Per-Henrik Groop

Professor

20052019
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Research Output 2005 2019

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Article
2019

Hemodynamic effects of the dipeptidyl peptidase-4 inhibitor linagliptin with renin-angiotensin system inhibitors in type 2 diabetic patients with albuminuria

Cooper, M. E., Perkovic, V., Groop, P. H., Hocher, B., Hehnke, U., Meinicke, T., Koitka-Weber, A., van der Walt, S. & von Eynatten, M., 1 Jun 2019, In : Journal of Hypertension. 37, 6, p. 1294-1300 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2018

A genome-wide association study of diabetic kidney disease in subjects with type 2 diabetes

Van Zuydam, N. R., Ahlqvist, E., Sandholm, N., Deshmukh, H., William Rayner, N., Abdalla, M., Ladenvall, C., Ziemek, D., Fauman, E., Robertson, N. R., McKeigue, P. M., Valo, E., Forsblom, C., Harjutsalo, V., Perna, A., Rurali, E., Loredana Marcovecchio, M., Igo, R. P., Salem, R. M., Perico, N. & 64 othersLajer, M., Käräjämäki, A., Imamura, M., Kubo, M., Takahashi, A., Sim, X., Liu, J., Van Dam, R. M., Jiang, G., Tam, C. H. T., Luk, A. O. Y., Lee, H. M., Lim, C. K. P., Szeto, C. C., So, W. Y., Chan, J. C. N., Ang, S. F., Dorajoo, R., Wang, L., Clara, T. S. H., McKnight, A. J., Duffy, S., Warren, Pezzolesi, M. G., Marre, M., Gyorgy, B., Hadjadj, S., Hiraki, L. T., Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group, Ahluwalia, T. S., Almgren, P., Schulz, C. A., Orho-Melander, M., Linneberg, A., Christensen, C., Witte, D. R., Grarup, N., Brandslund, I., Melander, O., Paterson, A. D., Tregouet, D., Maxwell, A. P., Lim, S. C., Ma, R. C. W., Shyong Tai, E., Maeda, S., Lyssenko, V., Tuomi, T., Krolewski, A. S., Rich, S. S., Hirschhorn, J. N., Florez, J. C., Dunger, D., Pedersen, O., Hansen, T., Rossing, P., Remuzzi, G., SUrrogate markers for Micro- and Macrovascular hard endpoints for Innovative diabetes Tools (SUMMIT) Consortium, Brosnan, M. J., Palmer, C. N. A., Groop, P. H., Colhoun, H. M., Groop, L. C. & McCarthy, M. I., 1 Jul 2018, In : Diabetes. 67, 7, p. 1414-1427 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Excess mortality in patients with type 1 diabetes without albuminuriadseparating the contribution of early and late risks

Groop, P. H., Thomas, M., Feodoroff, M., Forsblom, C. & Harjutsalo, V., 1 Apr 2018, In : Diabetes Care. 41, 4, p. 748-754 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Risk of coronary artery disease and stroke according to sex and presence of diabetic nephropathy in type 1 diabetes

Harjutsalo, V., Thomas, M. C., Forsblom, C., Groop, P. H. & On Behalf of the FinnDiane Study Group, 1 Dec 2018, In : Diabetes, Obesity and Metabolism. 20, 12, p. 2759-2767 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Linagliptin and its effects on hyperglycaemia and albuminuria in patients with type 2 diabetes and renal dysfunction: The randomized MARLINA-T2D trial

Groop, P-H., Cooper, M. E., Perkovic, V., Hocher, B., Kanasaki, K., Haneda, M., Schernthaner, G., Sharma, S. K., Stanton, R. C., Toto, R., Cescutti, J., Gordat, M., Meinicke, T., Koitka-Weber, A., Thiemann, S. & Eynatten, M. V., Nov 2017, In : Diabetes, Obesity and Metabolism. 19, 11, p. 1610-1619 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2016

Management of patients with diabetes and CKD: conclusions from a “Kidney Disease: Improving Global Outcomes” (KDIGO) Controversies Conference

Perkovic, V., Agarwal, R., Fioretto, P., Hemmelgarn, B. R., Levin, A., Thomas, M. C., Wanner, C., Kasiske, B. L., Wheeler, D. C., Groop, P-H., Bakris, G. L. & for Conference Participants, 1 Dec 2016, In : Kidney International. 90, 6, p. 1175-1183 9 p.

Research output: Contribution to journalArticleOtherpeer-review

The effect of sodium glucose cotransporter 2 inhibition with empagliflozin on microalbuminuria and macroalbuminuria in patients with type 2 diabetes

Cherney, D., Lund, S. S., Perkins, B. A., Groop, P. H., Cooper, M. E., Kaspers, S., Pfarr, E., Woerle, H. J. & von Eynatten, M., 1 Sep 2016, In : Diabetologia. 59, 9, p. 1860-1870 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Dipeptidyl peptidase-4 inhibition with linagliptin and effects on hyperglycaemia and albuminuria in patients with type 2 diabetes and renal dysfunction: Rationale and design of the MARLINA-T2D trial

Groop, P-H., Cooper, M. E., Perkovic, V., Sharma, K., Schernthaner, G., Haneda, M., Hocher, B., Gordat, M., Cescutti, J., Woerle, H. J. & Von Eynatten, M., 1 Nov 2015, In : Diabetes and Vascular Disease Research. 12, 6, p. 455-462 8 p.

Research output: Contribution to journalArticleOtherpeer-review

Kidney disease end points in a pooled analysis of individual patient-level data from a large clinical trials program of the dipeptidyl peptidase 4 inhibitor linagliptin in type 2 diabetes

Cooper, M. E., Perkovic, V., McGill, J. B., Groop, P-H., Wanner, C., Rosenstock, J., Hehnke, U., Woerle, H. J. & Von Eynatten, M., 1 Sep 2015, In : American Journal of Kidney Diseases. 66, 3, p. 441-449 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Added value of soluble tumor necrosis factor-α receptor 1 as a biomarker of ESRD risk in patients with type 1 diabetes

Forsblom, C., Moran, J., Harjutsalo, V., Loughman, T., Wadén, J., Tolonen, N., Thorn, L., Saraheimo, M., Gordin, D., Groop, P. H., Thomas, M. C. & On Behalf of the FinnDiane Study Group, 1 Jan 2014, In : Diabetes Care. 37, 8, p. 2334-2342 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Osteopontin is a strong predictor of incipient diabetic nephropathy, cardiovascular disease, and all-cause mortality in patients with type 1 diabetes

Gordin, D., Forsblom, C., Panduru, N. M., Thomas, M. C., Bjerre, M., Soro-Paavonen, A., Tolonen, N., Sandholm, N., Flyvbjerg, A., Harjutsalo, V., Groop, P. H. & On Behalf of the FinnDiane Study Group, 1 Jan 2014, In : Diabetes Care. 37, 9, p. 2593-2600 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2013

Association of dietary sodium intake with atherogenesis in experimental diabetes and with cardiovascular disease in patients with Type 1 diabetes

Tikellis, C., Pickering, R., Tsorotes, D., Harjutsalo, V., Thorn, L., Ahola, A., Waden, J., Tolonen, N., Saraheimo, M., Gordin, D., Forsblom, C., Groop, P-H., Cooper, M. E., Moran, J. L. & Thomas, M. C., 2013, In : Clinical Science. 124, 10, p. 617 - 626 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Linagliptin lowers albuminuria on top of recommended standard treatment in patients with type 2 diabetes and renal dysfunction

Groop, P. H., Cooper, M. E., Perkovic, V., Emser, A., Woerle, H-J. & Eynatten, M. V., Nov 2013, In : Diabetes Care. 36, 11, p. 3460-3468 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Osteoprotegerin is an independent predictor of vascular events in finnish adults with type 1 diabetes

Gordin, D., Soro-Paavonen, A., Thomas, M. C., Harjutsalo, V., Saraheimo, M., Bjerre, M., Forsblom, C., Flyvbjerg, A. & Groop, P. H., 28 Oct 2013, In : Diabetes Care. 36, 7, p. 1827-1833 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2012

Circulating ACE2 activity is increased in patients with type 1 diabetes and vascular complications

Soro-Paavonen, A., Gordin, D., Forsblom, C., Rosengard-Barlund, M., Waden, J., Thorn, L., Sandholm, N., Thomas, M. C. & Groop, P. H., 1 Feb 2012, In : Journal of Hypertension. 30, 2, p. 375-383 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Advanced glycation end products are direct modulators of beta-cell function

Coughlan, M. T., Yap, F., Tong, D., Andrikopoulos, S., Gasser, A., Thallas-Bonke, V., Webster, D., Miyazaki, J., Kay, T., Slattery, R., Kaye, D., Drew, B., Kingwell, B., Fourlanos, S., Groop, P-H., Harrison, L., Knip, M. & Forbes, J., 2011, In : Diabetes. 60, 10, p. 2523 - 2532 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Competing-risk analysis of ESRD and death among patients with type 1 diabetes and macroalbuminuria

Forsblom, C., Harjutsalo, V., Thorn, L. M., Wadén, J., Tolonen, N., Saraheimo, M., Gordin, D., Moran, J. L., Thomas, M. C. & Groop, P. H., 1 Mar 2011, In : Journal of the American Society of Nephrology. 22, 3, p. 537-544 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Genetic examination of SETD7 and SUV39H1/H2 methyltransferases and the risk of diabetes complications in patients with type 1 diabetes

Syreeni, A., El-Osta, A., Forsblom, C., Sandholm, N., Parkkonen, M., Tarnow, L., Parving, H. H., McKnight, A. J., Maxwell, A. P., Cooper, M. E., Groop, P. H. & the FinnDiane Study Group, Nov 2011, In : Diabetes. 60, 11, p. 3073-3080 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes

Forbes, J., Soderlund, J., Yap, F., Knip, M., Andrikopoulos, S., Ilonen, J., Simell, O., Veijola, R., Sourris, K., Coughlan, M. T., Forsblom, C., Slattery, R. M., Grey, S., Wessman, M., Yamamoto, H., Bierhaus, A., Cooper, M. & Groop, P., 2011, In : Diabetologia. 54, 5, p. 1032 - 1042 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Serum adiponectin concentration is a positive predictor of all-cause and cardiovascular mortality in type 1 diabetes

Forsblom, C., Thomas, M. C., Moran, J., Saraheimo, M., Thorn, L., Wadén, J., Gordin, D., Frystyk, J., Flyvbjerg, A., Groop, P. H. & On Behalf of the FinnDiane Study Group, 1 Jan 2011, In : Journal of Internal Medicine. 270, 4, p. 346-355 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Soluble receptor for AGE (RAGE) is a novel independent predictor of all-cause and cardiovascular mortality in type 1 diabetes

Thomas, M. C., Söderlund, J., Lehto, M., Mäkinen, V. P., Moran, J. L., Cooper, M. E., Forsblom, C., Groop, P. H. & the FinnDiane Study Group, Oct 2011, In : Diabetologia. 54, 10, p. 2669-2677 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The association between dietary sodium intake, ESRD, and all-cause mortality in patients with type 1 diabetes

Thomas, M. C., Moran, J., Forsblom, C., Harjutsalo, V., Thorn, L., Ahola, A., Wadén, J., Tolonen, N., Saraheimo, M., Gordin, D. & Groop, P. H., 1 Apr 2011, In : Diabetes Care. 34, 4, p. 861-866 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2010

Association of the SLC22A1, SLC22A2, and SLC22A3 genes encoding organic cation transporters with diabetic nephropathy and hypertension

Sallinen, R., Kaunisto, M. A., Forsblom, C., Thomas, M., Fagerudd, J., Pettersson-Fernholm, K., Groop, P. H., Wessman, M. & on behalf of the Finnish Diabetic Nephropathy Study Group, 1 Jan 2010, In : Annals of Medicine. 42, 4, p. 296-304 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

The MIF receptor CD74 in diabetic podocyte injury

Sanchez-Niño, M. D., Sanz, A. B., Ihalmo, P., Lassila, M., Holthofer, H., Mezzano, S., Aros, C., Groop, P. H., Saleem, M. A., Mathieson, P. W., Langham, R., Kretzler, M., Nair, V., Lemley, K. V., Nelson, R. G., Mervaala, E., Mattinzoli, D., Rastaldi, M. P., Ruiz-Ortega, M., Martin-Ventura, J. L. & 1 othersOrtiz, J. E., Feb 2009, In : Journal of the American Society of Nephrology. 20, 2, p. 353-362 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The presence and severity of chronic kidney disease predicts all-cause mortality in type 1 diabetes

Groop, P. H., Thomas, M. C., Moran, J. L., Wadèn, J., Thorn, L. M., Mäkinen, V. P., Rosengård-Bärlund, M., Saraheimo, M., Hietala, K., Heikkilä, O. & Forsblom, C., 1 Jan 2009, In : Diabetes. 58, 7, p. 1651-1658 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2005

Mechanisms of disease: Pathway-selective insulin resistance and microvascular complications of diabetes.

Groop, P-H., Forsblom, C. & Thomas, M. C., 2005, In : Nature Clinical Practice Endocrinology & Metabolism. 1, 2, p. 100 - 110 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Polymorphisms in the angiotensin-converting enzyme 2 gene and diabetic nephropathy.

Fröjdö, S., sjolind, L., Parkkonen, M., Mäkinen, V. P., Kilpikari, R., pettersson-fernholm, K., Forsblom, C., fagerudd, J., Tikellis, C., Cooper, M. E., Wessman, M. & Groop, P-H., 2005, In : Diabetologia. 48, 11, p. 2278-2281 3 p.

Research output: Contribution to journalArticleResearchpeer-review