Philip Wai Hong Chan

Professor

19972019
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Research Output 1997 2019

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2019

Aurone derivatives as Vps34 inhibitors that modulate autophagy

Li, G., Boyle, J. W., Ko, C. N., Zeng, W., Wong, V. K. W., Wan, J. B., Chan, P. W. H., Ma, D. L. & Leung, C. H., 1 Jan 2019, In : Acta Pharmaceutica Sinica B. 9, 3, p. 537–544 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Gold Catalyzed Photoredox C1-Alkynylation of N-Alkyl-1,2,3,4- tetrahydroisoquinolines by 1-Bromoalkynes with UVA LED Light

Zhao, Y., Jin, J. & Chan, P. W. H., 1 Jan 2019, In : Advanced Synthesis and Catalysis. 361, 6, p. 1313-1321 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Brønsted acid-catalysed allylic amination of 1-(2-aminoaryl)prop-2-en-1-ols to 1,2-dihydroquinolines

Day, D. P., Henry, S. A., Zhao, Y., Jin, J., Clarkson, G. J. & Chan, P. W. H., 19 Jun 2018, In : Australian Journal of Chemistry. 71, 9, p. 673-681 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Chiral Brønsted acid and gold catalyzed enantioselective synthesis of 1,8-dihydroindeno[2,1-b]pyrroles

Jin, J., Zhao, Y., Sze, E. M. L., Kothandaraman, P. & Chan, P. W. H., 21 Dec 2018, In : Advanced Synthesis and Catalysis. 360, 24, p. 4744-4753 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Chiral Brønsted acid catalyzed enantioselective dehydrative nazarov-type electrocyclization of aryl and 2-thienyl vinyl alcohols

Jin, J., Zhao, Y., Gouranourimi, A., Ariafard, A. & Chan, P. W. H., 2 May 2018, In : Journal of the American Chemical Society. 140, 17, p. 5834-5841 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Gold-catalyzed double cycloisomerization of 1-ene-4,10-diynyl esters to bicyclo[6.3.0]undeca-2,4,9-trienyl esters

Mathiew, M., Tan, J. K. & Chan, P. W. H., 22 Oct 2018, In : Angewandte Chemie - International Edition. 57, 43, p. 14235-14239 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Gold-Catalyzed Formal [4 + 2] Cycloaddition of 5-(Ethynylamino)pent-2-yn-1-yl Esters to 1,2,3,5-Tetrahydrobenzo [g] quinolines

Chen, X., Merrett, J. T. & Hong Chan, P. W., 16 Mar 2018, In : Organic Letters. 20, 6, p. 1542-1545 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Brønsted Acid-Mediated Cycloaromatization of 1H-Indol-2-yl Propargyl Benzoates to 7H-Benzo[c]carbazoles

Tan, J. K., Mathiew, M., Nayak, S. & Chan, P. W. H., 4 Jul 2017, In : Chemistry - An Asian Journal. 12, 13, p. 1475-1479 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Brønsted Base-Mediated Aziridination of 2-Alkyl-Substituted-1,3-Dicarbonyl Compounds and 2-Acyl-Substituted-1,4-Dicarbonyl Compounds by Iminoiodanes

Tejo, C., Tirtorahardjo, D., Day, D. P., Ma, D-L. E., Leung, C-H. D. & Chan, P. W. H., 2017, In : Australian Journal of Chemistry. 70, 4, p. 430-435 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Gold-Catalyzed Dehydrogenative Cycloisomerization of 1,4-Enyne Esters to 3,5-Disubstituted Phenol Derivatives

Chen, C., Chen, X., Zhang, X., Wang, S., Rao, W. & Chan, P. W. H., 19 Dec 2017, In : Advanced Synthesis and Catalysis. 359, 24, p. 4359-4368 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Silver-Catalyzed 1,3-Acyloxy Migration/Diels-Alder Reaction of 1,9-Dien-4-yne Esters to Partially Hydrogenated Isoquinolines

Zhao, Y., Jin, J., Boyle, J. W., Lee, B. R., Day, D. P., Susanti, D., Clarkson, G. J. & Chan, P. W. H., 17 Mar 2017, In : Journal of Organic Chemistry. 82, 6, p. 2826-2834 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Copper-Mediated Cross-Dehydrogenative Coupling of 2-Methylpyridine and 8-Methylquinoline with Methyl Ketones and Benzamides

Kumar, G. S., Boyle, J. W., Tejo, C. & Chan, P. W. H., 4 Feb 2016, In : Chemistry - An Asian Journal. 11, 3, p. 385-389 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Gold- and Brønsted Acid-Catalyzed Cycloisomerization of 1,8-Diynyl Vinyl Acetates to Bicyclo[2.2.1]hept-2-en-7-ones

Chen, X., Day, D. P., Teo, W. T. & Chan, P. W. H., 18 Nov 2016, In : Organic Letters. 18, 22, p. 5936-5939 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Gold-Catalyzed Aminoalkenylation of β-Amino-1,n-Diynols to Cycloalkyl-, Piperidinyl- and Pyranyl-Fused Pyrroles

Kothandaraman, P., Zhao, Y., Lee, B. R., Le Ng, C. J., Lee, J. Y., Ayers, B. J. & Chan, P. W. H., 28 Apr 2016, In : Advanced Synthesis and Catalysis. 358, 9, p. 1385-1391 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Gold-Catalyzed Sequential Cyclization of 1-En-3,9-Diyne Esters to Partially Hydrogenated 3H-Dicyclopenta[a,b]naphthalenes

Rao, W., Boyle, J. W. & Chan, P. W. H., 4 May 2016, In : Chemistry - A European Journal. 22, 19, p. 6532-6536 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Gold-Catalyzed Tandem 1,3-Migration/Double Cyclopropanation of 1-Ene-4,n-diyne Esters to Tetracyclodecene and Tetracycloundecene Derivatives

Chen, C., Zou, Y., Chen, X., Zhang, X., Rao, W. & Chan, P. W. H., 16 Sep 2016, In : Organic Letters. 18, 18, p. 4730-4733 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin-MLL interaction

Zhong, H-J., Lee, B. R., Boyle, J. W., Wang, W., Ma, D-L. E., Hong Chan, P. W. & Leung, C-H. D., 30 Apr 2016, In : Chemical Communications. 52, 34, p. 5788-5791 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of 1,4-amino alcohols by Grignard reagent addition to THF and N-tosyliminobenzyliodinane

Tejo, C., See, Y. F. A., Mathiew, M. & Chan, P. W. H., 2016, In : Organic and Biomolecular Chemistry. 14, 3, p. 844-848 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

A label-free G-quadruplex-based mercury detection assay employing the exonuclease III-mediated cleavage of T-Hg2+-T mismatched DNA

Wang, W., Kang, T-S., Chan, P. W. H., Lu, J-J., Chen, X-P., Leung, C-H. D. & Ma, D-L. E., 2015, In : Science and Technology of Advanced Materials. 16, 6, p. 1-6 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Crystal structure of (Z)-1-phenyl-3-styrylundeca-2-en-4, 10-diyn-1-ol

Ganguly, R., Sally, U. & Chan, P. W. H., 2015, In : Acta Crystallographica Section E: Structure Reports Online. 71, 1, p. 64 - 64 1 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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Discovery of a small-molecule inhibitor of STAT3 by ligand-based pharmacophore screening

Leung, K-H., Liu, L-J., Lin, S., Lu, L., Zhong, H-J., Susanti, D., Rao, W., Wang, M., Che, W. I., Chan, D. S-H., Leung, C-H. D., Chan, P. W. H. & Ma, D-L. E., 2015, In : Methods. 71, C, p. 38-43 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Gold-catalyzed cycloisomerization and Diels-Alder reaction of 1,4,9-dienyne esters to 3 a,6-methanoisoindole esters with pro-inflammatory cytokine antagonist activity

Susanti, D., Liu, L-J., Rao, W., Lin, S., Ma, D-L. E., Leung, C-H. D. & Chan, P. W. H., 2015, In : Chemistry - A European Journal. 21, 25, p. 9111-9118 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Gold-catalyzed cycloisomerization and Diels-Alder reaction of 1,6-diyne esters with alkenes and diazenes to hydronaphthalenes and -cinnolines

Yan, J., Tay, G. L., Neo, C., Lee, B. R. & Chan, P. W. H., 2015, In : Organic Letters. 17, 17, p. 4176-4179 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Harnessing the versatile reactivity of propargyl alcohols and their derivatives for sustainable complex molecule synthesis

Ayers, B. J. & Chan, P. W. H., 2015, In : Synlett. 26, 10, p. 1305-1339 35 p.

Research output: Contribution to journalArticleResearchpeer-review

Iminoiodane- and Bronsted base-mediated cross dehydrogenative coupling of cyclic ethers with 1,3-dicarbonyl compounds

Tejo, C., Sim, X. R., Lee, B. R., Ayers, B. J., Leung, C-H. D., Ma, D-L. E. & Chan, P. W. H., 2015, In : Molecules. 20, 7, p. 13336-13353 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Ligand-controlled product selectivity in gold-catalyzed double cycloisomerization of 1,11-dien-3,9-diyne benzoates

Rao, W., Susanti, D., Ayers, B. J. & Chan, P. W. H., 2015, In : Journal of the American Chemical Society. 137, 19, p. 6350-6355 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Pharmacophore modeling for the identification of small-molecule inhibitors of TACE

Liu, L-J., Leung, K-H., Lin, S., Chan, D. S-H., Susanti, D., Rao, W., Chan, P. W. H., Ma, D-L. E. & Leung, C-H. D., 2015, In : Methods. 71, p. 92 - 97 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Silver Triflate Catalyzed Cyclopropyl Carbinol Rearrangement for Benzo[b]oxepine and 2H-Chromene Synthesis

Chan, P. W. H., Teo, W. T., Koh, S. W. Y., Lee, B. R., Ayers, B. J., Ma, D-L. E. & Leung, C-H. D., 1 Jul 2015, In : European Journal of Organic Chemistry. 2015, 20, p. 4447-4456 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

A G-quadruplex-based platform for the detection of Hg2+ ions using a luminescent iridium(III) complex

Lin, S., He, B., Chan, D. S-H., Chan, P. W. H., Leung, C-H. D. & Ma, D-L. E., 2014, In : RSC Advances. 4, 97, p. 54826 - 54831 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Bronsted acid catalyzed amination of 1,3-dicarbonyl compounds by iminoiodanes

Tejo, C., Yeo, H. Q. & Chan, P. W. H., 2014, In : Synlett. 25, 2, p. 201 - 204 4 p.

Research output: Contribution to journalArticleOtherpeer-review

Discovery of a natural product-like iNOS inhibitor by molecular docking with potential neuroprotective effects in vivo

Zhong, H-J., Liu, L-J., Chong, C-M., Lu, L., Wang, M., Chan, D. S-H., Chan, P. W. H., Lee, S. M-Y., Ma, D-L. E. & Leung, C-H. D., 2014, In : PLoS ONE. 9, 4, p. 1-10 10 p., e92905.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Gold-catalyzed [2+2+1] cycloaddition of 1,6-diyne carbonates and esters with aldehydes to 4-(cyclohexa-1,3-dienyl)-1,3-dioxolanes

Rao, W. & Chan, P. W. H., 2014, In : Chemistry - A European Journal. 20, 3, p. 713 - 718 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Gold-catalyzed benzannulation of 5-hydroxy-3-oxoalk-6-ynoate esters to o-phenolic esters

Teo, W. T., Rao, W., Ng, C. J. H., Koh, S. W. Y. & Chan, P. W. H., 2014, In : Organic Letters. 16, 4, p. 1248 - 1251 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Gold-catalyzed cycloisomerization of 1,6,8-dienyne carbonates and esters to cis-cyclohepta-4,8-diene-fused pyrrolidines

Rao, W., Sally, Berry, S. N. & Chan, P. W. H., 2014, In : Chemistry - A European Journal. 20, 41, p. 13174 - 13180 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Gold-catalyzed cycloisomerization of 1,6-diyne esters to 1H-cyclopenta[b]naphthalenes, cis-cyclopenten-2-yl delta-diketones, and bicyclo[3.2.0]hepta-1,5-dienes

Li, D., Rao, W., Tay, G. L., Ayers, B. J. & Chan, P. W. H., 2014, In : Journal of Organic Chemistry. 79, 23, p. 11301 - 11315 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Silica gel-mediated hydroamination/semipinacol rearrangement of 2-alkylaminophenylprop-1-yn-3-ols: synthesis of 2-oxindoles from alkynes and 1-(2-aminophenyl) ketones

Susanti, D., Ng, L. L. R. & Chan, P. W. H., 2014, In : Advanced Synthesis and Catalysis. 356, 2-3, p. 353 - 358 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Silver-catalyzed tandem hydroamination/hydroarylation of 1-(2-allylamino)phenyl-4-hydroxy-but-2-yn-1-ones to 1 '-allylspiro[indene-1,2 '-indolin]-3 '-ones

Mothe, S. R., Novianti, M. L., Ayers, B. J. & Chan, P. W. H., 2014, In : Organic Letters. 16, 16, p. 4110 - 4113 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure-based repurposing of FDA-approved drugs as inhibitors of NEDD8-activating enzyme

Zhong, H-J., Liu, L-J., Chan, D. S-H., Wang, H-M. D., Chan, P. W. H., Ma, D-L. E. & Leung, C-H. D., 2014, In : Biochimie. 102, 1, p. 211 - 215 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of highly substituted indene derivatives by Bronsted acid catalyzed Friedel-Crafts reaction of homoallylic alcohols

Zhang, X., Teo, W. T., Rao, W., Ma, D-L. E., Leung, C-H. D. & Chan, P. W. H., 2014, In : Tetrahedron Letters. 55, 29, p. 3881 - 3884 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Ytterbium(III) triflate catalyzed annulation of propargylic 1,4-diols with aryl sulfonamides to give highly substituted pyrrole derivatives

Zhang, X., Teo, J. W., Ma, D-L. E., Leung, C-H. D. & Chan, P. W. H., 2014, In : Tetrahedron Letters. 55, 49, p. 6703 - 6707 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

1-(2′-Anilinyl)prop-2-yn-1-ol rearrangement for oxindole synthesis

Kothandaraman, P., Koh, B. Q., Limpanuparb, T., Hirao, H. & Chan, P. W. H., 4 Feb 2013, In : Chemistry - A European Journal. 19, 6, p. 1978-1985 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Gold-catalyzed cycloisomerization of 1,6-diyne carbonates and esters to 2,4a-dihydro-1H-fluorenes

Rao, W., Koh, M. J., Li, D., Hirao, H. & Chan, P. W. H., 2013, In : Journal of the American Chemical Society. 135, 21, p. 7926 - 7932 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Gold-catalyzed cycloisomerization of 1,7-enyne esters to structurally diverse cis-1,2,3,6-tetrahydropyridin-4-y1 ketones

Rao, W., Sally, U., Koh, M. J. & Chan, P. W. H., 2013, In : Journal of Organic Chemistry. 78, 7, p. 3183 - 3195 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Gold-catalyzed domino aminocyclization/1,3-sulfonyl migration of N-substituted N-sulfonyl-aminobut-3-yn-2-ols to 1-substituted 3-sulfonyl-1H-pyrroles

Teo, W. T., Rao, W., Koh, M. J. & Chan, P. W. H., 2013, In : Journal of Organic Chemistry. 78, 15, p. 7508 - 7517 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Metal-free synthesis of 1H-indole-2-carbaldehydes by N-iodosuccinimide-mediated cyclization of 1-(2 '-anilinyl)prop-2-yn-1-ols in water. A formal synthesis of (R)-calindol

Kothandaraman, P., Lauw, S. J. L. & Chan, P. W. H., 2013, In : Tetrahedron. 69, 35, p. 7471 - 7480 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of (Z)-1,2-dihydro-1-tosylbenzo[b]azepin-3-ones by two-step, one-pot gold-catalyzed tandem heterocyclization/Petasis-Ferrier rearrangement of 2-(N-(prop-2-ynyl)-N-tosylamino)benzaldehydes

Sze, E. M. L., Koh, M. J., Tjia, Y. M., Rao, W. & Chan, P. W. H., 2013, In : Tetrahedron. 69, 26, p. 5558 - 5565 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Bronsted acid-catalyzed cycloisomerization of but-2-yne-1,4-diols with or without 1,3-dicarbonyl compounds to tri- and tetrasubstituted furans

Mothe, S. R., Lauw, S. J. L., Kothandaraman, P. & Chan, P. W. H., 2012, In : Journal of Organic Chemistry. 77, 16, p. 6937 - 6947 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Copper(II) triflate catalyzed amination and aziridination of 2-alkyl substituted 1,3-dicarbonyl compounds

Ton, T. M. U., Tejo, C., Tiong, D. L. Y. & Chan, P. W. H., 2012, In : Journal of the American Chemical Society. 134, 17, p. 7344 - 7350 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Copper(II) triflate catalyzed amination of 1,3-dicarbonyl compounds

Ton, T. M. U., Himawan, F., Chang, J. W. W. & Chan, P. W. H., 17 Sep 2012, In : Chemistry - A European Journal. 18, 38, p. 12020-12027 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Gold-catalyzed cycloisomerization of 1,7-diyne benzoates to indeno[1,2-c]azepines and azabicyclo[4.2.0]octa-1(8),5-dines

Rao, W., Koh, M. J., Kothandaraman, P. & Chan, P. W. H., 2012, In : Journal of the American Chemical Society. 134, 26, p. 10811 - 10814 4 p.

Research output: Contribution to journalArticleResearchpeer-review