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Personal profile



Associate Dean (Research Training)
Faculty of Pharmacy and Pharmaceutical Sciences

Medicinal Chemistry
Monash Institute of Pharmaceutical Sciences

Research interests

Research in our group has a general focus on Structure-based Design and Synthesis of kinase inhibitors , epigenetic modulators and phosphodiesterase inhibitors. We have particular expertise in Peptides and Peptidomimetics.

Our major current programs deal with

  • isoform selective inhibition of the PI3 kinase family
  • new chemotypes as PDE inhibitors and PDE inhibitors against parasitic diseases
  • polymyxin-based antibacterial agents
  • fluorescent labels for peptides
  • modulators of epigenetic proteins

Monash teaching commitment

B Pharm and B Pharm Sci - 1st Year Bio-organic and Medicinal Chemistry
B Pharm - PAC4441 Integrated therapeutics: Endocrinology and renal
B Pharm Sci - PSC3091 Molecular basis of drug action
B Pharm Sci - PSC3122 Synthetic Medicinal Chemistry




  • Kinase Inhibitors
  • Peptides and Peptidomimetics
  • Structure-Based Design and Synthesis of Kinase
  • Epigenetics

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2003 2022

Research Output 1997 2018

Methionine ameliorates polymyxin-induced nephrotoxicity by attenuating cellular oxidative stress

Azad, M. A. K., Sivanesan, S., Wang, J., Chen, K., Nation, R. L., Thompson, P. E., Roberts, K. D., Velkov, T. & Li, J. 1 Jan 2018 In : Antimicrobial Agents and Chemotherapy. 62, 1, 9 p., e01254

Research output: Contribution to journalArticleResearchpeer-review

Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria

Velkov, T. , Gallardo-Godoy, A. , Swarbrick, J. D. , Blaskovich, M. A. T. , Elliott, A. G. , Han, M. , Thompson, P. E. , Roberts, K. D. , Huang, J. X. , Becker, B. , Butler, M. S. , Lash, L. H. , Henriques, S. T. , Nation, R. L. , Sivanesan, S. , Sani, M. A. , Separovic, F. , Mertens, H. , Bulach, D. , Seemann, T. & 3 others Owen, J., Li, J. & Cooper, M. A. 19 Apr 2018 In : Cell Chemical Biology. 25, 4, p. 380-391 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Characterization of the Polymyxin D Synthetase Biosynthetic Cluster and Product Profile of Paenibacillus polymyxa ATCC 10401

Galea, C. A., Han, M., Zhu, Y., Roberts, K., Wang, J., Thompson, P. E., Li, J. & Velkov, T. 26 May 2017 In : Journal of Natural Products. 80, 5, p. 1264-1274 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Class II phosphoinositide 3-kinases as novel drug targets

Falasca, M., Hamilton, J. R., Selvadurai, M. V., Sundaram, K., Adamska, A. & Thompson, P. 12 Jan 2017 In : Journal of Medicinal Chemistry. 60, 1, p. 47-65 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Design and evaluation of novel polymyxin fluorescent probes

Yun, B., Roberts, K. D., Thompson, P. E., Nation, R. L., Velkov, T. & Li, J. 11 Nov 2017 In : Sensors. 17, 11, 8 p., 2598

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Activities 2011 2011

  • 1 Grant review responsibilities

Medicinal Chemistry and Drug Action

Thompson, P. (Member)
22 Sep 2011

Activity: Grant review responsibilities