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Personal profile


Medicinal Chemistry Theme Leader, Monash Institute of Pharmaceutical Sciences

Associate Dean, Research, Faculty of Pharmacy & Pharmaceutical Sciences

Research interests

  • Allosteric modulators and bitopic ligands acting at G protein-coupled receptors
  • The design and synthesis of cancer therapeutics based on Noscapine
  • New methodology for the preparation of semi-synthetic opioid pharmaceuticals
  • The development of M1 and M17 aminopeptidase inhibitors as antimalarial agents
  • Applications of ionic liquids in pharmaceutical synthesis and drug delivery

Monash teaching commitment

Bachelor of Pharmaceutical Science:

  • PSC2021 Structural Organic Chemistry I (Unit Coordinator)
  • PSC3121 Synthetic Medicinal Chemistry (Lecturer)

Education/Academic qualification

PhD, Griffith University

B.Sc. (Hons), Griffith University

External positions

Adjunct Professor, Deakin University

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Projects 2001 2024

Research Output 1986 2019

6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity

Jorg, M. T., van der Westhuizen, E. T., Khajehali, E., Burger, W. A. C., White, J., Choy, K. H. C., Tobin, A. B., Sexton, P. M., Valant, C., Capuano, B., Christopoulos, A. & Scammells, P. J., 20 Mar 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1099-1114 16 p.

Research output: Contribution to journalArticleResearchpeer-review

A Novel Class of N-Sulfonyl and N-Sulfamoyl Noscapine Derivatives that Promote Mitotic Arrest in Cancer Cells

Yong, C., Devine, S. M., Gao, X., Yan, A., Callaghan, R., Capuano, B. & Scammells, P. J., 1 Jan 2019, (Accepted/In press) In : ChemMedChem.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

A Thieno[2,3-d]pyrimidine Scaffold is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor

Fyfe, T. J., Zarzycka, B., Lim, H. D., Kellam, B., Mistry, S. N., Katrich, V., Scammells, P. J., Lane, J. R. & Capuano, B., 1 Oct 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 174-206 33 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs

Hollingsworth, S. A., Kelly, B., Valant, C., Michaelis, J. A., Mastromihalis, O., Thompson, G., Venkatakrishnan, A. J., Hertig, S., Scammells, P. J., Sexton, P. M., Felder, C. C., Christopoulos, A. & Dror, R. O., 1 Dec 2019, In : Nature Communications. 10, 1, p. 1-9 9 p., 3289.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1 Citation (Scopus)

Effects of VCP979 Novel p38 Mitogen Activated Protein Kinase Inhibitor on Progression of Pancreatic Cancer in Mouse Model with Diabetic Conditions

Xu, T., Ding, J., Ge, H., Xu, X., Scammells, P., Wang, B. & Ju, S., 1 Jun 2019, In : Journal of Biomedical Nanotechnology. 15, 6, p. 1325-1333 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Activities 2013 2013

  • 1 Grant review responsibilities

Theme Leader

Peter Scammells (Member)
12 Aug 2013

Activity: External Academic EngagementGrant review responsibilities