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Research Output 2001 2018

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2018

Proteome-wide mapping of immune features onto Plasmodium protein three-dimensional structures

Guy, A. J., Irani, V., Beeson, J. G., Webb, B., Sali, A., Richards, J. S. & Ramsland, P. A., 12 Mar 2018, In : Scientific Reports. 8, 1, 16 p., 4355.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Structural basis for antibody targeting of the broadly expressed microbial polysaccharide poly-N-acetylglucosamine

Soliman, C., Walduck, A. K., Yuriev, E., Richards, J. S., Cywes-Bentley, C., Pier, G. B. & Ramsland, P. A., 1 Jan 2018, In : Journal of Biological Chemistry. 293, 14, p. 5079-5089 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Virtual Screening Against Carbohydrate-Binding Proteins: Evaluation and Application to Bacterial Burkholderia ambifaria Lectin

Dingjan, T., Gillon, É., Imberty, A., Pérez, S., Titz, A., Ramsland, P. A. & Yuriev, E., 24 Sep 2018, In : Journal of Chemical Information and Modeling. 58, 9, p. 1976-1989 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Molecular simulations of carbohydrates with a fucose-binding Burkholderia ambifaria lectin suggest modulation by surface residues outside the fucose-binding pocket

Dingjan, T., Imberty, A., Pérez, S., Yuriev, E. & Ramsland, P. A., 21 Jun 2017, In : Frontiers in Pharmacology. 8, JUN, 393.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Shear-sensitive nanocapsule drug release for site-specific inhibition of occlusive thrombus formation

Molloy, C. P., Yao, Y., Kammoun, H., Bonnard, T., Hoefer, T., Alt, K., Tovar-Lopez, F., Rosengarten, G., Ramsland, P. A., van der Meer, A. D., van den Berg, A., Murphy, A. J., Hagemeyer, C. E., Peter, K. & Westein, E., May 2017, In : Journal of Thrombosis and Haemostasis. 15, 5, p. 972-982 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The cationic small molecule GW4869 is cytotoxic to high phosphatidylserine-expressing myeloma cells

Vuckovic, S., Vandyke, K., Rickards, D. A., Mccauley Winter, P., Brown, S. H. J., Mitchell, T. W., Liu, J., Lu, J., Askenase, P. W., Yuriev, E., Capuano, B., Ramsland, P., Hill, G. R., Zannettino, A. C. W. & Hutchinson, A. T., May 2017, In : British Journal of Haematology. 177, 3, p. 423-440 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016

Cross-species analysis of Fc engineered anti-Lewis-Y human IgG1 variants in human neonatal receptor transgenic mice reveal importance of S254 and Y436 in binding human neonatal Fc receptor

Burvenich, I. J. G., Farrugia, W., Lee, F. T., Catimel, B., Liu, Z., Makris, D., Cao, D., O'Keefe, G. J., Brechbiel, M. W., King, D., Spirkoska, V., Allan, L. C., Ramsland, P. A. & Scott, A. M., 18 May 2016, In : mAbs. 8, 4, p. 775-786 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Engineering anti-Lewis-Y hu3S193 antibodies with improved therapeutic ratio for radioimmunotherapy of epithelial cancers

Burvenich, I. J. G., Lee, F-T., O’Keefe, G. J., Makris, D., Cao, D. X., Gong, S. J., Rigopoulos, A., Allan, L. C., Brechbiel, M. W., Liu, Z., Ramsland, P. A. & Scott, A. M., 1 Dec 2016, In : EJNMMI Research. 6, 1, 13 p., 26.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2015

Acquisition of functional antibodies that block the binding of erythrocyte-binding antigen 175 and protection against plasmodium falciparum malaria in children

Irani, V. R., Ramsland, P. A., Guy, A. J., Siba, P. M., Mueller, I., Richards, J. S. & Beeson, J. G., 2015, In : Clinical Infectious Diseases. 61, 8, p. 1244 - 1252 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Antimicrobial and immune modulatory effects of lactic acid and short chain fatty acids produced by vaginal microbiota associated with eubiosis and bacterial vaginosis

Aldunate, M. C., Srbinovski, D., Hearps, A. C., Latham, C. F., Ramsland, P. A., Gugasyan, R., Cone, R. A. & Tachedjian, G., 2015, In : Frontiers in Physiology. 6, 23 p., 164.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Improvements, trends, and new ideas in molecular docking: 2012-2013 in review

Yuriev, E., Holien, J. & Ramsland, P. A., 2015, In : Journal of Molecular Recognition. 28, 10, p. 581-604 24 p.

Research output: Contribution to journalArticleResearchpeer-review

Insights into the immunological properties of intrinsically disordered malaria proteins using proteome scale predictions

Guy, A. J., Irani, V. R., MacRaild, C. A., Anders, R. F., Norton, R. S., Beeson, J. G., Richards, J. S. & Ramsland, P. A., 2015, In : PLoS ONE. 10, 10, 22 p., e0141729.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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MYB elongation is regulated by the nucleic acid binding of NF?B p50 to the intronic stem-loop region

Pereira, L. A., Hugo, H. J., Malaterre, J., Xu, H., Sonza, S., Cures, A., Purcell, D. F. J., Ramsland, P. A., Gerondakis, S. D., Gonda, T. J. & Ramsay, R. G., 2015, In : PLoS ONE. 10, 4 (Art. No: e0122919), p. 1 - 25 25 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Structural biology of antibody recognition of carbohydrate epitopes and potential uses for targeted cancer immunotherapies

Dingjan, T., Spendlove, I., Durrant, L. G., Scott, A. M., Yuriev, E. & Ramsland, P. A., 2015, In : Molecular Immunology. 67, 2, p. 75-88 14 p.

Research output: Contribution to journalArticleResearchpeer-review

The carbohydrate-binding promiscuity of Euonymus europaeus lectin is predicted to involve a single binding site

Agostino, M. J., Velkov, T., Dingjan, T., Williams, S. J., Yuriev, E. & Ramsland, P. A., 2015, In : Glycobiology. 25, 1, p. 101 - 114 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Covariance of charged amino acids at positions 322 and 440 of HIV-1 Env contributes to coreceptor specificity of subtype B viruses, and can be used to improve the performance of V3 sequence-based coreceptor usage prediction algorithms

Cashin, K., Sterjovski, J., Harvey, K. L., Ramsland, P. A., Churchill, M. J. & Gorry, P. R., 2014, In : PLoS ONE. 9, 10, 11 p., e109771.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Distinct patterns of diversity, population structure and evolution in the AMA1 genes of sympatric Plasmodium falciparum and Plasmodium vivax populations of Papua New Guinea from an area of similarly high transmission

Arnott, A., Wapling, J. A., Mueller, I., Ramsland, P. A., Siba, P. M., Reeder, J. C. & Barry, A. E., 2014, In : Malaria Journal. 13, 1 (Art. No.:233), p. 1 - 16 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Polymorphisms and interspecies differences of the activating and inhibitory Fc{gamma}RII of Macaca nemestrina influence the binding of human IgG subclasses

Trist, H., Tan, P., Wines, B. D., Ramsland, P. A., Orlowski, E., Stubbs, J., Gardiner, E. E., Pietersz, G. A., Kent, S. J., Stratov, I., Burton, D. & Hogarth, P. M., 2014, In : Journal of Immunology. 192, 2, p. 792 - 803 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations

Roche, M. J., Salimi, H., Duncan, R. C., Wilkinson, B., Chikere, K., Moore, M. S., Webb, N., Zappi, H., Sterjovski, J., Flynn, J. K., Ellett, A., Gray, L. R., Lee, B., Jubb, B., Westby, M., Ramsland, P. A., Lewin, S. R., Payne, R. J., Churchill, M. & Gorry, P. R., 2013, In : Retrovirology. 10, 1 (Art. No.: 43), p. 1 - 20 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Allosteric modulation of the HIV-1 gp120-gp41 association site by adjacent gp120 variable region 1 (V1) N-glycans linked to neutralization sensitivity

Drummer, H. E., Hill, M. K., Maerz, A. L., Wood, S. J., Ramsland, P. A., Mak, J. & Poumbourios, P., 2013, In : PLoS ONE. 9, 4, 18 p., e1003218.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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AutoMap: A tool for analyzing protein-ligand recognition using multiple ligand binding modes

Agostino, M. J., Mancera, R., Ramsland, P. A. & Yuriev, E., 2013, In : Journal of Molecular Graphics and Modelling. 40, p. 80 - 90 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Cold-induced precipitation of a monoclonal IgM: a negative activation enthalpy reaction

Meliga, S. C., Farrugia, W., Ramsland, P. A. & Falconer, R. J., 2013, In : Journal of Physical Chemistry B. 117, 2, p. 490 - 494 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Formation of assemblies on cell membranes by secreted proteins: molecular studies of free lambda light chain aggregates found on the surface of myeloma cells

Hutchinson, A. T., Malik, A., Berkahn, M. B., Agostino, M. J., To, J., Tacchi, J. L., Djordjevic, S. P., Turnbull, L., Whitchurch, C. B., Edmundson, A. B., Jones, D. R., Raison, R. L. & Ramsland, P. A., 2013, In : Biochemical Journal. 454, 3, p. 479 - 489 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Global population structure of the genes encoding the Malaria vaccine candidate, Plasmodium vivax Apical Membrane Antigen 1 (PvAMA1)

Arnott, A., Mueller, I., Ramsland, P. A., Siba, P., Reeder, J. C. & Barry, A. E., 2013, In : PLoS Neglected Tropical Diseases. 7, 10, 14 p., e2506.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Latest developments in molecular docking: 2010-2011 in review

Yuriev, E. & Ramsland, P. A., 2013, In : Journal of Molecular Recognition. 26, 5, p. 215 - 239 25 p.

Research output: Contribution to journalArticleResearchpeer-review

Longitudinal analysis of CCR5 and CXCR4 usage in a cohort of antiretroviral therapy-naive subjects with progressive HIV-1 subtype C infection

Jakobsen, M. R., Cashin, K., Roche, M., Sterjovski, J., Ellett, A., Borm, K., Flynn, J. K., Erikstrup, C., Gouillou, M., Gray, L. R., Saksena, N. K., Wang, B., Purcell, D. F., Kallestrup, P., Zinyama-Gutsire, R., Gomo, E., Ullum, H., Ostergaard, L., Lee, B., Ramsland, P. A. & 2 others, Churchill, M. & Gorry, P. R., 2013, In : PLoS ONE. 8, 6, 13 p., e65950.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Macrophage-tropic HIV-1 variants from brain demonstrate alterations in the way gp120 engages both CD4 and CCR5

Salimiseyedabad, H., Roche, M., Webb, N., Gray, L. R., Chikere, K., Sterjovski, J., Ellett, A., Wesselingh, S. L., Ramsland, P. A., Lee, B., Churchill, M. & Gorry, P. R., 2013, In : Journal of leukocyte biology. 93, 1, p. 113 - 126 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Antibody recognition of cancer-related gangliosides and their mimics investigated using in silico site mapping

Agostino, M. J., Yuriev, E. & Ramsland, P. A., 2012, In : PLoS ONE. 7, 4, 12 p., e35457.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Identification of residues involved in NS2 homodimerization and elucidation of their impact on the HCV life cycle

Gorzin, A. A., Ramsland, P. A., Tachedjian, G. & Gowans, E. J., 2012, In : Journal of Viral Hepatitis. 19, 3, p. 189 - 198 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural elements of primary CCR5-using HIV-1 gp120 proteins influencing sensitivity and resistance to the broadly neutralizing monoclonal antibody b12

Sterjovski, J., Churchill, M., Ellett, A., Wesselingh, S. L., Ramsland, P. A. & Gorry, P. R., 2012, In : Virology. 432, 2, p. 394 - 404 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

A computational approach for exploring carbohydrate recognition by lectins in innate immunity

Agostino, M., Yuriev, E. & Ramsland, P. A., 2011, In : Frontiers in Immunology. 2, JUN, 14 p., 23.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Alternative coreceptor requirements for efficient CCR5- and CXCR4-mediated HIV-1 entry into macrophages

Cashin, K., Roche, M., Sterjovski, J., Ellett, A., Gray, L. R., Cunningham, A., Ramsland, P., Churchill, M. & Gorry, P., 2011, In : Journal of Virology. 85, 20, p. 10699 - 10709 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Carbohydrate-mimetic peptides: structural aspects of mimicry and therapeutic implications

Agostino, M., Sandrin, M., Thompson, P., Farrugia, W., Ramsland, P. & Yuriev, E., 2011, In : Expert Opinion on Biological Therapy. 11, 2, p. 211 - 224 14 p.

Research output: Contribution to journalArticleResearchpeer-review

CD4-binding site alterations in CCR5-using HIV-1 envelopes influencing gp120-CD4 interactions and fusogenicity

Sterjovski, J., Churchill, M. J., Roche, M., Ellett, A., Farrugia, W., Wesselingh, S. L., Cunningham, A. L., Ramsland, P. A. & Gorry, P. R., 20 Feb 2011, In : Virology. 410, 2, p. 418-428 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Challenges and advances in computational docking: 2009 in review

Yuriev, E., Agostino, M. & Ramsland, P., 2011, In : Journal of Molecular Recognition. 24, 2, p. 149 - 164 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Characterization of a unique conformational epitope on free immunoglobulin kappa light chains that is recognized by an antibody with therapeutic potential

Hutchinson, A. T., Alexova, R., Bockhorni, V., Ramsland, P. A., Jones, D. R., Jennings, C., Broady, K., Edmundson, A. B. & Raison, R. L., 2011, In : Molecular Immunology. 48, 9-10, p. 1245 - 1252 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Conformational alterations in the CD4 binding cavity of HIV-1 gp120 influencing gp120-CD4 interactions and fusogenicity of HIV-1 envelopes derived from brain and other tissues

Gray, L. R., Sterjovski, J., Ramsland, P., Churchill, M. & Gorry, P., 2011, In : Retrovirology. 8, 42, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

HIV-1 escape from the CCR5 antagonist maraviroc associated with an altered and less-efficient mechanism of gp120-CCR5 engagement that attenuates macrophage tropism

Roche, M., Jakobsen, M., Sterjovski, J., Ellett, A., Posta, F., Lee, B., Jubb, B., Westby, M., Lewin, S. R., Ramsland, P. A., Churchill, M. & Gorry, P. R., 2011, In : Journal of Virology. 85, 9, p. 4330 - 4342 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Interaction of human, rat, and mouse immunoglobulin A (IgA) with staphylococcal superantigen-like 7 (SSL7) decoy protein and leukocyte IgA receptor

Wines, B. D., Ramsland, P. A., Trist, H. M., Gardam, S., Brink, R., Fraser, J. D. & Hogarth, P. M., 23 Sep 2011, In : Journal of Biological Chemistry. 286, 38, p. 33118-33124 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Peptide inhibitors of xenoreactive antibodies mimic the interaction profile of the native carbohydrate antigens

Agostino, M., Sandrin, M., Thompson, P., Ramsland, P. & Yuriev, E., 2011, In : Biopolymers. 96, 2, p. 193 - 206 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Role for the terminal clasp of HIV-1 gp41 glycoprotein in the initiation of membrane fusion

Lay, C-S., Ludlow, L. E., Stapleton, D. I., Bellamy-McIntyre, A., Ramsland, P. A., Drummer, H. E. & Poumbourios, P., 2011, In : Journal of Biological Chemistry. 286, 48, p. 41331 - 41343 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural basis for FcγRIIa recognition of human IgG and formation of inflammatory signaling complexes

Ramsland, P. A., Farrugia, W., Bradford, T. M., Sardjono, C. T., Esparon, S. E., Trist, H. M., Powell, M. S., Tan, P. S., Cendron, A. C., Wines, B. D., Scott, A. M. & Hogarth, P. M., 15 Sep 2011, In : Journal of Immunology. 187, 6, p. 3208-3217 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Virucidal activity of the dendrimer microbicide SPL7013 against HIV-1

Telwatte, S., Moore, K., Johnson, A., Tyssen, D., Sterjovski, J., Aldunate, M., Gorry, P. R., Ramsland, P., Lewis, G., Paull, J., Sonza, S. & Tachedjian, G., 2011, In : Antiviral Research. 90, 3, p. 195 - 199 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopes

Sterjovski, J., Roche, M. J., Churchill, M., Ellett, A., Farrugia, W., Gray, L. R., Cowley, D., Poumbourios, P., Lee, B., Wesselingh, S. L., Cunningham, A. L., Ramsland, P. A. & Gorry, P. R., 2010, In : Virology. 404, 2, p. 269 - 278 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Free ig light chains interact with sphingomyelin and are found on the surface of myeloma plasma cells in an aggregated form

Hutchinson, A., Ramsland, P., Jones, D., Agostino, M., Lund, M., Jennings, C., Bockhorni, V., Yuriev, E., Edmundson, A. & Raison, R., 2010, In : Journal of Immunology. 185, p. 4179 - 4188 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of preferred carbohydrate binding modes in xenoreactive antibodies by combining conformational filters and binding site maps

Agostino, M., Sandrin, M., Thompson, P., Yuriev, E. & Ramsland, P., 2010, In : Glycobiology. 20, 6, p. 724 - 735 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure activity relationship of dendrimer microbicides with dual action antiviral activity

Tyssen, D., Henderson, S. A., Johnson, A., Sterjovski, J., Moore, K., La, J., Zanin, M. P., Sonza, S., Karellas, P., Giannis, M., Krippner, G. Y., Wesselingh, S. L., McCarthy, T. D., Gorry, P. R., Ramsland, P. A., Cone, R., Paull, J. RA., Lewis, G. R. & Tachedjian, G., 2010, In : PLoS ONE. 5, 8 (e12309), p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Altered peptide ligands of myelin basic protein (MBP87-99) conjugated to reduced mannan modulate immune responses in mice

Katsara, M., Yuriev, E., Ramsland, P. A., Tselios, T., Deraos, G., Lourbopoulos, A., Grigoriadis, N., Matsoukas, J. & Apostolopoulos, V., 2009, In : Immunology. 128, 4, p. 521 - 533 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of destructive autoimmune arthritis in FcgRIIa transgenic mice by small chemical entities

Pietersz, G. A., Mottram, P. L., van de Velde, N. C., Sardjono, C. T., Esparon, S. E., Ramsland, P. A., Moloney, G., Baell, J. B., McCarthy, T. D., Matthews, B. R., Powell, M. & Hogarth, P. M., 2009, In : Immunology and Cell Biology. 87, 1, p. 3 - 12 10 p.

Research output: Contribution to journalArticleResearchpeer-review

In silico analysis of antibody-carbohydrate interactions and its application to xenoreactive antibodies

Agostino, M. J., Sandrin, M. S., Thompson, P., Yuriev, E. & Ramsland, P. A., 2009, In : Molecular Immunology. 47, 2-3, p. 233 - 246 14 p.

Research output: Contribution to journalArticleResearchpeer-review