Projects per year
Personal profile
Biography
Professor Paul Lacaze is a leader in public health genomics and preventive medicine, with an established record of research translation, policy influence and program-building within the Australian health system. Since his appointment in 2015 as the Inaugural Head of Public Health Genomics at Monash University, Lacaze has built and led large-scale, multi-institutional research initiatives integrating genomics, epidemiology and health systems research to advance preventive care. Lacaze has secured over $40M in competitive research funding as Chief Investigator, including a dual appointment of NHMRC Investigator Grant (L1, 2024-29) and National Heart Foundation Future Leader Fellowship (L3, 2024-28). Lacaze's work has contributed directly to national policy reform, including federal legislation restricting the use of genetic test results in life insurance, and to the development of Australia’s first large-scale adult population DNA screening program. Professor Lacaze has extensive experience leading collaborative research networks, overseeing governance processes, managing research teams and budgets, and engaging government, consumer and clinical stakeholders. Lacaze is committed to strengthening interdisciplinary collaboration, mentoring emerging researchers, and advancing equitable and evidence-based public health innovation.
Education/Academic qualification
Genomics, PhD, Genomics, immunology, virology, University of Edinburgh
Award Date: 20 Apr 2011
Systems Biology, MSc, University of Edinburgh
2004 → 2005
Award Date: 30 Sept 2005
Science, BSc, Genomics & Biotechnology, University of Melbourne
2000 → 2003
Award Date: 30 Nov 2003
International Baccalaureate, Ivanhoe Grammar School
Award Date: 30 Dec 2000
Research area keywords
- Public Health
- Human genomics
- Clinical translation
- Preventive Medicine
- Genetics
- population genetics and genomics
- Ageing
- Dementia
- Cancer
- Cardiovascular Disease
- coronary heart disease
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 9 Industry, Innovation, and Infrastructure
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SDG 11 Sustainable Cities and Communities
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ASPREE Proteomics & Genomics - WEHI & SPHPM - Colonial Centre
Lacaze, P. (Primary Chief Investigator (PCI))
1/01/25 → 31/12/26
Project: Research
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Precision prevention of cardiovascular disease using genomic risk stratification
Yu, C. (Primary Chief Investigator (PCI)), Lacaze, P. (Chief Investigator (CI)), Nicholls, S. (Chief Investigator (CI)) & McNeil, J. (Chief Investigator (CI))
1/01/25 → 31/12/26
Project: Research
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Aspirin, Lp(a) and Primary Prevention of Cardiovascular Events
Tsimikas, S. (Primary Chief Investigator (PCI)), Wolfe, R. (Chief Investigator (CI)), Tonkin, A. (Chief Investigator (CI)), Lacaze, P. (Chief Investigator (CI)), Bhatia, H. S. (Chief Investigator (CI)), Armitage, J. (Chief Investigator (CI)) & Hopewell, J. C. (Chief Investigator (CI))
1/09/23 → 31/07/27
Project: Research
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The Australian Genetic Diversity Database: towards a more equitable future for genomic medicine in Australia
MacArthur, D. (Primary Chief Investigator (PCI)), Savulescu, J. (Chief Investigator (CI)), Best, S. (Chief Investigator (CI)), Young, M. A. (Chief Investigator (CI)), Goranitis, I. (Chief Investigator (CI)), Brown, A. D. H. (Chief Investigator (CI)), Vears, D. F. (Chief Investigator (CI)), Lacaze, P. (Chief Investigator (CI)), Boughtwood, T. (Chief Investigator (CI)), Hermes, A. (Chief Investigator (CI)), Irving, D. O. (Chief Investigator (CI)), Ingles, J. (Chief Investigator (CI)), Geronimo, M. A. (Chief Investigator (CI)), Deveson, I. W. (Chief Investigator (CI)), Yengo, L. (Chief Investigator (CI)), Southey, M. (Chief Investigator (CI)), McEwen , A. R. (Chief Investigator (CI)), Baynam, G. (Chief Investigator (CI)), Meldrum, C. (Chief Investigator (CI)), Lundie, B. (Chief Investigator (CI)), Lunke, S. (Chief Investigator (CI)), Bennetts, B. (Chief Investigator (CI)), Kassahn, K. (Chief Investigator (CI)), Davis, M. R. (Chief Investigator (CI)), Saleh , M. (Chief Investigator (CI)), Kummerfeld, S. (Chief Investigator (CI)), Delatycki, M. (Chief Investigator (CI)), Kirk, E. P. (Chief Investigator (CI)), Wake, M. (Chief Investigator (CI)), McNamara, M. (Chief Investigator (CI)), Rehm, H. L. (Chief Investigator (CI)), Talkowski, M. (Chief Investigator (CI)), Thorpe, R. (Chief Investigator (CI)), Karki, S. (Chief Investigator (CI)), Powell, J. E. (Chief Investigator (CI)), Amare, A. T. (Chief Investigator (CI)), Benyamin, B. (Chief Investigator (CI)), Hong Lee, S. (Chief Investigator (CI)), Shah, S. (Chief Investigator (CI)) & Wray, N. R. (Chief Investigator (CI))
1/06/22 → 31/05/27
Project: Research
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Clonal haematopoiesis of indeterminate potential and ageing-related diseases: the ASPREE-CHIP Extension (ASPREE-CHIP-XT) Study
McQuilten, Z. (Primary Chief Investigator (PCI)), Curtis, D. (Chief Investigator (CI)), McNeil, J. (Chief Investigator (CI)), Woods, R. (Chief Investigator (CI)), Murphy, A. J. (Chief Investigator (CI)), Wolfe, R. (Chief Investigator (CI)), Lacaze, P. (Chief Investigator (CI)), Bick, A. G. (Chief Investigator (CI)), Le, T. (Chief Investigator (CI)), Wood, E. (Chief Investigator (CI)), Singh, J. (Associate Investigator (AI)), Wong, N. (Associate Investigator (AI)) & Bakshi, A. (Associate Investigator (AI))
Project: Research
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Are Genetics Useful to Guide Ablation Strategies in Patients With Persistent Atrial Fibrillation?
Lim, M. W., Kistler, P. M., Curtin, A. G., Chieng, D., William, J., Segan, L., Crowley, R., Soka, M. J., Young, P. E., Rath, E. M., Yu, C., Ohanian, M., Johnson, R., Lacaze, P., Giannoulatou, E., Voskoboinik, A., Prabhu, S., Sugumar, H., Fatkin, D. & Kalman, J. M., May 2026, In: Journal of Cardiovascular Electrophysiology. 37, 5, p. 917-924 8 p.Research output: Contribution to journal › Article › Research › peer-review
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Clonal Hematopoiesis and Kidney Function in the ASPREE Cohort
Singh, J. (Leading Author), Polkinghorne, K. R., Wolfe, R., Wong, N. C., Byars, S., Leichter, A., Lacaze, P., McNeil, J. J., Orchard, S. G., Phung, J., Ramshaw, H. S., Thao, L. T. P., Wetmore, J. B., Wood, E. M., Woods, R. L., Curtis, D. J. & McQuilten, Z. K. (Leading Author), Feb 2026, In: Kidney International Reports. 11, 2, 9 p., 103714.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Link opens in a new tab Citation (Scopus) -
Sepsis risk associated with clonal hematopoiesis of indeterminate potential (CHIP): a secondary analysis of the ASPREE trial
Singh, J. (Leading Author), Eisen, D. P., Byars, S. G., Leichter, A., Lacaze, P., McNeil, J. J., Orchard, S. G., Phung, J., Ramshaw, H. S., Thao, L. T. P., Wolfe, R., Wood, E. M., Woods, R. L., Curtis, D. J. & McQuilten, Z. K. (Leading Author), Jul 2026, In: Leukemia. 40, 7, p. 1535-1537 3 p.Research output: Contribution to journal › Letter › Research › peer-review
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Whole genome sequencing analysis of over 3500 individuals dementia-free over 85 years old
Peloso, G. M., Wang, D., Abbruzzese, S. M., Bis, J. C., Choi, S. H., Beiser, A., Bressler, J., Dupuis, J., Fohner, A. E., Ghanbari, M., Gibbs, R. A., Heard-Costa, N., Ikram, M. A., Lacaze, P., Le Grand, Q., Lopez, O. L., Mosley, T. H., Riaz, M., Soumaré, A. & Yaqub, A. & 6 others, , Jun 2026, In: Journal of Alzheimer's Disease. 111, 4, p. 1772-1782 11 p.Research output: Contribution to journal › Article › Research › peer-review
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Clonal Hematopoiesis and Cardiovascular Disease and Bleeding Risk and the Effectiveness of Aspirin
McQuilten, Z. K. (Leading Author), Thao, L. T. P., Bick, A. G., Byars, S., Chan, A. T., Ford, L., Leichter, A., McNeil, J. J., Murray, A. M., Murphy, A. J., Orchard, S. G., Phung, J., Ramshaw, H. S., Singh, J., Tonkin, A. M., Umar, A., Wolfe, R., Wood, E. M., Woods, R. L. & Lacaze, P. & 1 others, , Dec 2025, In: JAMA Cardiology. 10, 12, p. 1257-1266 10 p.Research output: Contribution to journal › Article › Research › peer-review
4 Link opens in a new tab Citations (Scopus)
Prizes
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Australian Government Department of Health – 2022 MRFF Profile
Lacaze, P. (Recipient), 2022
Prize: Prize (including medals and awards)
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European Society of Human Genetics, Top 10 Abstracts selected for oral presentation
Lacaze, P. (Recipient), 2018
Prize: National/international honour
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Human Genome Analysis: Genetic Analysis of Multifactorial Diseases , Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
Lacaze, P. (Recipient), 2016
Prize: Prize (including medals and awards)
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Ivanhoe Grammar School ‐ Scholarship, Rhodes Awards for General Excellence
Lacaze, P. (Recipient), 1997
Prize: Prize (including medals and awards)
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Millennium Science Outstanding Achievement for Technical Support
Lacaze, P. (Recipient), 2013
Prize: Prize (including medals and awards)
Activities
- 2 Other
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Invited Guest Lecturer: Diagnostic genomics
Lacaze, P. (Speaker)
2018 → …Activity: Other Teaching Engagements and non-HDR Supervisions › Other
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Invited Guest Lecturer: Genetics, Health and Society
Lacaze, P. (Speaker)
2017 → …Activity: Other Teaching Engagements and non-HDR Supervisions › Other
Press/Media
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Genetic testing for all could reduce the risk of heart disease
Ademi Delaney, Z., Marquina Hernandez, C. & Lacaze, P.
21/02/22
1 Media contribution
Press/Media: Research