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Research Output 1992 2019

2019

An apically located hybrid guanylate cyclase-ATPase is critical for the initiation of Ca2+ signaling and motility in Toxoplasma gondii

Yang, L., Uboldi, A. D., Seizova, S., Wilde, M. L., Coffey, M. J., Katris, N. J., Yamaryo-Botté, Y., Kocan, M., Bathgate, R. A. D., Stewart, R. J., McConville, M. J., Thompson, P. E., Botté, C. Y. & Tonkin, C. J., 31 May 2019, In : Journal of Biological Chemistry. 294, 22, p. 8959-8972 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Controlled Construction of Cyclic d / l Peptide Nanorods

Silk, M. R., Mohanty, B., Sampson, J. B., Scanlon, M. J., Thompson, P. E. & Chalmers, D. K., 8 Jan 2019, In : Angewandte Chemie - International Edition. 58, 2, p. 596-601 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural Determinants of Isoform Selectivity in PI3K Inhibitors

Miller, M. S., Thompson, P. E. & Gabelli, S. B., 26 Feb 2019, In : Biomolecules. 9, 3, 35 p., 82.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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2018

A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent

Sadek, M. M., Barlow, N., Leung, E. W. W., Williams-Noonan, B. J., Yap, B. K., Shariff, F. M., Caradoc-Davies, T. T., Nicholson, S. E., Chalmers, D. K., Thompson, P. E., Law, R. H. P. & Norton, R. S., 19 Oct 2018, In : ACS Chemical Biology. 13, 10, p. 2930-2938 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Cyclic Hexapeptide Mimics of the LEDGF Integrase Recognition Loop in Complex with HIV-1 Integrase

Northfield, S. E., Wielens, J., Headey, S. J., Williams-Noonan, B. J., Mulcair, M., Scanlon, M., Parker, M. W., Thompson, P. E. & Chalmers, D. K., 10 Aug 2018, In : ChemMedChem. 13, 15, p. 1555-1565 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Methionine ameliorates polymyxin-induced nephrotoxicity by attenuating cellular oxidative stress

Azad, M. A. K., Sivanesan, S., Wang, J., Chen, K., Nation, R. L., Thompson, P. E., Roberts, K. D., Velkov, T. & Li, J., 1 Jan 2018, In : Antimicrobial Agents and Chemotherapy. 62, 1, 9 p., e01254.

Research output: Contribution to journalArticleResearchpeer-review

Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria

Velkov, T., Gallardo-Godoy, A., Swarbrick, J. D., Blaskovich, M. A. T., Elliott, A. G., Han, M., Thompson, P. E., Roberts, K. D., Huang, J. X., Becker, B., Butler, M. S., Lash, L. H., Henriques, S. T., Nation, R. L., Sivanesan, S., Sani, M. A., Separovic, F., Mertens, H., Bulach, D., Seemann, T. & 3 othersOwen, J., Li, J. & Cooper, M. A., 19 Apr 2018, In : Cell Chemical Biology. 25, 4, p. 380-391 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Characterization of the Polymyxin D Synthetase Biosynthetic Cluster and Product Profile of Paenibacillus polymyxa ATCC 10401

Galea, C. A., Han, M., Zhu, Y., Roberts, K., Wang, J., Thompson, P. E., Li, J. & Velkov, T., 26 May 2017, In : Journal of Natural Products. 80, 5, p. 1264-1274 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Class II phosphoinositide 3-kinases as novel drug targets

Falasca, M., Hamilton, J. R., Selvadurai, M. V., Sundaram, K., Adamska, A. & Thompson, P., 12 Jan 2017, In : Journal of Medicinal Chemistry. 60, 1, p. 47-65 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Design and evaluation of novel polymyxin fluorescent probes

Yun, B., Roberts, K. D., Thompson, P. E., Nation, R. L., Velkov, T. & Li, J., 11 Nov 2017, In : Sensors. 17, 11, 8 p., 2598.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Functional characterization of the unique terminal thioesterase domain from polymyxin synthetase

Galea, C., Roberts, K. D., Zhu, Y., Thompson, P. E., Li, J. & Velkov, T., 31 Jan 2017, In : Biochemistry. 56, 4, p. 657-668 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Investigating the Interaction of Octapeptin A3 with Model Bacterial Membranes

Han, M. L., Shen, H. H., Hansford, K. A., Schneider, E. K., Sivanesan, S., Roberts, K. D., Thompson, P. E., Le Brun, A. P., Zhu, Y., Sani, M-A., Separovic, F., Blaskovich, M. A. T., Baker, M. A., Moskowitz, S. M., Cooper, M. A., Li, J. & Velkov, T., 11 Aug 2017, In : ACS Infectious Diseases. 3, 8, p. 606-619 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Parallel and antiparallel cyclic d/l peptide nanotubes

Silk, M. R., Newman, J., Ratcliffe, J. C., White, J. F., Caradoc-Davies, T., Price, J. R., Perrier, S., Thompson, P. E. & Chalmers, D. K., 2017, In : Chemical Communications. 53, 49, p. 6613-6616 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Pharmacokinetics of the individual major components of polymyxin B and colistin in rats

Sivanesan, S., Roberts, K., Wang, J., Cheah, S-E., Thompson, P. E., Li, J., Nation, R. & Velkov, T., 27 Jan 2017, In : Journal of Natural Products. 80, 1, p. 225-229 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and biological evaluation of 8-aryl-2-morpholino-7-O-substituted benzo[e][1,3]oxazin-4-ones against DNA-PK, PI3K, PDE3A enzymes and platelet aggregation

Saifuzzaman, M., Morrison, R., Zheng, Z., Orive, S., Hamilton, J., Thompson, P. E. & Al-Rawi, J. M. A., 15 Oct 2017, In : Bioorganic and Medicinal Chemistry. 25, 20, p. 5531-5536 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

A novel chemical biology approach for mapping of polymyxin lipopeptide antibody binding epitopes

Velkov, T., Yun, B., Schneider, E. K., Azad, M. A. K., Dolezal, O., Morris, F. C., Nation, R. L., Wang, J., Chen, K., Yu, H., Wang, L., Thompson, P. E., Roberts, K. D. & Li, J., 2016, In : ACS Infectious Diseases. 2, 5, p. 341-351 11 p.

Research output: Contribution to journalArticleResearchpeer-review

A novel serpin regulatory mechanism: SERPINB9 is reversibly inhibited by vicinal disulfide bond formation in the reactive center loop

Mangan, M. S. J., Bird, C. H., Kaiserman, D., Matthews, A. Y., Hitchen, C., Steer, D. L., Thompson, P. E. & Bird, P. I., 12 Feb 2016, In : Journal of Biological Chemistry. 291, 7, p. 3626-3638 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Beta amino acid-modified and fluorescently labelled kisspeptin analogues with potent KISS1R activity

Camerino, M., Liu, M., Moriya, S., Kitahashi, T., Mahgoub, A., Mountford, S., Chalmers, D. K., Soga, T., Parhar, I. & Thompson, P., 1 Jun 2016, In : Journal of Peptide Science. 22, 6, p. 406-414 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Development of single and mixed isoform selectivity PI3Kδ inhibitors by targeting Asn836 of PI3Kδ

Miller, M. S., Mountford, S. J., Pinson, J-A., Zheng, Z., Künzli, M., Patel, V., Hogg, S. J., Shortt, J., Jennings, I. G. & Thompson, P. E., 1 Oct 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 19, p. 4790-4794 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922)

Zheng, Z., Pinson, J. A., Mountford, S. J., Orive, S., Schoenwaelder, S. M., Shackleford, D., Powell, A., Nelson, E. M., Hamilton, J. R., Jackson, S., Jennings, I. G. & Thompson, P. E., 21 Oct 2016, In : European Journal of Medicinal Chemistry. 122, p. 339-351 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of a cyanine-dye labeled peptidic ligand for Y1R and Y4R, based upon the neuropeptide y C-terminal analogue, BVD-15

Liu, M., Richardson, R. R., Mountford, S. J., Zhang, L., Tempone, M. H., Herzog, H., Holliday, N. D. & Thompson, P. E., 21 Sep 2016, In : Bioconjugate Chemistry. 27, 9, p. 2166-2175 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Optically pure, structural, and fluorescent analogues of a dimeric Y4 receptor agonist derived by an olefin metathesis approach

Liu, M., Mountford, S. J., Richardson, R. R., Groenen, M., Holliday, N. D. & Thompson, P. E., 14 Jul 2016, In : Journal of Medicinal Chemistry. 59, 13, p. 6059-6069 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Polymyxins: a new hope in combating Gram-negative superbugs?

Velkov, T., Roberts, K. D., Thompson, P. E. & Li, J., 1 Jun 2016, In : Future Medicinal Chemistry. 8, 10, p. 1017-1025 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Quantitation of polymyxin-lipopolysaccharide interactions using an image-based fluorescent probe

McInerney, M. P., Roberts, K. D., Thompson, P. E., Li, J., Nation, R. L., Velkov, T. & Nicolazzo, J. A., 2016, In : Journal of Pharmaceutical Sciences. 105, 2, p. 1006-1010 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Redox-stable cyclic peptide inhibitors of the SPSB2-iNOS interaction

Yap, B. K., Harjani, J. R., Leung, E. W. W., Nicholson, S. E., Scanlon, M. J., Chalmers, D. K., Thompson, P. E., Baell, J. B. & Norton, R. S., 1 Mar 2016, In : FEBS Letters. 590, 6, p. 696-704 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure–activity studies of β-hairpin peptide inhibitors of the Plasmodium falciparum AMA1–RON2 interaction

Wang, G., Drinkwater, N., Drew, D. R., MacRaild, C. A., Chalmers, D. K., Mohanty, B., Lim, S. S., Anders, R. F., Beeson, J. G., Thompson, P. E., McGowan, S., Simpson, J. S., Norton, R. S. & Scanlon, M. J., 9 Oct 2016, In : Journal of Molecular Biology. 428, 20, p. 3986-3998 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines

Morrison, R., Al-Rawi, J. M. A., Jennings, I. G., Thompson, P. E. & Angove, M. J., 3 Mar 2016, In : European Journal of Medicinal Chemistry. 110, p. 326-339 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of linear and angular aryl-morpholino-naphth-oxazines, their DNA-PK, PI3K, PDE3A and antiplatelet activity

Morrison, R., Zheng, Z., Jennings, I. G., Thompson, P. E. & Al-Rawi, J. M. A., 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 22, p. 5534-5538 5 p.

Research output: Contribution to journalArticleResearchpeer-review

The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonism

Wootten, D., Reynolds, C. A., Smith, K. J., Mobarec, J. C., Koole, C., Savage, E. E., Pabreja, K., Simms, J., Sridhar, R., Furness, S. G. B., Liu, M., Thompson, P. E., Miller, L. J., Christopoulos, A. & Sexton, P. M., 16 Jun 2016, In : Cell. 165, 7, p. 1632-1643 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Transcriptomic analysis of the activity of a novel polymyxin against Staphylococcus aureus

Zhao, J., Cheah, S-E., Roberts, K. D., Nation, R. L., Thompson, P. E., Velkov, T., Du, Z., Johnson, M. D. & Li, J., 2016, In : mSphere. 1, 4, 13 p., e00119-16.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Cellular uptake and localization of polymyxins in renal tubular cells using rationally designed fluorescent probes

Yun, B., Azad, M. A. K., Nowell, C. J., Nation, R. L., Thompson, P. E., Roberts, K. D., Velkov, T. & Li, J., 2015, In : Antimicrobial Agents and Chemotherapy. 59, 12, p. 7489-7496 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Class II but not second class - prospects for the development of class II PI3K inhibitors

Mountford, S. J., Zheng, Z., Sundaram, K., Jennings, I., Hamilton, J. R. & Thompson, P., 2015, In : A C S Medicinal Chemistry Letters. 6, 1, p. 3 - 6 4 p.

Research output: Contribution to journalEditorialResearchpeer-review

Identification of potent phosphodiesterase inhibitors that demonstrate cyclic nucleotide-dependent functions in apicomplexan parasites

Howard, B. L., Harvey, K. L., Stewart, R. J., Azevedo, M. F., Crabb, B. S., Jennings, I., Sanders, P. R., Manallack, D. T., Thompson, P., Tonkin, C. J. & Gilson, P. R., 2015, In : ACS Chemical Biology. 10, 4, p. 1145 - 1154 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Imaging the distribution of polymyxins in the kidney

Yun, B., Azad, M. A. K., Wang, J., Nation, R. L., Thompson, P., Roberts, K. D., Velkov, T. & Li, J., 2015, In : Journal of Antimicrobial Chemotherapy. 70, 3, p. 827 - 829 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Propargyloxyproline regio- and stereoisomers for click-conjugation of peptides: synthesis and application in linear and cyclic peptides

Northfield, S. E., Mountford, S. J., Wielens, J., Liu, M., Zhang, L., Herzog, H., Holliday, N. D., Scanlon, M., Parker, M. W., Chalmers, D. K. & Thompson, P., 2015, In : Australian Journal of Chemistry. 68, 9, p. 1365-1372 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Significant accumulation of polymyxin in single renal tubular cells: a medicinal chemistry and triple correlative microscopy approach

Azad, M. A. K., Roberts, K. D., Yu, H., Liu, B., Schofield, A. V., James, S. A., Howard, D. L., Nation, R. L., Rogers, K. L., de Jonge, M. D., Thompson, P., Fu, J., Velkov, T. & Li, J., 2015, In : Analytical Chemistry. 87, 3, p. 1590 - 1595 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2014

A potent cyclic peptide targeting SPSB2 protein as a potential anti-infective agent

Yap, B. K., Leung, E. W. W., Yagi, H., Galea, C., Chhabra, S., Chalmers, D. K., Nicholson, S. E., Thompson, P. & Norton, R. S., 2014, In : Journal of Medicinal Chemistry. 57, 16, p. 7006 - 7015 10 p.

Research output: Contribution to journalArticleResearchpeer-review

A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity

Deris, Z. Z., Akter, J., Sivanesan, S., Roberts, K. D., Thompson, P., Nation, R. L., Li, J. & Velkov, T., 2014, In : Journal of Antibiotics. 67, 2, p. 147 - 151 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Discovery of phosphodiesterase-4 inhibitors: Serendipity and rational drug design

Feil, S. C., Holien, J. K., Morton, C. J., Hancock, N. C., Thompson, P. & Parker, M. W., 2014, In : Australian Journal of Chemistry. 67, 12, p. 1780 - 1785 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Measuring polymyxin uptake by renal tubular cells: Is bodipy-polymyxin B an appropriate probe?

Azad, M. A. K., Yun, B., Roberts, K. D., Nation, R. L., Thompson, P., Velkov, T. & Li, J., 1 Oct 2014, In : Antimicrobial Agents and Chemotherapy. 58, 10, p. 6337-6338 2 p.

Research output: Contribution to journalLetterOtherpeer-review

Open Access

Probing the penetration of antimicrobial polymyxin lipopeptides into gram-negative bacteria

Deris, Z. Z., Swarbrick, J. D., Roberts, K. D., Azad, M. A. K., Akter, J., Horne, A. S., Nation, R. L., Rogers, K. L., Thompson, P., Velkov, T. & Li, J., 2014, In : Bioconjugate Chemistry. 25, 4, p. 750 - 760 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Structural basis of nSH2 regulation and lipid binding in PI3Ka

Miller, M. S., Schmidt-Kittler, O., Bolduc, D. M., Brower, E. T., Chaves-Moreira, D., Allaire, M., Kinzler, K. W., Jennings, I., Thompson, P., Cole, P. A., Amzel, L. M., Vogelstein, B. & Gabelli, S. B., 2014, In : Oncotarget. 5, 14, p. 5198 - 5208 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Synthesis, structure-activity relationships and brain uptake of a novel series of benzopyran inhibitors of insulin-regulated aminopeptidase

Mountford, S. J., Albiston, A. L., Charman, W. N., Ng, L., Holien, J. K., Parker, M. W., Nicolazzo, J., Thompson, P. & Chai, S. Y., 2014, In : Journal of Medicinal Chemistry. 57, 4, p. 1368 - 1377 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthetic routes to the Neuropeptide Y Y1 receptor antagonist 1229U91 and related analogues for SAR studies and cell-based imaging

Mountford, S. J., Liu, M., Zhang, L., Groenen, M., Herzog, H., Holliday, N. D. & Thompson, P., 2014, In : Organic and Biomolecular Chemistry. 12, 20, p. 3271 - 3281 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Teaching 'old' polymyxins new tricks: New-generation lipopeptides targeting gram-negative 'superbugs'

Velkov, T., Roberts, K. D., Nation, R. L., Wang, J., Thompson, P. & Li, J., 2014, In : ACS Chemical Biology. 9, 5, p. 1172 - 1177 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The drug vehicle and solvent N-Methylpyrrolidone is an immunomodulator and antimyeloma compound

Shortt, J., Hsu, A. K., Martin, B. P., Doggett, K., Matthews, G. M., Doyle, M. A., Ellul, J., Jockel, T. E., Andrews, D. M. K., Hogg, S. J., Reitsma, A. J., Faulkner, D., Bergsagel, P. L., Chesi, M., Heath, J. K., Denny, W. A., Thompson, P., Neeson, P., Ritchie, D., McArthur, G. A. & 1 othersJohnstone, R. W., 2014, In : Cell Reports. 7, 4, p. 1009 - 1019 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2013

(+)-Fluorenylethylchloroformate (FLEC) - improved synthesis for application in chiral analysis and peptidomimetic synthesis

Camerino, M. A., Chalmers, D. K. & Thompson, P., 2013, In : Organic and Biomolecular Chemistry. 11, 16, p. 2571 - 2573 3 p.

Research output: Contribution to journalArticleResearchpeer-review

L-aminoacyl-triazine derivatives are isoform-selective PI3KB inhibitors that target nonconserved Asp862 of PI3KB

Pinson, J-A., Zheng, Z., Miller, M. S., Chalmers, D. K., Jennings, I. & Thompson, P., 2013, In : A C S Medicinal Chemistry Letters. 4, 2, p. 206 - 210 5 p.

Research output: Contribution to journalArticleResearchpeer-review