Paul Coughlin

Adj ClinAssProf

1993 …2020
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Research Output 1993 2017

2017

Primary analysis of a phase II open-label trial of INCB039110, a selective JAK1 inhibitor, in patients with myelofibrosis

Mascarenhas, J. O., Talpaz, M., Gupta, V., Foltz, L. M., Savona, M. R., Paquette, R. L., Turner, A. R., Coughlin, P., Winton, E. F., Burn, T. C., O'Neill, P., Clark, J. V., Hunter, D. S., Assad, A., Hoffman, R. & Verstovsek, S., 2017, In : Haematologica: the hematology journal. 102, 2, p. 327-335 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The fibrinolysis inhibitor α2-antiplasmin restricts lymphatic remodelling and metastasis in a mouse model of cancer

Paquet-Fifield, S., Roufail, S., Zhang, Y. F., Sofian, T., Byrne, D. J., Coughlin, P. B., Fox, S. B., Stacker, S. A. & Achen, M. G., 11 Jul 2017, In : Growth Factors. 35, 2-3, p. 61-75 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2013

Implementation of a clinical prediction tool for pulmonary embolism diagnosis in a tertiary teaching hospital reduces the number of computed tomography pulmonary angiograms performed

Ong, C., Malipatil, V., Lavercombe, M., Teo, K. G. W., Coughlin, P. B., Leach, D. S., Spanger, M. & Thien, F., 2013, In : Internal Medicine Journal. 43, 2, p. 169 - 174 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

The x-ray crystal structure of full-length human plasminogen

Law, R. HP., Caradoc-Davies, T. T., Cowieson, N. P., Horvath, A. J., Quek, A. J., Amarante Da Encarnacao, J., Steer, D. L., Cowan, A. D., Zhang, Q., Lu, B. GC., Pike, R. N., Smith, A. I., Coughlin, P. B. & Whisstock, J. C., 2012, In : Cell Reports. 1, 3, p. 185 - 190 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Two missense mutations identified in venous thrombosis patients impair the inhibitory function of the protein Z dependent protease inhibitor

Young, L., Birch, N., Browett, P. J., Coughlin, P. B., Horvath, A. J., van de Water, N. S., Ockelford, P. A. & Harper, P. L., 2012, In : Thrombosis and Haemostasis. 107, 5, p. 854 - 863 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Contribution of conserved lysine residues in the alpha{2}-antiplasmin C terminus to plasmin binding and inhibition

Lu, B. G. C., Sofian, T., Law, R. HP., Coughlin, P. B. & Horvath, A. J., 2011, In : Journal of Biological Chemistry. 286, 28, p. 24544 - 24552 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Desmoteplase-mediated plasminogen activation and clot lysis are inhibited by the lysine analogue tranexamic acid

Niego, B., Horvath, A. J., Coughlin, P. B., Pugsley, M. K. & Medcalf, R. L., 2008, In : Blood Coagulation and Fibrinolysis. 19, 4, p. 322 - 324 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Expression of the serpin centerin defines a germinal center phenotype in B-cell lymphomas

Paterson, M. A., Hosking, P. & Coughlin, P. B., 2008, In : American Journal of Clinical Pathology. 130, 1, p. 117 - 126 10 p.

Research output: Contribution to journalArticleResearchpeer-review

X-ray crystal structure of the fibrinolysis inhibitor alpha2-antiplasmin

Law, R. H. P., Sofian, T., Kan, W-T., Horvath, A. J., Hitchen, C. R., Langendorf, C., Buckle, A. M., Whisstock, J. & Coughlin, P. B., 2008, In : Blood. 111, p. 2049 - 2052 3 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

Molecular characterization of centerin, a germinal centre cell serpin

Paterson, M. A., Horvath, A. J., Pike, R. N. & Coughlin, P. B., 2007, In : Biochemical Journal. 405, 3, p. 489 - 494 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Mouse Serpins and Transgenic Studies

Askew, D. J., Coughlin, P. B. & Bird, P. I., 2007, Molecular and Cellular Aspects of the Serpinopathies and Disorders in Serpin Activity. Silverman, G. A. & Lomas, D. A. (eds.). 1st ed. Singapore: World Scientific Publishing, p. 101 - 130 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

2006

Scurvy in an otherwise well young man

Mapp, S. J. & Coughlin, P. B., 2006, In : Medical Journal of Australia. 185, 6, p. 331 - 332 2 p.

Research output: Contribution to journalArticleOther

Stage specific gene expression of serpins and their cognate proteases during myeloid differentiation

Missen, M. A., Haylock, D. N., Whitty, G., Medcalf, R. L. & Coughlin, P. B., 2006, In : British Journal of Haematology. 135, 5, p. 715 - 724 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2005

Antiplasmin: the forgotten serpin?

Coughlin, P. B., 2005, In : FEBS Journal. 272, 19, p. 4852 - 4857 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization

Winkler, I. G., Hendy, J. A., Coughlin, P. B., Horvath, A. J. & Levesque, J-P., 2005, In : Journal of Experimental Medicine. 201, 7, p. 1077 - 1088 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The Australian Cancer Anaemia Survey: a snapshot of anaemia in adult patients with cancer

Sheshadri, T. B., Prince, M. H., Bell, D. R., Coughlin, P. B., James, P. P., Richardson, G. E., Chern, B., Briggs, P., Norman, J., Olver, I. N., Karapetis, C. & Stewart, J., 2005, In : Medical Journal of Australia. 182, 9, p. 453 - 457 5 p.

Research output: Contribution to journalArticleResearchpeer-review

The murine orthologue of human antichymotrypsin: a structural paradigm for CLADE A3 serpins

Horvath, A. J., Irving, J. A., Rossjohn, J., Law, R. H. P., Bottomley, S. P., Quinsey, N. S., Pike, R. N., Coughlin, P. B. & Whisstock, J., 2005, In : Journal of Biological Chemistry. 280, 52, p. 43168 - 43178 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2004

Expression Patterns of Murine Antichymotrypsin-like Genes Reflect Evolutionary Divergence at the Serpina3 Locus

Horvath, A. J., Forsyth, S. L. & Coughlin, P. B., 2004, In : Journal of Molecular Evolution. 59, 4, p. 488 - 497 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Warfarin reversal: consensus guidelines, on behalf of the Australasian Society of Thrombosis and Haemostasis

Baker, R. I., Coughlin, P. B., Gallus, A. S., Harper, P. L., Salem, H. H. & Wood, E. M., 2004, In : Medical Journal of Australia. 181, 9, p. 492 - 497 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2003

A review and comparison of the murine a1-antitrypsin and a1 -antichymotrypsin multigene clusters with the human clade A serpins

Forsyth, S. L., Horvath, A. J. & Coughlin, P. B., 2003, In : Genomics. 81, p. 336 - 345 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Introduction of a mutation in the shutter region of antithrombin (Phe77 Leu) increases affinity for heparin and decreases thermal stability

Quinsey, N. S., Fitton, H. L., Coughlin, P. B., Whisstock, J. C., Dafforn, T. R., Carrell, R. W., Bottomley, S. P. & Pike, R. N., 2003, In : Biochemistry. 42, 34, p. 10169 - 10173 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Murine serpin 2A is a redox-sensitive intracellular protein

Morris, E. C., Dafforn, T. R., Forsyth, S. L., Missen, M. A., Horvath, A. J., Hampson, L., Hampson, I. N., Currie, G., Carrell, R. W. & Coughlin, P. B., 2003, In : Biochemical Journal. 371, 1, p. 165 - 173 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2001

The serpins are an expanding superfamily of structurally similar but functionally diverse proteins

Silverman, G. A., Bird, P. I., Carrell, R. W., Church, F. C., Coughlin, P. B., Gettins, P. G. W., Irving, J., Lomas, D. A., Luke, C., Moyer, R. W., Pemberton, P. A., Remold-O'Donnell, E., Salvesen, G. S., Travis, J. & Whisstock, J. C., 2001, In : Journal of Biological Chemistry. 276, 36, p. 33293 - 33296 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2000

The role of granzymes and serpins in regulating cell growth and death

Coughlin, P. B., Morris, E. & Hampson, L., 2000, Programmed celll death in animals and plants. Oxford UK: BIOS Scientific Publishers, p. 55 - 64 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

1998

Angiotensinogen cleavage by renin: importance of a structurally constrained N-terminus

Streatfeild-James, R. M., Williamson, D., Pike, R. N., Tewksbury, D., Carrell, R. W. & Coughlin, P. B., 1998, In : FEBS Letters. p. 267 - 270 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Proteinase inhibitor 6 (PI-6) expression in human skin: Induction of PI-6 and a PI-6/Proteinase complex during keratinocyte differentiation

Bird, P. I., Cerruti, L., Scott, F. L., Coughlin, P. B., Salem, H. H. & Paddle-Ledinek, J. E., 1998, In : Experimental Cell Research. p. 263 - 271 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1996

A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes

Sun, J., Bird, C. H., Sutton, V., McDonald, L., Coughlin, P. B., De Jong, T. A., Trapani, J. A. & Bird, P. I., 13 Nov 1996, In : Journal of Biological Chemistry. 271, 44, p. 27802-27809 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Proteinase inhibitor 6 cannot be secreted, which suggests it is a new type of cellular serpin

Scott, F. L., Coughlin, P. B., Bird, C., Cerruti, L., Hayman, J. A. & Bird, P., 19 Jan 1996, In : Journal of Biological Chemistry. 271, 3, p. 1605-1612 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1995

Chromosomal mapping of the human proteinase inhibitor 6 (PI6) gene to 6p25 by fluorescence in situ hybridization

Coughlin, P., Nicholl, J., Sun, J., Salem, H., Bird, P. & Sutherland, G. R., 1 Jan 1995, In : Genomics. 26, 2, p. 431-433 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Production and characterization of recombinant human proteinase inhibitor 6 expressed in Pichia pastoris

Sun, J., Coughlin, P., Salem, H. H. & Bird, P., 27 Sep 1995, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1252, 1, p. 28-34 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1993

Cloning and molecular characterization of a human intracellular serine proteinase inhibitor

Coughlin, P., Sun, J., Cerruti, L., Salem, H. H. & Bird, P., 3 Nov 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 20, p. 9417-9421 5 p.

Research output: Contribution to journalArticleResearchpeer-review