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Personal profile

Biography

Protein Interaction and Cancer Lab (Acting Head). Our principal interest is cell surface proteins that promote tumour growth, in the context of the tumour microenvironment, and may be targeted by therapeutic antibodies. Our focus is on Eph receptor tyrosine kinases, due to their critical roles in tumour tissue patterning and stem cell maintenance, and on ADAM metalloproteases, which regulate signalling by diverse cell surface receptors including Ephs, erbBs and Notch. We employ various biochemical, structure/function and imaging techniques using tumour models in vitro and in vivo. Our antibodies against EphA3 and ADAM10 inhibit tumour growth in mice, and the EphA3 antibody is currently entering Phase II clinical trials.

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Projects 2001 2019

Research Output 1994 2017

25 Citations (Scopus)

Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10

Seegar, T. C. M., Killingsworth, L. B., Saha, N., Meyer, P. A., Patra, D., Zimmerman, B., Janes, P. W., Rubinstein, E., Nikolov, D. B., Skiniotis, G., Kruse, A. C. & Blacklow, S. C., 14 Dec 2017, In : Cell. 171, 7, p. 1638-1648 11 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth

Atapattu, L., Saha, N., Chheang, C., Eissman, M. F., Xu, K., Vail, M. E., Hii, L., Llerena, C., Liu, Z., Horvay, K., Abud, H. E., Kusebauch, U., Moritz, R. L., Ding, B-S., Cao, Z., Rafii, S., Ernst, M., Scott, A. M., Nikolov, D. B., Lackmann, M. & 1 others, Janes, P. W., 8 Aug 2016, In : Journal of Experimental Medicine. 213, 9, p. 1741-1757 17 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

PTP-PEST controls EphA3 activation and ephrin-induced cytoskeletal remodelling

Mansour, M., Nievergall, E., Gegenbauer, K., Llerena, C., Atapattu, L., Halle, M., Tremblay, M. L., Janes, P. W. & Lackmann, M., 2016, In : Journal of Cell Science. 129, 2, p. 277-289 13 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

A mathematical model for Eph/ephrin-directed segregation of intermingled cells

Aharon, R., Janes, P. W., Burgess, A., Hamza, K., Klebaner, F. C. & Lackmann, M., 2014, In : PLoS ONE. 9, 12, 19 p., e111803.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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22 Citations (Scopus)

EphA3 biology and cancer

Janes, P. W., Slape, C. I., Farnsworth, R. H., Atapattu Mudiyanselage, L. S. K., Scott, A. M. & Vail, M. E., 2014, In : Growth Factors. 32, 6, p. 176 - 189 14 p.

Research output: Contribution to journalArticleResearchpeer-review