Projects per year
Personal profile
Biography
Position
Medicinal Chemistry
Monash Institute of Pharmaceutical Sciences
Research interests
Research in our group has a general focus on Structure-based Design and Synthesis of kinase inhibitors , epigenetic modulators and phosphodiesterase inhibitors. We have particular expertise in Peptides and Peptidomimetics.
Our major current programs deal with
- isoform selective inhibition of the PI3 kinase family
- new chemotypes as PDE inhibitors and PDE inhibitors against parasitic diseases
- polymyxin-based antibacterial agents
- fluorescent labels for peptides
- modulators of epigenetic proteins
Monash teaching commitment
B Pharm and B Pharm Sci - 1st Year Bio-organic and Medicinal Chemistry
B Pharm - PAC4441 Integrated therapeutics: Endocrinology and renal
B Pharm Sci - PSC3091 Molecular basis of drug action
B Pharm Sci - PSC3122 Synthetic Medicinal Chemistry
Research area keywords
- Kinase Inhibitors
- Peptides and Peptidomimetics
- Structure-Based Design and Synthesis of Kinase
- Epigenetics
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Development of a Novel Photo-Angioplasty Device for the Treatment of Occlusive Peripheral Vascular Disease
Dear, A. (Primary Chief Investigator (PCI)), Fraser, J. (Chief Investigator (CI)), Li Bassi, G. (Chief Investigator (CI)), Thompson, P. (Chief Investigator (CI)), Gaspari, T. (Associate Investigator (AI)) & Thissen, H. (Associate Investigator (AI))
1/01/22 → 31/12/26
Project: Research
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Improved glucose control, with lower insulin doses, for the treatment of type 1 diabetes
Cowley, M. (Primary Chief Investigator (PCI)) & Thompson, P. (Chief Investigator (CI))
1/06/25 → 31/08/25
Project: Research
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Improved glucose control, with lower insulin doses, for the treatment of type 1 diabetes
Cowley, M. (Primary Chief Investigator (PCI)), Simonds, S. (Chief Investigator (CI)), Thompson, P. (Chief Investigator (CI)), Pouton, C. (Chief Investigator (CI)) & Greenough, C. (Project Manager)
MTP-IIGC Ltd (trading as MTP Connect)
1/08/22 → 15/02/25
Project: Research
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Dual-targeted inhibitors of BET bromodomains and PI3-kinase for cancer therapy.
Shortt, J. (Primary Chief Investigator (PCI)) & Thompson, P. (Chief Investigator (CI))
1/02/22 → 1/02/24
Project: Research
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Lead optimisation of novel inhibitors of IRAP for the treatment of fibrosis in diabetes-induced renal and cardiovascular disease
Gaspari, T. (Primary Chief Investigator (PCI)), Chai, S. (Chief Investigator (CI)), Widdop, R. (Chief Investigator (CI)), Thompson, P. (Chief Investigator (CI)), Nielsen, K. (Chief Investigator (CI)), Perez, S. (Partner Investigator (PI)), Dear, A. (Chief Investigator (CI)), Yun, B. (Chief Investigator (CI)), Pfleger, K. (Chief Investigator (CI)) & Barlow, N. (Chief Investigator (CI))
1/10/21 → 30/11/23
Project: Research
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Discovery and Characterization of VPRBP/DCAF1 Kinase Inhibitor Analogs as Microtubular Destabilizing Agents with Potent Antimyeloma Activity
Susanto, O., Gruber, E. (Leading Author), Wun, C. M. (Leading Author), Franich, R. L., Ma, X., Sabouri-Thompson, Z., Porter, Z. J., Murray, H. C., Cluse, L. A., Maher, B., Brasacchio, D., Martin, B. P., Fraser, P. J., Nikolic, I., Arnau, G. M., Sandow, J. J., Simpson, K. J., Verrills, N. M., Johnstone, R. W. & Thompson, P. E. & 2 others, , 1 Mar 2026, In: Molecular Cancer Therapeutics. 25, 3, p. 416-434 19 p.Research output: Contribution to journal › Article › Research › peer-review
1 Link opens in a new tab Citation (Scopus) -
Correction to “Synthesis of a New Purine Analogue Class with Antifungal Activity and Improved Potency against Fungal IP3–4K”
Desmarini, D., Truong, D., Sethiya, P., Liu, G., Bowring, B., Jessen, H., Dinh, H., Cain, A. K., Thompson, P. E. & Djordjevic, J. T., 12 Dec 2025, In: ACS Infectious Diseases. 11, 12, p. 3646-3648 3 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access -
Methods to accelerate PROTAC drug discovery
Osman, J., Thompson, P. E., Jörg, M. & Scanlon, M. J., 25 Jun 2025, In: Biochemical Journal. 482, 13, p. 921–937 17 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access17 Link opens in a new tab Citations (Scopus) -
Synthesis of a New Purine Analogue Class with Antifungal Activity and Improved Potency against Fungal IP3-4K
Desmarini, D., Truong, D., Sethiya, P., Liu, G., Bowring, B., Jessen, H., Dinh, H., Cain, A. K., Thompson, P. E. & Djordjevic, J. T., 11 Apr 2025, In: ACS Infectious Diseases. 11, 4, p. 940-953 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access9 Link opens in a new tab Citations (Scopus) -
Targeted protein degraders of SARS-CoV-2 Mpro are more active than enzymatic inhibition alone with activity against nirmatrelvir resistant virus
Pan, B., Mountford, S. J., Kiso, M., Anderson, D. E., Papadakis, G., Jarman, K. E., Tilmanis, D. R., Maher, B., Tran, T., Shortt, J., Yamayoshi, S., Kawaoka, Y., Thompson, P. E., Greenall, S. A. & Warner, N., 26 Apr 2025, In: Communications Medicine. 5, 1, 12 p., 140.Research output: Contribution to journal › Article › Research › peer-review
Open Access14 Link opens in a new tab Citations (Scopus)
Prizes
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Team Award for Research Impact [Economic and Social] (Faculty of Pharmacy and Pharmaceutical Sciences, Monash University)
Nation, R. (Recipient), Velkov, T. (Recipient), Li, J. (Recipient), Roberts, K. (Recipient) & Thompson, P. (Recipient), 2016
Prize: Prize (including medals and awards)
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Vice-Chancellor's Award for Excellence in Research Engagement and Impact (Monash University)
Nation, R. (Recipient), Li, J. (Recipient), Roberts, K. (Recipient), Velkov, T. (Recipient) & Thompson, P. (Recipient), 2022
Prize: Prize (including medals and awards)
Activities
- 1 Grant review responsibilities
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Medicinal Chemistry and Drug Action
Thompson, P. (Member)
22 Sept 2011Activity: External Academic Engagement › Grant review responsibilities