Projects per year
Personal profile
Biography
Position
Medicinal Chemistry
Monash Institute of Pharmaceutical Sciences
Research interests
Research in our group has a general focus on Structure-based Design and Synthesis of kinase inhibitors , epigenetic modulators and phosphodiesterase inhibitors. We have particular expertise in Peptides and Peptidomimetics.
Our major current programs deal with
- isoform selective inhibition of the PI3 kinase family
- new chemotypes as PDE inhibitors and PDE inhibitors against parasitic diseases
- polymyxin-based antibacterial agents
- fluorescent labels for peptides
- modulators of epigenetic proteins
Monash teaching commitment
B Pharm and B Pharm Sci - 1st Year Bio-organic and Medicinal Chemistry
B Pharm - PAC4441 Integrated therapeutics: Endocrinology and renal
B Pharm Sci - PSC3091 Molecular basis of drug action
B Pharm Sci - PSC3122 Synthetic Medicinal Chemistry
Keywords
- Kinase Inhibitors
- Peptides and Peptidomimetics
- Structure-Based Design and Synthesis of Kinase
- Epigenetics
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2003 2022
Novel Treatment of Type 1 Diabetes via Melanocortin 5 Agoinsm
Cowley, M., Sleeman, M., Thompson, P., Wentworth, J., Wilks, A. F., Le Roux, C. W. & Kelly, L.
Department of Health and Human Services (DHHS) (VIC), Synthesis Pty Ltd, Monash University – Internal School Contribution
6/02/19 → 5/08/20
Project: Research
Development of a Microfluidic Blood Platelet Analyser
Nesbitt, W., Mitchell, A., Nandurkar, H., Hamilton, J., Thompson, P., Tran, H., Elliott, S. & Macfarlane, I.
National Health & Medical Research Council (NHMRC)
1/01/19 → 31/12/21
Project: Research
Oral Peptides Research Program
Pouton, C., Thompson, P. & Porter, C.
20/06/18 → 20/06/21
Project: Research
Targeting a novel anti-platelet mechanism for improved anti-thrombotic therapy
Hamilton, J., Thompson, P., Nandurkar, H., Andrews, R. & Nesbitt, W.
National Health & Medical Research Council (NHMRC)
1/01/18 → 31/12/21
Project: Research
Targeting the Urgent Need for New Antibiotics against Gram-negative ‘Superbugs’
Li, J., Velkov, T., Roberts, K., Thompson, P. & Nation, R.
1/08/17 → 31/07/22
Project: Research
Research Output 1997 2019
Controlled Construction of Cyclic d / l Peptide Nanorods
Silk, M. R., Mohanty, B., Sampson, J. B., Scanlon, M. J., Thompson, P. E. & Chalmers, D. K., 8 Jan 2019, In : Angewandte Chemie - International Edition. 58, 2, p. 596-601 6 p.Research output: Contribution to journal › Article › Research › peer-review
A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent
Sadek, M. M., Barlow, N., Leung, E. W. W., Williams-Noonan, B. J., Yap, B. K., Shariff, F. M., Caradoc-Davies, T. T., Nicholson, S. E., Chalmers, D. K., Thompson, P. E., Law, R. H. P. & Norton, R. S., 19 Oct 2018, In : ACS Chemical Biology. 13, 10, p. 2930-2938 9 p.Research output: Contribution to journal › Article › Research › peer-review
Cyclic Hexapeptide Mimics of the LEDGF Integrase Recognition Loop in Complex with HIV-1 Integrase
Northfield, S. E., Wielens, J., Headey, S. J., Williams-Noonan, B. J., Mulcair, M., Scanlon, M., Parker, M. W., Thompson, P. E. & Chalmers, D. K., 10 Aug 2018, In : ChemMedChem. 13, 15, p. 1555-1565 11 p.Research output: Contribution to journal › Article › Research › peer-review
Methionine ameliorates polymyxin-induced nephrotoxicity by attenuating cellular oxidative stress
Azad, M. A. K., Sivanesan, S., Wang, J., Chen, K., Nation, R. L., Thompson, P. E., Roberts, K. D., Velkov, T. & Li, J., 1 Jan 2018, In : Antimicrobial Agents and Chemotherapy. 62, 1, 9 p., e01254.Research output: Contribution to journal › Article › Research › peer-review
Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria
Velkov, T., Gallardo-Godoy, A., Swarbrick, J. D., Blaskovich, M. A. T., Elliott, A. G., Han, M., Thompson, P. E., Roberts, K. D., Huang, J. X., Becker, B., Butler, M. S., Lash, L. H., Henriques, S. T., Nation, R. L., Sivanesan, S., Sani, M. A., Separovic, F., Mertens, H., Bulach, D., Seemann, T. & 3 others, 19 Apr 2018, In : Cell Chemical Biology. 25, 4, p. 380-391 12 p.Research output: Contribution to journal › Article › Research › peer-review
Activities 2011 2011
- 1 Grant review responsibilities
Medicinal Chemistry and Drug Action
Philip Thompson (Member)22 Sep 2011
Activity: External Academic Engagement › Grant review responsibilities