Projects per year
Personal profile
Biography
Position
Medicinal Chemistry
Monash Institute of Pharmaceutical Sciences
Research interests
Research in our group has a general focus on Structure-based Design and Synthesis of kinase inhibitors , epigenetic modulators and phosphodiesterase inhibitors. We have particular expertise in Peptides and Peptidomimetics.
Our major current programs deal with
- isoform selective inhibition of the PI3 kinase family
- new chemotypes as PDE inhibitors and PDE inhibitors against parasitic diseases
- polymyxin-based antibacterial agents
- fluorescent labels for peptides
- modulators of epigenetic proteins
Monash teaching commitment
B Pharm and B Pharm Sci - 1st Year Bio-organic and Medicinal Chemistry
B Pharm - PAC4441 Integrated therapeutics: Endocrinology and renal
B Pharm Sci - PSC3091 Molecular basis of drug action
B Pharm Sci - PSC3122 Synthetic Medicinal Chemistry
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Kinase Inhibitors
- Peptides and Peptidomimetics
- Structure-Based Design and Synthesis of Kinase
- Epigenetics
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Improved glucose control, with lower insulin doses, for the treatment of type 1 diabetes
Cowley, M., Simonds, S., Thompson, P., Pouton, C. & Greenough, C.
1/08/22 → 15/09/24
Project: Research
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Dual-targeted inhibitors of BET bromodomains and PI3-kinase for cancer therapy.
1/02/22 → 1/02/24
Project: Research
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Development of a Novel Photo-Angioplasty Device for the Treatment of Occlusive Peripheral Vascular Disease
Dear, A., Kaye, D., Byrne, M. J., Thompson, P., Gaspari, T. & Thissen, H.
1/01/22 → 31/12/24
Project: Research
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Targeting DCAF1 as a novel treatment strategy for therapy resistant multiple myeloma
Kats, L., Shortt, J., Thompson, P. & Ott, C. J.
1/10/21 → 30/09/24
Project: Research
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Lead optimisation of novel inhibitors of IRAP for the treatment of fibrosis in diabetes-induced renal and cardiovascular disease
Gaspari, T., Chai, S., Widdop, R., Thompson, P., Nielsen, K., Perez, S., Dear, A., Yun, B., Pfleger, K. & Barlow, N.
1/10/21 → 30/11/23
Project: Research
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Advances in Design and Development of Lumi-Solve: A Novel Drug-Eluting Photo-Angioplasty Device
Sangeetha Menon, A., Subasic de Azevedo, I., Choong, K., Bhatnagar, D., Wang, C., Sluka, P., Chisholm, D. R., Pasic, P., Thissen, H., Sama, G., Robinson, A., Rodda, A., Tria, A., Spiegel, L., Dharma, A., Kaipananickal, H., Okabe, J., El-Osta, A., Mountford, S., Thompson, P., & 1 others, Aug 2023, In: Cardiovascular Engineering and Technology. 14, p. 605–614 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Critical Role of Position 10 Residue in the Polymyxin Antimicrobial Activity
Patil, N. A., Ma, W., Jiang, X., He, X., Yu, H. H., Wickremasinghe, H., Wang, J., Thompson, P. E., Velkov, T., Roberts, K. D. & Li, J., 6 Feb 2023, In: Journal of Medicinal Chemistry. 66, 4, p. 2865–2876 12 p.Research output: Contribution to journal › Article › Research › peer-review
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Rationally designed chimeric PI3K-BET bromodomain inhibitors elicit curative responses in MYC-driven lymphoma
Oh, D. H., Ma, X., Hogg, S. J., He, J., Kearney, C., Brasacchio, D., Susanto, O., Maher, B., Jennings, I. G., Newbold, A., Fraser, P., Gruber, E., Kats, L. M., Gregory, G. P., Johnstone, R. W., Thompson, P. E. & Shortt, J., 5 Sept 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 36, 9 p., e2306414120.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Targeting Melanocortin Receptors Using SNAr-Type Macrocyclization: A Doubly Orthogonal Route to Cyclic Peptide Conjugates
Yue, W. K., Zhang, T., Shandre Mugan, R., Barlow, N., Chalmers, D. K., Pouton, C. W. & Thompson, P. E., 21 Feb 2023, In: Journal of Medicinal Chemistry. 66, 5, p. 3273-3283 11 p.Research output: Contribution to journal › Article › Research › peer-review
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Transcriptomic Responses to Polymyxin B and Analogues in Human Kidney Tubular Cells
Li, M., Azad, M. A. K., Thompson, P. E., Roberts, K. D., Velkov, T., Zhu, Y. & Li, J., Feb 2023, In: Antibiotics. 12, 2, 14 p., 415.Research output: Contribution to journal › Article › Research › peer-review
Open Access
Activities
- 1 Grant review responsibilities
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Medicinal Chemistry and Drug Action
Philip Thompson (Member)
22 Sept 2011Activity: External Academic Engagement › Grant review responsibilities