Research Output per year
Research Output 1992 2019
- 1 - 50 out of 142 results
- Publication Year, Title (descending)
2019
An apically located hybrid guanylate cyclase-ATPase is critical for the initiation of Ca2+ signaling and motility in Toxoplasma gondii
Yang, L., Uboldi, A. D., Seizova, S., Wilde, M. L., Coffey, M. J., Katris, N. J., Yamaryo-Botté, Y., Kocan, M., Bathgate, R. A. D., Stewart, R. J., McConville, M. J., Thompson, P. E., Botté, C. Y. & Tonkin, C. J., 31 May 2019, In : Journal of Biological Chemistry. 294, 22, p. 8959-8972 14 p.Research output: Contribution to journal › Article › Research › peer-review
Controlled Construction of Cyclic d / l Peptide Nanorods
Silk, M. R., Mohanty, B., Sampson, J. B., Scanlon, M. J., Thompson, P. E. & Chalmers, D. K., 8 Jan 2019, In : Angewandte Chemie - International Edition. 58, 2, p. 596-601 6 p.Research output: Contribution to journal › Article › Research › peer-review
Structural Determinants of Isoform Selectivity in PI3K Inhibitors
Miller, M. S., Thompson, P. E. & Gabelli, S. B., 26 Feb 2019, In : Biomolecules. 9, 3, 35 p., 82.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access
File
2018
A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent
Sadek, M. M., Barlow, N., Leung, E. W. W., Williams-Noonan, B. J., Yap, B. K., Shariff, F. M., Caradoc-Davies, T. T., Nicholson, S. E., Chalmers, D. K., Thompson, P. E., Law, R. H. P. & Norton, R. S., 19 Oct 2018, In : ACS Chemical Biology. 13, 10, p. 2930-2938 9 p.Research output: Contribution to journal › Article › Research › peer-review
Cyclic Hexapeptide Mimics of the LEDGF Integrase Recognition Loop in Complex with HIV-1 Integrase
Northfield, S. E., Wielens, J., Headey, S. J., Williams-Noonan, B. J., Mulcair, M., Scanlon, M., Parker, M. W., Thompson, P. E. & Chalmers, D. K., 10 Aug 2018, In : ChemMedChem. 13, 15, p. 1555-1565 11 p.Research output: Contribution to journal › Article › Research › peer-review
Methionine ameliorates polymyxin-induced nephrotoxicity by attenuating cellular oxidative stress
Azad, M. A. K., Sivanesan, S., Wang, J., Chen, K., Nation, R. L., Thompson, P. E., Roberts, K. D., Velkov, T. & Li, J., 1 Jan 2018, In : Antimicrobial Agents and Chemotherapy. 62, 1, 9 p., e01254.Research output: Contribution to journal › Article › Research › peer-review
Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria
Velkov, T., Gallardo-Godoy, A., Swarbrick, J. D., Blaskovich, M. A. T., Elliott, A. G., Han, M., Thompson, P. E., Roberts, K. D., Huang, J. X., Becker, B., Butler, M. S., Lash, L. H., Henriques, S. T., Nation, R. L., Sivanesan, S., Sani, M. A., Separovic, F., Mertens, H., Bulach, D., Seemann, T. & 3 others, 19 Apr 2018, In : Cell Chemical Biology. 25, 4, p. 380-391 12 p.Research output: Contribution to journal › Article › Research › peer-review
2017
Characterization of the Polymyxin D Synthetase Biosynthetic Cluster and Product Profile of Paenibacillus polymyxa ATCC 10401
Galea, C. A., Han, M., Zhu, Y., Roberts, K., Wang, J., Thompson, P. E., Li, J. & Velkov, T., 26 May 2017, In : Journal of Natural Products. 80, 5, p. 1264-1274 11 p.Research output: Contribution to journal › Article › Research › peer-review
Class II phosphoinositide 3-kinases as novel drug targets
Falasca, M., Hamilton, J. R., Selvadurai, M. V., Sundaram, K., Adamska, A. & Thompson, P., 12 Jan 2017, In : Journal of Medicinal Chemistry. 60, 1, p. 47-65 19 p.Research output: Contribution to journal › Article › Research › peer-review
Design and evaluation of novel polymyxin fluorescent probes
Yun, B., Roberts, K. D., Thompson, P. E., Nation, R. L., Velkov, T. & Li, J., 11 Nov 2017, In : Sensors. 17, 11, 8 p., 2598.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Functional characterization of the unique terminal thioesterase domain from polymyxin synthetase
Galea, C., Roberts, K. D., Zhu, Y., Thompson, P. E., Li, J. & Velkov, T., 31 Jan 2017, In : Biochemistry. 56, 4, p. 657-668 12 p.Research output: Contribution to journal › Article › Research › peer-review
Investigating the Interaction of Octapeptin A3 with Model Bacterial Membranes
Han, M. L., Shen, H. H., Hansford, K. A., Schneider, E. K., Sivanesan, S., Roberts, K. D., Thompson, P. E., Le Brun, A. P., Zhu, Y., Sani, M-A., Separovic, F., Blaskovich, M. A. T., Baker, M. A., Moskowitz, S. M., Cooper, M. A., Li, J. & Velkov, T., 11 Aug 2017, In : ACS Infectious Diseases. 3, 8, p. 606-619 14 p.Research output: Contribution to journal › Article › Research › peer-review
Parallel and antiparallel cyclic d/l peptide nanotubes
Silk, M. R., Newman, J., Ratcliffe, J. C., White, J. F., Caradoc-Davies, T., Price, J. R., Perrier, S., Thompson, P. E. & Chalmers, D. K., 2017, In : Chemical Communications. 53, 49, p. 6613-6616 4 p.Research output: Contribution to journal › Article › Research › peer-review
Pharmacokinetics of the individual major components of polymyxin B and colistin in rats
Sivanesan, S., Roberts, K., Wang, J., Cheah, S-E., Thompson, P. E., Li, J., Nation, R. & Velkov, T., 27 Jan 2017, In : Journal of Natural Products. 80, 1, p. 225-229 5 p.Research output: Contribution to journal › Article › Research › peer-review
Synthesis and biological evaluation of 8-aryl-2-morpholino-7-O-substituted benzo[e][1,3]oxazin-4-ones against DNA-PK, PI3K, PDE3A enzymes and platelet aggregation
Saifuzzaman, M., Morrison, R., Zheng, Z., Orive, S., Hamilton, J., Thompson, P. E. & Al-Rawi, J. M. A., 15 Oct 2017, In : Bioorganic and Medicinal Chemistry. 25, 20, p. 5531-5536 6 p.Research output: Contribution to journal › Article › Research › peer-review
2016
A novel chemical biology approach for mapping of polymyxin lipopeptide antibody binding epitopes
Velkov, T., Yun, B., Schneider, E. K., Azad, M. A. K., Dolezal, O., Morris, F. C., Nation, R. L., Wang, J., Chen, K., Yu, H., Wang, L., Thompson, P. E., Roberts, K. D. & Li, J., 2016, In : ACS Infectious Diseases. 2, 5, p. 341-351 11 p.Research output: Contribution to journal › Article › Research › peer-review
A novel serpin regulatory mechanism: SERPINB9 is reversibly inhibited by vicinal disulfide bond formation in the reactive center loop
Mangan, M. S. J., Bird, C. H., Kaiserman, D., Matthews, A. Y., Hitchen, C., Steer, D. L., Thompson, P. E. & Bird, P. I., 12 Feb 2016, In : Journal of Biological Chemistry. 291, 7, p. 3626-3638 13 p.Research output: Contribution to journal › Article › Research › peer-review
Beta amino acid-modified and fluorescently labelled kisspeptin analogues with potent KISS1R activity
Camerino, M., Liu, M., Moriya, S., Kitahashi, T., Mahgoub, A., Mountford, S., Chalmers, D. K., Soga, T., Parhar, I. & Thompson, P., 1 Jun 2016, In : Journal of Peptide Science. 22, 6, p. 406-414 9 p.Research output: Contribution to journal › Article › Research › peer-review
Design, synthesis, and characterization of cyclic peptidomimetics of the inducible nitric oxide synthase binding epitope that disrupt the protein-protein interaction involving SPRY domain-containing suppressor of cytokine signaling box protein (SPSB) 2 and inducible nitric oxide synthase
Harjani, J. R., Yap, B. K., Leung, E. W. W., Lucke, A., Nicholson, S. E., Scanlon, M. J., Chalmers, D. K., Thompson, P. E., Norton, R. S. & Baell, J. B., 23 Jun 2016, In : Journal of Medicinal Chemistry. 59, 12, p. 5799-5809 11 p.Research output: Contribution to journal › Article › Research › peer-review
Development of single and mixed isoform selectivity PI3Kδ inhibitors by targeting Asn836 of PI3Kδ
Miller, M. S., Mountford, S. J., Pinson, J-A., Zheng, Z., Künzli, M., Patel, V., Hogg, S. J., Shortt, J., Jennings, I. G. & Thompson, P. E., 1 Oct 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 19, p. 4790-4794 5 p.Research output: Contribution to journal › Article › Research › peer-review
Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922)
Zheng, Z., Pinson, J. A., Mountford, S. J., Orive, S., Schoenwaelder, S. M., Shackleford, D., Powell, A., Nelson, E. M., Hamilton, J. R., Jackson, S., Jennings, I. G. & Thompson, P. E., 21 Oct 2016, In : European Journal of Medicinal Chemistry. 122, p. 339-351 13 p.Research output: Contribution to journal › Article › Research › peer-review
Identification of a cyanine-dye labeled peptidic ligand for Y1R and Y4R, based upon the neuropeptide y C-terminal analogue, BVD-15
Liu, M., Richardson, R. R., Mountford, S. J., Zhang, L., Tempone, M. H., Herzog, H., Holliday, N. D. & Thompson, P. E., 21 Sep 2016, In : Bioconjugate Chemistry. 27, 9, p. 2166-2175 10 p.Research output: Contribution to journal › Article › Research › peer-review
Optically pure, structural, and fluorescent analogues of a dimeric Y4 receptor agonist derived by an olefin metathesis approach
Liu, M., Mountford, S. J., Richardson, R. R., Groenen, M., Holliday, N. D. & Thompson, P. E., 14 Jul 2016, In : Journal of Medicinal Chemistry. 59, 13, p. 6059-6069 11 p.Research output: Contribution to journal › Article › Research › peer-review
Polymyxins: a new hope in combating Gram-negative superbugs?
Velkov, T., Roberts, K. D., Thompson, P. E. & Li, J., 1 Jun 2016, In : Future Medicinal Chemistry. 8, 10, p. 1017-1025 9 p.Research output: Contribution to journal › Review Article › Research › peer-review
Quantitation of polymyxin-lipopolysaccharide interactions using an image-based fluorescent probe
McInerney, M. P., Roberts, K. D., Thompson, P. E., Li, J., Nation, R. L., Velkov, T. & Nicolazzo, J. A., 2016, In : Journal of Pharmaceutical Sciences. 105, 2, p. 1006-1010 5 p.Research output: Contribution to journal › Article › Research › peer-review
Redox-stable cyclic peptide inhibitors of the SPSB2-iNOS interaction
Yap, B. K., Harjani, J. R., Leung, E. W. W., Nicholson, S. E., Scanlon, M. J., Chalmers, D. K., Thompson, P. E., Baell, J. B. & Norton, R. S., 1 Mar 2016, In : FEBS Letters. 590, 6, p. 696-704 9 p.Research output: Contribution to journal › Article › Research › peer-review
Structure–activity studies of β-hairpin peptide inhibitors of the Plasmodium falciparum AMA1–RON2 interaction
Wang, G., Drinkwater, N., Drew, D. R., MacRaild, C. A., Chalmers, D. K., Mohanty, B., Lim, S. S., Anders, R. F., Beeson, J. G., Thompson, P. E., McGowan, S., Simpson, J. S., Norton, R. S. & Scanlon, M. J., 9 Oct 2016, In : Journal of Molecular Biology. 428, 20, p. 3986-3998 13 p.Research output: Contribution to journal › Article › Research › peer-review
Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines
Morrison, R., Al-Rawi, J. M. A., Jennings, I. G., Thompson, P. E. & Angove, M. J., 3 Mar 2016, In : European Journal of Medicinal Chemistry. 110, p. 326-339 14 p.Research output: Contribution to journal › Article › Research › peer-review
Synthesis of linear and angular aryl-morpholino-naphth-oxazines, their DNA-PK, PI3K, PDE3A and antiplatelet activity
Morrison, R., Zheng, Z., Jennings, I. G., Thompson, P. E. & Al-Rawi, J. M. A., 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 22, p. 5534-5538 5 p.Research output: Contribution to journal › Article › Research › peer-review
The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonism
Wootten, D., Reynolds, C. A., Smith, K. J., Mobarec, J. C., Koole, C., Savage, E. E., Pabreja, K., Simms, J., Sridhar, R., Furness, S. G. B., Liu, M., Thompson, P. E., Miller, L. J., Christopoulos, A. & Sexton, P. M., 16 Jun 2016, In : Cell. 165, 7, p. 1632-1643 12 p.Research output: Contribution to journal › Article › Research › peer-review
Transcriptomic analysis of the activity of a novel polymyxin against Staphylococcus aureus
Zhao, J., Cheah, S-E., Roberts, K. D., Nation, R. L., Thompson, P. E., Velkov, T., Du, Z., Johnson, M. D. & Li, J., 2016, In : mSphere. 1, 4, 13 p., e00119-16.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
2015
Antimicrobial activity and toxicity of the major lipopeptide components of polymyxin B and colistin: last-line antibiotics against multidrug-resistant gram-negative bacteria
Roberts, K. D., Azad, M. A. K., Wang, J., Horne, A. S., Thompson, P. E., Nation, R. L., Velkov, T. & Li, J., 2015, In : ACS Infectious Diseases. 1, 11, p. 568-575 8 p.Research output: Contribution to journal › Article › Research › peer-review
Cellular uptake and localization of polymyxins in renal tubular cells using rationally designed fluorescent probes
Yun, B., Azad, M. A. K., Nowell, C. J., Nation, R. L., Thompson, P. E., Roberts, K. D., Velkov, T. & Li, J., 2015, In : Antimicrobial Agents and Chemotherapy. 59, 12, p. 7489-7496 8 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Class II but not second class - prospects for the development of class II PI3K inhibitors
Mountford, S. J., Zheng, Z., Sundaram, K., Jennings, I., Hamilton, J. R. & Thompson, P., 2015, In : A C S Medicinal Chemistry Letters. 6, 1, p. 3 - 6 4 p.Research output: Contribution to journal › Editorial › Research › peer-review
Identification of potent phosphodiesterase inhibitors that demonstrate cyclic nucleotide-dependent functions in apicomplexan parasites
Howard, B. L., Harvey, K. L., Stewart, R. J., Azevedo, M. F., Crabb, B. S., Jennings, I., Sanders, P. R., Manallack, D. T., Thompson, P., Tonkin, C. J. & Gilson, P. R., 2015, In : ACS Chemical Biology. 10, 4, p. 1145 - 1154 10 p.Research output: Contribution to journal › Article › Research › peer-review
Imaging the distribution of polymyxins in the kidney
Yun, B., Azad, M. A. K., Wang, J., Nation, R. L., Thompson, P., Roberts, K. D., Velkov, T. & Li, J., 2015, In : Journal of Antimicrobial Chemotherapy. 70, 3, p. 827 - 829 3 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Propargyloxyproline regio- and stereoisomers for click-conjugation of peptides: synthesis and application in linear and cyclic peptides
Northfield, S. E., Mountford, S. J., Wielens, J., Liu, M., Zhang, L., Herzog, H., Holliday, N. D., Scanlon, M., Parker, M. W., Chalmers, D. K. & Thompson, P., 2015, In : Australian Journal of Chemistry. 68, 9, p. 1365-1372 8 p.Research output: Contribution to journal › Article › Research › peer-review
Significant accumulation of polymyxin in single renal tubular cells: a medicinal chemistry and triple correlative microscopy approach
Azad, M. A. K., Roberts, K. D., Yu, H., Liu, B., Schofield, A. V., James, S. A., Howard, D. L., Nation, R. L., Rogers, K. L., de Jonge, M. D., Thompson, P., Fu, J., Velkov, T. & Li, J., 2015, In : Analytical Chemistry. 87, 3, p. 1590 - 1595 6 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
2014
A potent cyclic peptide targeting SPSB2 protein as a potential anti-infective agent
Yap, B. K., Leung, E. W. W., Yagi, H., Galea, C., Chhabra, S., Chalmers, D. K., Nicholson, S. E., Thompson, P. & Norton, R. S., 2014, In : Journal of Medicinal Chemistry. 57, 16, p. 7006 - 7015 10 p.Research output: Contribution to journal › Article › Research › peer-review
A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity
Deris, Z. Z., Akter, J., Sivanesan, S., Roberts, K. D., Thompson, P., Nation, R. L., Li, J. & Velkov, T., 2014, In : Journal of Antibiotics. 67, 2, p. 147 - 151 5 p.Research output: Contribution to journal › Article › Research › peer-review
Discovery of phosphodiesterase-4 inhibitors: Serendipity and rational drug design
Feil, S. C., Holien, J. K., Morton, C. J., Hancock, N. C., Thompson, P. & Parker, M. W., 2014, In : Australian Journal of Chemistry. 67, 12, p. 1780 - 1785 6 p.Research output: Contribution to journal › Article › Research › peer-review
Measuring polymyxin uptake by renal tubular cells: Is bodipy-polymyxin B an appropriate probe?
Azad, M. A. K., Yun, B., Roberts, K. D., Nation, R. L., Thompson, P., Velkov, T. & Li, J., 1 Oct 2014, In : Antimicrobial Agents and Chemotherapy. 58, 10, p. 6337-6338 2 p.Research output: Contribution to journal › Letter › Other › peer-review
Open Access
Probing the penetration of antimicrobial polymyxin lipopeptides into gram-negative bacteria
Deris, Z. Z., Swarbrick, J. D., Roberts, K. D., Azad, M. A. K., Akter, J., Horne, A. S., Nation, R. L., Rogers, K. L., Thompson, P., Velkov, T. & Li, J., 2014, In : Bioconjugate Chemistry. 25, 4, p. 750 - 760 11 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
Structural basis of nSH2 regulation and lipid binding in PI3Ka
Miller, M. S., Schmidt-Kittler, O., Bolduc, D. M., Brower, E. T., Chaves-Moreira, D., Allaire, M., Kinzler, K. W., Jennings, I., Thompson, P., Cole, P. A., Amzel, L. M., Vogelstein, B. & Gabelli, S. B., 2014, In : Oncotarget. 5, 14, p. 5198 - 5208 11 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
Synthesis, structure-activity relationships and brain uptake of a novel series of benzopyran inhibitors of insulin-regulated aminopeptidase
Mountford, S. J., Albiston, A. L., Charman, W. N., Ng, L., Holien, J. K., Parker, M. W., Nicolazzo, J., Thompson, P. & Chai, S. Y., 2014, In : Journal of Medicinal Chemistry. 57, 4, p. 1368 - 1377 10 p.Research output: Contribution to journal › Article › Research › peer-review
Synthetic routes to the Neuropeptide Y Y1 receptor antagonist 1229U91 and related analogues for SAR studies and cell-based imaging
Mountford, S. J., Liu, M., Zhang, L., Groenen, M., Herzog, H., Holliday, N. D. & Thompson, P., 2014, In : Organic and Biomolecular Chemistry. 12, 20, p. 3271 - 3281 11 p.Research output: Contribution to journal › Article › Research › peer-review
Teaching 'old' polymyxins new tricks: New-generation lipopeptides targeting gram-negative 'superbugs'
Velkov, T., Roberts, K. D., Nation, R. L., Wang, J., Thompson, P. & Li, J., 2014, In : ACS Chemical Biology. 9, 5, p. 1172 - 1177 6 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
The drug vehicle and solvent N-Methylpyrrolidone is an immunomodulator and antimyeloma compound
Shortt, J., Hsu, A. K., Martin, B. P., Doggett, K., Matthews, G. M., Doyle, M. A., Ellul, J., Jockel, T. E., Andrews, D. M. K., Hogg, S. J., Reitsma, A. J., Faulkner, D., Bergsagel, P. L., Chesi, M., Heath, J. K., Denny, W. A., Thompson, P., Neeson, P., Ritchie, D., McArthur, G. A. & 1 others, 2014, In : Cell Reports. 7, 4, p. 1009 - 1019 11 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
2013
(+)-Fluorenylethylchloroformate (FLEC) - improved synthesis for application in chiral analysis and peptidomimetic synthesis
Camerino, M. A., Chalmers, D. K. & Thompson, P., 2013, In : Organic and Biomolecular Chemistry. 11, 16, p. 2571 - 2573 3 p.Research output: Contribution to journal › Article › Research › peer-review
L-aminoacyl-triazine derivatives are isoform-selective PI3KB inhibitors that target nonconserved Asp862 of PI3KB
Pinson, J-A., Zheng, Z., Miller, M. S., Chalmers, D. K., Jennings, I. & Thompson, P., 2013, In : A C S Medicinal Chemistry Letters. 4, 2, p. 206 - 210 5 p.Research output: Contribution to journal › Article › Research › peer-review