Research output per year
Research output per year
Personal profile
Research interests
My research focuses on exploring the role of neuroinflammation in the development of acquired epilepsy through the utilization of preclinical models. I investigate the underlying mechanisms and assess the potential of measuring brain inflammation as a biomarker for abnormalities in epileptic brains. In the course of my study, I introduce a novel animal model dedicated to epilepsy research and propose innovative strategies to modulate brain inflammation as a potential therapeutic target in preventing the development of epilepsy.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Epilepsy
- Neuroinflammation
- Neurobiology
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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In vivo biomarkers of GABAergic function in epileptic rats treated with the GAT-1 inhibitor E2730
Ali, I., Jupp, B., Hudson, M. R., Major, B., Silva, J., Yamakawa, G. R., Casillas-Espinosa, P. M., Braine, E., Thergarajan, P., Haskali, M. B., Vivash, L., Brkljaca, R., Shultz, S. R., Kwan, P., Fukushima, K., Sachdev, P., Cheng, J. Y., Mychasiuk, R., Jones, N. C. & Wright, D. K. & 1 others, , Nov 2024, In: Epilepsia. 65, 11, p. 3376-3390 15 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Cardiac structural and functional abnormalities in epilepsy: A systematic review and meta-analysis
Liu, Z., Thergarajan, P., Antonic-Baker, A., Chen, Z., Sparks, P. B., Lannin, N. A., Kwan, P., Jones, N. C., Casillas-Espinosa, P. M., Perucca, P., O'Brien, T. J. & Sivathamboo, S., Mar 2023, In: Epilepsia Open. 8, 1, p. 46-59 14 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access12 Citations (Scopus) -
E2730, an uncompetitive γ-aminobutyric acid transporter-1 inhibitor, suppresses epileptic seizures in a rat model of chronic mesial temporal lobe epilepsy
Ali, I., Silva, J., Casillas-Espinosa, P. M., Braine, E., Yamakawa, G. R., Hudson, M. R., Brady, R. D., Major, B., Thergarajan, P., Haskali, M. B., Wright, D. K., Jupp, B., Vivash, L., Shultz, S. R., Mychasiuk, R., Kwan, P., Jones, N. C., Fukushima, K., Sachdev, P. & Cheng, J. Y. & 1 others, , Oct 2023, In: Epilepsia. 64, 10, p. 2806-2817 12 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Characterising seizure development, behavioural comorbidities and neuroinflammation in a self-sustained electrical status epilepticus model of mesial temporal lobe epilepsy in C57BL/6J mice
Thergarajan, P., Hudson, M. R., Carmichael, I., Clasadonte, J., Dedeurwaerdere, S., O'Brien, T. J., Jones, N. C. & Ali, I., 15 Jun 2022, In: Neurobiology of Disease. 168, 10 p., 105688.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
Microglial polarization in posttraumatic epilepsy: Potential mechanism and treatment opportunity
Therajaran, P., Hamilton, J. A., O'Brien, T. J., Jones, N. C. & Ali, I., Feb 2020, In: Epilepsia. 61, 2, p. 203-215 13 p.Research output: Contribution to journal › Review Article › Research › peer-review
44 Citations (Scopus)