Research output per year
Research output per year
Accepting PhD Students
PhD projects
- A novel approach in improving lipidomics throughput for population profiling
- Development and validation of a high throughput clinical lipidomics platform
- Integration of population level ‘omics' data to target cardiometabolic disease
- Plasma lipidomic profiling in type 2 diabetes and coronary artery disease
- Plasmalogen modulation as a therapeutic approach for fatty liver disease
Research activity per year
Peter Meikle is an Adjunct Professor in the Department of Diabetes at the School of Translational Medicine, Monash University. He is also an NHMRC Senior Research Fellow. He leads the Obesity and Diabetes Program and is Head of the Metabolomics laboratory. He is Editor in Chief of the journal Metabolites and also holds affiliate positions at the University of Melbourne, and the NHMRC Clinical Trials Centre, University of Sydney.
Professor Meikle has been working in the field of metabolomics and lipidomics for over 25 years. His laboratory has developed state of the art lipid profiling technology and has used this to characterise the plasma lipidome associated with obesity, prediabetes and diabetes, stable and unstable coronary artery disease and Alzheimer’s disease. More recently his lab has performed the largest GWAS of the plasma lipidome and identified new links to coronary artery disease. The Metabolomics laboratory with funding support from the National Health and Medical Research Council (Australia), the Medical Research Future Fund (Australia), the National Institutes of Health (USA) and the National Heart Foundation (Australia) is continually improving its lipidomic profiling technology. These resources, including our existing disease/lifestyle/drug specific lipidomic profiles, our lipidomic GWAS asinternational collaborationsical and biostatistical expertise in lipidomics are made available to the research community through our publications, our web portal (https://metabolomics.baker.edu.au/) and our many national and international collaborations.
Professor Meikle has been involved in NHMRC review panels, and he regularly reviews for NHMRC, NHF, ARC and Diabetes Australia. Internationally he reviews for NMRC (Singapore, International Expert Panel) Diabetes UK, British Heart Foundation, French National Research Agency. He also reviews for many of the top journals (Nature, Circulation, Science, Diabetes and others).
Alterations in metabolism underpin many chronic diseases including obesity, type 2 diabetes, cardiovascular disease and age related dementia. While some metabolic pathways are well characterised, their dysregulation resulting from environmental and genetic influences are less well understood, particularly in a setting of chronic disease.
The Metabolomics laboratory uses state of the art tandem mass spectrometry to obtain metabolic profiles from cell and animal models in addition to clinically relevant human samples. This approach is providing an improved understanding of disease mechanisms leading to new biomarkers for improved diagnosis and risk assessment as well as new therapeutic strategies in the areas of obesity, diabetes and cardiovascular disease.
The lipidomic platform developed by Professor Meikle is one of the most advanced nationally or internationally and has made a substantial contribution to many collaborative projects both in Australia and internationally. Professor Meikle has identified lipidomic signatures that can improve upon traditional risk factors for the prediction of diabetes, cardiovascular disease and Alzheimer’s disease. He is currently working with commercial partners to translate these developments into clinical tests and new therapeutics.
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
PhD, James Cook University
… → 1986
Co-director, Australian Cardiovascular Alliance, Australian Cardiovascular Alliance
Senior Principal Research Fellow, Baker Heart and Diabetes Institute
Head, Metabolomics Laboratory, Baker Heart and Diabetes Institute
Co-lead, Obesity and Lipids Program, Baker Heart and Diabetes Institute
Head, Systems Biology Domain, Baker Heart and Diabetes Institute
Head of Department of Cardiovascular Research Translation and Implementation, La Trobe University
Research output: Contribution to journal › Article › Research › peer-review
Research output: Contribution to journal › Article › Research › peer-review
Research output: Contribution to journal › Article › Research › peer-review
Research output: Contribution to journal › Article › Research › peer-review
Research output: Contribution to journal › Article › Research › peer-review
Peter Meikle (Director)
Activity: Community Talks, Presentations, Exhibitions and Events › Public lecture/debate/seminar
Peter Meikle (Editor in chief)
Activity: Publication peer-review and editorial work types › Editorial responsibility