Projects per year
Personal profile
Biography
From their birth till their destruction, RNAs are always associated with proteins. Deciphering the language of how RNAs interact with specific RNA-binding proteins is a fundamentally important concept in modern molecular cell biology. Our laboratory has two main focuses. First, we are working on understanding how specific mRNAs are selected for post-transcriptional gene regulation during germ cell development. Second, we are investigating the biogenesis and function of a new family of small RNAs (22G endo-siRNAs) and how they help to maintain the genome integrity by modulation the transcriptional program of germ cells. We use a diverse set of experimental approaches, including cell biology, genetics, biochemistry and genomics to study the RNA pathways of the multicellular eukaryotic model organism C. elegans.
External positions
Adjunct, The University of Melbourne
Keywords
- Small RNA
- Development
- C. elegans
- Genomics
- RNA Biology
Network
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Projects 2010 2019
Harnessing next-generation technologies to tackle major food-borne parasites and design new interventions
Boag, P., Gasser, R., Young, N., Chang, B., Pozio, E. & Sternberg, P.
Australian Research Council (ARC)
Project: Research
Function and Structure of RIO kinases
Boag, P., Gasser, R. & Hofmann, A.
National Health & Medical Research Council (NHMRC)
1/01/13 → 31/12/15
Project: Research
The 3' UTR codes that control mRNA translation in development
National Health & Medical Research Council (NHMRC)
1/01/13 → 31/12/15
Project: Research
Research Output 2000 2019
Transcriptional alterations in Caenorhabditis elegans following exposure to an anthelmintic fraction of the plant Picria fel-terrae Lour
Kumarasingha, R., Young, N. D., Yeo, T. C., Lim, DI. S. L., Tu, C. L., Palombo, E. A., Shaw, J. M., Gasser, R. B. & Boag, P. R., 25 Apr 2019, In : Parasites and Vectors. 12, 1, 9 p., 181.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Chromatin Modifiers SET-25 and SET-32 Are Required for Establishment but Not Long-Term Maintenance of Transgenerational Epigenetic Inheritance
Woodhouse, R. M., Buchmann, G., Hoe, M., Harney, D. J., Low, J. K. K., Larance, M., Boag, P. R. & Ashe, A., 20 Nov 2018, In : Cell Reports. 25, 8, p. 2259-2272 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
The TRIM-NHL protein NHL-2 is a co-factor in the nuclear and somatic RNAi pathways in C. Elegans
Davis, G. M., Tu, S., Anderson, J. WT., Colson, R. N., Gunzburg, M. J., Francisco, M. A., Ray, D., Shrubsole, S. P., Sobotka, J. A., Seroussi, U., Lao, R. X., Maity, T., Wu, M. Z., McJunkin, K., Morris, Q. D., Hughes, T. R., Wilce, J. A., Claycomb, J. M., Weng, Z. & Boag, P. R., 21 Dec 2018, In : eLife. 7, 29 p., e35478.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Automated three-dimensional reconstruction of the Caenorhabditis elegans germline
Gopal, S., Boag, P. & Pocock, R., 15 Dec 2017, In : Developmental Biology. 432, 2, p. 222-228 7 p.Research output: Contribution to journal › Article › Research › peer-review
Exploring potential Germline-Associated roles of the TRIM-NHL Protein NHL-2 through RNAi screening
Davis, G. M., Low, W. Y., Anderson, J. W. T. & Boag, P. R., 1 Oct 2017, In : G3: Genes, Genomes, Genetics. 7, 10, p. 3251-3256 6 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File