Projects per year
Personal profile
Biography
Dr Paul Yeh is a consultant haematologist and clinician-scientist with dual appointments at Monash Health and Monash University. He is the Head of the Blood Cancer Biomarkers Laboratory in the School of Clinical Sciences at Monash Health. His laboratory’s research interest is in the use of blood based molecular biomarkers to understand normal and malignant haematopoiesis. The aim of the research is to translate novel biomarker discoveries from the bench into clinical practice to improve outcomes in patients with haematological malignancies.
Dr Yeh has been the finalist of the Victorian Premier’s Awards for Health and Medical Research (Clinical Researcher) and a recipient of the EHA/ASH translational research in Haematology (TRTH) scholar award. He is currently a recipient of a NHMRC/MRFF Emerging Leadership Fellow Grant.
His clinical interest is in molecular haematology and myeloid neoplasms where he is a consultant haematopathologist in the molecular pathology department and the clinical lead for myeloproliferative neoplasms at Monash Health.
Education/Academic qualification
Medicine, PhD, Molecular monitoring and screening in haematological malignancies, University of Melbourne
Award Date: 7 Nov 2018
Bachelor of Medicine, Bachelor of Surgery, MBBS, University of Melbourne
Award Date: 3 Dec 2005
Bachelor of Medical Science, BMedSci
Award Date: 3 Dec 2005
Research area keywords
- Haematology
- haematological malignancies
- clonal haematopoiesis
- Myeloid leukaemia
- Myeloproliferative Diseases
- Genomics & Transcriptomics
- Next Generation Sequencing
- circulating tumour DNA
- Whole genome sequencing
- bioinformatics
- Multi-omics
- Biomarkers
- Lymphoid Malignancies
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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A Phase 1, Open-Label, Multi-Center, Safety and Efficacy Study of PRT12396 in Participants with Polycythaemia Vera and Myelofibrosis
Yeh, P. (Primary Chief Investigator (PCI))
24/08/26 → 23/08/31
Project: Research
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Plasma immunopeptidomics for actionable target discovery in Acute Myeloid Leukaemia
Scull, K. (Primary Chief Investigator (PCI)), Pandey, K. (Chief Investigator (CI)), Yeh, P. (Chief Investigator (CI)) & Purcell, A. (Chief Investigator (CI))
1/06/26 → 1/06/28
Project: Research
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A Phase 3, Randomized, Double-Blind, Active-Control Study of Pelabresib (DAK539) and Ruxolitinib vs. Placebo and Ruxolitinib in Adult Patients with Myelofibrosis who are JAK inhibitor naïve
Yeh, P. (Primary Chief Investigator (PCI))
11/05/26 → 10/05/31
Project: Research
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From gut to brain: the impact of gut health and clonal haematopoiesis on neurocognitive decline and frailty in ageing people living with HIV
Dharan, N. (Primary Chief Investigator (PCI)), Yeh, P. (Chief Investigator (CI)) & Eron, J. J. (Chief Investigator (CI))
1/04/26 → 31/03/28
Project: Research
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Uncovering epigenetic evolution in myeloid malignancies
Yeh, P. (Primary Chief Investigator (PCI))
27/02/26 → 27/07/27
Project: Research
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Clonal hematopoiesis of indeterminate potential (CHIP): A need for standardized definition and criteria for translational research studies
Harraka, P., Yeh, P., Nicholls, S. J. & Southey, M. C., Apr 2026, In: Genetics in Medicine. 28, 4, 4 p., 102530.Research output: Contribution to journal › Comment / Debate › Other › peer-review
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Gut health is associated with clonal haematopoiesis in older adults with and without HIV: the ARCHIVE longitudinal cohort study
Donoghoe, M. W., Sazzad, H. M. S., Han, W. M., Bloch, M., Baker, D. A., Eu, B., Bowden-Reid, E., Smith, D. E., Hoy, J. F., Woolley, I. J., Finlayson, R., Templeton, D. J., Matthews, G., Costello, J., Dawson, M. A., Dawson, S. J., Polizzotto, M. N., Agbosu, E., Kelleher, A. D. & Petoumenos, K. & 4 others, , 2026, (Accepted/In press) In: Gut. 3 p., 337620.Research output: Contribution to journal › Letter › Other › peer-review
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Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 coactivation
Shah, V., Giotopoulos, G., Osaki, H., Meyerhöfer, M., Meduri, E., Gallego-Crespo, A., Behrendt, M. A., Saura-Pañella, M., Tarkar, A., Schubert, B., Yun, H., Horton, S. J., Agrawal-Singh, S., Haehnel, P. S., Basheer, F., Lugo, D., Eleftheriadou, I., Barbash, O., Dhar, A. & Kühn, M. W. M. & 9 others, , 13 Feb 2025, In: Blood. 145, 7, p. 748-764 17 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access23 Link opens in a new tab Citations (Scopus) -
mirrorCheck: an R package facilitating informed use of DESeq2’s lfcShrink() function for differential gene expression analysis of clinical samples
Scull, K. E., Behrouzfar, K., Brasacchio, D., Lam, E. Y. N., Chandrananda, D. & Yeh, P., 2025, In: Bioinformatics Advances. 5, 1, 8 p., vbaf070.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Link opens in a new tab Citations (Scopus) -
Next-generation sequencing RNA fusion panel for the diagnosis of haematological malignancies
Ngo, T. Q., Goh, A. F. N., Dorwal, P., Leong, E., Shortt, J., Fedele, P. L., Gilbertson, M., Fong, C. Y., Shanmuganathan, N., Kumar, B. & Yeh, P., Apr 2025, In: Pathology. 57, 3, p. 340-347 8 p.Research output: Contribution to journal › Article › Research › peer-review
9 Link opens in a new tab Citations (Scopus)
Prizes
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EHA/ASH translational research in Haematology program (TRTH) scholar
Yeh, P. (Recipient), 2018
Prize: National/international honour
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