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Research Output 1975 2019

2019

A cell type-specific transcriptomic approach to map B cell and monocyte type I interferon-linked pathogenic signatures in Multiple Sclerosis

Severa, M., Rizzo, F., Srinivasan, S., Di Dario, M., Giacomini, E., Buscarinu, M. C., Cruciani, M., Etna, M. P., Sandini, S., Mechelli, R., Farina, A., Trivedi, P., Hertzog, P. J., Salvetti, M., Farina, C. & Coccia, E. M., 1 Jul 2019, In : Journal of Autoimmunity. 101, p. 1-16 16 p.

Research output: Contribution to journalArticleResearchpeer-review

A structural "star" in interferon gamma signaling

Hertzog, P. J. & de Weerd, N. A., 1 May 2019, In : Immunology and Cell Biology. 97, 5, p. 442-444 3 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access

Comparative metabolomics and transcriptomics reveal multiple pathways associated with polymyxin killing in pseudomonas aeruginosa

Han, M-L., Zhu, Y., Creek, D. J., Lin, Y-W., Gutu, A. D., Hertzog, P., Purcell, T., Shen, H-H., Moskowitz, S. M., Velkov, T. & Li, J., 1 Jan 2019, In : mSystems. 4, 1, 18 p., e00149-18.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2018

A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans

Zhang, G., Deweerd, N. A., Stifter, S. A., Liu, L., Zhou, B., Wang, W., Zhou, Y., Ying, B., Hu, X., Matthews, A. Y., Ellis, M., Triccas, J. A., Hertzog, P. J., Britton, W. J., Chen, X. & Feng, C. G., 1 Dec 2018, In : Nature Communications. 9, 1, 9 p., 85.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands

Faridi, P., Li, C., Ramarathinam, S. H., Vivian, J. P., Illing, P. T., Mifsud, N. A., Ayala, R., Song, J., Gearing, L. J., Hertzog, P. J., Ternette, N., Rossjohn, J., Croft, N. P. & Purcell, A. W., 12 Oct 2018, In : Science Immunology. 3, 28, 12 p., eaar3947.

Research output: Contribution to journalArticleResearchpeer-review

Concurrent host-pathogen transcriptional responses in a clostridium perfringens murine myonecrosis infection

Low, L-Y., Harrison, P. F., Gould, J., Powell, D. R., Choo, J. M., Forster, S. C., Chapman, R., Gearing, L. J., Cheung, J. K., Hertzog, P. & Rood, J. I., 1 Mar 2018, In : mBio. 9, 2, 15 p., e00473-18.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Defining the distinct, intrinsic properties of the novel type i interferon, IFNϵ

Stifter, S. A., Matthews, A. Y., Mangan, N. E., Fung, K. Y., Drew, A., Tate, M. D., Soares Da Costa, T. P., Hampsey, D., Mayall, J., Hansbro, P. M., Minambres, A. G., Eid, S. G., Mak, J., Scoble, J., Lovrecz, G., DeWeerd, N. A. & Hertzog, P. J., 1 Jan 2018, In : Journal of Biological Chemistry. 293, 9, p. 3168-3179 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Plasmacytoid dendritic cell heterogeneity is defined by CXCL10 expression following TLR7 stimulation

Marsman, C., Lafouresse, F., Liao, Y., Baldwin, T. M., Mielke, L. A., Hu, Y., Mack, M., Hertzog, P. J., de Graaf, C. A., Shi, W. & Groom, J. R., 1 Nov 2018, In : Immunology and Cell Biology. 96, 10, p. 1083-1094 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

A hot spot on interferon α/β receptor subunit 1 (IFNAR1) underpins its interaction with interferon-β and dictates signaling

de Weerd, N. A., Matthews, A. Y., Pattie, P. R., Bourke, N. M., Lim, S. S., Vivian, J. P., Rossjohn, J. & Hertzog, P. J., 5 May 2017, In : Journal of Biological Chemistry. 292, 18, p. 7554-7565 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Interferon epsilon promotes HIV restriction at multiple steps of viral replication

Garcia-Minambres, A., Eid, S. G., Mangan, N. E., Pade, C., Lim, S. S., Matthews, A. Y., de Weerd, N. A., Hertzog, P. J. & Johnson, M., May 2017, In : Immunology and Cell Biology. 95, 5, p. 478-483 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Mechanism of interferon-stimulated gene induction in HIV-1- infected macrophages

Nasr, N., Alshehri, A. A., Wright, T. K., Shahid, M., Heiner, B. M., Harman, A. N., Botting, R. A., Helbig, K. J., Beard, M. R., Suzuki, K., Kelleher, A. D., Hertzog, P. & Cunningham, A. L., 1 Oct 2017, In : Journal of Virology. 91, 20, 19 p., e00744-17.

Research output: Contribution to journalArticleResearchpeer-review

Regulation of H3K4me3 at Transcriptional Enhancers Characterizes Acquisition of Virus-Specific CD8+ T Cell-Lineage-Specific Function

Russ, B. E., Olshansky, M., Li, J., Nguyen, M. L. T., Gearing, L. J., Nguyen, T. H. O., Olson, M. R., McQuilton, H. A., Nüssing, S., Khoury, G., Purcell, D. F. J., Hertzog, P. J., Rao, S. & Turner, S. J., 19 Dec 2017, In : Cell Reports. 21, 12, p. 3624-3636 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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RNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammation

Wilson, J. A. C., Prow, N. A., Schroder, W. A., Ellis, J. J., Cumming, H. E., Gearing, L. J., Poo, Y. S., Taylor, A., Hertzog, P. J., Di Giallonardo, F., Hueston, L., Le Grand, R., Tang, B., Le, T. T., Gardner, J., Mahalingam, S., Roques, P., Bird, P. I. & Suhrbier, A., 16 Feb 2017, In : PLoS Pathogens. 13, 2, 32 p., e1006155.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Transcriptional dysregulation of Interferome in experimental and human Multiple Sclerosis

Srinivasan, S., Severa, M., Rizzo, F., Menon, R., Brini, E., Mechelli, R., Martinelli, V., Hertzog, P., Salvetti, M., Furlan, R., Martino, G., Comi, G., Coccia, E. & Farina, C., 1 Dec 2017, In : Scientific Reports. 7, 1, 9 p., 8981.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Type-I interferon signalling through IFNAR1 plays a deleterious role in the outcome after stroke

Zhang, M., Downes, C. E., Wong, C., Brody, K. M., Guio-Agulair, P. L., Gould, J., Ates, R., Hertzog, P. J., Taylor, J. M. & Crack, P. J., 1 Sep 2017, In : Neurochemistry International. 108, p. 472-480 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Antitumour actions of interferons: Implications for cancer therapy

Parker, B. S., Rautela, J. & Hertzog, P. J., 1 Mar 2016, In : Nature Reviews Cancer. 16, 3, p. 131-144 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii

Maifiah, M. H. M., Cheah, S-E., Johnson, M. D., Han, M., Boyce, J. D., Thamlikitkul, V., Forrest, A., Kaye, K. S., Hertzog, P., Purcell, A. W., Song, J., Velkov, T., Creek, D. J. & Li, J., 29 Feb 2016, In : Scientific Reports. 6, 17 p., 22287.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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IFNAR1-Signalling Obstructs ICOS-mediated Humoral Immunity during Non-lethal Blood-Stage Plasmodium Infection

Sebina, I., James, K. R., Soon, M. S. F., Fogg, L. G., Best, S. E., de Labastida Rivera, F. R., Montes de Oca, M., Amante, F. H., Thomas, B. S., Beattie, L., Souza-Fonseca-Guimaraes, F., Smyth, M. J., Hertzog, P. J., Hill, G. R., Hutloff, A., Engwerda, C. R. & Haque, A. K. M. N., 1 Nov 2016, In : PLoS Pathogens. 12, 11, e1005999.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Induction and suppression of antiviral RNA interference by influenza A virus in mammalian cells

Li, Y., Basavappa, M., Lu, J., Dong, S., Cronkite, D. A., Prior, J. T., Reinecker, H. C., Hertzog, P., Han, Y., Li, W. X., Cheloufi, S., Karginov, F. V., Ding, S. W. & Jeffrey, K. L., 5 Dec 2016, In : Nature Microbiology. 2, 9 p., 16250.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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New Interferons

Hertzog, P. J., Bourke, N. M., De Weerd, N. A. & Mangan, N. E., 27 Apr 2016, Encyclopedia of Immunobiology: Molecular Immunology. Radcliffe, M. J. H. (ed.). Oxford UK: Elsevier, Vol. 2. p. 501-508 8 p.

Research output: Chapter in Book/Report/Conference proceedingEncyclopaedia / Dictionary EntryOtherpeer-review

Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition

Tate, M. D., Ong, J. DH., Dowling, J. K., McAuley, J. L., Robertson, A. B., Latz, E., Drummond, G. R., Cooper, M. A., Hertzog, P. J. & Mansell, A., 10 Jun 2016, In : Scientific Reports. 6, 8 p., 27912.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons

Carroll, E. C., Jin, L., Mori, A., Muñoz-Wolf, N., Oleszycka, E., Moran, H. B. T., Mansouri, S., McEntee, C. P., Lambe, E. M., Agger, E. M., Andersen, P., Cunningham, C., Hertzog, P., Fitzgerald, K. A., Bowie, A. G. & Lavelle, E. C., 15 Mar 2016, In : Immunity. 44, 3, p. 597-608 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Blocking HIV-1 transmission in the female reproductive tract: from microbicide development to exploring local antiviral responses

Eid, S. G., Mangan, N., Hertzog, P. J. & Mak, J., 2015, In : Clinical and Translational Immunology. 4, 10, 9 p., e43.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Cytokine Receptors and Their Ligands

Dhagat, U., Nero, T. L., Kan, W. L., Hercus, T. R., Broughton, S. E., De Weerd, N. A., Jenkins, B. J., Mansell, A., Guthridge, M. A., Hertzog, P. J., Lopez, A. F. & Parker, M. W., 1 Jan 2015, Encyclopedia of Cell Biology: Functional Cell Biology. Bradshaw, R. A. & Stahl, P. D. (eds.). Waltham MA USA: Elsevier, Vol. 3. p. 22-36 15 p.

Research output: Chapter in Book/Report/Conference proceedingEncyclopaedia / Dictionary EntryOtherpeer-review

Dynamic control of type I interferon signalling by an integrated network of negative regulators

Porritt, R. A. & Hertzog, P. J., 2015, In : Trends in Immunology. 36, 3, p. 150 - 160 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Loss of host type-I IFN signaling accelerates metastasis and impairs NK-cell antitumor function in multiple models of breast cancer

Rautela, J., Baschuk, N., Slaney, C. Y., Jayatilleke, K. M., Xiao, K., Bidwell, B. N., Lucas, E. C., Hawkins, E., Lock, P., Wong, C. S. F., Chen, W., Anderson, R. L., Hertzog, P. J., Andrews, D. M., Moller, A. & Parker, B. S., 2015, In : Cancer Immunology Research. 3, 11, p. 1207 - 1217 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

MicroRNA as type I interferon-regulated transcripts and modulators of the innate immune response

Forster, S., Tate, M. & Hertzog, P. J., 2015, In : Frontiers in Immunology. 6, 9 p., 334.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Spatiotemporal requirements for IRF7 in mediating type I IFN-dependent susceptibility to blood-stage Plasmodium infection

Edwards, C. L., Best, S. E., Gun, S. Y., Claser, C., James, K. R., Montes de Oca, M., Sebina, I., de Labastida Rivera, F. R., Amante, F. H., Hertzog, P. J., Engwerda, C. R., Renia, L. & Haque, A. K. M. N., 2015, In : European Journal of Immunology. 45, 1, p. 130 - 141 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Antiviral responses in adipocytes - Viruses 'chew the fat'?

Hertzog, P. J., 2014, In : Immunology and Cell Biology. 92, 2, p. 100 - 102 3 p.

Research output: Contribution to journalLetterOther

Glucocorticosteroids enhance replication of respiratory viruses: effect of adjuvant interferon

Thomas, B., Porritt, R. A., Hertzog, P. J., Bardin, P. G. & Tate, M., 2014, In : Scientific Reports. 4, Art. ID: 7176, p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Identification of a pathogenic variant in TREX1 in early-onset cerebral systemic lupus erythematosus by Whole-exome sequencing

Ellyard, J. I., Jerjen, R., Martin, J. L., Lee, A. Y. S., Field, M. A., Jiang, S. H., Capello, J., Naumann, S. K., Andrews, T. D., Scott, H. S., Casarotto, M. G., Goodnow, C., Chaitow, J., Pascual, V., Hertzog, P. J., Alexander, S. I., Cook, M. C. & Vinuesa, C. G., 2014, In : Arthritis and Rheumatology. 66, 12, p. 3382 - 3386 5 p.

Research output: Contribution to journalArticleResearchpeer-review

In vivo comparison of local versus systemic delivery of immunostimulating siRNA in HPV-driven tumours

Khairuddin, N., Blake, S., Firdaus, F., Steptoe, R. J., Behlke, M. A., Hertzog, P. J. & McMillan, N. A. J., 2014, In : Immunology and Cell Biology. 92, 2, p. 156 - 163 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Production and action of Type 1 interferons in host defense

Hertzog, P. J., 2014, Bacterial Activation of Type I Interferons. Parker, D. (ed.). 1st ed. Switzerland: Springer, p. 1 - 15 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Purification and biological characterization of soluble, recombinant mouse IFNbeta expressed in insect cells

Stifter, S. A., Gould, J. A., Mangan, N., Reid, H. H., Rossjohn, J., Hertzog, P. J. & De Weerd, N. A., 2014, In : Protein Expression and Purification. 94, p. 7 - 14 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Soluble IFN receptor potentiates in vivo type I IFN signaling and exacerbates TLR4-mediated septic shock

Samarajiwa, S. A., Mangan, N., Hardy, M. P. A., Najdovska, M., Dubach, D., Braniff, S-J., Owczarek, C. M. & Hertzog, P. J., 2014, In : Journal of Immunology. 192, 9, p. 4425 - 4435 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The early monocytic response to cytomegalovirus infection is MyD88 dependent but occurs independently of common inflammatory cytokine signals

Wikstrom, M. E., Khong, A., Fleming, P., Kuns, R. D., Hertzog, P. J., Frazer, I. H., Andoniou, C. E., Hill, G. R. & Degli-Esposti, M. A., 2014, In : European Journal of Immunology. 44, 2, p. 409 - 419 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The role of Ets2 transcription factor in the induction of microRNA-155 (miR-155) by lipopolysaccharide and its targeting by interleukin-10

Quinn, S. R., Mangan, N., Caffrey, B. E., Gantier, M. P. M., Williams, B. R. G., Hertzog, P. J., McCoy, C. & O'Neill, L. A. J., 2014, In : Journal of Biological Chemistry. 289, 7, p. 4316 - 4325 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Type I IFN signaling in CD8- DCs impairs Th1-dependent malaria immunity

Haque, A. K. M. N., Best, S. E., Montes de Oca, M., James, K. R., Ammerdorffer, A., Edwards, C. L., de Labastida Rivera, F. R., Amante, F. H., Bunn, P. T., Sheel, M., Sebina, I., Koyama, M., Varelias, A., Hertzog, P. J., Kalinke, U., Gun, S. Y., Renia, L., Ruedl, C., MacDonald, K. P. A., Hill, G. R. & 1 othersEngwerda, C. R., 2014, In : Journal of Clinical Investigation. 124, 6, p. 2483 - 2496 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

CpG pretreatment enhances antiviral T-cell immunity against cytomegalovirus

Ong, M., Wikstrom, M. E., Fleming, P., Estcourt, M. J., Hertzog, P. J., Hill, G. R., Andoniou, C. E. & Degli-Esposti, M. A., 2013, In : Blood. 122, 1, p. 55 - 60 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Fine tuning type I interferon responses

Hertzog, P. J. & Williams, B. R. G., 2013, In : Cytokine and Growth Factor Reviews. 24, 3, p. 217 - 225 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Helicobacter pylori VacA suppresses Lactobacillus acidophilus-induced interferon beta signaling in macrophages via alterations in the endocytic pathway

Weiss, G., Forster, S., Irving, A. T., Tate, M., Ferrero, R. L., Hertzog, P. J., Frokiaer, H. & Liaskos, M., 2013, In : mBio. 4, 3, p. 1 - 10 10 p., e00609-12.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

IFNbeta-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage

Cheon, H., Holvey-Bates, E., Schoggins, J. W., Forster, S., Hertzog, P. J., Imanaka, N., Rice, C. M., Jackson, M. W., Junk, D. J. & Stark, G., 2013, In : EMBO Journal. 32, 20, p. 2751 - 2763 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Interferome v2.0: an updated database of annotated interferon-regulated genes

Rusinova, I., Forster, S., Yu, S. X., Kannan, A., Masse, M., Cumming, H. E., Chapman, R. & Hertzog, P. J., 2013, In : Nucleic Acids Research. 41, D1, p. D1040-D1046 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Interferon-epsilon protects the female reproductive tract from viral and bacterial infection

Fung, K. Y., Mangan, N., Cumming, H. E., Horvat, J. C., Mayall, J. R., Stifter, S. A., De Weerd, N. A., Roisman, L. C., Rossjohn, J., Roberston, S. A., Schjenken, J. E., Parker, B. S., Gargett, C. E., Nguyen, H. P. T., Carr, D. J. J., Hansbro, P. M. & Hertzog, P. J., 2013, In : Science. 339, 6123, p. 1088 - 1092 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Mitochondrially localised MUL1 is a novel modulator of antiviral signaling

Jenkins, K. A., Khoo, J. J., Sadler, A. J., Piganis, R. A. R., Wang, D., Borg, N., Hjerrild, K., Gould, J. A., Thomas, B., Nagley, P., Hertzog, P. J. & Mansell, A. S., 2013, In : Immunology and Cell Biology. 91, 4, p. 321 - 330 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Non-essential role for TLR2 and its signaling adaptor Mal/TIRAP in preserving normal lung architecture in mice

Ruwanpura, S. M., McLeod, L., Lilja, A., Brooks, G. D. C., Dousha, L., Seow, H. J., Bozinovski, S., Vlahos, R., Hertzog, P. J., Anderson, G. & Jenkins, B. J., 2013, In : PLoS ONE. 8, 10, 9 p., e78095.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Overview of cytokine and growth factor review focus on Australia

Hertzog, P. J. & Mangan, N., 2013, In : Cytokine and Growth Factor Reviews. 24, 3, p. 175 - 177 3 p.

Research output: Contribution to journalLetterOther

RNA-eXpress annotates novel transcript features in RNA-seq data

Forster, S., Finkel, A. M., Gould, J. A. & Hertzog, P. J., 2013, In : Bioinformatics. 29, 6, p. 810 - 812 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Structural basis of a unique interferon-beta signaling axis mediated via the receptor IFNAR1

De Weerd, N. A., Vivian, J., Nguyen, T. K., Mangan, N., Gould, J. A., Braniff, S-J., Zaker-Tabrizi, L., Fung, K. Y., Forster, S., Beddoe, T. C., Reid, H. H., Rossjohn, J. & Hertzog, P. J., 2013, In : Nature Immunology. 14, 9, p. 901 - 907 7 p.

Research output: Contribution to journalArticleResearchpeer-review

The role of Type I interferons in immunoregulation of breast cancer metastasis to the bone

Slaney, C. Y., Moller, A., Hertzog, P. J. & Parker, B. S., 2013, In : OncoImmunology. 2, 1 (Article #e22339), p. 1 - 3 3 p.

Research output: Contribution to journalLetterOther