Projects per year
Personal profile
Biography
Dr Paul Yeh is a consultant haematologist and clinician-scientist with dual appointments at Monash Health and Monash University. He is the Head of the Blood Cancer Biomarkers Laboratory in the School of Clinical Sciences at Monash Health. His laboratory’s research interest is in the use of blood based molecular biomarkers to understand normal and malignant haematopoiesis. The aim of the research is to translate novel biomarker discoveries from the bench into clinical practice to improve outcomes in patients with haematological malignancies.
Dr Yeh has been the finalist of the Victorian Premier’s Awards for Health and Medical Research (Clinical Researcher) and a recipient of the EHA/ASH translational research in Haematology (TRTH) scholar award. He is currently a recipient of a NHMRC/MRFF Emerging Leadership Fellow Grant.
His clinical interest is in molecular haematology and myeloid neoplasms where he is a consultant haematopathologist in the molecular pathology department and the clinical lead for myeloproliferative neoplasms at Monash Health.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medicine, PhD, Molecular monitoring and screening in haematological malignancies, University of Melbourne
Award Date: 7 Nov 2018
Bachelor of Medicine, Bachelor of Surgery, MBBS, University of Melbourne
Award Date: 3 Dec 2005
Bachelor of Medical Science, BMedSci
Award Date: 3 Dec 2005
Research area keywords
- Haematology
- haematological malignancies
- clonal haematopoiesis
- Myeloid leukaemia
- Myeloproliferative Diseases
- Genomics & Transcriptomics
- Next Generation Sequencing
- circulating tumour DNA
- Whole genome sequencing
- bioinformatics
- Multi-omics
- Biomarkers
- Lymphoid Malignancies
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ctDNA to monitor non-genomic evolution in peripheral T-cell lymphoma.
Yeh, P., Shortt, J. & Chandrananda, D.
1/01/23 → 31/12/25
Project: Research
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An Open-Label, Phase 2a/2b Study of KRT-232 in Subjects With Primary Myelofibrosis (PMF), Post–Polycythemia Vera MF (Post-PV-MF), Or Post–Essential Thrombocythemia MF(Post–ET-MF) Who Have Failed Prior Treatment with a JAK Inhibitor (KRT-232-101)
Perkins, A., Ross, D. M., Kennedy, N., Yeh, P. & Wright, M.
20/01/20 → 31/12/25
Project: Research
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Defining de novo intratumoural mutational profiles associated with response to novel therapies in Mantle Cell Lymphoma.
Costacurta, M. & Yeh, P.
Project: Research
Research output
- 12 Article
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Single-cell sequencing demonstrates complex resistance landscape in CLL and MCL treated with BTK and BCL2 inhibitors
Thompson, E. R., Nguyen, T., Kankanige, Y., Markham, J. F., Anderson, M. A., Handunnetti, S. M., Thijssen, R., Sung-Hao Yeh, P., Tam, C. S., Seymour, J. F., Roberts, A. W., Westerman, D. A. & Blombery, P., 25 Jan 2022, In: Blood Advances. 6, 2, p. 503-508 6 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access13 Citations (Scopus) -
Clonal independence of JAK2 and CALR or MPL mutations in comutated myeloproliferative neoplasms demonstrated by single cell DNA sequencing
Thompson, E. R., Nguyen, T., Kankanige, Y., Yeh, P., Ingbritsen, M., McBean, M., Semple, T., Arnau, G. M., Burbury, K., Lee, N., Khot, A., Westerman, D. & Blombery, P., Jan 2021, In: Haematologica. 106, 1, p. 313-315 3 p.Research output: Contribution to journal › Article › Other › peer-review
Open Access17 Citations (Scopus) -
HIV is associated with an increased risk of age-related clonal hematopoiesis among older adults
Dharan, N. J., Yeh, P., Bloch, M., Yeung, M. M., Baker, D., Guinto, J., Roth, N., Ftouni, S., Ognenovska, K., Smith, D., Hoy, J. F., Woolley, I., Pell, C., Templeton, D. J., Fraser, N., Rose, N., Hutchinson, J., Petoumenos, K., Dawson, S. J., Polizzotto, M. N., & 2 others, Jun 2021, In: Nature Medicine. 27, 6, p. 1006-1011 6 p.Research output: Contribution to journal › Article › Research › peer-review
46 Citations (Scopus) -
HBO1 is required for the maintenance of leukaemia stem cells
MacPherson, L., Anokye, J., Yeung, M. M., Lam, E. Y. N., Chan, Y. C., Weng, C. F., Yeh, P., Knezevic, K., Butler, M. S., Hoegl, A., Chan, K. L., Burr, M. L., Gearing, L. J., Willson, T., Liu, J., Choi, J., Yang, Y., Bilardi, R. A., Falk, H., Nguyen, N., & 28 others, 9 Jan 2020, In: Nature. 577, p. 266–270 5 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile80 Citations (Scopus) -
Dynamic molecular monitoring reveals that SWI–SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma
Agarwal, R., Chan, Y. C., Tam, C. S., Hunter, T., Vassiliadis, D., Teh, C. E., Thijssen, R., Yeh, P., Wong, S. Q., Ftouni, S., Lam, E. Y. N., Anderson, M. A., Pott, C., Gilan, O., Bell, C. C., Knezevic, K., Blombery, P., Rayeroux, K., Zordan, A., Li, J., & 7 others, Jan 2019, In: Nature Medicine. 25, 1, p. 119-129 11 p.Research output: Contribution to journal › Article › Research › peer-review
124 Citations (Scopus)
Prizes
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EHA/ASH translational research in Haematology program (TRTH) scholar
Yeh, Paul (Recipient), 2018
Prize: National/international honour
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HSANZ young investigator award
Yeh, Paul (Recipient), 2016
Prize: Prize (including medals and awards)
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