Projects per year
Personal profile
Biography
Paul is Director of Medicinal Chemistry for Cancer Therapeutics CRC and is responsible for leading a team of post-doctoral medicinal chemists at Monash Institute for Pharmaceutical Sciences. Prior to joining CTx in 2012, Paul worked at the Pfizer laboratories in Sandwich, UK where he led medicinal teams which contributed to the delivery of numerous clinical candidates, of which three have so far reached Phase II clinical trials.
Prior to joining Pfizer in 2000, Paul completed his undergraduate and postgraduate studies at the University of Oxford, UK.
Related Links:
- Cancer Therapeutics CRC
Research interests
Small molecule drug discovery for oncology
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Organic Chemistry, DPhil, University of Oxford
1 Oct 1996 → 20 Dec 1999
Award Date: 31 Jan 2000
Chemistry, BA, University of Oxford
1 Oct 1992 → 31 Jul 1996
Award Date: 31 Aug 1996
External positions
Director, Medicinal Chemistry, CANthera
1 Jan 2021 → …
Director, Medicinal Chemistry, Cancer Therapeutics (CRC)
24 Jan 2012 → 31 Dec 2020
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Manufacturing and commercialization of [18F]-PET radiotracers
Stupple, P., Baell, J., Hawkey, L., Mudududdla, R., O'Brien, T., Vivash, L., Jupp, B., Santamaria, G., Ware, R., Stephens, A. & Mueller, A.
10/04/21 → 26/09/25
Project: Research
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CANthera 2021
Stupple, P., Bozikis, Y., Camerino, M., Doherty, J., Khoo, P. S., Revalde, J., Yow, T., Falk, H. & Cahir, N.
1/01/21 → 31/12/21
Project: Research
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Multidrug Resistance Protein 1 inhibitors to sensitise cancers to chemotherapy
Haber, M., Norris, M. D., Street, I. P., Stupple, P., Fletcher, J. I. & Solomon, B. J.
1/01/18 → 30/06/21
Project: Research
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Erratum: Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma (Proceedings of the National Academy of Sciences of the United States of America (2019)116(17990-18000)Doi: 10.1073/pnas.1901323116)
Hammad, S. A., Cullinane, C., Martin, C., Bacolas, Z., Ward, T., Chen, H., Slater, A., Ardley, K., Kirby, L., Chan, K. T., Brajanovski, N., Smith, L. K., Rao, A. D., Lelliott, E. J., Kleinschmidt, M., Vergara, I. A., Papenfuss, A. T., Lau, P., Ghosh, P., Haupt, S., & 12 others, 28 Apr 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 17, p. 9644-9645 2 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access1 Citation (Scopus) -
HBO1 is required for the maintenance of leukaemia stem cells
MacPherson, L., Anokye, J., Yeung, M. M., Lam, E. Y. N., Chan, Y. C., Weng, C. F., Yeh, P., Knezevic, K., Butler, M. S., Hoegl, A., Chan, K. L., Burr, M. L., Gearing, L. J., Willson, T., Liu, J., Choi, J., Yang, Y., Bilardi, R. A., Falk, H., Nguyen, N., & 28 others, 9 Jan 2020, In: Nature. 577, p. 266–270 5 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile71 Citations (Scopus) -
Temporal Analysis of Brd4 Displacement in the Control of B Cell Survival, Proliferation, and Differentiation
Kong, I. Y., Rimes, J. S., Light, A., Todorovski, I., Jones, S., Morand, E., Knight, D. A., Bergman, Y. E., Hogg, S. J., Falk, H., Monahan, B. J., Stupple, P. A., Street, I. P., Heinzel, S., Bouillet, P., Johnstone, R. W., Hodgkin, P. D., Vervoort, S. J. & Hawkins, E. D., 20 Oct 2020, In: Cell Reports. 33, 3, 22 p., 108290.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus) -
Fragment screening for a protein-protein interaction inhibitor to WDR5
Dennis, M. L., Morrow, B., Dolezal, O., Cuzzupe, A. N., Stupple, A., Newman, J., Bentley, J., Hattarki, M., Nuttall, S. D., Foitzik, R., Street, I. P., Stupple, P. A., Monahan, B. J. & Peat, T. S., 1 Nov 2019, In: Structural Dynamics. 6, 6, 20 p., 064701.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile5 Citations (Scopus) -
Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma
AbuHammad, S., Cullinane, C., Martin, C., Bacolas, Z., Ward, T., Chen, H., Slater, A., Ardley, K., Kirby, L., Chan, K. T., Brajanovski, N., Smith, L. K., Rao, A. D., Lelliott, E. J., Kleinschmidt, M., Vergara, I. A., Papenfuss, A. T., Lau, P., Ghosh, P., Haupt, S., & 12 others, 3 Sep 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 36, p. 17990-18000 11 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile59 Citations (Scopus)
Equipment
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Australian Translational Medicinal Chemistry Facility (ATMCF)
Paul Stupple (Manager)
Faculty of Pharmacy and Pharmaceutical SciencesFacility/equipment: Facility