Paul Gorry

Professor

20042020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2020

CXCR4-Using HIV Strains Predominate in Naive and Central Memory CD4+ T Cells in People Living with HIV on Antiretroviral Therapy: Implications for How Latency Is Established and Maintained

Roche, M., Tumpach, C., Symons, J., Gartner, M., Anderson, J. L., Khoury, G., Cashin, K., Cameron, P. U., Churchill, M. J., Deeks, S. G., Gorry, P. R. & Lewin, S. R., Mar 2020, In : Journal of Virology. 94, 6, 20 p., e01736-19.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)
2019

Flow Cytometry Analysis to Identify Human CD4+ T Cell Subsets

Flynn, J. & Gorry, P., 1 Jan 2019, In Vitro Differentiation of T-Cells: Methods and Protocols. Kaneko, S. (ed.). New York, NY: Humana Press, p. 15-25 11 p. (Methods in Molecular Biology; vol. 2048).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Flow Cytometry Analysis to Identify Human CD8+ T Cells

Flynn, J. & Gorry, P., 1 Jan 2019, In Vitro Differentiation of T-Cells: Methods and Protocols. Kaneko, S. (ed.). New York, NY: Humana Press, p. 1-13 13 p. (Methods in Molecular Biology; vol. 2048).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2017

Analysis of Clinical HIV-1 Strains with Resistance to Maraviroc Reveals Strain-Specific Resistance Mutations, Variable Degrees of Resistance, and Minimal Cross-Resistance to Other CCR5 Antagonists

Flynn, J. K., Ellenberg, P. C., Duncan, R., Ellett, A., Zhou, J., Sterjovski, J., Cashin, K., Borm, K., Gray, L. R., Lewis, M., Jubb, B., Westby, M., Lee, B., Lewin, S., Churchill, M., Roche, M. J. & Gorry, P. R., 1 Dec 2017, In : AIDS Research and Human Retroviruses. 33, 12, p. 1220-1235 16 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Professor Mark Wainberg

Benkirane, M., Berkhout, B., Borrow, P., Fassati, A., Fujii, M., Garcia, J. V., Gorry, P., Lever, A. M. L., Mak, J., Nijhuis, M., Strebel, K., Venter, F. & Weiss, R. A., 5 May 2017, In : Retrovirology. 14, 1, 30.

Research output: Contribution to journalEditorialOtherpeer-review

1 Citation (Scopus)
2016

CNS-specific regulatory elements in brain-derived HIV-1 strains affect responses to latency-reversing agents with implications for cure strategies

Gray, L. R., Cowley, D., Welsh, C., Lu, H. K., Brew, B. J., Lewin, S. R., Wesselingh, S. L., Gorry, P. R. & Churchill, M. J., 1 Apr 2016, In : Molecular Psychiatry. 21, 4, p. 574-584 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
16 Citations (Scopus)

Frequency and Env determinants of HIV-1 subtype C strains from antiretroviral therapy-naive subjects that display incomplete inhibition by maraviroc

Borm, K., Jakobsen, M. R., Cashin, K., Flynn, J. K., Ellenberg, P., Ostergaard, L., Lee, B., Churchill, M. J., Roche, M. & Gorry, P. R., 3 Nov 2016, In : Retrovirology. 13, 1, 13 p., 74.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
4 Citations (Scopus)

Genotypic Prediction of Co-receptor Tropism of HIV-1 Subtypes A and C

Riemenschneider, M., Cashin, K. Y., Budeus, B., Sierra, S., Shirvani-Dastgerdi, E., Bayanolhagh, S., Kaiser, R., Gorry, P. R. & Heider, D., 29 Apr 2016, In : Scientific Reports. 6, 9 p., 24883.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
17 Citations (Scopus)

i-bodies, human single domain antibodies that antagonize chemokine receptor CXCR4

Griffiths, K. M., Dolezal, O., Cao, B., Nilsson, S. K., See, H. B., Pfleger, K. D. G., Roche, M., Gorry, P. R., Pow, A., Viduka, K., Lim, K., Lu, B. G. C., Chang, D. H. C., Murray-Rust, T., Kvansakul, M., Perugini, M. A., Dogovski, C., Doerflinger, M., Zhang, Y., Parisi, K. & 3 others, Casey, J. L., Nuttall, S. D. & Foley, M., 10 Jun 2016, In : The Journal of Biological Chemistry. 291, 24, p. 12641-12657 27 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Molecular gymnastics: Mechanisms of HIV-1 resistance to CCR5 antagonists and impact on virus phenotypes

Roche, M., Borm, K., Flynn, J. K., Lewin, S. R., Churchill, M. J. & Gorry, P. R., 2016, In : Current Topics in Medicinal Chemistry. 16, 10, p. 1091-1106 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

5 Citations (Scopus)

Toxicity and in vitro activity of HIV-1 latency-reversing agents in primary CNS cells

Gray, L. R., On, H., Roberts, E., Lu, H. K., Moso, M. A., Raison, J. A., Papaioannou, C., Cheng, W-J., Ellett, A. M., Jacobson, J. C., Purcell, D. F. J., Wesselingh, S. L., Gorry, P. R., Lewin, S. R. & Churchill, M. J., 1 Aug 2016, In : Journal of Neurovirology. 22, 4, p. 455-463 9 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)
2015

HIV-1 transcriptional regulation in the central nervous system and implications for HIV cure research

Churchill, M. J., Cowley, D. J., Wesselingh, S. L., Gorry, P. R. & Gray, L. R., 16 Jun 2015, In : Journal of Neurovirology. 21, 3, p. 290-300 11 p.

Research output: Contribution to journalArticleOtherpeer-review

20 Citations (Scopus)

Inhibition of catechol-O-methyl transferase (COMT) by tolcapone restores reductions in microtubule-associated protein 2 (MAP2) and synaptophysin (SYP) following exposure of neuronal cells to neurotropic HIV

Lee, T. T., Chana, G., Gorry, P. R., Ellett, A., Bousman, C. A., Churchill, M. J., Gray, L. R. & Everall, I. P., Oct 2015, In : Journal of Neurovirology. 21, 5, p. 535-543 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
4 Citations (Scopus)

Reliable genotypic tropism tests for the major HIV-1 subtypes

Cashin, K., Gray, L. R., Harvey, K. L., Perez-Bercoff, D., Lee, G. Q., Sterjovski, J., Roche, M., Demarest, J. F., Drummond, F., Harrigan, P. R., Churchill, M. J. & Gorry, P. R., 25 Feb 2015, In : Scientific Reports. 5, 8 p., 8543.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
31 Citations (Scopus)

Role of macrophages in the immunopathogenesis of HIV-1 infection

Flynn, J. K. & Gorry, P. R., 1 Jan 2015, Global Virology I-Identifying and Investigating Viral Diseases. Shapshak, P., Sinnott, J. T., Somboonwit, C. & Kuhn, J. H. (eds.). New York NY USA: Springer, p. 723-744 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

1 Citation (Scopus)

T cell therapies-are T memory stem cells the answer?

Flynn, J. K. & Gorry, P. R., 1 Oct 2015, In : Annals of Translational Medicine. 3, 17, 251.

Research output: Contribution to journalEditorialOtherpeer-review

3 Citations (Scopus)
2014

Covariance of charged amino acids at positions 322 and 440 of HIV-1 Env contributes to coreceptor specificity of subtype B viruses, and can be used to improve the performance of V3 sequence-based coreceptor usage prediction algorithms

Cashin, K., Sterjovski, J., Harvey, K. L., Ramsland, P. A., Churchill, M. J. & Gorry, P. R., 2014, In : PLoS ONE. 9, 10, 11 p., e109771.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
9 Citations (Scopus)

Differences in coreceptor specificity contribute to alternative tropism of HIV-1 subtype C for CD4+ T-cell subsets, including stem cell memory T-cells

Cashin, K., Paukovics, G., Jakobsen, M. R., Østergaard, L., Churchill, M. J., Gorry, P. R. & Flynn, J. K., 12 Nov 2014, In : Retrovirology. 11, 1, 6 p., 97.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
20 Citations (Scopus)

Distinct HIV-1 entry phenotypes are associated with transmission, subtype specificity, and resistance to broadly neutralizing antibodies

Chikere, K., Webb, N. E., Chou, T., Borm, K., Sterjovski, J., Gorry, P. R. & Lee, B., 2014, In : Retrovirology. 11, 1 (Art. No.: 48), p. 1 - 19 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
19 Citations (Scopus)

Ex vivo response to histone deacetylase (HDAC) inhibitors of the HIV long terminal repeat (LTR) derived from HIV-infected patients on antiretroviral therapy

Lu, H. K., Gray, L. R., Wightman, F., Ellenberg, P. C., Khoury, G., Cheng, W-J., Mota, T. M., Wesselingh, S. L., Gorry, P. R., Cameron, P. U., Churchill, M. J. & Lewin, S. R., 2014, In : PLoS ONE. 9, 11, 9 p., e113341.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
14 Citations (Scopus)

HIV-1 entry and trans-infection of astrocytes involves CD81 vesicles

Gray, L. R., Turville, S., Hitchen, T. L., Cheng, W-J., Ellett, A., Salimi, H., Roche, M., Wesselingh, S. L., Gorry, P. R. & Churchill, M., 2014, In : PLoS ONE. 9, 2, 8 p., e90620.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
35 Citations (Scopus)

HIV-1 envelope-receptor interactions required for macrophage infection and implications for current HIV-1 cure strategies

Gorry, P. R., Francella, N., Lewin, S. R. & Collman, R. G., 2014, In : Journal of leukocyte biology. 95, 1, p. 71 - 81 11 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Inhibition of two temporal phases of HIV-1 transfer from primary langerhans cells to t cells: The role of langerin

Nasr, N., Lai, J., Botting, R. A., Mercier, S. K., Harman, A. N., Kim, M., Turville, S., Center, R. J., Domagala, T., Gorry, P. R., Olbourne, N. & Cunningham, A. L., 1 Sep 2014, In : Journal of Immunology. 193, 5, p. 2554-2564 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
22 Citations (Scopus)

Is the central nervous system a reservoir of HIV-1?

Gray, L. R., Roche, M., Flynn, J. K., Wesselingh, S. L., Gorry, P. R. & Churchill, M. J., 2014, In : Current Opinion in HIV and AIDS. 9, 6, p. 552-558 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

66 Citations (Scopus)

Quantifying susceptibility of CD4+ stem memory T-cells to infection by laboratory adapted and clinical HIV-1 strains

Flynn, J. K., Paukovics, G., Cashin, K., Borm, K., Ellett, A. M., Roche, M. J., Jakobsen, M. R., Churchill, M. J. & Gorry, P. R., 2014, In : Viruses. 6, 2, p. 709 - 726 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
16 Citations (Scopus)

Site-selective solid-phase synthesis of a CCR5 sulfopeptide library to interrogate HIV binding and entry

Liu, X., Malins, L. R., Roche, M. J., Sterjovski, J., Duncan, R., Garcia, M. L., Barnes, N., Anderson, D., Stone, M. J., Gorry, P. R. & Payne, R. J., 2014, In : ACS Chemical Biology. 9, 9, p. 2074 - 2081 8 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Stem memory T cells (TSCM)—their role in cancer and HIV immunotherapies

Flynn, J. K. & Gorry, P. R., 2014, In : Clinical & Translational Immunology. 3, 7, 7 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
File
2013

A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations

Roche, M. J., Salimi, H., Duncan, R. C., Wilkinson, B., Chikere, K., Moore, M. S., Webb, N., Zappi, H., Sterjovski, J., Flynn, J. K., Ellett, A., Gray, L. R., Lee, B., Jubb, B., Westby, M., Ramsland, P. A., Lewin, S. R., Payne, R. J., Churchill, M. & Gorry, P. R., 2013, In : Retrovirology. 10, 1 (Art. No.: 43), p. 1 - 20 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
50 Citations (Scopus)

Affinofile profiling: How efficiency of CD4/CCR5 usage impacts the biological and pathogenic phenotype of HIV

Chikere, K., Chou, T., Gorry, P. R. & Lee, B., 5 Jan 2013, In : Virology. 435, 1, p. 81-91 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

19 Citations (Scopus)

CoRSeqV3-C: a novel HIV-1 subtype C specific V3 sequence based coreceptor usage prediction algorithm

Cashin, K., Gray, L. R., Jakobsen, M. R., Sterjovski, J., Churchill, M. & Gorry, P. R., 2013, In : Retrovirology. 10, 1 (Art # 24), p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
25 Citations (Scopus)

Linkages between HIV-1 specificity for CCR5 or CXCR4 and in vitro usage of alternative coreceptors during progressive HIV-1 subtype C infection

Cashin, K., Jakobsen, M. R., Sterjovski, J., Roche, M. J., Ellett, A., Flynn, J. K., Borm, K., Gouillou, M., Churchill, M. & Gorry, P. R., 2013, In : Retrovirology. 10, 1 (Art. No.: 98), p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
14 Citations (Scopus)

Longitudinal analysis of CCR5 and CXCR4 usage in a cohort of antiretroviral therapy-naive subjects with progressive HIV-1 subtype C infection

Jakobsen, M. R., Cashin, K., Roche, M., Sterjovski, J., Ellett, A., Borm, K., Flynn, J. K., Erikstrup, C., Gouillou, M., Gray, L. R., Saksena, N. K., Wang, B., Purcell, D. F., Kallestrup, P., Zinyama-Gutsire, R., Gomo, E., Ullum, H., Ostergaard, L., Lee, B., Ramsland, P. A. & 2 others, Churchill, M. & Gorry, P. R., 2013, In : PLoS ONE. 8, 6, 13 p., e65950.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
23 Citations (Scopus)

Macrophage-tropic HIV-1 variants from brain demonstrate alterations in the way gp120 engages both CD4 and CCR5

Salimiseyedabad, H., Roche, M., Webb, N., Gray, L. R., Chikere, K., Sterjovski, J., Ellett, A., Wesselingh, S. L., Ramsland, P. A., Lee, B., Churchill, M. & Gorry, P. R., 2013, In : Journal of leukocyte biology. 93, 1, p. 113 - 126 14 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Reduced basal transcriptional activity of central nervous system-derived HIV type 1 long terminal repeats

Gray, L. R., Cowley, D., Crespan, E., Welsh, C., Mackenzie, C., Wesselingh, S. L., Gorry, P. R. & Churchill, M. J., 2013, In : AIDS Research and Human Retroviruses. 29, 2, p. 365 - 370 6 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

The magnitude of HIV-1 resistance to the CCR5 antagonist maraviroc may impart a differential alteration in HIV-1 tropism for macrophages and T-cell subsets

Flynn, J. K., Paukovics, G., Moore, M. S., Ellett, A., Gray, L. R., Duncan, R., Salimi, H., Jubb, B., Westby, M., Purcell, D. F. J., Lewin, S. R., Lee, B., Churchill, M., Gorry, P. R. & Roche, M. J., 2013, In : Virology. 422, 1, p. 51 - 58 8 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

The NRTIs lamivudine, stavudine and zidovudine have reduced HIV-1 inhibitory activity in astrocytes

Gray, L. R., Tachedjian, G., Ellett, A., Roche, M. J., Cheng, W-J., Guillemin, G. J., Brew, B. J., Turville, S., Wesselingh, S. L., Gorry, P. R. & Churchill, M., 2013, In : PLoS ONE. 8, 4, 7 p., e62196.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
34 Citations (Scopus)
2012

A new way of measuring apoptosis by absolute quantitation of inter-nucleosomally fragmented genomic DNA

Hooker, D. J., Mobarok, M., Anderson, J. L., Rajasuriar, R., Gray, L. R., Ellett, A. M., Lewin, S. R., Gorry, P. R. & Cherry, C. L., 2012, In : Nucleic Acids Research. 40, 15 (e113), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

Corrigendum to "V3 determinants of HIV-1 escape from the CCR5 inhibitors Maraviroc and Vicriviroc" [Virology 427 (2012) 158-165]

Berro, R., Klasse, P. J., Jakobsen, M. R., Gorry, P. R., Moore, J. P. & Sanders, R. W., 20 Jun 2012, In : Virology. 428, 1, p. 76 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Structural elements of primary CCR5-using HIV-1 gp120 proteins influencing sensitivity and resistance to the broadly neutralizing monoclonal antibody b12

Sterjovski, J., Churchill, M., Ellett, A., Wesselingh, S. L., Ramsland, P. A. & Gorry, P. R., 2012, In : Virology. 432, 2, p. 394 - 404 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)
2011

Alternative coreceptor requirements for efficient CCR5- and CXCR4-mediated HIV-1 entry into macrophages

Cashin, K., Roche, M., Sterjovski, J., Ellett, A., Gray, L. R., Cunningham, A., Ramsland, P., Churchill, M. & Gorry, P., 2011, In : Journal of Virology. 85, 20, p. 10699 - 10709 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
21 Citations (Scopus)

CD4 and MHC class 1 down-modulation activities of nef alleles from brain-and lymphoid tissue-derived primary HIV-1 isolates

Gray, L. R., Gabuzda, D., Cowley, D., Ellett, A., Chiavaroli, L., Wesselingh, S. L., Churchill, M. J. & Gorry, P. R., 2011, In : Journal of Neurovirology. 17, 1, p. 82 - 91 10 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

CD4-binding site alterations in CCR5-using HIV-1 envelopes influencing gp120-CD4 interactions and fusogenicity

Sterjovski, J., Churchill, M. J., Roche, M., Ellett, A., Farrugia, W., Wesselingh, S. L., Cunningham, A. L., Ramsland, P. A. & Gorry, P. R., 20 Feb 2011, In : Virology. 410, 2, p. 418-428 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
23 Citations (Scopus)

Conformational alterations in the CD4 binding cavity of HIV-1 gp120 influencing gp120-CD4 interactions and fusogenicity of HIV-1 envelopes derived from brain and other tissues

Gray, L. R., Sterjovski, J., Ramsland, P., Churchill, M. & Gorry, P., 2011, In : Retrovirology. 8, 42, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
9 Citations (Scopus)

Coreceptors and HIV-1 pathogenesis

Gorry, P. R. & Ancuta, P., Mar 2011, In : Current HIV/AIDS Reports. 8, 1, p. 45-53 9 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

90 Citations (Scopus)

Genetic and functional heterogeneity of CNS-derived tat alleles from patients with HIV-associated dementia

Cowley, D., Gray, L. R., Wesselingh, S. L., Gorry, P. R. & Churchill, M., 2011, In : Journal of Neurovirology. 17, p. 70 - 81 11 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

HIV-1 escape from the CCR5 antagonist maraviroc associated with an altered and less-efficient mechanism of gp120-CCR5 engagement that attenuates macrophage tropism

Roche, M., Jakobsen, M., Sterjovski, J., Ellett, A., Posta, F., Lee, B., Jubb, B., Westby, M., Lewin, S. R., Ramsland, P. A., Churchill, M. & Gorry, P. R., 2011, In : Journal of Virology. 85, 9, p. 4330 - 4342 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
62 Citations (Scopus)

HIV-1 predisposed to acquiring resistance to maraviroc (MVC) and other CCR5 antagonists in vitro has an inherent, low-level ability to utilize MVC-bound CCR5 for entry

Roche, M., Jakobsen, M., Ellett, A., Salimiseyedabad, H., Jubb, B., Westby, M., Lee, B., Lewin, S. R., Churchill, M. & Gorry, P. R., 2011, In : Retrovirology. 8, 89, p. 1 - 7 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
37 Citations (Scopus)

Increased sensitivity to broadly neutralizing antibodies of end-stage disease R5 HIV-1 correlates with evolution in Env glycosylation and charge

Borggren, M., Repits, J., Sterjovski, J., Uchtenhagen, H., Churchill, M. J., Karlsson, A., Albert, J., Achour, A., Gorry, P. R., Fenyo, E. M. & Jansson, M., 2011, In : PLoS ONE. 6, 6, 9 p., e20135.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
15 Citations (Scopus)

Virucidal activity of the dendrimer microbicide SPL7013 against HIV-1

Telwatte, S., Moore, K., Johnson, A., Tyssen, D., Sterjovski, J., Aldunate, M., Gorry, P. R., Ramsland, P., Lewis, G., Paull, J., Sonza, S. & Tachedjian, G., 2011, In : Antiviral Research. 90, 3, p. 195 - 199 5 p.

Research output: Contribution to journalArticleResearchpeer-review

68 Citations (Scopus)
2010

An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopes

Sterjovski, J., Roche, M. J., Churchill, M., Ellett, A., Farrugia, W., Gray, L. R., Cowley, D., Poumbourios, P., Lee, B., Wesselingh, S. L., Cunningham, A. L., Ramsland, P. A. & Gorry, P. R., 2010, In : Virology. 404, 2, p. 269 - 278 10 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)