20112020

Research output per year

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Research Output

2020

Tackling the complexities of orphan GPCR ligand discovery with rationally assisted approaches

So, S. S., Ngo, T., Keov, P., Smith, N. J. & Kufareva, I., Jan 2020, GPCRs: Structure, Function, and Drug Discovery. Jastrzebska, B. & Park, P. S-H. (eds.). London UK: Elsevier, p. 295-334 40 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

1 Citation (Scopus)
2019

I8-arachnotocin–an arthropod-derived G protein-biased ligand of the human vasopressin V2 receptor

Duerrauer, L., Muratspahić, E., Gattringer, J., Keov, P., Mendel, H. C., Pfleger, K. D. G., Muttenthaler, M. & Gruber, C. W., 17 Dec 2019, In : Scientific Reports. 9, 1, 11 p., 19295.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

The TRPV4 agonist GSK1016790A regulates the membrane expression of TRPV4 channels

Baratchi, S., Keov, P., Darby, W. G., Lai, A., Khoshmanesh, K., Thurgood, P., Vahidi, P., Ejendal, K. & McIntyre, P., 23 Jan 2019, In : Frontiers in Pharmacology. 10, JAN, 12 p., 00006.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
9 Citations (Scopus)
2018

Contractility measurements of human uterine smooth muscle to aid drug development

Arrowsmith, S., Keov, P., Muttenthaler, M. & Gruber, C. W., 26 Jan 2018, In : Journal of Visualized Experiments. 2018, 131, 12 p., e56639.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
File
3 Citations (Scopus)

Discovery of peptide probes to modulate oxytocin-type receptors of insects

Keov, P., Liutkevičiute, Z., Hellinger, R., Clark, R. J. & Gruber, C. W., 1 Dec 2018, In : Scientific Reports. 8, 1, 7 p., 10020.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
7 Citations (Scopus)
2017

Cyclotides isolated from an ipecac root extract antagonize the corticotropin releasing factor type 1 receptor

Fahradpour, M., Keov, P., Tognola, C., Perez-Santamarina, E., McCormick, P. J., Ghassempour, A. & Gruber, C. W., 25 Sep 2017, In : Frontiers in Pharmacology. 8, SEP, 14 p., 616.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
12 Citations (Scopus)

Development of a human vasopressin V 1a -receptor antagonist from an evolutionary-related insect neuropeptide

Di Giglio, M. G., Muttenthaler, M., Harpsøe, K., Liutkeviciute, Z., Keov, P., Eder, T., Rattei, T., Arrowsmith, S., Wray, S., Marek, A., Elbert, T., Alewood, P. F., Gloriam, D. E. & Gruber, C. W., 1 Feb 2017, In : Scientific Reports. 7, 15 p., 41002.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
17 Citations (Scopus)
2014

Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor

Abdul Ridha, A., Lopez, L., Keov, P., Thal, D., Mistry, S. N., Sexton, P., Lane, J. R. D., Canals, M. & Christopoulos, A., 2014, In : The Journal of Biological Chemistry. 289, 9, p. 6067 - 6079 13 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Molecular mechanisms of bitopic ligand engagement with the M1 muscarinic acetylcholine receptor

Keov, P., Lopez, L., Devine, S., Valant, C., Lane, J. R. D., Scammells, P. J., Sexton, P. & Christopoulos, A., 2014, In : The Journal of Biological Chemistry. 289, 34, p. 23817 - 23837 21 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)
2013
24 Citations (Scopus)
2011

Allosteric modulation of G protein-coupled receptors: A pharmacological perspective

Keov, P., Sexton, P. & Christopoulos, A., 2011, In : Neuropharmacology. 60, 1, p. 24 - 35 12 p.

Research output: Contribution to journalArticleResearchpeer-review

204 Citations (Scopus)