Projects per year
Personal profile
Biography
Position
Medicinal Chemistry
Monash Institute of Pharmaceutical Sciences
Research interests
Research in our group has a general focus on Structure-based Design and Synthesis of kinase inhibitors , epigenetic modulators and phosphodiesterase inhibitors. We have particular expertise in Peptides and Peptidomimetics.
Our major current programs deal with
- isoform selective inhibition of the PI3 kinase family
- new chemotypes as PDE inhibitors and PDE inhibitors against parasitic diseases
- polymyxin-based antibacterial agents
- fluorescent labels for peptides
- modulators of epigenetic proteins
Monash teaching commitment
B Pharm and B Pharm Sci - 1st Year Bio-organic and Medicinal Chemistry
B Pharm - PAC4441 Integrated therapeutics: Endocrinology and renal
B Pharm Sci - PSC3091 Molecular basis of drug action
B Pharm Sci - PSC3122 Synthetic Medicinal Chemistry
Research area keywords
- Kinase Inhibitors
- Peptides and Peptidomimetics
- Structure-Based Design and Synthesis of Kinase
- Epigenetics
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Dual-targeted inhibitors of BET bromodomains and PI3-kinase for cancer therapy.
1/02/22 → 1/02/24
Project: Research
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Development of a Novel Photo-Angioplasty Device for the Treatment of Occlusive Peripheral Vascular Disease
Dear, A., Kaye, D., Byrne, M. J., Thompson, P., Gaspari, T. & Thissen, H.
1/01/22 → 31/12/24
Project: Research
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Lead optimisation of novel inhibitors of IRAP for the treatment of fibrosis in diabetes-induced renal and cardiovascular disease
Gaspari, T., Chai, S., Widdop, R., Thompson, P., Nielsen, K., Perez, S., Dear, A., Yun, B., Pfleger, K. & Barlow, N.
1/10/21 → 30/11/23
Project: Research
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Integrating AI, Big Data and Smart Drug Design against 'Superbugs'
Song, J., Li, J., Patil, N., Schmidt, D. & Thompson, P.
1/01/20 → 31/12/23
Project: Research
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JDRF Strategic Research Agreement - Novel Adjunctive Therapeutic For T1D; a-MSH/MC5R agonist axis
Cowley, M., Sleeman, M., Thompson, P., Wentworth, J. & Kelly, L.
1/07/19 → 31/10/22
Project: Research
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A New Turn in Peptide-Based Imaging Agents: Foldamers Afford Improved Theranostics Targeting Cholecystokinin-2 Receptor-Positive Cancer
Corlett, A., Sani, M. A., Van Zuylekom, J., Ang, C. S., Von Guggenberg, E., Cullinane, C., Blyth, B., Hicks, R. J., Roselt, P. D., Thompson, P. E., Hutton, C. A. & Haskali, M. B., 7 Apr 2021, In: Journal of Medicinal Chemistry. 64, 8, p. 4841-4856 16 p.Research output: Contribution to journal › Article › Research › peer-review
6 Citations (Scopus) -
A novel chemical biology and computational approach to expedite the discovery of new-generation polymyxins against life-threateningAcinetobacter baumannii
Jiang, X., Patil, N. A., Azad, M. A. K., Wickremasinghe, H., Yu, H., Zhao, J., Zhang, X., Li, M., Gong, B., Wan, L., Ma, W., Thompson, P. E., Yang, K., Yuan, B., Schreiber, F., Wang, L., Velkov, T., Roberts, K. D. & Li, J., 28 Sep 2021, In: Chemical Science. 12, 36, p. 12211-12220 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus) -
Design, Development, In Vitro and Preliminary In Vivo Evaluation of a Novel Photo-Angioplasty Device: Lumi-Solve
Liu, H., Sama, G. R., Robinson, A., Mountford, S., E. Thompson, P., Rodda, A., Forsythe, J., Mornane, P. J., Pasic, P., Thissen, H., Byrne, M., Kaye, D. M. & Dear, A. E., Aug 2021, In: Cardiovascular Engineering and Technology. 12, p. 466–473 8 p.Research output: Contribution to journal › Article › Research › peer-review
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Lipophilic Salts and Lipid-Based Formulations: Enhancing the Oral Delivery of Octreotide
Li, P., Ford, L., Haque, S., McInerney, M. P., Williams, H. D., Scammells, P. J., Thompson, P. E., Jannin, V., Porter, C. J. H., Benameur, H. & Pouton, C. W., Jun 2021, In: Pharmaceutical Research. 38, 6, p. 1125–1137 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Molecular mechanisms of cereblon-interacting small molecules in multiple myeloma therapy
Costacurta, M., He, J., Thompson, P. E. & Shortt, J., Nov 2021, In: Journal of Personalized Medicine. 11, 11, 18 p., 1185.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access1 Citation (Scopus)
Activities
- 1 Grant review responsibilities
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Medicinal Chemistry and Drug Action
Philip Thompson (Member)
22 Sep 2011Activity: External Academic Engagement › Grant review responsibilities