• 15 Innovstion Walk, Building 75

    3800 Clayton

    Australia

20002019
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Personal profile

Biography

From their birth till their destruction, RNAs are always associated with proteins. Deciphering the language of how RNAs interact with specific RNA-binding proteins is a fundamentally important concept in modern molecular cell biology. Our laboratory has two main focuses. First, we are working on understanding how specific mRNAs are selected for post-transcriptional gene regulation during germ cell development. Second, we are investigating the biogenesis and function of a new family of small RNAs (22G endo-siRNAs) and how they help to maintain the genome integrity by modulation the transcriptional program of germ cells. We use a diverse set of experimental approaches, including cell biology, genetics, biochemistry and genomics to study the RNA pathways of the multicellular eukaryotic model organism C. elegans.

External positions

Adjunct, The University of Melbourne

Keywords

  • Small RNA
  • Development
  • C. elegans
  • Genomics
  • RNA Biology

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Projects 2010 2019

Research Output 2000 2019

Transcriptional alterations in Caenorhabditis elegans following exposure to an anthelmintic fraction of the plant Picria fel-terrae Lour

Kumarasingha, R., Young, N. D., Yeo, T. C., Lim, DI. S. L., Tu, C. L., Palombo, E. A., Shaw, J. M., Gasser, R. B. & Boag, P. R., 25 Apr 2019, In : Parasites and Vectors. 12, 1, 9 p., 181.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Chromatin Modifiers SET-25 and SET-32 Are Required for Establishment but Not Long-Term Maintenance of Transgenerational Epigenetic Inheritance

Woodhouse, R. M., Buchmann, G., Hoe, M., Harney, D. J., Low, J. K. K., Larance, M., Boag, P. R. & Ashe, A., 20 Nov 2018, In : Cell Reports. 25, 8, p. 2259-2272 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

The TRIM-NHL protein NHL-2 is a co-factor in the nuclear and somatic RNAi pathways in C. Elegans

Davis, G. M., Tu, S., Anderson, J. WT., Colson, R. N., Gunzburg, M. J., Francisco, M. A., Ray, D., Shrubsole, S. P., Sobotka, J. A., Seroussi, U., Lao, R. X., Maity, T., Wu, M. Z., McJunkin, K., Morris, Q. D., Hughes, T. R., Wilce, J. A., Claycomb, J. M., Weng, Z. & Boag, P. R., 21 Dec 2018, In : eLife. 7, 29 p., e35478.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Automated three-dimensional reconstruction of the Caenorhabditis elegans germline

Gopal, S., Boag, P. & Pocock, R., 15 Dec 2017, In : Developmental Biology. 432, 2, p. 222-228 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Exploring potential Germline-Associated roles of the TRIM-NHL Protein NHL-2 through RNAi screening

Davis, G. M., Low, W. Y., Anderson, J. W. T. & Boag, P. R., 1 Oct 2017, In : G3: Genes, Genomes, Genetics. 7, 10, p. 3251-3256 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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