Projects per year
Personal profile
Biography
Position
Medicinal Chemistry
Monash Institute of Pharmaceutical Sciences
Research interests
Research in our group has a general focus on Structure-based Design and Synthesis of kinase inhibitors , epigenetic modulators and phosphodiesterase inhibitors. We have particular expertise in Peptides and Peptidomimetics.
Our major current programs deal with
- isoform selective inhibition of the PI3 kinase family
- new chemotypes as PDE inhibitors and PDE inhibitors against parasitic diseases
- polymyxin-based antibacterial agents
- fluorescent labels for peptides
- modulators of epigenetic proteins
Monash teaching commitment
B Pharm and B Pharm Sci - 1st Year Bio-organic and Medicinal Chemistry
B Pharm - PAC4441 Integrated therapeutics: Endocrinology and renal
B Pharm Sci - PSC3091 Molecular basis of drug action
B Pharm Sci - PSC3122 Synthetic Medicinal Chemistry
Research area keywords
- Kinase Inhibitors
- Peptides and Peptidomimetics
- Structure-Based Design and Synthesis of Kinase
- Epigenetics
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects
Integrating AI, Big Data and Smart Drug Design against 'Superbugs'
Song, J., Li, J., Patil, N., Schmidt, D. & Thompson, P.
1/01/20 → 31/12/22
Project: Research
JDRF Strategic Research Agreement - Novel Adjunctive Therapeutic For T1D; a-MSH/MC5R agonist axis
Cowley, M., Sleeman, M., Thompson, P., Wentworth, J. & Kelly, L.
1/07/19 → 30/06/21
Project: Research
Novel Treatment of Type 1 Diabetes via Melanocortin 5 Agoinsm
Cowley, M., Sleeman, M., Thompson, P., Wentworth, J., Wilks, A. F., Le Roux, C. W. & Kelly, L.
Victorian Department of Health and Human Services, Synthesis Pty Ltd, Monash University – Internal School Contribution
6/02/19 → 30/09/21
Project: Research
Development of a Microfluidic Blood Platelet Analyser
Nesbitt, W., Mitchell, A., Nandurkar, H., Hamilton, J., Thompson, P., Tran, H., Elliott, S. & Macfarlane, I.
National Health & Medical Research Council (NHMRC)
1/01/19 → 31/12/21
Project: Research
Oral Peptides Research Program
Pouton, C., Thompson, P. & Porter, C.
20/06/18 → 20/06/21
Project: Research
Research Output
Application of a Sulfoxonium Ylide Electrophile to Generate Cathepsin X-Selective Activity-Based Probes
Mountford, S. J., Anderson, B. M., Xu, B., Tay, E. S. V., Szabo, M., Hoang, M-L., Diao, J., Aurelio, L., Campden, R. I., Lindström, E., Sloan, E. K., Yates, R. M., Bunnett, N. W., Thompson, P. E. & Edgington-Mitchell, L. E., 20 Mar 2020, In : ACS Chemical Biology. 15, 3, p. 718-727 10 p.Research output: Contribution to journal › Article › Research › peer-review
Macrocyclic peptidomimetics as inhibitors of insulin-regulated aminopeptidase (IRAP)
Barlow, N., Vanga, S. R., Sävmarker, J., Sandström, A., Burns, P., Hallberg, A., Åqvist, J., Gutiérrez-De-Terán, H., Hallberg, M., Larhed, M., Chai, S. Y. & Thompson, P. E., Feb 2020, In : RSC Medicinal Chemistry. 11, 2, p. 234-244 11 p.Research output: Contribution to journal › Article › Research › peer-review
Substituted 1-methyl-4-phenylpyrrolidin-2-ones – Fragment-based design of N-methylpyrrolidone-derived bromodomain inhibitors
Hilton-Proctor, J. P., Ilyichova, O., Zheng, Z., Jennings, I. G., Johnstone, R. W., Shortt, J., Mountford, S. J., Scanlon, M. J. & Thompson, P. E., 1 Apr 2020, In : European Journal of Medicinal Chemistry. 191, 112120.Research output: Contribution to journal › Article › Research › peer-review
(S)-(−)-Fluorenylethylchloroformate (FLEC); preparation using asymmetric transfer hydrogenation and application to the analysis and resolution of amines
Al Amin, M., Camerino, M. A., Mountford, S. J., Ma, X., Manallack, D. T., Chalmers, D. K., Wills, M. & Thompson, P. E., 1 Jan 2019, In : Tetrahedron. 75, 43, p. 1-7 7 p., 130591.Research output: Contribution to journal › Article › Research › peer-review
An apically located hybrid guanylate cyclase-ATPase is critical for the initiation of Ca2+ signaling and motility in Toxoplasma gondii
Yang, L., Uboldi, A. D., Seizova, S., Wilde, M. L., Coffey, M. J., Katris, N. J., Yamaryo-Botté, Y., Kocan, M., Bathgate, R. A. D., Stewart, R. J., McConville, M. J., Thompson, P. E., Botté, C. Y. & Tonkin, C. J., 31 May 2019, In : The Journal of Biological Chemistry. 294, 22, p. 8959-8972 14 p.Research output: Contribution to journal › Article › Research › peer-review
4
Citations
(Scopus)
Activities
- 1 Grant review responsibilities
Medicinal Chemistry and Drug Action
Philip Thompson (Member)
22 Sep 2011
Activity: External Academic Engagement › Grant review responsibilities