Projects per year
Personal profile
Biography
Medicinal Chemistry Theme Leader, Monash Institute of Pharmaceutical Sciences
Associate Dean, Research, Faculty of Pharmacy & Pharmaceutical Sciences
Research interests
- Allosteric modulators and bitopic ligands acting at G protein-coupled receptors
- The design and synthesis of cancer therapeutics based on Noscapine
- New methodology for the preparation of semi-synthetic opioid pharmaceuticals
- The development of M1 and M17 aminopeptidase inhibitors as antimalarial agents
- Applications of ionic liquids in pharmaceutical synthesis and drug delivery
Monash teaching commitment
Bachelor of Pharmaceutical Science:
-
BPS2021 Synthetic Chemistry I: Structure & Reactivity (Unit Coordinator)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Griffith University
Award Date: 2 Apr 1991
B.Sc. (Hons), Griffith University
Award Date: 2 Apr 1986
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Development of Allosteric and Bitopic Ligands to Tune Receptor Signalling
Scammells, P. (Primary Chief Investigator (PCI)) & Christopoulos, A. (Chief Investigator (CI))
Australian Research Council (ARC)
29/01/25 → 28/01/28
Project: Research
-
Harnessing Endogenous Opioids to Treat Gut Motility Disorders and Pain
Poole, D. (Primary Chief Investigator (PCI)), Valant, C. (Chief Investigator (CI)), Carbone, S. (Chief Investigator (CI)), Mobbs, J. (Chief Investigator (CI)), Thal, D. (Associate Investigator (AI)), Scammells, P. (Associate Investigator (AI)), King, S. K. (Associate Investigator (AI)), Imlach, W. (Associate Investigator (AI)), Hamilton, J. A. (Associate Investigator (AI)) & Veldhuis, N. (Associate Investigator (AI))
1/01/23 → 31/12/26
Project: Research
-
Pre-clinical evaluation of selective adenosine A1 receptor positive allosteric modulators for the treatment of drug-resistant epilepsy
Kwan, P. (Primary Chief Investigator (PCI)), May, L. (Chief Investigator (CI)), Rollo, B. (Chief Investigator (CI)), O'Brien, T. (Chief Investigator (CI)), Casillas-Espinosa, P. (Chief Investigator (CI)), Howden, S. (Chief Investigator (CI)), Christopoulos, A. (Chief Investigator (CI)), Gregory, K. (Chief Investigator (CI)), Scammells, P. (Chief Investigator (CI)), Baltos, J.-A. (Chief Investigator (CI)), Elliot, D. (Chief Investigator (CI)), TN Nguyen, A. (Chief Investigator (CI)), Langmead, C. (Chief Investigator (CI)), Antonic-Baker, A. (Chief Investigator (CI)), Sumer, H. (Chief Investigator (CI)), Javaid, S. (Associate Investigator (AI)) & Gu, J. (Chief Investigator (CI))
1/06/22 → 31/05/27
Project: Research
-
Positive allosteric modulation of anti-convulsant G protein-coupled receptor signalling to treat drug-resistant epilepsy
May, L. (Primary Chief Investigator (PCI)), Webb, G. (Chief Investigator (CI)), Carlsson, J. (Chief Investigator (CI)), Baltos, J.-A. (Chief Investigator (CI)), TN Nguyen, A. (Chief Investigator (CI)), Christopoulos, A. (Associate Investigator (AI)), Miao, Y. (Associate Investigator (AI)), O'Brien, T. (Associate Investigator (AI)), Rollo, B. (Associate Investigator (AI)), Casillas-Espinosa, P. (Associate Investigator (AI)), Gregory, K. (Associate Investigator (AI)), Scammells, P. (Associate Investigator (AI)) & Nguyen, T. (Associate Investigator (AI))
1/01/22 → 31/12/25
Project: Research
-
Multidisciplinary catalyst to discover and progress novel antimalarial drugs
Creek, D. (Primary Chief Investigator (PCI)), Charman, S. (Chief Investigator (CI)), de Koning-Ward, T. F. (Chief Investigator (CI)), Gilson, P. (Chief Investigator (CI)), McGowan, S. (Chief Investigator (CI)) & Scammells, P. (Chief Investigator (CI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/20 → 31/12/25
Project: Research
-
Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy
Giannangelo, C., Challis, M. P., Siddiqui, G., Edgar, R., Malcolm, T. R., Webb, C. T., Drinkwater, N., Vinh, N., Macraild, C., Counihan, N., Duffy, S., Wittlin, S., Devine, S. M., Avery, V. M., De Koning-Ward, T., Scammells, P., McGowan, S. & Creek, D. J., 8 Jul 2024, In: eLife. 13, 32 p., RP92990.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Discovery of 2-Methyl-5-(1H-pyrazol-4-yl)pyridines and Related Heterocycles as Promising M4 mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders
Liu, B., Thompson, G., Jörg, M., Barnes, N., Thal, D. M., Christopoulos, A., Capuano, B., Valant, C. & Scammells, P. J., 18 Jul 2024, In: Journal of Medicinal Chemistry. 67, 15, p. 13286–13304 19 p.Research output: Contribution to journal › Article › Research › peer-review
-
Ligand-Directed Labeling of the Adenosine A1 Receptor in Living Cells
Comeo, E., Goulding, J., Lin, C. Y., Groenen, M., Woolard, J., Kindon, N. D., Harwood, C. R., Platt, S., Briddon, S. J., Kilpatrick, L. E., Scammells, P. J., Hill, S. J. & Kellam, B., 12 Jul 2024, In: Journal of Medicinal Chemistry. 67, 14, p. 12099–12117 19 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus) -
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity
Edgar, R. C. S., Malcolm, T. R., Siddiqui, G., Giannangelo, C., Counihan, N. A., Challis, M., Duffy, S., Chowdhury, M., Marfurt, J., Dans, M., Wirjanata, G., Noviyanti, R., Daware, K., Suraweera, C. D., Price, R. N., Wittlin, S., Avery, V. M., Drinkwater, N., Charman, S. A. & Creek, D. J. & 3 others, , 12 Jun 2024, In: mBio. 15, 6, 27 p., e0096624.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl)pyridine positive allosteric modulators for the M4 mAChR
Jörg, M., van der Westhuizen, E. T., Lu, Y., Christopher Choy, K. H., Shackleford, D. M., Khajehali, E., Tobin, A. B., Thal, D. M., Capuano, B., Christopoulos, A., Valant, C. & Scammells, P. J., 5 Oct 2023, In: European Journal of Medicinal Chemistry. 258, 20 p., 115588.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus)
-
MONASH UNIVERSITY (Organisational unit)
Scammells, P. (Inventor) & Orbell, G. (Inventor)
3 Aug 2016Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
-
MONASH UNIVERSITY (Organisational unit)
Scammells, P. (Inventor) & Orbell, G. (Inventor)
14 Apr 2016Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
-
MONASH UNIVERSITY (Organisational unit)
Orbell, G. (Inventor) & Scammells, P. (Inventor)
7 Jul 2015Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
-
Theme Leader
Peter Scammells (Member)
12 Aug 2013Activity: External Academic Engagement › Grant review responsibilities