Philip Thompson

Professor

Professor, Medicinal Chemistry

https://orcid.org/0000-0002-5910-7625

EmailPhilip.Thompson@monash.edu

Research activity per year

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Personal profile

Biography

Position

Medicinal Chemistry
Monash Institute of Pharmaceutical Sciences

Research interests

Research in our group has a general focus on Structure-based Design and Synthesis of kinase inhibitors , epigenetic modulators and phosphodiesterase inhibitors. We have particular expertise in Peptides and Peptidomimetics.

Our major current programs deal with

isoform selective inhibition of the PI3 kinase family
new chemotypes as PDE inhibitors and PDE inhibitors against parasitic diseases
polymyxin-based antibacterial agents
fluorescent labels for peptides
modulators of epigenetic proteins

Monash teaching commitment

B Pharm and B Pharm Sci - 1st Year Bio-organic and Medicinal Chemistry

B Pharm - PAC4441 Integrated therapeutics: Endocrinology and renal

B Pharm Sci - PSC3091 Molecular basis of drug action

B Pharm Sci - PSC3122 Synthetic Medicinal Chemistry

Research area keywords

Kinase Inhibitors
Peptides and Peptidomimetics
Structure-Based Design and Synthesis of Kinase
Epigenetics

Network

Recent external collaboration on country level. Dive into details by clicking on the dots or

2 Curtailed
6 Active
25 Finished

Integrating AI, Big Data and Smart Drug Design against 'Superbugs'
Song, J., Li, J., Patil, N., Schmidt, D. & Thompson, P.
1/01/20 → 31/12/22
Project: Research
JDRF Strategic Research Agreement - Novel Adjunctive Therapeutic For T1D; a-MSH/MC5R agonist axis
Cowley, M., Sleeman, M., Thompson, P., Wentworth, J. & Kelly, L.
1/07/19 → 30/06/21
Project: Research
Novel Treatment of Type 1 Diabetes via Melanocortin 5 Agoinsm
Cowley, M., Sleeman, M., Thompson, P., Wentworth, J., Wilks, A. F., Le Roux, C. W. & Kelly, L.
Department of Health and Human Services (Victoria), Synthesis Pty Ltd, Monash University – Internal School Contribution
6/02/19 → 30/09/21
Project: Research
Development of a Microfluidic Blood Platelet Analyser
Nesbitt, W., Mitchell, A., Nandurkar, H., Hamilton, J., Thompson, P., Tran, H., Elliott, S. & Macfarlane, I.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/19 → 31/12/21
Project: Research
Targeting a novel anti-platelet mechanism for improved anti-thrombotic therapy
Hamilton, J., Thompson, P., Nandurkar, H., Andrews, R. & Nesbitt, W.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/18 → 31/12/21
Project: Research

131 Article
11 Abstract
4 Review Article
2 Chapter (Book)
More

Application of a Sulfoxonium Ylide Electrophile to Generate Cathepsin X-Selective Activity-Based Probes
Mountford, S. J., Anderson, B. M., Xu, B., Tay, E. S. V., Szabo, M., Hoang, M-L., Diao, J., Aurelio, L., Campden, R. I., Lindström, E., Sloan, E. K., Yates, R. M., Bunnett, N. W., Thompson, P. E. & Edgington-Mitchell, L. E., 20 Mar 2020, In: ACS Chemical Biology. 15, 3, p. 718-727 10 p.
Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)
Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation
Selvadurai, M. V., Moon, M. J., Mountford, S. J., Ma, X., Zheng, Z., Jennings, I. G., Setiabakti, N. M., Iman, R. P., Brazilek, R. J., Z Abidin, N. A., Chicanne, G., Severin, S., Nicholls, A. J., Wong, C. H. Y., Rinckel, J-Y., Eckly, A., Gachet, C., Nesbitt, W. S., Thompson, P. E. & Hamilton, J. R., 22 Jul 2020, In: Science Translational Medicine. 12, 553, 15 p., eaar8430.
Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)
Heterodimeric Analogues of the Potent Y1R Antagonist 1229U91, Lacking One of the Pharmacophoric C-Terminal Structures, Retain Potent Y1R Affinity and Show Improved Selectivity over Y4R
Richardson, R. R., Groenen, M., Liu, M., Mountford, S. J., Briddon, S. J., Holliday, N. D. & Thompson, P. E., 28 May 2020, In: Journal of Medicinal Chemistry. 63, 10, p. 5274-5286 13 p.
Research output: Contribution to journal › Article › Research › peer-review
Improving Membrane Permeation in the Beyond Rule-of-Five Space by Using Prodrugs to Mask Hydrogen Bond Donors
Barlow, N., Chalmers, D. K., Williams-Noonan, B. J., Thompson, P. E. & Norton, R. S., 21 Aug 2020, In: ACS Chemical Biology. 15, 8, p. 2070-2078 9 p.
Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)
IRAP Inhibitors: M1-Aminopeptidase Family Inspiration
Barlow, N. & Thompson, P. E., 25 Sep 2020, In: Frontiers in Pharmacology. 11, 8 p., 585930.
Research output: Contribution to journal › Review Article › Research › peer-review

Open Access

1 Citation (Scopus)

1 Grant review responsibilities

Medicinal Chemistry and Drug Action
Philip Thompson (Member)
22 Sep 2011
Activity: External Academic Engagement › Grant review responsibilities