Projects per year
Personal profile
Biography
Associate Professor Paul Lacaze is a pioneering researcher in public health genomics and population DNA screening. He holds a prestigious Heart Foundation Future Leader Fellowship and is the Cheif Investigator A (CIA) of the landmark DNA Screen national pilot study, offering preventive population DNA screening to 10,000 healthy adults for medically actionable conditions. Lacaze is also CIA of the Australian Genetics and Life Insurance Moratorium: Monitoring the Effectiveness and Response (A-GLIMMER) project. Lacaze leads the genomics research program for the ASPREE study, Australia’s largest randomised trial and genomic cohort of ageing. Lacaze is one of few Australian researchers to have designed, executed and analysed large genomic cohort studies (N > 10,000) within his own group. He also leads a parallel research stream focused on ethical, legal, social, health-economic and policy aspects of human genomics. He is an Affiliate Faculty Member, Massachusetts General Hospital, Boston, USA, an Honorary Fellow, Adult Genomic Medicine, Royal Melbourne Hospital, and a visiting Scientist, Garvan Institute of Medical Research.
Community service
A/Prof Lacaze regularly works with patient groups to deliver patient-centred research and advocate for issues in Australia. This includes working with the Familial Hypercholesterolemia Network Australia, Pink Hope, Lynch Syndrome Australia and Rare Voices Australia. Lacaze founded the Australian Genetic Non-Discrimination Working Group, and on behalf of the group, provided evidence to the 2017 Parliamentary inquiry into life insurance (Canberra). This has led to a moratorium on the use of genetic test results in Australian life insurance, is now directly benefiting Australian consumers, clinicians and researchers. Lacaze was recently selected to represent the Australian Cardiovascular Alliance as an EMCR at the Science Meets Parliament event in Canberra. Lacaze serves on the Scientific and Medical Advisory Committee of Rare Voices Australia.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Genomics, PhD, University of Edinburgh
Award Date: 20 Apr 2011
Systems Biology, MSc, University of Edinburgh
2004 → 2005
Award Date: 30 Sep 2005
Science, BSc, University of Melbourne
2000 → 2003
Award Date: 30 Nov 2003
International Baccalaureate, Ivanhoe Grammar School
Award Date: 30 Dec 2000
Research area keywords
- Public Health
- Human genomics
- Clinical translation
- Preventive Medicine
- Genetics
- population genetics and genomics
- Ageing
- Dementia
- Cancer
- Cardiovascular Disease
- coronary heart disease
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Additional Sequencing for the Alzheimer’s Disease Sequencing Project (ADSP) the Follow-Up Study (FUS), The Diverse Population Initiative
Kunkle, B. & Lacaze, P.
1/09/22 → 31/08/23
Project: Research
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Inclusion of sub-group of ASPREE samples into the ADSP
Pericak-Vance, M. A., Lacaze, P. & Vance, J. M.
30/09/21 → 30/06/23
Project: Research
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Australian Genomics Grant Program 2021-2023
North, K. N., Boughtwood, T., Braithwaite, J., Brown, A., Christodoulou , J., Dunwoodie, S. L., Gaff, C. L., Gécz, J., Hofmann, O., Kowal, E., MacArthur, D., McGaughran, J., Meldrum, C. J., Murray, S., Newson, A. J., Nowak, K. J., Scott, H. S., Spurdle, A. B., Stark, Z. L., Ward, R. L., Lacaze, P., Tiller, J. & Hunter, M.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/21 → 31/12/23
Project: Research
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Genetic protection against cardiovascular disease in the healthy elderly
1/01/20 → 31/12/23
Project: Research
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Prioritizing the detection of rare pathogenic variants in population screening
Lacaze, P., Manchanda, R. & Green, R. C., Jan 2023, (Accepted/In press) In: Nature Reviews Genetics. 2 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
1 Citation (Scopus) -
Aspirin and the Risk of Colorectal Cancer According to Genetic Susceptibility among Older Individuals
Bakshi, A., Cao, Y., Orchard, S. G., Carr, P. R., Joshi, A. D., Manning, A. K., Buchanan, D. D., Umar, A., Winship, I. M., Gibbs, P., Zalcberg, J. R., Macrae, F., McNeil, J. J., Lacaze, P. & Chan, A. T., Jul 2022, In: Cancer Prevention Research. 15, 7, p. 447-454 8 p.Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus) -
Aspirin for Primary Prevention of Cardiovascular Events in Relation to Lipoprotein(a) Genotypes
Lacaze, P., Bakshi, A., Riaz, M., Polekhina, G., Owen, A., Bhatia, H. S., Natarajan, P., Wolfe, R., Beilin, L., Nicholls, S. J., Watts, G. F., McNeil, J. J., Tonkin, A. M. & Tsimikas, S., 4 Oct 2022, In: Journal of the American College of Cardiology. 80, 14, p. 1287-1298 12 p.Research output: Contribution to journal › Article › Research › peer-review
12 Citations (Scopus) -
A step forward, but still inadequate: Australian health professionals' views on the genetics and life insurance moratorium
Tiller, J. M., Keogh, L. A., McInerney-Leo, A. M., Belcher, A., Barlow-Stewart, K., Boughtwood, T., Gleeson, P., Dowling, G., Prince, A., Bombard, Y., Joly, Y., Delatycki, M., Winship, I. M., Otlowski, M. & Lacaze, P., 1 Aug 2022, In: Journal of Medical Genetics. 59, 8, p. 817-826 10 p.Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus) -
Attitudes of Australian dermatologists on the use of genetic testing: A cross-sectional survey with a focus on melanoma
Primiero, C. A., Baker, A. M., Wallingford, C. K., Maas, E. J., Yanes, T., Fowles, L., Janda, M., Young, M. A., Nisselle, A., Terrill, B., Lodge, J. M., Tiller, J. M., Lacaze, P., Andersen, H., McErlean, G., Turbitt, E., Soyer, H. P. & McInerney-Leo, A. M., 24 Oct 2022, In: Frontiers in Genetics. 13, 12 p., 919134.Research output: Contribution to journal › Article › Research › peer-review
Open Access
Prizes
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European Society of Human Genetics, Top 10 Abstracts selected for oral presentation
Lacaze, Paul (Recipient), 2018
Prize: National/international honour
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Human Genome Analysis: Genetic Analysis of Multifactorial Diseases , Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
Lacaze, Paul (Recipient), 2016
Prize: Prize (including medals and awards)
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Ivanhoe Grammar School ‐ Scholarship, Rhodes Awards for General Excellence
Lacaze, Paul (Recipient), 1997
Prize: Prize (including medals and awards)
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Millennium Science Outstanding Achievement for Technical Support
Lacaze, Paul (Recipient), 2013
Prize: Prize (including medals and awards)
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Monash Emerging Academic Leaders Program, 2018, Monash University.
Lacaze, Paul (Recipient), 2018
Prize: Prize (including medals and awards)
Activities
- 2 Other
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Invited Guest Lecturer: Diagnostic genomics
Paul Lacaze (Speaker)
2018 → …Activity: Other Teaching Engagements and non-HDR Supervisions › Other
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Invited Guest Lecturer: Genetics, Health and Society
Paul Lacaze (Speaker)
2017 → …Activity: Other Teaching Engagements and non-HDR Supervisions › Other
Press/Media
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Genetic testing for all could reduce the risk of heart disease
Zanfina Ademi Delaney, Clara Marquina Hernandez & Paul Lacaze
21/02/22
1 Media contribution
Press/Media: Research