vandekerckhove, J. & Gevaert, K., 2011, In : Molecular & Cellular Proteomics. 10, 2 (Art. No: M110.003301), p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)
2010

A role for granzyme M in TLR4-driven inflammation and endotoxicosis

Anthony, D. A., Andrews, D., Chow, M., Watt, S. V., House, C. M., Akira, S., Bird, P. I., Trapani, J. A. & Smyth, M. J., 1 Jun 2010, In : Journal of Immunology. 185, 3, p. 1794 - 1803 10 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

Cathepsin H is an additional convertase of pro-granzyme B

D'Angelo, M., Bird, P. I., Peters, C., Reinheckel, T., Trapani, J. A. & Sutton, V. R., 2010, In : The Journal of Biological Chemistry. 285, 27, p. 20514 - 20519 6 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)