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Research Output 1975 2019

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Article
2001
77 Citations (Scopus)

The soluble murine type I interferon receptor Ifnar-2 is present in serum, is independently regulated, and has both agonistic and antagonistic properties

Hardy, M., Owczarek, C. M., Trajanovska, S., Liu, X., Kola, I. & Hertzog, P. J., 2001, In : Blood. 97, 2, p. 473 - 482 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2000
1 Citation (Scopus)

Assignment of protein kinase C mu (PRKCM) to human chromosome band 14q11 with somatic cell hybrids and radiation hybrids

Owczarek, C. M., Portbury, K. J., Kola, I. & Hertzog, P. J., 2000, In : Cytogenetics and Cell Genetics. p. 240 - 241 2 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Role of type I interferons during macrophage activation by lipopolysaccharide

Vadiveloo, P. K., Vairo, G., Hertzog, P. J., Kola, I. & Hamilton, J. A., 2000, In : Cytokine. p. 1639 - 1646 8 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Type I interferons mediate the lipopolysaccharide induction of macrophage cyclin D2

Vadiveloo, P. K., Christopoulos, H., Novak, U., Kola, I., Hertzog, P. J. & Hamilton, J. A., 2000, In : Journal of Interferon and Cytokine Research. p. 355 - 359 5 p.

Research output: Contribution to journalArticleResearchpeer-review

1999
381 Citations (Scopus)

Cathepsin K knockout mice develop osteopetrosis due to a deficit in matrix degradation but not demineralization

Gowen, M., Lazner, F., Dodds, R., Kapadia, R., Feild, J., Tavaria, M., Bertoncello, I., Drake, F., Zavarsek, S., Tellis, I., Hertzog, P. J., Debouck, C. & Kola, I., 1999, In : Journal of Bone and Mineral Research. p. 1654 - 1663 10 p.

Research output: Contribution to journalArticleResearchpeer-review

SCCS1 is a critical inhibitor of interferon Y signaling and prevents the potentially fatal neonatal actions of this cytokine

Alexander, W., Starr, R. J., Fenner, J., Scott, C. L., Handman, E., Sprigg, N. S., Corbin, J. E., Cornish, A. L., Darwiche, R., Owczarek, C. M., Kay, T. W., Nicola, N. A., Hertzog, P. J., Metcalf, D. & Hilton, D., 1999, In : Cell. p. 597 - 608 12 p.

Research output: Contribution to journalArticleResearchpeer-review

596 Citations (Scopus)

SOCS1 is a critical inhibitor of interferon γ signaling and prevents the potentially fatal neonatal actions of this cytokine

Alexander, W. S., Starr, R., Fenner, J. E., Scott, C. L., Handman, E., Sprigg, N. S., Corbin, J. E., Cornish, A. L., Darwiche, R., Owczarek, C. M., Kay, T. W. H., Nicola, N. A., Hertzog, P. J., Metcalf, D. & Hilton, D. J., 3 Sep 1999, In : Cell. 98, 5, p. 597-608 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1998
59 Citations (Scopus)

Administration of Imiquimod, an Interferon Inducer, in Asymptomatic Human Immunodeficiency Virus - Infected Persons to Determine Safety and Biologic Response Modification

Goldstein, D., Hertzog, P. J., Tomkinson, E., Couldwell, D., McCarville, S., Parrish, S., Cunningham, P., Newell, M., Owens, M. & Cooper, D. A., 1998, In : Journal of Infectious Diseases. p. 858 - 861 4 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Down syndrome and mouse models

Kola, I. & Hertzog, P. J., 1998, In : Current Opinion in Genetics and Development. p. 316 - 321 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptability to the oxidative stress-inducing agents parquat and hydrogen peroxide

De Haan, J. B., Bladier, C., Griffiths, P., Kelner, M. J., O'Shea, R. D., Cheung, N. S., Bronson, R. T., Silvestro, M. J., Wild, S., Zheng, S. S., Beart, P. M., Hertzog, P. J. & Kola, I., 1998, In : Journal of Biological Chemistry. p. 22528 - 22536 9 p.

Research output: Contribution to journalArticleResearchpeer-review

358 Citations (Scopus)

Mice with a Homozygous Null Mutation for the Most Abundant Glutathione Peroxidase, Gpx1, Show Increased Susceptibility to the Oxidative Stress-inducing Agents Paraquat and Hydrogen Peroxide

De Haan, J. B., Bladier, C., Griffiths, P., Kelner, M. J., Bronson, R. T., Silvestro, M. J., Wild, S., Zheng, S. S., Hertzog, P. J., Kola, I., O'Shea, R. D., Cheung, N. S. & Beart, P. M., 1998, In : Journal of Biological Chemistry. p. 22528 - 22536 9 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Recent advances in cytokines, Cytokine Receptors and Signal Transduction

Rubinstein, M., Dinarello, C. A., Oppenheim, J. J. & Hertzog, P. J., 1998, In : Cytokine and Growth Factor Reviews. p. 175 - 181 7 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

The Role of Ets-1 in Mast Cell Granulocyte-Macrophage Colony-Stimulating Factor Expression and Activation

McKinlay, L. H., Tymms, M. J., Thomas, R. S., Seth, A., Hasthorpe, S., Hertzog, P. J. & Kola, I., 1998, In : Journal of Immunology. p. 4099 - 4105 7 p.

Research output: Contribution to journalArticleResearchpeer-review

488 Citations (Scopus)

Type I IFNs Enhance the Terminal Differentiation of Dendritic Cells

Luft, T., Pang, K. C., Thomas, E., Hertzog, P. J., Hart, D. N. J., Trapani, J. A. & Cebon, J., 1998, In : Journal of Immunology. p. 1947 - 1953 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1997
14 Citations (Scopus)

A type I interferon signaling factor, ISF21, encoded on chromosome 21 is distinct from receptor components and their down-regulation and is necessary for transcriptional activation of interferon-regulated genes

Holland, K. A., Owczarek, C. M., Hwang, S. Y., Tymms, M. J., Constantinescu, S. N., Pfeffer, L. M., Kola, I. & Hertzog, P. J., 22 Aug 1997, In : Journal of Biological Chemistry. 272, 34, p. 21045-21051 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

A type I interferon signaling factor, ISF21, encoded on chromosome 21 is distinct from receptor components and their down-regulation and is necessary for transcritpional activation of interferon-regulated genes

Holland, K. A., Owczarek, C. M., Hwang, S. Y., Tymms, M. J., Constantinescu, S., Pfeffer, L. M., Kola, I. & Hertzog, P. J., 1997, In : Journal of Biological Chemistry. p. 21045 - 21051 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Cloning and characterisation of a novel component of the murine type I interferon receptor, IFNAR2

Hwang, S. Y., Owczarek, C. M., Holland, K. A., Weaver, B., Reich, N. C., Kola, I., Gulluyan, L. & Hertzog, P. J., 1997, In : Journal of Biological Chemistry. p. 23865 - 23870 6 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Cloning and characterization of soluble and transmembrane isoforms of a novel component of the murine type I interferon receptor, IFNAR 2

Owczarek, C. M., Hwang, S. Y., Holland, K. A., Gulluyan, L. M., Tavaria, M., Weaver, B., Reich, N. C., Kola, I. & Hertzog, P. J., 19 Sep 1997, In : Journal of Biological Chemistry. 272, 38, p. 23865-23870 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
5 Citations (Scopus)

Mechanisms of resistance of NSCLC to interferons Correlation with receptor regulation and type I IFN gene deletion

Hasthorpe, S., Holland, K. A., Nink, V., Lawler, C. B. & Hertzog, P. J., 1 Dec 1997, In : International journal of oncology. 10, 5, p. 933-938 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1996
18 Citations (Scopus)

Aberrant Activation of JAK/STAT Pathway Components in Response to G-CSF, Interferon-a/p and Interferon-y in NFS-60 Cells

Novak, U., Ward, A. C., Hertzog, P. J., Hamilton, J. A. & Paradiso, L., 1 Jan 1996, In : Growth Factors. 13, 42067, p. 251-260 10 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Binding of interferon-α and -β to a component of the human type I interferon receptor expressed in simian cells

Hwang, S. Y., Holland, K. A., Kola, I. & Hertzog, P. J., 1 Jan 1996, In : International Journal of Biochemistry and Cell Biology. 28, 8, p. 911-916 6 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Endogenous IFN-αβ suppresses colony-stimulating factor (CSF)-1-stimulated macrophage DNA synthesis and mediates inhibitory effects of lipopolysaccharide and TNF-α

Hamilton, J. A., Whitty, G. A., Kola, I. & Hertzog, P. J., 1 Apr 1996, In : Journal of Immunology. 156, 7, p. 2553-2557 5 p.

Research output: Contribution to journalArticleResearchpeer-review

1995
291 Citations (Scopus)

A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons α and β and alters macrophage responses

Hwang, S. Y., Hertzog, P. J., Holland, K. A., Sumarsono, S. H., Tymms, M. J., Hamilton, J. A., Whitty, G., Bertoncello, I. & Kola, I., 21 Nov 1995, In : Proceedings of the National Academy of Sciences of the United States of America. 92, 24, p. 11284-11288 5 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Constitutive and virus induced interferon production by peripheral blood leukocytes

Greenway, A. L., Hertzog, P. J., Devenish, R. J. & Linnane, A. W., 1 Jan 1995, In : Experimental Hematology. 23, 3, p. 229-235 7 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Human ERG is a proto-oncogene with mitogenic and transforming activity

Hart, A. H., Corrick, C. M., Tymms, M. J., Hertzog, P. J. & Kola, I., 1 Jan 1995, In : Oncogene. 10, 7, p. 1423-1430 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Structure-function studies based on in vitro expression.

Tymms, M. J. & Hertzog, P. J., 1 Jan 1995, In : Methods in molecular biology (Clifton, N.J.). 37, p. 317-335 19 p.

Research output: Contribution to journalArticleResearchpeer-review

1994
31 Citations (Scopus)

A gene on human chromosome 21 located in the region 21q22.2 to 21q22.3 encodes a factor necessary for signal transduction and antiviral response to type I interferons

Hertzog, P. J., Hwang, S. Y., Holland, K. A., Tymms, M. J., Iannello, R. & Kola, I., 13 May 1994, In : Journal of Biological Chemistry. 269, 19, p. 14088-14093 6 p.

Research output: Contribution to journalArticleResearchpeer-review

93 Citations (Scopus)

Decreased natural killer cell activity in endometriosis patients: Relationship to disease pathogenesis

Wilson, T. J., Hertzog, P. J., Angus, D., Munnery, L., Wood, E. C. & Kola, I., 1 Jan 1994, In : Fertility and Sterility. 62, 5, p. 1086-1088 3 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Detection of cells producing murine interferon‐α using antipeptide antibodies

Hwang, S. Y., Greenway, A. L., McMullen, G. L. L. & Hertzog, P. J., 1 Jan 1994, In : Immunology and Cell Biology. 72, 3, p. 234-240 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Detection of interferon‐alpha expression by PCR in patients with chronic hepatitis C and hepatitis non‐A, non‐B

Brandt, E. R. R., Devenish, R. J., Hertzog, P. J., Dudley, F. J. & Linnane, A. W., 1 Jan 1994, In : Journal of Gastroenterology and Hepatology. 9, 4, p. 373-380 8 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Immunolocalisation of interferon-alpha in hepatitis C patients and its correlation with response to interferon-alpha therapy

Greenway, A. L., Hertzog, P. J., Devenish, R. J., Dudley, F. J., McMullen, G. L. & Linnane, A. W., 1 Jan 1994, In : Journal of Hepatology. 21, 5, p. 842-852 11 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Structure-function analysis of human IFN-α: Mapping of a conformational epitope by homologue scanning

Wang, L., Hertzog, P. J., Galanis, M., Overall, M. L., Waine, G. J. & Linnane, A. W., 15 Jan 1994, In : Journal of Immunology. 152, 2, p. 705-715 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1993
8 Citations (Scopus)

Differentiation‐associated changes in mucin glycoprotein antigenicity in mucosa adjacent to rare gastrointestinal tract tumours of non‐mucosal origin

Pilbrow, S. J., Hertzog, P. J. & Linnane, A. W., 1 Jan 1993, In : Journal of Pathology. 169, 2, p. 259-267 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Expression of large intestinal mucin antigen (LIMA) epitopes in the normal and neoplastic gastrointestinal tract

Pilbrow, S. J., Hertzog, P. J., Pingzower, G. D. & Linnane, A. W., 1 Jan 1993, In : Journal of Pathology. 169, 3, p. 361-373 13 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Molecular detection of interferon-α expression in multiple sclerosis brain

Brandt, E. R., Mackay, I. R., Hertzog, P. J., Cheetham, B. F., Sherritt, M. & Bernard, C. C., 1993, In : Journal of Neuroimmunology. 44, 1, p. 1-5 5 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Post‐transcriptional regulation of interferon‐alpha 4 subtype production by lymphoblastoid cells

Greenway, A. L., Brandt, E. R., Hertzog, P. J., Devenish, R. J. & Linnane, A. W., 1 Jan 1993, In : Hematological Oncology. 11, 1, p. 7-21 15 p.

Research output: Contribution to journalArticleResearchpeer-review

1992
127 Citations (Scopus)

Antiproliferative potencies of interferons on melanoma cell lines and xenografts: Higher efficacy of interferon β

Johns, T. G., Mackay, I. R., Callister, K. A., Hertzog, P. J., Devenish, R. J. & Linnance, A. W., 5 Aug 1992, In : Journal of the National Cancer Institute. 84, 15, p. 1185-1190 6 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Different Interactions of Interferon-α Subtypes at the Surface of Epithelial and Lymphoid Cells

Overall, M. L., Chambers, P. & Hertzog, P. J., 1 Jan 1992, In : Journal of Interferon Research. 12, 4, p. 281-288 8 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Expression of a novel family of epitopes on small intestinal mucins in colorectal cancers, adjacent and remote mucosa

Pilbrow, S. J., Hertzog, P. J., Pinczower, G. D. & Linnane, A. W., 1 Jan 1992, In : Tumor Biology. 13, 5-6, p. 251-267 17 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Functional analysis of interferon-α subtypes using monoclonal antibodies to interferon-α 4a-subtype reactivity, neutralisation of biological activities and epitope analysis

Overall, M. L. & Hertzog, P. J., 1 Jan 1992, In : Molecular Immunology. 29, 3, p. 391-399 9 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Selective production of interferon-alpha subtypes by cultured peripheral blood mononuclear cells and lymphoblastoid cell lines

Greenway, A. L., Overall, M. L., Sattayasai, N., Rowley, M. J., Hertzog, P. J., McMullen, G. L., Cheetham, B. F. & Marzuki, S., 1 Jan 1992, In : Immunology. 75, 1, p. 182-188 7 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

The adenoma-carcinoma sequence in the colorectum - early appearance of a hierarchy of small intestinal mucin antigen (Sima) epitopes and correlation with malignant potential

Pilbrow, S. J., Hertzog, P. J. & Linnane, A. W., 1 Jan 1992, In : British Journal of Cancer. 66, 4, p. 748-757 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
132 Citations (Scopus)

Validation of the MTT dye assay for enumeration of cells in proliferative and antiproliferative assays

Loveland, B. E., Johns, T. G., Mackay, L. R., Vaillant, F., Wang, Z. X. & Hertzog, P. J., 1 Jan 1992, In : Biochemistry International. 27, 3, p. 501-510 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1991
12 Citations (Scopus)

Aberrant expression of intestinal mucin antigens associated with colorectal carcinoma defined by a panel of monoclonal antibodies

Hertzog, P. J., Pilbrow, S. J., Pedersen, J., Polglase, A. L., Lawson, M. & Linnane, A. W., 1 Jan 1991, In : British Journal of Cancer. 64, 5, p. 779-808 30 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
30 Citations (Scopus)

Intermittent interferonemia and interferon responses in multiple sclerosis

Hertzog, P. J., Wright, A., Harris, G., Linnane, A. W. & Mackay, I. R., 1 Jan 1991, In : Clinical Immunology and Immunopathology. 58, 1, p. 18-32 15 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Oncofetal expression of the human intestinal mucin glycoprotein antigens in gastrointestinal epithelium defined by monoclonal antibodies

Hertzog, P. J., Robinson, H. C., Ma, J., Mackay, I. R. & Linnane, A. W., 1 Jan 1991, In : International Journal of Cancer. 48, 3, p. 355-363 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Subtype-specificity of antipeptide antibodies raised against unique sequences of human interferons-α

Sattayasai, N., Marzuki, S., McMullen, G. L., Geysen, H. M., Mason, T. J., Hibbs, A. R., Overall, M., Hertzog, P. J. & Linnane, A. W., 1 Jan 1991, In : Molecular Immunology. 28, 9, p. 975-983 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1990
9 Citations (Scopus)

Comparative antiproliferative and receptor binding activities of interferons α and β on lymphoblastoid and melanoma cells

Hertzog, P. J., Johns, T. G., Callister, K. A., Dinatale, A. & Linnane, A. W., 1 Dec 1990, In : Biochemistry International. 22, 6, p. 1095-1102 8 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Pharmacokinetics, Tissue Distribution, and Cell Localization of [35S]Methionine-labeled Recombinant Human and Murine α Interferons in Mice

Johns, T. G., Kerry, J. A., Veitch, B. A. J., Mackay, I. R., Tutton, P. J., Tymms, M. J., Cheetham, B. F., Hertzog, P. J. & Linnane, A. W., 1 Aug 1990, In : Cancer Research. 50, 15, p. 4718-4723 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1989
3 Citations (Scopus)

Characterization of interferons produced by peripheral blood mononuclear cells from healthy subjects in response to Corynebacterium parvum or poly I: poly C

Hertzog, P. J., Cheetham, B. F., Sexton, J. L. & Linnane, A. W., 1 Dec 1989, In : Biochemistry International. 19, 6, p. 1427-1436 10 p.

Research output: Contribution to journalArticleResearchpeer-review