If you made any changes in Pure these will be visible here soon.

Research Output 2009 2019

2019

Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding

Quek, A. J. H., Mazzitelli, B. A., Wu, G., Leung, E. W. W., Caradoc-Davies, T. T., Lloyd, G. J., Jeevarajah, D., Conroy, P. J., Sanderson-Smith, M., Yuan, Y., Ayinuola, Y. A., Castellino, F. J., Whisstock, J. C. & Law, R. H. P., 8 Jul 2019, (Accepted/In press) In : Journal of Molecular Biology. 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Tranexamic acid is an active site inhibitor of urokinase plasminogen activator

Wu, G., Mazzitelli, B. A., Quek, A. J., Veldman, M. J., Conroy, P. J., Caradoc-Davies, T. T., Ooms, L. M., Tuck, K. L., Schoenecker, J. G., Whisstock, J. C. & Law, R. H. P., 12 Mar 2019, In : Blood Advances. 3, 5, p. 729-733 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3

Traore, D. A. K., Wisniewski, J. A., Flanigan, S. F., Conroy, P. J., Panjikar, S., Mok, Y-F., Lao, C., Griffin, M. D. W., Adams, V., Rood, J. I. & Whisstock, J. C., 13 Sep 2018, In : Nature Communications. 9, 1, 11 p., 3732.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin

Brennan, A. J., Law, R. H. P., Conroy, P. J., Noori, T., Lukoyanova, N., Saibil, H., Yagita, H., Ciccone, A., Verschoor, S., Whisstock, J. C., Trapani, J. A. & Voskoboinik, I., 7 Feb 2018, In : Cell Death and Differentiation. 25, p. 1517-1529 13 p.

Research output: Contribution to journalArticleResearchpeer-review

The first transmembrane region of complement component-9 acts as a brake on its self-assembly

Spicer, B. A., Law, R. H. P., Caradoc-Davies, T. T., Ekkel, S. M., Bayly-Jones, C., Pang, S-S., Conroy, P. J., Ramm, G., Radjainia, M., Venugopal, H., Whisstock, J. C. & Dunstone, M. A., 15 Aug 2018, In : Nature Communications. 9, 1, 7 p., 3266.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2017

Antibodies: From novel repertoires to defining and refining the structure of biologically important targets

Conroy, P. J., Law, R. H. P., Caradoc-Davies, T. T. & Whisstock, J. C., 1 Mar 2017, In : Methods. 116, p. 12-22 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Homodimerization attenuates the anti-inflammatory activity of interleukin-37

Ellisdon, A. M., Nold-Petry, C. A., D'Andrea, L., Cho, S. X., Lao, J. C., Rudloff, I., Ngo, D., Lo, C. Y., Soares da Costa, T. P., Perugini, M. A., Conroy, P. J., Whisstock, J. C. & Nold, M. F., 10 Feb 2017, In : Science Immunology. 2, 8, 12 p., eaaj1548.

Research output: Contribution to journalArticleResearchpeer-review

Perforin-A key (shaped) weapon in the immunological arsenal

Spicer, B. A., Conroy, P. J., Law, R. H. P., Voskoboinik, I. & Whisstock, J. C., Dec 2017, In : Seminars in Cell and Developmental Biology. 72, p. 117-123 7 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors

Law, R. H. P., Wu, G., Leung, E. W. W., Hidaka, K., Quek, A. J., Caradoc-Davies, T. T., Jeevarajah, D., Conroy, P. J., Kirby, N. M., Norton, R. S., Tsuda, Y. & Whisstock, J. C., 2017, In : Blood Advances. 1, 12, p. 766-771 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Circumventing the stability-function trade-off in an engineered FN3 domain

Porebski, B. T., Conroy, P. J., Drinkwater, N., Schofield, P., Vazquez-Lombardi, R., Hunter, M. R., Hoke, D. E., Christ, D., McGowan, S. & Buckle, A. M., 1 Nov 2016, In : Protein Engineering, Design and Selection. 29, 11, p. 541-550 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Comprehensive N-glycan profiling of avian immunoglobulin Y

Gilgunn, S., Martín, S. M., Wormald, M. R., Zapatero-Rodríguez, J., Conroy, P. J., O'Kennedy, R. J., Rudd, P. M. & Saldova, R., 26 Jul 2016, In : PLoS ONE. 11, 7, 14 p., e0159859.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

CORRIGENDUM: N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin

Smith, A. I., Rajapakse, N. W., Kleifeld, O., Lomonte, B., Sikanyika, N. L., Spicer, A. J., Hodgson, W. C., Conroy, P., Small, D. H., Kaye, D. M., Parkington, H. C., Whisstock, J. & Kuruppu, D. M. S., 2016, In : Scientific Reports. 6, Article # 24333, p. 1 - 1 1 p.

Research output: Contribution to journalArticleOther

Eosinophil peroxidase activates cells by HER2 receptor engagement and β1-integrin clustering with downstream MAPK cell signaling

Hennigan, K., Conroy, P. J., Walsh, M. T., Amin, M., O'Kennedy, R., Ramasamy, P., Gleich, G. J., Siddiqui, Z., Glynn, S., McCabe, O., Mooney, C., Harvey, B. J., Costello, R. W. & McBryan, J., 1 Oct 2016, In : Clinical Immunology. 171, p. 1-11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin

Smith, A. I., Rajapakse, N. W., Kleifeld, O., Lomonte, B., Sikanyika, N. L., Spicer, A. J., Hodgson, W. C., Conroy, P. J., Small, D. H., Kaye, D. M., Parkington, H. C., Whisstock, J. C. & Kuruppu, S. M. S., 2 Mar 2016, In : Scientific Reports. 6, 10 p., 22413.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Structure of the poly-C9 component of the complement membrane attack complex

Dudkina, N. V., Spicer, B. A., Reboul, C. F., Conroy, P. J., Lukoyanova, N., Elmlund, H., Law, R. HP., Ekkel, S. M., Kondos, S. C., Goode, R. J. A., Ramm, G., Whisstock, J. C., Saibil, H. R. & Dunstone, M. A., 4 Feb 2016, In : Nature Communications. 7, 6 p., 10588.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2015

Electrochemiluminescence platform for the detection of C-reactive proteins: application of recombinant antibody technology to cardiac biomarker detection

O'Reilly, E. J., Conroy, P. J., Hearty, S., Keyes, T. E., O'Kennedy, R., Forster, R. J. & Dennany, L., 31 Jul 2015, In : RSC Advances. 5, 83, p. 67874-67877 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Investigation of the mechanism of interaction between Mannose-binding lectin-associated serine protease-2 and complement C4

Drentin, N. C., Conroy, P., Gunzburg, M. J., Pike, R. N. & Wijeyewickrema, L. C., 2015, In : Molecular Immunology. 67, 2, p. 287 - 293 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes

Yagi, H., Conroy, P. J., Leung, E. W. W., Law, R. H. P., Trapani, J. A., Voskoboinik, I., Whisstock, J. & Norton, R. S., 2015, In : Journal of Biological Chemistry. 290, 42, p. 25213-25226 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Reconciling the structural attributes of avian antibodies

Conroy, P., Law, R. H. P., Gilgunn, S., Hearty, S., Caradoc-Davies, T. T., Lloyd, G., O'Kennedy, R. & Whisstock, J., 2014, In : Journal of Biological Chemistry. 289, 22, p. 15384 - 15392 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

Aberrant PSA glycosylation-a sweet predictor of prostate cancer

Gilgunn, S., Conroy, P., Saldova, R., Rudd, P. M. & O'Kennedy, R., 2013, In : Nature Reviews Urology. 10, 2, p. 99 - 107 9 p.

Research output: Contribution to journalArticleResearchpeer-review

A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications

Byrne, H., Conroy, P., Whisstock, J. & O'Kennedy, R., 2013, In : Trends in Biotechnology. 31, 11, p. 621 - 632 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Cardiac troponin I: a case study in rational antibody design for human diagnostics

Conroy, P., O'Kennedy, R. & Hearty, S., 2012, In : Protein Engineering, Design and Selection. 25, 6, p. 295 - 305 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

Surface plasmon resonance for vaccine design and efficacy studies: recent applications and future trends

Hearty, S., Conroy, P., Ayyar, B. V., Byrne, B. & O'Kennedy, R., 2010, In : Expert Review of Vaccines. 9, 6, p. 645 - 664 20 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Antibody production, design and use for biosensor-based applications

Conroy, P., Hearty, S., Leonard, P. & O'Kennedy, R., 2009, In : Seminars in Cell and Developmental Biology. 20, 1, p. 10 - 26 17 p.

Research output: Contribution to journalArticleResearchpeer-review