Peter Meikle

Professor

20082019
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Research Output 2008 2019

Acetylation of trehalose mycolates is required for efficient MmpL-mediated membrane transport in Corynebacterineae

Yamaryo, Y., Rainczuk, A. A. K., Lea-Smith, D. J., Brammananth, R., Van Der Peet, P. L., Meikle, P. J., Ralton, J. E., Rupasinghe, T. W. T., Williams, S. J., Coppel, R. L., Crellin, P. K. & McConville, M. J., 2015, In : ACS Chemical Biology. 10, 3, p. 734 - 746 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism

Chaurasia, B., Kaddai, V. A., Lancaster, G. I., Henstridge, D. C., Sriram, S., Galam, D. L. A., Gopalan, V., Prakash, K. N. B., Velan, S. S., Bulchand, S., Tsong, T. J., Wang, M., Siddique, M. M., Yuguang, G., Sigmundsson, K., Mellet, N. A., Weir, J. M., Meikle, P. J., Bin M. Yassin, M. S., Shabbir, A. & 5 othersShayman, J. A., Hirabayashi, Y., Shiow, S. A. T. E., Sugii, S. & Summers, S. A., 13 Dec 2016, In : Cell Metabolism. 24, 6, p. 820-834 15 p.

Research output: Contribution to journalArticleResearchpeer-review

A distinct plasma lipid signature associated with poor prognosis in castration-resistant prostate cancer

Lin, H-M., Mahon, K. L., Weir, J. M., Mundra, P. A., Spielman, C., Briscoe, K., Gurney, H., Mallesara, G., Marx, G. M., Stockler, M. R., PRIMe Consortium, Parton, R. G., Hoy, A. J., Daly, R. J., Meikle, P. J. & Horvath, L. G., 15 Nov 2017, In : International Journal of Cancer. 141, 10, p. 2112-2120 9 p.

Research output: Contribution to journalArticleResearchpeer-review

A mouse model of harlequin ichthyosis delineates a key role for Abca12 in lipid homeostasis

Smyth, I. M., Hacking, D. F., Hilton, A. A., Mukhamedova, N., Meikle, P. J., Ellis, S. L., Slattery, K., Collinge, J. E., de Graaf, C. A., Bahlo, M., Sviridov, D., Kile, B. & Hilton, D., 2008, In : PLoS Genetics. 4, 9 (e1000192), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Analysis of the liver lipidome reveals insights into the protective effect of exercise on high-fat diet-induced hepatosteatosis in mice

Jordy, A. B., Kraakman, M. J., Gardner, T., Estevez, E., Kammoun, H. L., Weir, J. M., Kiens, B., Meikle, P. J., Febbraio, M. A. & Henstridge, D. C., May 2015, In : American Journal of Physiology - Endocrinology and Metabolism. 308, 9, p. E778-E791 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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APP deficiency results in resistance to obesity but impairs glucose tolerance upon high fat feeding

Czeczor, J. K., Genders, A. J., Aston-Mourney, K., Connor, T., Hall, L. G., Hasebe, K., Ellis, M., De Jong, K. A., Henstridge, D. C., Meikle, P. J., Febbraio, M. A., Walder, K. & McGee, S. L., 1 Jun 2018, In : Journal of Endocrinology. 237, 3, p. 311-322 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Baseline serum phosphatidylcholine plasmalogen concentrations are inversely associated with incident myocardial infarction in patients with mixed peripheral artery disease presentations

Moxon, J. V., Jones, R. E., Wong, G., Weir, J. M., Mellett, N. A., Kingwell, B. A., Meikle, P. J. & Golledge, J., 1 Aug 2017, In : Atherosclerosis. 263, p. 301-308 8 p.

Research output: Contribution to journalArticleResearchpeer-review

BJD Research Letter: A profile of lipid dysregulation in Harlequin Ichthyosis

Ip, S. C. I., Cottle, D. L., Jones, L. K., Weir, J. M., Kelsell, D. P., O'Toole, E. A., Meikle, P. J. & Smyth, I. M., Nov 2017, In : British Journal of Dermatology. 177, 5, p. e217-e219 3 p.

Research output: Contribution to journalLetterResearchpeer-review

Breaking up prolonged sitting alters the postprandial plasma lipidomic profile of adults with type 2diabetes

Grace, M. S., Dempsey, P. C., Sethi, P., Mundra, P. A., Mellett, N. A., Weir, J. M., Owen, N., Dunstan, D. W., Meikle, P. J. & Kingwell, B. A., 1 Jun 2017, In : Journal of Clinical Endocrinology and Metabolism. 102, 6, p. 1991-1999 9 p.

Research output: Contribution to journalArticleResearchpeer-review

cAMP response element binding protein1 is essential for activation of steroyl co-enzyme a desaturase 1 (Scd1) in mouse lung type II epithelial cells

Antony, N., Weir, J. R., McDougall, A. R. A., Mantamadiotis, T., Meikle, P. J., Cole, T. J. & Bird, A. D., 2013, In : PLoS ONE. 8, 4 , 12 p., e59763.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Caveolin-1 plays a critical role in the differentiation of monocytes into macrophages

Fu, Y., Moore, X. L., Lee, M. K. S., Fernández-Rojo, M. A., Parat, M-O., Parton, R. G., Meikle, P. J., Sviridov, D. & Chin-Dusting, J. P. F., Sep 2012, In : Arteriosclerosis, Thrombosis and Vascular Biology. 32, 9

Research output: Contribution to journalArticleResearchpeer-review

Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance

Boon, J. Y. C., Hoy, A. J., Stark, R., Brown, R. D., Meex, R. CR., Henstridge, D. C., Schenk, S., Meikle, P. J., Horowitz, J. F., Kingwell, B. A., Bruce, C. & Watt, M. J., 2013, In : Diabetes. 62, 2, p. 401 - 410 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Changes in lipids and inflammatory markers after consuming diets high in red meat or dairy for four weeks

Turner, K. M., Keogh, J. B., Meikle, P. J. & Clifton, P. M., 17 Aug 2017, In : Nutrients. 9, 8, 11 p., 886.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Changes in plasma lipidome following initiation of antiretroviral therapy

Trevillyan, J. M., Wong, G., Puls, R., Petoumenos, K., Emery, S., Mellett, N. A., Mundra, P. A., Meikle, P. J., Hoy, J. F. & for the ALTAIR Study Group, 1 Aug 2018, In : PLoS ONE. 13, 8, 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Circulating lipids are associated with alcoholic liver cirrhosis and represent potential biomarkers for risk assessment

Meikle, P. J., Mundra, P. A., Wong, G., Rahman, K., Huynh, K., Barlow, C. K., Duly, A. M. P., Haber, P. S., Whitfield, J. B. & Seth, D., 24 Jun 2015, In : PLoS ONE. 10, 6, 13 p., e0130346.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Circulating microparticles generate and transport monomeric C-reactive protein in patients with myocardial infarction

Habersberger, J. P., Strang, F., Scheichl, A., Htun, N., Bassler, N., Merivirta, R-M., Diehl, P., Krippner, G. Y., Meikle, P. J., Eisenhardt, S. U., Meredith, I. T. & Peter, K., 2012, In : Cardiovascular Research. 96, 1, p. 64 - 72 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparison of the serum lipidome in patients with abdominal aortic aneurysm and peripheral artery disease

Moxon, J. V., Liu, D., Wong, G., Weir, J. M., Behl-Gilhotra, R., Bradshaw, B., Kingwell, B. A., Meikle, P. J. & Golledge, J., 2014, In : Circulation: Cardiovascular Genetics. 7, 1, p. 71-79 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Consumption of a high-fat diet, but not regular endurance exercise training, regulates hypothalamic lipid accumulation in mice

Borg, M. L., Omran, S. F., Weir, J. M., Meikle, P. J. & Watt, M. J., 2012, In : The Journal of Physiology. 590, 17, p. 4377 - 4389 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Cytomegalovirus Restructures Lipid Rafts via a US28/CDC42-Mediated Pathway, Enhancing Cholesterol Efflux from Host Cells

Low, H., Mukhamedova, N., Cui, H. L., McSharry, B. P., Avdic, S., Hoang, A., Ditiatkovski, M., Liu, Y., Fu, Y., Meikle, P. J., Blomberg, M., Polyzos, K. A., Miller, W. E., Religa, P., Bukrinsky, M., Soderberg-Naucler, C., Slobedman, B. & Sviridov, D., 28 Jun 2016, In : Cell Reports. 16, 1, p. 186-200 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

Turner, N., Kowalski, G., Leslie, S. J., Risis, S., Yang, C., Lee-Young, R. S., Babb, J. R., Meikle, P. J., Lancaster, G. I., Henstridge, D. C., White, P. J., Kraegen, E. W., Marette, A., Cooney, G. J., Febbraio, M. A. & Bruce, C., 2013, In : Diabetologia. 56, 7, p. 1638 - 1648 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of low-fat or full-fat fermented and non-fermented dairy foods on selected cardiovascular biomarkers in overweight adults

Nestel, P. J., Mellett, N. A., Pally, S., Wong, G., Barlow, C. K., Croft, K., Mori, T. A. & Meikle, P. J., 28 Dec 2013, In : British Journal of Nutrition. 110, 12, p. 2242-2249 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of prenatal ethanol exposure on the lungs of postnatal lambs

Sozo, F., Vela, M., Stokes, V., Kenna, K. R., Meikle, P. J., De Matteo, R. M., Walker, D. W., Brien, J. F., Bocking, A. D. & Harding, R. L., 2011, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 300, 1, p. L139 - L147 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of the BET-inhibitor, RVX-208 on the HDL lipidome and glucose metabolism in individuals with prediabetes: A randomized controlled trial

Siebel, A. L., Trinh, S. K., Formosa, M. F., Mundra, P. A., Natoli, A. K., Reddy-Luthmoodoo, M., Huynh, K., Khan, A. A., Carey, A. L., van Hall, G., Cobelli, C., Dalla-Man, C., Otvos, J. D., Rye, K-A., Johansson, J. E., Gordon, A., Wong, N. C. W., Sviridov, D., Barter, P. J., Duffy, S. J. & 2 othersMeikle, P. J. & Kingwell, B. A., 1 Jun 2016, In : Metabolism. 65, 6, p. 904-914 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Erratum: Corrigendum to “Plasmalogen modulation attenuates atherosclerosis in ApoE- and ApoE/GPx1-deficient mice” (Atherosclerosis (2015) 243(2) (598–608) (S0021915015301805) (10.1016/j.atherosclerosis.2015.10.096))

Rasmiena, A. A., Barlow, C. K., Stefanovic, N., Huynh, K., Tan, R., Sharma, A., Tull, D., de Haan, J. B. & Meikle, P. J., 1 Nov 2016, In : Atherosclerosis. 254, p. 314-315 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Erratum: LICRE: unsupervised feature correlation reduction for lipidomics (Bioinformatics (2014) 30:19 (2832-2833) DOI: 10.1093/bioinformatics/btu381)

Wong, G., Chan, J., Kingwell, B. A., Leckie, C. & Meikle, P. J., 15 Feb 2015, In : Bioinformatics. 31, 4, p. 619 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism

Lancaster, G. I., Langley, K. G., Berglund, N. A., Kammoun, H. L., Reibe, S., Estevez, E., Weir, J., Mellett, N. A., Pernes, G., Conway, J. R. W., Lee, M. K. S., Timpson, P., Murphy, A. J., Masters, S. L., Gerondakis, S., Bartonicek, N., Kaczorowski, D. C., Dinger, M. E., Meikle, P. J., Bond, P. J. & 1 othersFebbraio, M. A., 1 May 2018, In : Cell Metabolism. 27, 5, p. 1096-1110 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Exercise early in life in rats born small does not normalize reductions in skeletal muscle PGC-1α in adulthood

Laker, R. C., Wlodek, M. E., Wadley, G. D., Gallo, L. A., Meikle, P. J. & McConell, G. K., 15 May 2012, In : American Journal of Physiology - Endocrinology and Metabolism. 302, 10

Research output: Contribution to journalArticleResearchpeer-review

Fetal inhibition of inflammation improves disease phenotypes in harlequin ichthyosis

Cottle, D. L., Ursino, G. M. A., Ip, S. C. L., Jones, L. K., Ditommaso, T. M., Hacking, D. F., Mangan, N. E., Mellett, N. A., Henley, K. J., Sviridov, D., Nold-Petry, C. A., Nold, M. F., Meikle, P. J., Kile, B. T. & Smyth, I. M., 2015, In : Human Molecular Genetics. 24, 2, p. 436-449 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Genetic correlation of the plasma lipidome with type 2 diabetes, prediabetes and insulin resistance in Mexican American families

Kulkarni, H., Mamtani, M., Wong, G., Weir, J. M., Barlow, C. K., Dyer, T. D., Almasy, L., Mahaney, M. C., Comuzzie, A. G., Duggirala, R., Meikle, P. J., Blangero, J. & Curran, J. E., 19 May 2017, In : BMC Genetics. 18, 1, 8 p., 48.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Genetic manipulation of cardiac Hsp72 levels does not alter substrate metabolism but reveals insights into high-fat feeding-induced cardiac insulin resistance

Henstridge, D. C., Estevez, E., Allen, T. L., Heywood, S. E., Gardner, T., Yang, C., Mellett, N. A., Kingwell, B. A., Meikle, P. J. & Febbraio, M. A., 1 May 2015, In : Cell Stress and Chaperones. 20, 3, p. 461-472 12 p.

Research output: Contribution to journalArticleResearchpeer-review

GM3 ganglioside and phosphatidylethanolamine-containing lipids are adipose tissue markers of insulin resistance in obese women

Wentworth, J. M., Naselli, G., Ngui, K., Smyth, G. K., Liu, R., O'Brien, P. E., Bruce, C., Weir, J., Cinel, M., Meikle, P. J. & Harrison, L. C., 1 Apr 2016, In : International Journal of Obesity. 40, 4, p. 706-713 8 p.

Research output: Contribution to journalArticleResearchpeer-review

High density lipoprotein efficiently accepts surface but not internal oxidised lipids from oxidised low density lipoprotein

Rasmiena, A. A., Barlow, C. K., Ng, T. W., Tull, D. & Meikle, P. J., 1 Feb 2016, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1861, 2, p. 69-77 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Human plasma lipidome is pleiotropically associated with cardiovascular risk factors and death

Bellis, C., Kulkarni, H., Mamtani, M., Kent Jr, J. W., Wong, G., Weir, J. M., Barlow, C. K., Diego, V., de Almeida, M. A. A., Dyer, T. D., Göring, H. H. H., Almasy, L., Mahaney, M. C., Comuzzie, A. G., Williams-Blangero, S., Meikle, P. J., Blangero, J. & Curran, J. E., 1 Dec 2014, In : Circulation: Cardiovascular Genetics. 7, 6, p. 854-863 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Immunometabolic and Lipidomic Markers Associated With the Frailty Index and Quality of Life in Aging HIV+ Men on Antiretroviral Therapy

Yeoh, H. L., Cheng, A. C., Cherry, C. L., Weir, J. M., Meikle, P. J., Hoy, J. F., Crowe, S. M. & Palmer, C. S., Aug 2017, In : EBioMedicine. 22, p. 112-121 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Inclusion of plasma lipid species improves classification of individuals at risk of type 2 diabetes

Wong, G., Barlow, C. K., Weir, J. M., Jowett, J. B. M., Magliano, D. J., Zimmet, P., Shaw, J. & Meikle, P. J., 8 Oct 2013, In : PLoS ONE. 8, 10, 8 p., e76577.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Interleukin 10 antioxidant effect decreases leukocytes/endothelial interaction induced by tumor necrosis factor α

Huet, O., Laemmel, E., Fu, Y., Dupic, L., Aprico, A., Andrews, K. L., Moore, S. L., Harrois, A., Meikle, P. J., Vicaut, E., Chin-Dusting, J. P. F. & Duranteau, J., Jan 2013, In : Shock. 39, 1, p. 83-88 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

Matthews, V. B., Allen, T. L., Risis, S., Chan, M. H. S., Henstridge, D. C., Watson, N., Zaffino, L. A., Babb, J. R., Boon, J. Y. C., Meikle, P. J., Jowett, J. B., Watt, M. J., Jansson, J. -O., Bruce, C. R. & Febbraio, M. A., 2010, In : Diabetologia. 53, 11, p. 2431 - 2441 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Investigating the pathogenesis and risk of Type 2 diabetes: clinical applications of metabolomics

Ng, T. W., Khan, A. A. & Meikle, P. J., 2012, In : Journal of Clinical Lipidology. 7, 6, p. 641 - 659 19 p.

Research output: Contribution to journalArticleOther

LICRE: Unsupervised feature correlation reduction for lipidomics

Wong, G., Chan, J., Kingwell, B. A., Leckie, C. & Meikle, P. J., 2 Apr 2014, In : Bioinformatics. 30, 19, p. 2832-2833 2 p.

Research output: Contribution to journalArticleResearchpeer-review

Lipid metabolism in patients infected with Nef-deficient HIV-1 strain

Low, H., Cheng, L., Di Yacovo, M. S., Churchill, M. J., Meikle, P., Bukrinsky, M., Hill, A. F. & Sviridov, D., 1 Jan 2016, In : Atherosclerosis. 244, p. 22-28 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Lipidomic dataset of plasma from patients infected with wild type and nef-deficient HIV-1 strain

Meikle, P., Low, H., Churchill, M. J., Bukrinsky, M. & Sviridov, D., 1 Mar 2016, In : Data in Brief. 6, p. 168-175 8 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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Lipidomic Profiles in Diabetes and Dementia

Huynh, K., Martins, R. N. & Meikle, P. J., 2017, In : Journal of Alzheimer's Disease. 59, 2, p. 433-444 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Lipidomic profiling in inflammatory bowel disease: Comparison between ulcerative colitis and Crohn's disease

Fan, F., Mundra, P. A., Fang, L., Galvin, A., Moore, X. L., Weir, J. M., Wong, G., White, D. A., Chin-Dusting, J., Sparrow, M. P., Meikle, P. J. & Dart, A. M., Jul 2015, In : Inflammatory Bowel Diseases. 21, 7, p. 1511-1518 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Lipidomic profiling of chylomicron triacylglycerols in response to high fat meals

Bonham, M. P., Linderborg, K. M., Dordevic, A., Larsen, A. E., Nguo, K., Weir, J. M., Gran, P., Luotonen, M. K., Meikle, P. J., Cameron-Smith, D., Kallio, H. P. T. & Sinclair, A. J., 2013, In : Lipids. 48, 1, p. 39 - 50 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Lipidomic profiling reveals early-stage metabolic dysfunction in overweight or obese humans

Mousa, A., Naderpoor, N., Mellett, N., Wilson, K. L., Plebanski, M., Meikle, P. J. & de Courten, B., 1 Mar 2019, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1864, 3, p. 335-343 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Lipidomic risk score independently and cost-effectively predicts risk of future type 2 diabetes: Results from diverse cohorts

Mamtani, M., Kulkarni, H., Wong, G., Weir, J. M., Barlow, C. K., Dyer, T. D., Almasy, L., Mahaney, M. C., Comuzzie, A. G., Glahn, D. C., Magliano, D. J., Zimmet, P., Shaw, J., Williams-Blangero, S., Duggirala, R., Blangero, J., Meikle, P. J. & Curran, J. E., 4 Apr 2016, In : Lipids in Health and Disease. 15, 12 p., 67.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Lipidomics: Potential role in risk prediction and therapeutic monitoring for diabetes and cardiovascular disease

Meikle, P. J., Wong, G., Barlow, C. K. & Kingwell, B. A., 2014, In : Pharmacology and Therapeutics. 143, 1, p. 12-23 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Lipidomics is providing new insight into the metabolic syndrome and its sequelae

Meikle, P. J. & Christopher, M. J., 2011, In : Current Opinion in Lipidology. 22, 3, p. 210-215 6 p.

Research output: Contribution to journalArticleOtherpeer-review

Low-Density Lipoprotein Receptor-Dependent and Low-Density Lipoprotein Receptor-Independent Mechanisms of Cyclosporin A-Induced Dyslipidemia

Kockx, M., Glaros, E. N., Leung, B., Ng, T. W., Berbée, J. F. P., Deswaerte, V., Nawara, D., Quinn, C., Rye, K-A., Jessup, W., Rensen, P. C. N., Meikle, P. J. & Kritharides, L., 1 Jul 2016, In : Arteriosclerosis, Thrombosis and Vascular Biology. 36, 7, p. 1338-1349 12 p.

Research output: Contribution to journalArticleResearchpeer-review