Projects per year
Personal profile
Biography
Position
Associate Dean (Research Training)
Faculty of Pharmacy and Pharmaceutical Sciences
Medicinal Chemistry
Monash Institute of Pharmaceutical Sciences
Research interests
Research in our group has a general focus on Structure-based Design and Synthesis of kinase inhibitors , epigenetic modulators and phosphodiesterase inhibitors. We have particular expertise in Peptides and Peptidomimetics.
Our major current programs deal with
- isoform selective inhibition of the PI3 kinase family
- new chemotypes as PDE inhibitors and PDE inhibitors against parasitic diseases
- polymyxin-based antibacterial agents
- fluorescent labels for peptides
- modulators of epigenetic proteins
Monash teaching commitment
B Pharm and B Pharm Sci - 1st Year Bio-organic and Medicinal Chemistry
B Pharm - PAC4441 Integrated therapeutics: Endocrinology and renal
B Pharm Sci - PSC3091 Molecular basis of drug action
B Pharm Sci - PSC3122 Synthetic Medicinal Chemistry
Keywords
- Kinase Inhibitors
- Peptides and Peptidomimetics
- Structure-Based Design and Synthesis of Kinase
- Epigenetics
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2003 2022
Novel Treatment of Type 1 Diabetes via Melanocortin 5 Agoinsm
Cowley, M. A., Sleeman, M., Thompson, P., Wentworth, J., Wilks, A. F., Le Roux, C. W. & Kelly, L.
Department of Health and Human Services (DHHS) (VIC), Synthesis Pty Ltd, Monash University – Internal School Contribution
6/02/19 → 5/08/20
Project: Research
Development of a Microfluidic Blood Platelet Analyser
Nesbitt, W., Mitchell, A., Nandurkar, H. H., Hamilton, J. R., Thompson, P., Tran, H., Elliott, S. & Macfarlane, I.
National Health & Medical Research Council (NHMRC)
1/01/19 → 31/12/21
Project: Research
Oral Peptides Research Program
Pouton, C. W., Thompson, P. & Porter, C. J.
20/06/18 → 20/06/21
Project: Research
Targeting a novel anti-platelet mechanism for improved anti-thrombotic therapy
Hamilton, J. R., Thompson, P., Nandurkar, H. H., Andrews, R. K. & Nesbitt, W.
National Health & Medical Research Council (NHMRC)
1/01/18 → 31/12/21
Project: Research
Targeting the Urgent Need for New Antibiotics against Gram-negative ‘Superbugs’
Li, J., Velkov, T., Roberts, K. D., Thompson, P. & Nation, R. L.
1/08/17 → 31/07/22
Project: Research
Research Output 1997 2018
A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent
Sadek, M. M., Barlow, N., Leung, E. W. W., Williams-Noonan, B. J., Yap, B. K., Shariff, F. M., Caradoc-Davies, T. T., Nicholson, S. E., Chalmers, D. K., Thompson, P. E., Law, R. H. P. & Norton, R. S., 19 Oct 2018, In : ACS Chemical Biology. 13, 10, p. 2930-2938 9 p.Research output: Contribution to journal › Article › Research › peer-review
Cyclic Hexapeptide Mimics of the LEDGF Integrase Recognition Loop in Complex with HIV-1 Integrase
Northfield, S. E., Wielens, J., Headey, S. J., Williams-Noonan, B. J., Mulcair, M., Scanlon, M., Parker, M. W., Thompson, P. E. & Chalmers, D. K., 10 Aug 2018, In : ChemMedChem. 13, 15, p. 1555-1565 11 p.Research output: Contribution to journal › Article › Research › peer-review
Methionine ameliorates polymyxin-induced nephrotoxicity by attenuating cellular oxidative stress
Azad, M. A. K., Sivanesan, S., Wang, J., Chen, K., Nation, R. L., Thompson, P. E., Roberts, K. D., Velkov, T. & Li, J., 1 Jan 2018, In : Antimicrobial Agents and Chemotherapy. 62, 1, 9 p., e01254.Research output: Contribution to journal › Article › Research › peer-review
Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria
Velkov, T., Gallardo-Godoy, A., Swarbrick, J. D., Blaskovich, M. A. T., Elliott, A. G., Han, M., Thompson, P. E., Roberts, K. D., Huang, J. X., Becker, B., Butler, M. S., Lash, L. H., Henriques, S. T., Nation, R. L., Sivanesan, S., Sani, M. A., Separovic, F., Mertens, H., Bulach, D., Seemann, T. & 3 others, 19 Apr 2018, In : Cell Chemical Biology. 25, 4, p. 380-391 12 p.Research output: Contribution to journal › Article › Research › peer-review
Characterization of the Polymyxin D Synthetase Biosynthetic Cluster and Product Profile of Paenibacillus polymyxa ATCC 10401
Galea, C. A., Han, M., Zhu, Y., Roberts, K., Wang, J., Thompson, P. E., Li, J. & Velkov, T., 26 May 2017, In : Journal of Natural Products. 80, 5, p. 1264-1274 11 p.Research output: Contribution to journal › Article › Research › peer-review
Activities 2011 2011
- 1 Grant review responsibilities
Medicinal Chemistry and Drug Action
Philip Thompson (Member)22 Sep 2011
Activity: External Academic Engagement › Grant review responsibilities