Photo of Philip Thompson

View Scopus Profile

Philip Thompson

Professor

 https://orcid.org/0000-0002-5910-7625
1992 …2022
If you made any changes in Pure these will be visible here soon.

Personal profile

Biography

Position

 

Medicinal Chemistry
Monash Institute of Pharmaceutical Sciences

Research interests

Research in our group has a general focus on Structure-based Design and Synthesis of kinase inhibitors , epigenetic modulators and phosphodiesterase inhibitors. We have particular expertise in Peptides and Peptidomimetics.

Our major current programs deal with

  • isoform selective inhibition of the PI3 kinase family
  • new chemotypes as PDE inhibitors and PDE inhibitors against parasitic diseases
  • polymyxin-based antibacterial agents
  • fluorescent labels for peptides
  • modulators of epigenetic proteins

Monash teaching commitment

B Pharm and B Pharm Sci - 1st Year Bio-organic and Medicinal Chemistry
B Pharm - PAC4441 Integrated therapeutics: Endocrinology and renal
B Pharm Sci - PSC3091 Molecular basis of drug action
B Pharm Sci - PSC3122 Synthetic Medicinal Chemistry

 

 

Research area keywords

  • Kinase Inhibitors
  • Peptides and Peptidomimetics
  • Structure-Based Design and Synthesis of Kinase
  • Epigenetics

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2003 2022

JDRF Strategic Research Agreement - Novel Adjunctive Therapeutic For T1D; a-MSH/MC5R agonist axis

Cowley, M., Sleeman, M., Thompson, P., Wentworth, J. & Kelly, L.

1/07/19 → 30/06/21

Project: Research

Novel Treatment of Type 1 Diabetes via Melanocortin 5 Agoinsm

Cowley, M., Sleeman, M., Thompson, P., Wentworth, J., Wilks, A. F., Le Roux, C. W. & Kelly, L.

Department of Health and Human Services (DHHS) (VIC), Synthesis Pty Ltd, Monash University – Internal School Contribution

6/02/19 → 5/08/20

Project: Research

Development of a Microfluidic Blood Platelet Analyser

Nesbitt, W., Mitchell, A., Nandurkar, H., Hamilton, J., Thompson, P., Tran, H., Elliott, S. & Macfarlane, I.

National Health & Medical Research Council (NHMRC)

1/01/19 → 31/12/21

Project: Research

Oral Peptides Research Program

Pouton, C., Thompson, P. & Porter, C.

Lonza (Belgium)

20/06/18 → 20/06/21

Project: Research

Targeting a novel anti-platelet mechanism for improved anti-thrombotic therapy

Hamilton, J., Thompson, P., Nandurkar, H., Andrews, R. & Nesbitt, W.

National Health & Medical Research Council (NHMRC)

1/01/18 → 31/12/21

Project: Research

Research Output 1992 2019

An apically located hybrid guanylate cyclase-ATPase is critical for the initiation of Ca2+ signaling and motility in Toxoplasma gondii

Yang, L., Uboldi, A. D., Seizova, S., Wilde, M. L., Coffey, M. J., Katris, N. J., Yamaryo-Botté, Y., Kocan, M., Bathgate, R. A. D., Stewart, R. J., McConville, M. J., Thompson, P. E., Botté, C. Y. & Tonkin, C. J., 31 May 2019, In : Journal of Biological Chemistry. 294, 22, p. 8959-8972 14 p.

Research output: Contribution to journal › Article › Research › peer-review

Controlled Construction of Cyclic d / l Peptide Nanorods

Silk, M. R., Mohanty, B., Sampson, J. B., Scanlon, M. J., Thompson, P. E. & Chalmers, D. K., 8 Jan 2019, In : Angewandte Chemie - International Edition. 58, 2, p. 596-601 6 p.

Research output: Contribution to journal › Article › Research › peer-review

Structural Determinants of Isoform Selectivity in PI3K Inhibitors

Miller, M. S., Thompson, P. E. & Gabelli, S. B., 26 Feb 2019, In : Biomolecules. 9, 3, 35 p., 82.

Research output: Contribution to journal › Review Article › Research › peer-review

Open Access
File

A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent

Sadek, M. M., Barlow, N., Leung, E. W. W., Williams-Noonan, B. J., Yap, B. K., Shariff, F. M., Caradoc-Davies, T. T., Nicholson, S. E., Chalmers, D. K., Thompson, P. E., Law, R. H. P. & Norton, R. S., 19 Oct 2018, In : ACS Chemical Biology. 13, 10, p. 2930-2938 9 p.

Research output: Contribution to journal › Article › Research › peer-review

Cyclic Hexapeptide Mimics of the LEDGF Integrase Recognition Loop in Complex with HIV-1 Integrase

Northfield, S. E., Wielens, J., Headey, S. J., Williams-Noonan, B. J., Mulcair, M., Scanlon, M., Parker, M. W., Thompson, P. E. & Chalmers, D. K., 10 Aug 2018, In : ChemMedChem. 13, 15, p. 1555-1565 11 p.

Research output: Contribution to journal › Article › Research › peer-review

Activities 2011 2011

  • 1 Grant review responsibilities

Medicinal Chemistry and Drug Action

Philip Thompson (Member)
22 Sep 2011

Activity: External Academic Engagement › Grant review responsibilities