19942017

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Article
2017

Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10

Seegar, T. C. M., Killingsworth, L. B., Saha, N., Meyer, P. A., Patra, D., Zimmerman, B., Janes, P. W., Rubinstein, E., Nikolov, D. B., Skiniotis, G., Kruse, A. C. & Blacklow, S. C., 14 Dec 2017, In : Cell. 171, 7, p. 1638-1648 11 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)
2016

An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth

Atapattu, L., Saha, N., Chheang, C., Eissman, M. F., Xu, K., Vail, M. E., Hii, L., Llerena, C., Liu, Z., Horvay, K., Abud, H. E., Kusebauch, U., Moritz, R. L., Ding, B-S., Cao, Z., Rafii, S., Ernst, M., Scott, A. M., Nikolov, D. B., Lackmann, M. & 1 others, Janes, P. W., 8 Aug 2016, In : Journal of Experimental Medicine. 213, 9, p. 1741-1757 17 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

PTP-PEST controls EphA3 activation and ephrin-induced cytoskeletal remodelling

Mansour, M., Nievergall, E., Gegenbauer, K., Llerena, C., Atapattu, L., Halle, M., Tremblay, M. L., Janes, P. W. & Lackmann, M., 2016, In : Journal of Cell Science. 129, 2, p. 277-289 13 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)
2014

A mathematical model for Eph/ephrin-directed segregation of intermingled cells

Aharon, R., Janes, P. W., Burgess, A., Hamza, K., Klebaner, F. C. & Lackmann, M., 2014, In : PLoS ONE. 9, 12, 19 p., e111803.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

EphA3 biology and cancer

Janes, P. W., Slape, C. I., Farnsworth, R. H., Atapattu Mudiyanselage, L. S. K., Scott, A. M. & Vail, M. E., 2014, In : Growth Factors. 32, 6, p. 176 - 189 14 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Hypoxia-controlled EphA3 marks a human endometrium-derived multipotent mesenchymal stromal cell that supports vascular growth

To, C., Farnsworth, R. H., Vail, M. E., Chheang, C., Gargett, C. E., Murone, C., Llerena, C. O., Major, A., Scott, A. M., Janes, P. W. & Lackmann, M., 2014, In : PLoS ONE. 9, 11, p. 1 - 27 27 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
8 Citations (Scopus)

Targeting EphA3 inhibits cancer growth by disrupting the tumor stromal microenvironment

Vail, M. E., Murone, C., Tan, Y. L. A., Hii, L. L. P., Abebe, D. B., Janes, P. W., Lee, F-T., Baer, M. E., Palath, V., Bebbington, C. R., Yarranton, G. T., Llerena, C. O., Garic, S., Abramson, D. A., Cartwright, G. A., Scott, A. M. & Lackmann, M., 2014, In : Cancer Research. 74, 16, p. 4470 - 4481 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
46 Citations (Scopus)

The role of proteases in regulating Eph/ephrin signaling

Atapattu Mudiyanselage, L. S. K., Lackmann, M. & Janes, P. W., 2014, In : Cell Adhesion and Migration. 8, 4, p. 294 - 307 14 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)
2012

Antibodies binding the ADAM10 substrate recognition domain inhibit Eph function

Atapattu Mudiyanselage, L. SK., Saha, N., Llerena, C. O., Vail, M. E., Scott, A. M., Nikolov, D. B., Lackmann, M. & Janes, P. W., 2012, In : Journal of Cell Science. 125, Pt 24, p. 6084 - 6093 10 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Concepts and consequences of Eph receptor clustering

Janes, P. W., Nievergall, E. & Lackmann, M., 2012, In : Seminars in Cell and Developmental Biology. 23, 1, p. 43 - 50 8 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)

Eph-dependent cell-cell adhesion and segregation in development and cancer

Nievergall, E., Lackmann, M. & Janes, P. W., 2012, In : Cellular and Molecular Life Sciences. 69, 11, p. 1813 - 1842 30 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)
2011

Eph receptor function is modulated by heterooligomerization of A and B type Eph receptors

Janes, P. W., Griesshaber, B., Atapattu Mudiyanselage, L. SK., Nievergall, E., Hii, L. LP., Mensinga, A., Chheang, C., Day, B. W., Boyd, A. W., Bastiaens, P. I., Jorgensen, C., Pawson, T. & Lackmann, M., 2011, In : Journal of Cell Biology. 195, 6, p. 1033 - 1045 13 p.

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)
2010

Architecture of Eph receptor clusters

Himanen, J-P., Yermekbayeva, L., Janes, P. W., Walker, J. R., Xu, K., Atapattu Mudiyanselage, L. SK., Rajashankar, K. R., Mensinga, A., Lackmann, M., Nikolov, D. B. & Dhe-Paganon, S., 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 24, p. 10860 - 10865 6 p.

Research output: Contribution to journalArticleResearchpeer-review

156 Citations (Scopus)

PTP1B regulates Eph receptor function and trafficking

Nievergall, E., Janes, P. W., Stegmayer, C., Vail, M. E., Haj, F. G., Teng, S. W., Neel, B. G., Bastiaens, P. I. & Lackmann, M., 2010, In : Journal of Cell Biology. 191, 6, p. 1189 - 1203 15 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)
2009

Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10

Janes, P. W., Wimmer-Kleikamp, S. H., Frangakis, A. S., Treble, K., Griesshaber, B., Sabet, O., Grabenbauer, M., Ting, A. Y., Saftig, P., Bastiaens, P. I. & Lackmann, M., 2009, In : PLoS Biology. 7, 10, p. e1000215-1 - e1000215-17 17 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)
2008

Eph/ephrin signalling and function in oncogenesis: Lessons from embryonic development

Janes, P. W., Adikari, S. H. & Lackmann, M., 2008, In : Current Cancer Drug Targets. 8, 6, p. 473 - 489 17 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)
2005

Adam Meets Eph: An ADAM Substrate Recognition Module Acts as a Molecular Switch for Ephrin Cleavage In trans

Janes, P. W., Saha, N., Barton, W. A., Kolev, M. V., Wimmer-Kleikamp, S. H., Nievergall, E., Blobel, C. P., Himanen, J-P., Lackmann, M. & Nikolov, D. B., 2005, In : Cell. 123, 2, p. 291 - 304 14 p.

Research output: Contribution to journalArticleResearchpeer-review

329 Citations (Scopus)
2004

Recruitment of Eph receptors into signaling clusters does not require ephrin contact

Wimmer-Kleikamp, S. H., Janes, P. W., Squire, A., Bastiaens, P. I. H. & Lackmann, M., 2004, In : Journal of Cell Biology. 164, 5, p. 661 - 666 6 p.

Research output: Contribution to journalArticleResearchpeer-review

97 Citations (Scopus)
2003

Generation and analysis of Siah2 mutant mice

Frew, I. J., Hammond, V. E., Dickins, R. A., Quinn, J. M. W., Walkley, C. R., Sims, N. A., Schnall, R., Della, N. G., Holloway, A. J., Digby, M. R., Janes, P. W., Tarlinton, D. M., Purton, L. E., Gillespie, M. T. & Bowtell, D. D. L., 2003, In : Molecular and Cellular Biology. 23, 24, p. 9150 - 9161 12 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)
2002

Stress-induced decrease in TRAF2 stability is mediated by Siah2

Habelhah, H., Frew, I. J., Laine, A., Janes, P. W., Relaix, F., Sassoon, D., Bowtell, D. D. L. & Ronai, Z., 2002, In : The EMBO Journal. 21, 21, p. 5756 - 5765 10 p.

Research output: Contribution to journalArticleResearchpeer-review

95 Citations (Scopus)
2000

Expression of c-erB receptors, heregulin and oestrogen receptor in human breast cell lines

DeFazio, A., Chiew, Y., Sini, R. L., Janes, P. W. & Sutherland, R. L., 2000, In : International Journal of Cancer. 87, 4, p. 487 - 498 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1998

Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3

Fiddes, R. J., Campbell, D. H., Janes, P. W., Sivertsen, S. P., Sasaki, H., Wallasch, C. & Daly, R. J., 27 Mar 1998, In : The Journal of Biological Chemistry. 273, 13, p. 7717-7724 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
70 Citations (Scopus)

Inhibition of the MAP kinase cascade blocks heregulin-induced cell cycle progression in T-47D human breast cancer cells

Fiddes, R. J., Janes, P. W., Sivertsen, S. P., Sutherland, R. L., Musgrove, E. A. & Daly, R. J., 28 May 1998, In : Oncogene. 16, 21, p. 2803-2813 11 p.

Research output: Contribution to journalArticleResearchpeer-review

61 Citations (Scopus)
1997

Structural determinants of the interaction between the erbB2 receptor and the Src homology 2 domain of Grb7

Janes, P. W., Lackmann, M., Church, W. B., Sanderson, G. M., Sutherland, R. L. & Daly, R. J., 28 Mar 1997, In : The Journal of Biological Chemistry. 272, 13, p. 8490-8497 8 p.

Research output: Contribution to journalArticleResearchpeer-review

65 Citations (Scopus)
1996

Cloning and characterization of GRB14, a novel member of the GRB7 gene family

Daly, R. J., Sanderson, G. M., Janes, P. W. & Sutherland, R. L., 28 May 1996, In : The Journal of Biological Chemistry. 271, 21, p. 12502-12510 9 p.

Research output: Contribution to journalArticleResearchpeer-review

102 Citations (Scopus)
1995

Heregulin (HRG)-induced mitogenic signaling and cytotoxic activity of a HRG/PE40 ligand toxin in human breast cancer cells

Fiddes, R. J., Janes, P. W., Sanderson, G. M., Sivertsen, S. P., Sutherland, R. L. & Daly, R. J., 1 Jan 1995, In : Cell Growth and Differentiation. 6, 12, p. 1567-1577 11 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)
1994

Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2

Janes, P. W., Daly, R. J., DeFazio, A. & Sutherland, R. L., 1 Dec 1994, In : Oncogene. 9, 12, p. 3601-3608 8 p.

Research output: Contribution to journalArticleResearchpeer-review

184 Citations (Scopus)