Projects per year
Personal profile
Biography
Position
Medicinal Chemistry
Monash Institute of Pharmaceutical Sciences
Research interests
Research in our group has a general focus on Structure-based Design and Synthesis of kinase inhibitors , epigenetic modulators and phosphodiesterase inhibitors. We have particular expertise in Peptides and Peptidomimetics.
Our major current programs deal with
- isoform selective inhibition of the PI3 kinase family
- new chemotypes as PDE inhibitors and PDE inhibitors against parasitic diseases
- polymyxin-based antibacterial agents
- fluorescent labels for peptides
- modulators of epigenetic proteins
Monash teaching commitment
B Pharm and B Pharm Sci - 1st Year Bio-organic and Medicinal Chemistry
B Pharm - PAC4441 Integrated therapeutics: Endocrinology and renal
B Pharm Sci - PSC3091 Molecular basis of drug action
B Pharm Sci - PSC3122 Synthetic Medicinal Chemistry
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Kinase Inhibitors
- Peptides and Peptidomimetics
- Structure-Based Design and Synthesis of Kinase
- Epigenetics
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Improved glucose control, with lower insulin doses, for the treatment of type 1 diabetes
Cowley, M., Simonds, S., Thompson, P., Pouton, C. & Greenough, C.
1/08/22 → 15/09/24
Project: Research
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Dual-targeted inhibitors of BET bromodomains and PI3-kinase for cancer therapy.
1/02/22 → 1/02/24
Project: Research
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Development of a Novel Photo-Angioplasty Device for the Treatment of Occlusive Peripheral Vascular Disease
Dear, A., Kaye, D., Byrne, M. J., Thompson, P., Gaspari, T. & Thissen, H.
1/01/22 → 31/12/24
Project: Research
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Lead optimisation of novel inhibitors of IRAP for the treatment of fibrosis in diabetes-induced renal and cardiovascular disease
Gaspari, T., Chai, S., Widdop, R., Thompson, P., Nielsen, K., Perez, S., Dear, A., Yun, B., Pfleger, K. & Barlow, N.
1/10/21 → 30/11/23
Project: Research
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Targeting DCAF1 as a novel treatment strategy for therapy resistant multiple myeloma
Kats, L., Shortt, J., Thompson, P. & Ott, C. J.
1/10/21 → 30/09/24
Project: Research
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Critical Role of Position 10 Residue in the Polymyxin Antimicrobial Activity
Patil, N. A., Ma, W., Jiang, X., He, X., Yu, H. H., Wickremasinghe, H., Wang, J., Thompson, P. E., Velkov, T., Roberts, K. D. & Li, J., 6 Feb 2023, In: Journal of Medicinal Chemistry. 66, 4, p. 2865–2876 12 p.Research output: Contribution to journal › Article › Research › peer-review
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An extensional strain sensing mechanosome drives adhesion-independent platelet activation at supraphysiological hemodynamic gradients
Zainal Abidin, N. A., Poon, E. K. W., Szydzik, C., Timofeeva, M., Akbaridoust, F., Brazilek, R. J., Tovar Lopez, F. J., Ma, X., Lav, C., Marusic, I., Thompson, P. E., Mitchell, A., Ooi, A. S. H., Hamilton, J. R. & Nesbitt, W. S., Dec 2022, In: BMC Biology. 20, 1, 22 p., 73.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens
Roberts, K. D., Zhu, Y., Azad, M. A. K., Han, M. L., Wang, J., Wang, L., Yu, H. H., Horne, A. S., Pinson, J. A., Rudd, D., Voelcker, N. H., Patil, N. A., Zhao, J., Jiang, X., Lu, J., Chen, K., Lomovskaya, O., Hecker, S. J., Thompson, P. E., Nation, R. L., & 4 others, 2022, In: Nature Communications. 13, 1, 15 p., 1625.Research output: Contribution to journal › Article › Research › peer-review
Open Access22 Citations (Scopus) -
Enhanced nitric oxide production by macrophages treated with a cell-penetrating peptide conjugate
Rahman, A., Matthews, M. A., Nowell, C. J., Chalmers, D. K., Thompson, P. E., Nicholson, S. E., Barlow, N. & Norton, R. S., Jun 2022, In: Bioorganic Chemistry. 123, 9 p., 105763.Research output: Contribution to journal › Article › Research › peer-review
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Membrane Permeating Macrocycles: Design Guidelines from Machine Learning
Williams-Noonan, B. J., Speer, M. N., Le, T. C., Sadek, M. M., Thompson, P. E., Norton, R. S., Yuriev, E., Barlow, N., Chalmers, D. K. & Yarovsky, I., 30 Sep 2022, In: Journal of Chemical Information and Modeling. 62, 19, p. 4605–4619 15 p.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus)
Activities
- 1 Grant review responsibilities
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Medicinal Chemistry and Drug Action
Philip Thompson (Member)
22 Sep 2011Activity: External Academic Engagement › Grant review responsibilities