Paul Stupple


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Personal profile


Paul is Director of Medicinal Chemistry for Cancer Therapeutics CRC and is responsible for leading a team of post-doctoral medicinal chemists at Monash Institute for Pharmaceutical Sciences. Prior to joining CTx in 2012, Paul worked at the Pfizer laboratories in Sandwich, UK where he led medicinal teams which contributed to the delivery of numerous clinical candidates, of which three have so far reached Phase II clinical trials.

Prior to joining Pfizer in 2000, Paul completed his undergraduate and postgraduate studies at the University of Oxford, UK.

Related Links:

  • Cancer Therapeutics CRC

Research interests

Small molecule drug discovery for oncology

Education/Academic qualification

Organic Chemistry, DPhil, University of Oxford

1 Oct 199620 Dec 1999

Chemistry, BA, University of Oxford

1 Oct 199231 Jul 1996

External positions

Director of Medicinal Chemistry, Cancer Therapeutics Cooperative Research Centre (CRC)

24 Jan 2012 → …

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2014 2020

Multidrug Resistance Protein 1 inhibitors to sensitise cancers to chemotherapy

Haber, M., Norris, M. D., Street, I. P., Stupple, P., Fletcher, J. I. & Solomon, B.


Project: Research

Research Output 1997 2019

Fragment screening for a protein-protein interaction inhibitor to WDR5

Dennis, M. L., Morrow, B., Dolezal, O., Cuzzupe, A. N., Stupple, A., Newman, J., Bentley, J., Hattarki, M., Nuttall, S. D., Foitzik, R., Street, I. P., Stupple, P. A., Monahan, B. J. & Peat, T. S., 1 Nov 2019, In : Structural Dynamics. 6, 6, 20 p., 064701.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1 Citation (Scopus)

Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

AbuHammad, S., Cullinane, C., Martin, C., Bacolas, Z., Ward, T., Chen, H., Slater, A., Ardley, K., Kirby, L., Chan, K. T., Brajanovski, N., Smith, L. K., Rao, A. D., Lelliott, E. J., Kleinschmidt, M., Vergara, I. A., Papenfuss, A. T., Lau, P., Ghosh, P., Haupt, S. & 12 others, Haupt, Y., Sanij, E., Poortinga, G., Pearson, R. B., Falk, H., Curtis, D. J., Stupple, P., Devlin, M., Street, I., Davies, M. A., McArthur, G. A. & Sheppard, K. E., 3 Sep 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 36, p. 17990-18000 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
29 Citations (Scopus)

Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7

Swain, N. A., Batchelor, D., Beaudoin, S., Bechle, B. M., Bradley, P. A., Brown, A. D., Brown, B., Butcher, K. J., Butt, R. P., Chapman, M. L., Denton, S., Ellis, D., Galan, S. R. G., Gaulier, S. M., Greener, B. S., De Groot, M. J., Glossop, M. S., Gurrell, I. K., Hannam, J., Johnson, M. S. & 14 others, Lin, Z., Markworth, C. J., Marron, B. E., Millan, D. S., Nakagawa, S., Pike, A., Printzenhoff, D., Rawson, D. J., Ransley, S. J., Reister, S. M., Sasaki, K., Storer, R. I., Stupple, P. A. & West, C. W., 24 Aug 2017, In : Journal of Medicinal Chemistry. 60, 16, p. 7029-7042 14 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

The discovery of a potent Nav1.3 inhibitor with good oral pharmacokinetics

Pryde, D. C., Swain, N. A., Stupple, P. A., West, C. W., Marron, B., Markworth, C. J., Printzenhoff, D., Lin, Z., Cox, P. J., Suzuki, R., McMurray, S., Waldron, G. J., Payne, C. E., Warmus, J. S. & Chapman, M. L., 2017, In : MedChemComm. 8, 6, p. 1255-1267 13 p.

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)

Subtype-selective small molecule inhibitors reveal a fundamental role for Nav1.7 in nociceptor electrogenesis, axonal conduction and presynaptic release

Alexandrou, A. J., Brown, A. R., Chapman, M. L., Estacion, M., Turner, J., Mis, M. A., Wilbrey, A., Payne, E. C., Gutteridge, A., Cox, P. J., Doyle, R., Printzenhoff, D., Lin, Z., Marron, B. E., West, C., Swain, N. A., Storer, R. I., Stupple, P. A., Castle, N. A., Hounshell, J. A. & 8 others, Rivara, M., Randall, A., Dib-Hajj, S. D., Krafte, D. S., Waxman, S. G., Patel, M. K., Butt, R. P. & Stevens, E. B., 1 Apr 2016, In : PLoS ONE. 11, 4, 22 p., e0152405.

Research output: Contribution to journalArticleResearchpeer-review

Open Access