19952020
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Research Output 1995 2019

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Article

Self-Crosslinking Lipopeptide/DNA/PEGylated Particles: A New Platform for DNA Vaccination Designed for Assembly in Aqueous Solution

Ho, J. K., White, P. J. & Pouton, C. W., 7 Sep 2018, In : Molecular Therapy - Nucleic Acids. 12, p. 504-517 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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α1A-Adrenoceptors activate mTOR signalling and glucose uptake in cardiomyocytes

Sato, M., Evans, B. A., Sandström, A. L., Chia, L. Y., Mukaida, S., Thai, B. S., Nguyen, A., Lim, L., Tan, C. Y. R., Baltos, J. A., White, P. J., May, L. T., Hutchinson, D. S., Summers, R. J. & Bengtsson, T., 1 Feb 2018, In : Biochemical Pharmacology. 148, p. 27-40 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2017

A suicidal strain of Listeria monocytogenes is effective as a DNA vaccine delivery system for oral administration

Sinha, S., Kuo, C. Y., Ho, J. K., White, P. J., Jazayeri, J. A. & Pouton, C. W., 2017, In : Vaccine. 35, 38, 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Capadenoson, a clinically trialed partial adenosine A1 receptor agonist, can stimulate adenosine A2B receptor biased agonism

Baltos, J-A., Vecchio, E. A., Harris, M. A., Qin, C. X., Ritchie, R. H., Christopoulos, A., White, P. J. & May, L. T., 1 Jul 2017, In : Biochemical Pharmacology. 135, p. 79–89 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Student engagement with a flipped classroom teaching design affects pharmacology examination performance in a manner dependent on question type

White, P. J., Naidu, S., Yuriev, E., Short, J. L., McLaughlin, J. E. & Larson, I. C., 2017, In : American Journal of Pharmaceutical Education. 81, 9, p. 10-23 14 p., 5931.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2016

Adopting an active learning approach to teaching in a research-intensive higher education context transformed staff teaching attitudes and behaviours

White, P. J., Larson, I., Styles, K., Yuriev, E., Evans, D. R., Rangachari, P. K., Short, J. L., Exintaris, B., Malone, D. T., Davie, B., Eise, N., McNamara, K. & Naidu, S., 2016, In : Higher Education Research and Development. 35, 3, p. 619-633 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Extracellular loop 2 of the adenosine A1 receptor has a key role in orthosteric ligand affinity and agonist efficacy

Nguyen, A. T. N., Baltos, J-A., Thomas, T., Nguyen, T. D., Lopez Munoz, L., Gregory, K. J., White, P. J., Sexton, P. M., Christopoulos, A. & May, L. T., 1 Dec 2016, In : Molecular Pharmacology. 90, 6, p. 703-714 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Flipped classroom implementation: A case report of two higher education institutions in the United States and Australia

McLaughlin, J. E., White, P. J., Khanova, J. & Yuriev, E., 2016, In : Computers in the Schools. 33, 1, p. 24-37 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Ligand-independent adenosine A2B receptor constitutive activity as a promoter of prostate cancer cell proliferation

Vecchio, E. A., Tan, C. Y. R., Gregory, K., Christopoulos, A., White, P. J. & May, L. T., 1 Apr 2016, In : Journal of Pharmacology and Experimental Therapeutics. 357, 1, p. 36-44 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel irreversible agonists acting at the A1 adenosine receptor

Jorg, M., Glukhova, A., Abdul Ridha, A., Vecchio, E. A., Nguyen, A., Sexton, P., White, P., May, L., Christopoulos, A. & Scammells, P., 22 Dec 2016, In : Journal of Medicinal Chemistry. 59, 24, p. 11182-11194 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Quantification of adenosine A1 receptor biased agonism: Implications for drug discovery

Baltos, J-A., Gregory, K. J., White, P. J., Sexton, P. M., Christopoulos, A. & May, L. T., 1 Jan 2016, In : Biochemical Pharmacology. 99, p. 101-112 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of the second extracellular loop of the adenosine A1 receptor on allosteric modulator binding, signaling, and cooperativity

Nguyen, A. T. N., Vecchio, E. A., Thomas, T., Nguyen, T. D., Aurelio, L., Scammells, P. J., White, P. J., Sexton, P. M., Gregory, K. J., May, L. T. & Christopoulos, A., 1 Dec 2016, In : Molecular Pharmacology. 90, 6, p. 715-725 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The hybrid molecule, VCP746, is a potent adenosine A2B receptor agonist that stimulates anti-fibrotic signalling

Vecchio, L., Chuo, C. H., Baltos, J-A., Ford, L., Scammells, P. J., Wang, B. H., Christopoulos, A., White, P. J. & May, L. T., 1 Oct 2016, In : Biochemical Pharmacology. 117, p. 46-56 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Tissue-specific calibration of real-time PCR facilitates absolute quantification of plasmid DNA in biodistribution studies

Ho, J. K., White, P. J. & Pouton, C. W., 4 Oct 2016, In : Molecular Therapy - Nucleic Acids. 5, 10, 9 p., e371.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Mapping of the Australian Qualifications Framework standards onto an undergraduate Bachelor of Pharmacy course

Malone, D. T., Short, J. L., Naidu, S., White, P. J. & Kirkpatrick, C. M., 2015, In : Pharmacy Education. 15, 1, p. 261-269 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of six mexiletine derivatives with isoindolines attached as potential antioxidants and their evaluation as cardioprotective agents

Chau, B. A., Drummond, G. R., Jackson, W. R., Jarrott, B., Miller, A. A., Subasinghe, K. R., Tan, C. Y. R., White, P. J., Wright, C. E. & Ziogas, J., 2015, In : MedChemComm. 6, 4, p. 634-639 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Using active learning strategies to shift student attitudes and behaviours about learning and teaching in a research intensive educational context

White, P. J., Larson, I., Styles, K., Yuriev, E., Evans, D. R., Short, J. L., Rangachari, P. K., Malone, D. T., Davie, B., Naidu, S. & Eise, N., 2015, In : Pharmacy Education. 15, 1, p. 116-126 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

HCN channelopathy and cardiac electrophysiologic dysfunction in genetic and acquired rat epilepsy models

Powell, K. L., Jones, N. C., Kennard, J. T., Ng, C., Urmaliya, V., Lau, S., Tran, A., Zheng, T., Ozturk, E., Dezsi, G., Megatia, I., Delbridge, L. M. D., Pinault, D., Reid, C. A., White, P. J. & O'Brien, T. J., 2014, In : Epilepsia. 55, 4, p. 609 - 620 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2013

An allosteric modulator of the adenosine A1 receptor improves cardiac function following ischaemia in murine isolated hearts

Butcher, A., Scammells, P. J., White, P. J., Devine, S. & Rose'Meyer, R. B., 2013, In : Pharmaceuticals. 6, 4, p. 546 - 556 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2012

Colloidal characteristics and formulation of pure protein particulate vaccines

White, P. J., Hickey, P. LC., Tu, L. S., Headey, S. J., Scanlon, M., Boyd, B. J. & Pouton, C. W., 2012, In : Journal of Pharmacy and Pharmacology. 64, 10, p. 1386 - 1393 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Enhanced extravasation, stability and in vivo cardiac gene silencing via in situ siRNA-albumin conjugation

Lau, S., Graham, B., Cao, N., Boyd, B. J., Pouton, C. W. & White, P. J., 2012, In : Molecular Pharmaceutics. 9, 1, p. 71 - 80 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and biological evaluation of adenosines with heterobicyclic and polycyclic N6-substituents as adenosine A1 receptor agonists

Gosling, J. I., Baker, S. P., Haynes, J. M., Kassiou, M., Pouton, C. W., Warfe, L., White, P. J. & Scammells, P. J., 2012, In : ChemMedChem. 7, 7, p. 1191 - 1201 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and pharmacological evaluation of dual acting antioxidant A2A adenosine receptor agonists

Hausler, N., Devine, S., McRobb, F. M., Warfe, L., Pouton, C. W., Haynes, J. M., Bottle, S. E., White, P. J. & Scammells, P. J., 2012, In : Journal of Medicinal Chemistry. 55, 7, p. 3521 - 3534 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Commercially supplied amine-modified siRNAs may require ultrafiltration prior to conjugation with amine-reactive compounds

Lau, S., Graham, B., Boyd, B., Pouton, C. & White, P., 2011, In : Journal of Nucleic Acids. 2011, 154609, p. 1 - 5 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Edaravone containing isoindoline nitroxides for the potential treatment of cardiovascular ischaemia

Walker, J., Fairfull-Smith, K., Anzai, K., Lau, S., White, P., Scammells, P. & Bottle, S. E., 2011, In : MedChemComm. 2, 5, p. 436 - 441 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Tissue dependent differences in G-protein coupled receptor kinases associated with 5-HT4 receptor desensitization in the rat gastro-intestinal tract

Megersa, T., White, P., Coupar, I. & Irving, H., 2011, In : Biochemical Pharmacology. 81, 1, p. 123 - 133 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Binding mode prediction of PDE4 inhibitors: a comparison of modelling methods

Neale, D., Thompson, P., White, P., Chalmers, D., Yuriev, E. & Manallack, D., 2010, In : Australian Journal of Chemistry. 63, 3, p. 396 - 404 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Cooperative cardioprotection through adenosine A1 and A 2A receptor agonism in ischemia-reperfused isolated mouse heart

Urmaliya, V., Pouton, C., Ledent, C., Short, J. & White, P., 2010, In : Journal of Cardiovascular Pharmacology. 56, 4, p. 379 - 388 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Delineating the mode of action of adenosine A1 receptor allosteric modulators

Valant, C., Aurelio, L., Urmaliya, V., White, P., Scammells, P., Sexton, P. & Christopoulos, A., 2010, In : Molecular Pharmacology. 78, 3, p. 444 - 455 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Interaction of viruses with host cell molecular motors

Hsieh, M. J., White, P. J. & Pouton, C. W., 2010, In : Current Opinion in Biotechnology. 21, p. 633 - 639 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and evaluation of new N6-substituted adenosine-5'-N-methylcarboxamides as A3 adenosine receptor agonists

Devine, S. M., Gregg, A., Figler, H., McIntosh, K., Urmaliya, V., Linden, J., Pouton, C. W., White, P. J., Bottle, S. E. & Scammells, P. J., 2010, In : Bioorganic and Medicinal Chemistry Letters. 18, 9, p. 3078 - 3087 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Use of Kv1.3 blockers for inflammatory skin conditions

Nguyen, W., Neale, D., Howard, B., Thompson, P., White, P., Wulff, H. & Manallack, D., 2010, In : Current Medicinal Chemistry. 17, 26, p. 2882 - 2896 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Cardioprotection induced by adenosine A1 receptor agonists in a cardiac cell ischemia model involves cooperative activation of adenosine A2A and A2B receptors by endogenous adenosine

Urmaliya, V., Church, J. E., Coupar, I. M., Rose'Meyer, R. B., Pouton, C. W. & White, P. J., 2009, In : Journal of Cardiovascular Pharmacology. 53, 5, p. 424 - 433 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Overcoming biological barriers to in vivo efficacy of antisense oligonucleotides.

White, P. J., Anastasopoulos, F., Pouton, C. W. & Boyd, B. J., 2009, In : Expert Reviews in Molecular Medicine. 11, e10, p. 1 - 19 19 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Barriers to successful delivery of short interfering RNA after systemic administration

White, P. J., 2008, In : Clinical and Experimental Pharmacology and Physiology. 35, 11, p. 1371 - 1376 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Generic construction of single component particles that elicit humoural and cellular immune responses without the need for adjuvants

White, P. J., Anastasopoulos, F., Church, J. E., Kuo, C-Y. J., Boyd, B. J., Hickey, P. LC., Sze Tu, L., Burns, P., Lew, A. M., Heath, W. R., Davey, G. M. & Pouton, C. W., 2008, In : Vaccine. 26, 52, p. 6824 - 6831 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

Dual acting antioxidant A1 adenosine receptor agonists

Gregg, A. D., Bottle, S. E., Devine, S., Figler, H., Linden, J., White, P. J., Pouton, C. W., Urmaliya, V. & Scammells, P. J., 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 19, p. 5437 - 5441 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

Characterization of the acute cardiovascular effects of intravenously administered insulin-like growth factor-I in conscious Sprague-Dawley rats

Cao, N., Lau, S., Nguyen, T. T. & White, P. J., 2006, In : Clinical and Experimental Pharmacology and Physiology. 33, 12, p. 1190 - 1195 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparison of opioid receptor distributions in the rat central nervous system

Gray, A. C., Coupar, I. M. & White, P. J., 2006, In : Life Sciences. 79, 7, p. 674 - 685 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparison of opioid receptor distributions in the rat ileum

Gray, A. C., Coupar, I. M. & White, P. J., 2006, In : Life Sciences. 78, 14, p. 1610 - 1616 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2005

Characterisation of opioid receptors involved in modulating circular and longitudinal muscle contraction in the rat ileum

Gray, A. C., White, P. J. & Coupar, I. M., 2005, In : British Journal of Pharmacology. 144, 5, p. 687 - 694 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Intravenous IGF-I receptor antisense reduces IGF-IR expression and diminishes pressor responses to angiotensin II in conscious normotensive rats

Nguyen, T. T. L. & White, P. J., 2005, In : British Journal of Pharmacology. 146, 7, p. 935 - 941 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2004

Antisense oligonucleotide treatments for psoriasis

White, P. J., Atley, L. M. & Wraight, C., 2004, In : Expert Opinion on Biological Therapy. 4, 1, p. 75 - 81 7 p.

Research output: Contribution to journalArticleResearchpeer-review