Projects per year
Personal profile
Biography
Medicinal Chemistry Theme Leader, Monash Institute of Pharmaceutical Sciences
Associate Dean, Research, Faculty of Pharmacy & Pharmaceutical Sciences
Research interests
- Allosteric modulators and bitopic ligands acting at G protein-coupled receptors
- The design and synthesis of cancer therapeutics based on Noscapine
- New methodology for the preparation of semi-synthetic opioid pharmaceuticals
- The development of M1 and M17 aminopeptidase inhibitors as antimalarial agents
- Applications of ionic liquids in pharmaceutical synthesis and drug delivery
Monash teaching commitment
Bachelor of Pharmaceutical Science:
- PSC2021 Structural Organic Chemistry I (Unit Coordinator)
- PSC3121 Synthetic Medicinal Chemistry (Lecturer)
External positions
Adjunct Professor, Deakin University
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2001 2018
Allosteric and Bitopic Ligands Acting at G Protein-Coupled Receptors
Scammells, P. J. & Christopoulos, A.
Australian Research Council (ARC), Monash University
1/01/16 → 31/12/18
Project: Research
Anti-Malarial Agents Targeting Apical Membrane Antigen 1
Norton, R. S., McGowan, S., Scammells, P. J. & Scanlon, M.
National Health & Medical Research Council (NHMRC)
1/01/16 → 31/12/18
Project: Research
DsbA inhibitors: from hits to leads
Martin, J., Scanlon, M., Heras, B., Scammells, P. J. & Torsika, M.
1/01/16 → 31/12/18
Project: Research
Melbourne Biomolecular NMR Network
Stone, M. J., Bottomley, S., Gooley, P., Langford, S., Reynolds, E., Scammells, P. J., Scanlon, M., Separovic, F., Tuck, K. L., Whisstock, J. & Wilce, J. A.
Australian Research Council (ARC), The University of Melbourne, Monash University
1/01/09 → …
Project: Research
Research Output 2000 2018
Assessment of the molecular mechanisms of action of novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one allosteric modulators at the M1 muscarinic acetylcholine receptors
Van Der Westhuizen, E. T., Spathis, A., Khajehali, E., Jorg, M., Mistry, S. N., Capuano, B., Tobin, A. B., Sexton, P. M., Scammells, P. J., Valant, C. & Christopoulos, A. 24 Apr 2018 (Accepted/In press) In : Molecular Pharmacology. 50 p.Research output: Research - peer-review › Article
A Thieno[2,3-d]pyrimidine Scaffold is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor
Fyfe, T. J., Zarzycka, B., Lim, H. D., Kellam, B., Mistry, S. N., Katrich, V., Scammells, P. J., Lane, J. R. & Capuano, B. 2018 (Accepted/In press) In : Journal of Medicinal Chemistry. 82 p.Research output: Research - peer-review › Article
Synthesis and Pharmacological Evaluation of Heterocyclic Carboxamides: Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor with Weak Agonist Activity and Diverse Modulatory Profiles
Dallagnol, J. C. C., Khajehali, E., Van Der Westhuizen, E. T., Jörg, M., Valant, C., Gonçalves, A. G., Capuano, B., Christopoulos, A. & Scammells, P. J. 12 Apr 2018 In : Journal of Medicinal Chemistry. 61, 7, p. 2875-2894 20 p.Research output: Research - peer-review › Article
The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions
Draper-Joyce, C. J., Verma, R. K., Michino, M., Shonberg, J., Kopinathan, A., Klein Herenbrink, C., Scammells, P. J., Capuano, B., Abramyan, A. M., Thal, D. M., Javitch, J. A., Christopoulos, A., Shi, L. & Lane, J. R. 1 Dec 2018 In : Scientific Reports. 8, 1, 12 p., 1208Research output: Research - peer-review › Article
Open Access
File
The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D2 receptor
Draper-Joyce, C. J., Michino, M., Verma, R. K., Klein Herenbrink, C., Shonberg, J., Kopinathan, A., Scammells, P. J., Capuano, B., Thal, D. M., Javitch, J. A., Christopoulos, A., Shi, L. & Lane, J. R. 1 Feb 2018 In : Biochemical Pharmacology. 148, p. 315-328 14 p.Research output: Research - peer-review › Article