• 23 Innovation Walk, Building 77

    3800 Clayton

    Australia

1980 …2020
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Personal profile

Biography

I am a professor in the Department of Biochemistry and Molecular Biology at Monash University. The Department is part of the School of Biomedical Sciences and the Biomedicine Discovery Institute within the Faculty of Medicine, Nursing and Health Sciences.

I am a molecular cell biologist interested in proteases and their regulators operating in the immune and neural systems. I use biochemistry, structural biology, model cell systems and model organisms (mice, zebrafish) in my research.

I received my PhD in E.coli molecular genetics from the University of Melbourne in 1984. I then spent three years in the USA as a Damon Runyon-Walter Winchell Cancer Foundation Fellow working with Professor Joe Sambrook (FRS) on eukaryotic protein trafficking, first at the Cold Spring Harbor Laboratory and then at the University of Texas in Dallas. On my return to Australia I worked at the Commonwealth Serum Laboratories on the cloning and characterizing of pathogen antigens, and then joined the Department of Medicine at Monash University to work on the molecular regulation of blood coagulation. During this time I discovered a new group of human intracellular protease inhibitors (serpins), and my current research interests are focused on the biology of these proteins and their target proteases.

Research area keywords

  • Molecular Cell Biology
  • Protease Biology

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Projects 2000 2020

Research Output 1980 2019

RNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammation

Wilson, J. A. C., Prow, N. A., Schroder, W. A., Ellis, J. J., Cumming, H. E., Gearing, L. J., Poo, Y. S., Taylor, A., Hertzog, P. J., Di Giallonardo, F., Hueston, L., Le Grand, R., Tang, B., Le, T. T., Gardner, J., Mahalingam, S., Roques, P., Bird, P. I. & Suhrbier, A., 16 Feb 2017, In : PLoS Pathogens. 13, 2, 32 p., e1006155.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Granzyme B promotes cytotoxic lymphocyte transmigration via basement membrane remodeling

Prakash, M. D., Munoz, M., Jain, R., Tong, P. L., Koskinen, A. M. L., Regner, M., Kleifeld, O., Ho, B. K-C., Olson, M. R., Turner, S. J., Mrass, P., Weninger, W. & Bird, P. I., 2014, In : Immunity. 41, 6, p. 960 - 972 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Absence of SERPINB6A causes sensorineural hearing loss with multiple histopathologies in the mouse inner ear

Tan, J., Prakash, M. D., Kaiserman, D. & Bird, P. I., 2013, In : American Journal of Pathology. 183, 1, p. 49 - 59 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi

D'Angelo, M., Dunstone, M. A., Whisstock, J. C., Trapani, J. & Bird, P. I., 2012, In : BMC Evolutionary Biology. 12, Art. ID: 59, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency

Hirst, C. E., Buzza, M. S., Bird, C. H., Warren, H. S., Cameron, P. U., Zhang, M., Ashton-Rickardt, P. G. & Bird, P. I., 2003, In : Journal of Immunology. 170, 2, p. 805 - 815 11 p.

Research output: Contribution to journalArticleResearchpeer-review