Projects per year
Personal profile
Biography
Protein Interaction and Cancer Lab (Acting Head). Our principal interest is cell surface proteins that promote tumour growth, in the context of the tumour microenvironment, and may be targeted by therapeutic antibodies. Our focus is on Eph receptor tyrosine kinases, due to their critical roles in tumour tissue patterning and stem cell maintenance, and on ADAM metalloproteases, which regulate signalling by diverse cell surface receptors including Ephs, erbBs and Notch. We employ various biochemical, structure/function and imaging techniques using tumour models in vitro and in vivo. Our antibodies against EphA3 and ADAM10 inhibit tumour growth in mice, and the EphA3 antibody is currently entering Phase II clinical trials.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Targeted antibody therapy for malignant mesothelioma
Janes, P. (Primary Chief Investigator (PCI)), Scott, A. (Chief Investigator (CI)) & John, T. (Chief Investigator (CI))
1/01/17 → 30/06/18
Project: Other
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Novel therapeutic antibodies to fight drug resistant breast cancers
Janes, P. (Primary Chief Investigator (PCI)), Lim, E. (Chief Investigator (CI)) & Nikolov, D. (Chief Investigator (CI))
1/01/16 → 31/12/18
Project: Research
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Humanisation and pre-clinical validation of a therapeutic anti-cancer antibody
Janes, P. (Primary Chief Investigator (PCI)), Nikolov, D. (Chief Investigator (CI)), Scott, A. M. (Chief Investigator (CI)) & Sleeman, M. (Chief Investigator (CI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/15 → 31/12/17
Project: Research
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Control of gastrointestinal tumour progression by therapeutic interference with myeloid derived cells
Ernst, M. R. W. (Chief Investigator (CI)) & Janes, P. (Chief Investigator (CI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/14 → 31/12/17
Project: Research
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Antibody-based inhibition of ADAM10 as cancer immunotherapy
Janes, P. (Primary Chief Investigator (PCI)), Moritz, R. (Chief Investigator (CI)), Nikolov, D. (Chief Investigator (CI)), Vail, M. (Chief Investigator (CI)) & Scott, A. M. (Associate Investigator (AI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/14 → 31/12/17
Project: Research
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Co-clustering of EphB6 and ephrinB1 in trans restrains cancer cell invasion
Liang, L. Y., Geoghegan, N. D., Mlodzianoski, M., Leis, A., Whitehead, L. W., Surudoi, M. G., Young, S. N., Janes, P., Shepherd, D., Ghosal, D., Rogers, K. L., Murphy, J. M. & Lucet, I. S., Dec 2024, In: Communications Biology. 7, 1, 13 p., 461.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Link opens in a new tab Citations (Scopus) -
Inhibition of EphA3 Expression in Tumour Stromal Cells Suppresses Tumour Growth and Progression
Vail, M. E., Farnsworth, R. H., Hii, L., Allen, S., Arora, S., Anderson, R. L., Dickins, R. A., Orimo, A., Wu, S. Z., Swarbrick, A., Scott, A. M. & Janes, P. W., Sept 2023, In: Cancers. 15, 18, 16 p., 4646.Research output: Contribution to journal › Article › Research › peer-review
Open Access10 Link opens in a new tab Citations (Scopus) -
Preferential Antibody and Drug Conjugate Targeting of the ADAM10 Metalloprotease in Tumours
Yan, H., Vail, M. E., Hii, L., Guo, N., McMurrick, P. J., Oliva, K., Wilkins, S., Saha, N., Nikolov, D. B., Lee, F. T., Scott, A. M. & Janes, P. W., 1 Jul 2022, In: Cancers. 14, 13, 13 p., 3171.Research output: Contribution to journal › Article › Research › peer-review
Open Access11 Link opens in a new tab Citations (Scopus) -
The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs
Liang, L. Y., Roy, M., Horne, C. R., Sandow, J. J., Surudoi, M., Dagley, L. F., Young, S. N., Dite, T., Babon, J. J., Janes, P. W., Patel, O., Murphy, J. M. & Lucet, I. S., Sept 2021, In: Biochemical Journal. 478, 17, p. 3351-3371 21 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access13 Link opens in a new tab Citations (Scopus) -
Eph receptor signalling: from catalytic to non-catalytic functions
Liang, L. Y., Patel, O., Janes, P. W., Murphy, J. M. & Lucet, I. S., 26 Sept 2019, In: Oncogene. 38, 39, p. 6567-6584 18 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access117 Link opens in a new tab Citations (Scopus)