Projects per year
Personal profile
Biography
Professor Peter Currie is a world-renowned developmental evolutionary and stem cell biologist who studies the genetic basis of skeletal muscle stem cell action during development, evolution, regeneration and disease. His key discoveries utilise several models, chiefly the zebrafish, to define the genetic and evolutionary basis for muscle formation and growth throughout vertebrate phylogeny. Prof Currie has played a key role globally in developing zebrafish as a disease model for human muscle disease and regeneration biology. He has also been instrumental in establishing shark embryology as a modern evolutionary paradigm to understand the evolutionary origins of the vertebrate body plan.
In 2016, Professor Peter Currie was appointed Director of Research of the Australian Regenerative Medicine Institute at Monash University in Melbourne, Australia. He is a recipient of a European Molecular Biology Organization Young Investigators Award and a Wellcome Trust International Research Fellowship and currently is a Principal Research Fellow with the National Health and Medical Research Council in Australia and an elected Fellow of the Australian Academy of Science.
Research interests
- Dissecting molecular mechanisms that act to pattern the vertebrate embryo.
- Discovering how specific muscle cell types are determined within the developing embryo.
- Discovering how different muscle cell types have evolved.
- Determining how muscle cell types grow and regenerate after injury.
- Large-sale mutagenesis of the zebrafish genome to produce different classes of mutations which disrupt gene function.
Research area keywords
- muscle development and disease
Network
Recent external collaboration on country level. Dive into details by clicking on the dots or
Projects
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Fins to Limbs: Investigating the Evolution of complex Limb Musculature
Currie, P., Trinajstic, K. M. & Tulenko, F.
12/02/20 → 31/12/22
Project: Research
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Correcting muscle stem cell dynamics in Duchenne Muscular Dystrophy
1/08/19 → 31/07/22
Project: Research
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Defining the molecular basis of macrophage-mediated muscle stem cell activation.
1/01/19 → 31/12/22
Project: Research
Research output
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Asymmetric division of clonal muscle stem cells coordinates muscle regeneration in vivo
Gurevich, D. B., Nguyen, P. D. N., Siegel, A. L., Ehrlich, O. V., Sonntag, C., Phan, J. M. N., Berger, S., Ratnayake, D., lkkno1, L. K., Berger, J., Verkade, H., Hall, T. E. & Currie, P. D., 8 Jul 2016, In : Science. 353, 6295, 12 p., aad9969.Research output: Contribution to journal › Article › Research › peer-review
64 Citations (Scopus) -
A somitic contribution to the apical ectodermal ridge is essential for fin formation
Masselink, W., Cole, N. J., Fenyes, F., Berger, S., Sonntag, C., Wood, A., Nguyen, P. D., Cohen, N., Knopf, F., Weidinger, G., Hall, T. E. & Currie, P. D., 28 Jul 2016, In : Nature. 535, 7613, p. 542-546 5 p.Research output: Contribution to journal › Article › Research › peer-review
13 Citations (Scopus) -
Muscle Stem Cells Undergo Extensive Clonal Drift during Tissue Growth via Meox1-Mediated Induction of G2 Cell-Cycle Arrest
Nguyen, P. D., Gurevich, D. B., Sonntag, C., Hersey, L., Alaei, S., Nim, H. T., Siegel, A., Hall, T. E., Rossello, F. J., Boyd, S. E., Polo, J. M. & Currie, P. D., 6 Jul 2017, In : Cell Stem Cell. 21, 1, p. 107-119.e6 19 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile28 Citations (Scopus) -
In Vivo Function of the Chaperonin TRiC in α-Actin Folding during Sarcomere Assembly
Berger, J., Berger, S., Li, M., Jacoby, A. S., Arner, A., Bavi, N., Stewart, A. G. & Currie, P. D., 9 Jan 2018, In : Cell Reports. 22, 2, p. 313-322 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile11 Citations (Scopus) -
Cellular rescue in a zebrafish model of congenital muscular dystrophy type 1A
Hall, T., Wood, A., Ehrlich, O. V., Li, M., Sonntag, C., Cole, N. J., Huttner, I. G., Sztal, T. & Currie, P., 1 Dec 2019, In : npj Regenerative Medicine. 4, 1, 13 p., 21.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile5 Citations (Scopus)