Projects per year
Personal profile
Biography
Position
Medicinal Chemistry
Monash Institute of Pharmaceutical Sciences
Research interests
Research in our group has a general focus on Structure-based Design and Synthesis of kinase inhibitors , epigenetic modulators and phosphodiesterase inhibitors. We have particular expertise in Peptides and Peptidomimetics.
Our major current programs deal with
- isoform selective inhibition of the PI3 kinase family
- new chemotypes as PDE inhibitors and PDE inhibitors against parasitic diseases
- polymyxin-based antibacterial agents
- fluorescent labels for peptides
- modulators of epigenetic proteins
Monash teaching commitment
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Kinase Inhibitors
- Peptides and Peptidomimetics
- Structure-Based Design and Synthesis of Kinase
- Epigenetics
Collaborations and top research areas from the last five years
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Improved glucose control, with lower insulin doses, for the treatment of type 1 diabetes
Cowley, M., Simonds, S., Thompson, P., Pouton, C. & Greenough, C.
MTP-IIGC Ltd (trading as MTP Connect)
1/08/22 → 15/02/25
Project: Research
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Development of a Novel Photo-Angioplasty Device for the Treatment of Occlusive Peripheral Vascular Disease
Dear, A., Fraser, J., Li Bassi, G., Thompson, P., Gaspari, T. & Thissen, H.
1/01/22 → 31/12/25
Project: Research
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JDRF Strategic Research Agreement - Novel Adjunctive Therapeutic For T1D; a-MSH/MC5R agonist axis
Cowley, M., Sleeman, M., Thompson, P., Wentworth, J. & Kelly, L.
1/07/19 → 28/02/25
Project: Research
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Dual-targeted inhibitors of BET bromodomains and PI3-kinase for cancer therapy.
1/02/22 → 1/02/24
Project: Research
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Lead optimisation of novel inhibitors of IRAP for the treatment of fibrosis in diabetes-induced renal and cardiovascular disease
Gaspari, T., Chai, S., Widdop, R., Thompson, P., Nielsen, K., Perez, S., Dear, A., Yun, B., Pfleger, K. & Barlow, N.
1/10/21 → 30/11/23
Project: Research
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PmxPred: A data-driven approach for the identification of active polymyxin analogues against gram-negative bacteria
Wang, X., Patil, N., Li, F., Wang, Z., Zhan, H., Schmidt, D. F., Thompson, P. E., Guo, Y., Landersdorfer, C. B., Shen, H-H., Peleg, A. Y., Li, J. & Song, J., 2024, In: Computers in Biology and Medicine. 168, 10 p., 107681.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Citations (Scopus) -
Advances in Design and Development of Lumi-Solve: A Novel Drug-Eluting Photo-Angioplasty Device
Sangeetha Menon, A., Subasic de Azevedo, I., Choong, K., Bhatnagar, D., Wang, C., Sluka, P., Chisholm, D. R., Pasic, P., Thissen, H., Sama, G., Robinson, A., Rodda, A., Tria, A., Spiegel, L., Dharma, A., Kaipananickal, H., Okabe, J., El-Osta, A., Mountford, S., Thompson, P., & 1 others , Aug 2023, In: Cardiovascular Engineering and Technology. 14, p. 605–614 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Critical Role of Position 10 Residue in the Polymyxin Antimicrobial Activity
Patil, N. A., Ma, W., Jiang, X., He, X., Yu, H. H., Wickremasinghe, H., Wang, J., Thompson, P. E., Velkov, T., Roberts, K. D. & Li, J., 6 Feb 2023, In: Journal of Medicinal Chemistry. 66, 4, p. 2865–2876 12 p.Research output: Contribution to journal › Article › Research › peer-review
5 Citations (Scopus) -
Development of Highly Potent Clinical Candidates for Theranostic Applications against Cholecystokinin-2 Receptor Positive Cancers
Corlett, A., Pinson, J. A., Rahimi, M. N., Zuylekom, J. V., Cullinane, C., Blyth, B., Thompson, P. E., Hutton, C. A., Roselt, P. D. & Haskali, M. B., 10 Aug 2023, In: Journal of Medicinal Chemistry. 66, 15, p. 10289-10303 15 p.Research output: Contribution to journal › Article › Research › peer-review
3 Citations (Scopus) -
Leveraging the MMV Pathogen Box to Engineer an Antifungal Compound with Improved Efficacy and Selectivity against Candida auris
Pan, B., Weerasinghe, H., Sezmis, A., McDonald, M. J., Traven, A., Thompson, P. & Simm, C., 13 Oct 2023, In: ACS Infectious Diseases. 9, 10, p. 1901–1917 17 p.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus)
Prizes
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Team Award for Research Impact [Economic and Social] (Faculty of Pharmacy and Pharmaceutical Sciences, Monash University)
Nation, Roger (Recipient), Velkov, Tony (Recipient), Li, Jian (Recipient), Roberts, Kade (Recipient) & Thompson, Philip (Recipient), 2016
Prize: Prize (including medals and awards)
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Vice-Chancellor's Award for Excellence in Research Engagement and Impact (Monash University)
Nation, Roger (Recipient), Li, Jian (Recipient), Roberts, Kade (Recipient), Velkov, Tony (Recipient) & Thompson, Philip (Recipient), 2022
Prize: Prize (including medals and awards)
Activities
- 1 Grant review responsibilities
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Medicinal Chemistry and Drug Action
Philip Thompson (Member)
22 Sept 2011Activity: External Academic Engagement › Grant review responsibilities