Projects per year
Personal profile
Biography
Associate Professor Paul Lacaze is a pioneering researcher in public health genomics and population DNA screening. He holds a prestigious Heart Foundation Future Leader Fellowship and is the Cheif Investigator A (CIA) of the landmark DNA Screen national pilot study, offering preventive population DNA screening to 10,000 healthy adults for medically actionable conditions. Lacaze is also CIA of the Australian Genetics and Life Insurance Moratorium: Monitoring the Effectiveness and Response (A-GLIMMER) project. Lacaze leads the genomics research program for the ASPREE study, Australia’s largest randomised trial and genomic cohort of ageing. Lacaze is one of few Australian researchers to have designed, executed and analysed large genomic cohort studies (N > 10,000) within his own group. He also leads a parallel research stream focused on ethical, legal, social, health-economic and policy aspects of human genomics. He is an Affiliate Faculty Member, Massachusetts General Hospital, Boston, USA, an Honorary Fellow, Adult Genomic Medicine, Royal Melbourne Hospital, and a visiting Scientist, Garvan Institute of Medical Research.
Community service
A/Prof Lacaze regularly works with patient groups to deliver patient-centred research and advocate for issues in Australia. This includes working with the Familial Hypercholesterolemia Network Australia, Pink Hope, Lynch Syndrome Australia and Rare Voices Australia. Lacaze founded the Australian Genetic Non-Discrimination Working Group, and on behalf of the group, provided evidence to the 2017 Parliamentary inquiry into life insurance (Canberra). This has led to a moratorium on the use of genetic test results in Australian life insurance, is now directly benefiting Australian consumers, clinicians and researchers. Lacaze was recently selected to represent the Australian Cardiovascular Alliance as an EMCR at the Science Meets Parliament event in Canberra. Lacaze serves on the Scientific and Medical Advisory Committee of Rare Voices Australia.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Genomics, PhD, University of Edinburgh
Award Date: 20 Apr 2011
Systems Biology, MSc, University of Edinburgh
2004 → 2005
Award Date: 30 Sep 2005
Science, BSc, University of Melbourne
2000 → 2003
Award Date: 30 Nov 2003
International Baccalaureate, Ivanhoe Grammar School
Award Date: 30 Dec 2000
Research area keywords
- Public Health
- Human genomics
- Clinical translation
- Preventive Medicine
- Genetics
- population genetics and genomics
- Ageing
- Dementia
- Cancer
- Cardiovascular Disease
- coronary heart disease
Projects
- 9 Active
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Inclusion of sub-group of ASPREE samples into the ADSP
Pericak-Vance, M. A., Lacaze, P. & Vance, J. M.
30/09/21 → 30/06/22
Project: Research
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Population genomic screening of young adults to prevent cancer in Australia
Lacaze, P., McNeil, J., Zalcberg, J., Thomas, D., Milne, R., James, P., Delatycki, M., Young, M., Nowak, K., Nguyen, T., Southey, M., Winship, I. M., Ademi Delaney, Z., Tiller, J., Bruinsma, F., Riaz, M., Terrill, B., Kirk, J., Tucker, K. L. & Andrews, L.
1/07/21 → 30/06/25
Project: Research
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Prospective study of the gut microbiome in aging
Chan, A. T., Woods, R., Orchard, S., Ryan, J., Lacaze, P. & McNeil, J.
15/09/20 → 31/08/22
Project: Research
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Genetics and Life Insurance Moratorium: Measuring the impact
Lacaze, P., Tiller, J., Otlowski, M. F. A., Barlow-Stewart, K., McInerney-Leo, A., Keogh, L., Winship, I. M. & Delatycki, M.
1/07/20 → 30/06/22
Project: Research
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Loss of Y and clonal hematopoiesis in blood—two sides of the same coin?
Ljungström, V., Mattisson, J., Halvardson, J., Pandzic, T., Davies, H., Rychlicka-Buniowska, E., Danielsson, M., Lacaze, P., Cavelier, L., Dumanski, J. P., Baliakas, P. & Forsberg, L. A., Mar 2022, In: Leukemia. 36, 3, p. 889-891 3 p.Research output: Contribution to journal › Letter › Other › peer-review
Open Access1 Citation (Scopus) -
Population DNA screening for medically actionable disease risk in adults
Lacaze, P., Tiller, J., Winship, I. & For the DNA Screen Investigator Group, Mar 2022, (Accepted/In press) In: The Medical Journal of Australia. 3 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access -
Prognostic Value of a Polygenic Risk Score for Coronary Heart Disease in Individuals Aged 70 Years and Older
Neumann, J. T., Riaz, M., Bakshi, A., Polekhina, G., Thao, L. T. P., Nelson, M. R., Woods, R. L., Abraham, G., Inouye, M., Reid, C. M., Tonkin, A. M., McNeil, J. & Lacaze, P., Feb 2022, In: Circulation: Genomic and Precision Medicine. 15, 1, p. 26-32 7 p., e003429.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Accelerated epigenetic aging in peripheral blood does not predict dementia risk
Fransquet, P. D., Lacaze, P., Saffery, R., Shah, R. C., Vryer, R., Murray, A., Woods, R. L. & Ryan, J., 2021, In: Current Alzheimer Research. 18, 5, p. 443-451 9 p.Research output: Contribution to journal › Review Article › Research › peer-review
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A meta-analysis of genome-wide association studies identifies new genetic loci associated with all-cause and vascular dementia
Fongang, B., Weinstein, G., Guðjónsson, A., Mishra, A., Bis, J. C., Yang, Q., Winsvold, B., Sargurupremraj, M., Fan, K. H., Kamboh, M. I., Li, G., Yang, J., Hilal, S., Satizabal, C. L., Jian, X., Knol, M. J., Concas, M. P., Girotto, G., Riaz, M., Lacaze, P. & 21 others, , Dec 2021, In: Alzheimer's and Dementia. 17, S3, 3 p., e056081.Research output: Contribution to journal › Meeting Abstract › Other › peer-review
Prizes
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European Society of Human Genetics, Top 10 Abstracts selected for oral presentation
Lacaze, Paul (Recipient), 2018
Prize: National/international honour
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Human Genome Analysis: Genetic Analysis of Multifactorial Diseases , Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
Lacaze, Paul (Recipient), 2016
Prize: Prize (including medals and awards)
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Ivanhoe Grammar School ‐ Scholarship, Rhodes Awards for General Excellence
Lacaze, Paul (Recipient), 1997
Prize: Prize (including medals and awards)
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Millennium Science Outstanding Achievement for Technical Support
Lacaze, Paul (Recipient), 2013
Prize: Prize (including medals and awards)
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Monash Emerging Academic Leaders Program, 2018, Monash University.
Lacaze, Paul (Recipient), 2018
Prize: Prize (including medals and awards)
Activities
- 2 Other
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Invited Guest Lecturer: Diagnostic genomics
Paul Lacaze (Speaker)
2018 → …Activity: Other Teaching Engagements and non-HDR Supervisions › Other
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Invited Guest Lecturer: Genetics, Health and Society
Paul Lacaze (Speaker)
2017 → …Activity: Other Teaching Engagements and non-HDR Supervisions › Other