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Research Output 2009 2019

2019

Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding

Quek, A. J. H., Mazzitelli, B. A., Wu, G., Leung, E. W. W., Caradoc-Davies, T. T., Lloyd, G. J., Jeevarajah, D., Conroy, P. J., Sanderson-Smith, M., Yuan, Y., Ayinuola, Y. A., Castellino, F. J., Whisstock, J. C. & Law, R. H. P., 6 Sep 2019, In : Journal of Molecular Biology. 431, 19, p. 3804-3813 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1

Pang, S. S., Bayly-Jones, C., Radjainia, M., Spicer, B. A., Law, R. H. P., Hodel, A. W., Parsons, E. S., Ekkel, S. M., Conroy, P. J., Ramm, G., Venugopal, H., Bird, P. I., Hoogenboom, B. W., Voskoboinik, I., Gambin, Y., Sierecki, E., Dunstone, M. A. & Whisstock, J. C., 19 Sep 2019, In : Nature Communications. 10, 1, 9 p., 4288.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Tranexamic acid is an active site inhibitor of urokinase plasminogen activator

Wu, G., Mazzitelli, B. A., Quek, A. J., Veldman, M. J., Conroy, P. J., Caradoc-Davies, T. T., Ooms, L. M., Tuck, K. L., Schoenecker, J. G., Whisstock, J. C. & Law, R. H. P., 12 Mar 2019, In : Blood Advances. 3, 5, p. 729-733 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2018
6 Citations (Scopus)

Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3

Traore, D. A. K., Wisniewski, J. A., Flanigan, S. F., Conroy, P. J., Panjikar, S., Mok, Y-F., Lao, C., Griffin, M. D. W., Adams, V., Rood, J. I. & Whisstock, J. C., 13 Sep 2018, In : Nature Communications. 9, 1, 11 p., 3732.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin

Brennan, A. J., Law, R. H. P., Conroy, P. J., Noori, T., Lukoyanova, N., Saibil, H., Yagita, H., Ciccone, A., Verschoor, S., Whisstock, J. C., Trapani, J. A. & Voskoboinik, I., 7 Feb 2018, In : Cell Death and Differentiation. 25, p. 1517-1529 13 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

The first transmembrane region of complement component-9 acts as a brake on its self-assembly

Spicer, B. A., Law, R. H. P., Caradoc-Davies, T. T., Ekkel, S. M., Bayly-Jones, C., Pang, S-S., Conroy, P. J., Ramm, G., Radjainia, M., Venugopal, H., Whisstock, J. C. & Dunstone, M. A., 15 Aug 2018, In : Nature Communications. 9, 1, 7 p., 3266.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017
2 Citations (Scopus)

Antibodies: From novel repertoires to defining and refining the structure of biologically important targets

Conroy, P. J., Law, R. H. P., Caradoc-Davies, T. T. & Whisstock, J. C., 1 Mar 2017, In : Methods. 116, p. 12-22 11 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Homodimerization attenuates the anti-inflammatory activity of interleukin-37

Ellisdon, A. M., Nold-Petry, C. A., D'Andrea, L., Cho, S. X., Lao, J. C., Rudloff, I., Ngo, D., Lo, C. Y., Soares da Costa, T. P., Perugini, M. A., Conroy, P. J., Whisstock, J. C. & Nold, M. F., 10 Feb 2017, In : Science Immunology. 2, 8, 12 p., eaaj1548.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Perforin-A key (shaped) weapon in the immunological arsenal

Spicer, B. A., Conroy, P. J., Law, R. H. P., Voskoboinik, I. & Whisstock, J. C., Dec 2017, In : Seminars in Cell and Developmental Biology. 72, p. 117-123 7 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

6 Citations (Scopus)

X-ray crystal structure of plasmin with tranexamic acid–derived active site inhibitors

Law, R. H. P., Wu, G., Leung, E. W. W., Hidaka, K., Quek, A. J., Caradoc-Davies, T. T., Jeevarajah, D., Conroy, P. J., Kirby, N. M., Norton, R. S., Tsuda, Y. & Whisstock, J. C., 9 May 2017, In : Blood Advances. 1, 12, p. 766-771 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016
6 Citations (Scopus)

Circumventing the stability-function trade-off in an engineered FN3 domain

Porebski, B. T., Conroy, P. J., Drinkwater, N., Schofield, P., Vazquez-Lombardi, R., Hunter, M. R., Hoke, D. E., Christ, D., McGowan, S. & Buckle, A. M., 1 Nov 2016, In : Protein Engineering, Design and Selection. 29, 11, p. 541-550 9 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Comprehensive N-glycan profiling of avian immunoglobulin Y

Gilgunn, S., Martín, S. M., Wormald, M. R., Zapatero-Rodríguez, J., Conroy, P. J., O'Kennedy, R. J., Rudd, P. M. & Saldova, R., 26 Jul 2016, In : PLoS ONE. 11, 7, 14 p., e0159859.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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CORRIGENDUM: N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin

Smith, A. I., Rajapakse, N. W., Kleifeld, O., Lomonte, B., Sikanyika, N. L., Spicer, A. J., Hodgson, W. C., Conroy, P., Small, D. H., Kaye, D. M., Parkington, H. C., Whisstock, J. & Kuruppu, D. M. S., 2016, In : Scientific Reports. 6, Article # 24333, p. 1 - 1 1 p.

Research output: Contribution to journalArticleOther

3 Citations (Scopus)

Eosinophil peroxidase activates cells by HER2 receptor engagement and β1-integrin clustering with downstream MAPK cell signaling

Hennigan, K., Conroy, P. J., Walsh, M. T., Amin, M., O'Kennedy, R., Ramasamy, P., Gleich, G. J., Siddiqui, Z., Glynn, S., McCabe, O., Mooney, C., Harvey, B. J., Costello, R. W. & McBryan, J., 1 Oct 2016, In : Clinical Immunology. 171, p. 1-11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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8 Citations (Scopus)

N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin

Smith, A. I., Rajapakse, N. W., Kleifeld, O., Lomonte, B., Sikanyika, N. L., Spicer, A. J., Hodgson, W. C., Conroy, P. J., Small, D. H., Kaye, D. M., Parkington, H. C., Whisstock, J. C. & Kuruppu, S. M. S., 2 Mar 2016, In : Scientific Reports. 6, 10 p., 22413.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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48 Citations (Scopus)

Structure of the poly-C9 component of the complement membrane attack complex

Dudkina, N. V., Spicer, B. A., Reboul, C. F., Conroy, P. J., Lukoyanova, N., Elmlund, H., Law, R. HP., Ekkel, S. M., Kondos, S. C., Goode, R. J. A., Ramm, G., Whisstock, J. C., Saibil, H. R. & Dunstone, M. A., 4 Feb 2016, In : Nature Communications. 7, 6 p., 10588.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2015
16 Citations (Scopus)

Electrochemiluminescence platform for the detection of C-reactive proteins: application of recombinant antibody technology to cardiac biomarker detection

O'Reilly, E. J., Conroy, P. J., Hearty, S., Keyes, T. E., O'Kennedy, R., Forster, R. J. & Dennany, L., 31 Jul 2015, In : RSC Advances. 5, 83, p. 67874-67877 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
5 Citations (Scopus)

Investigation of the mechanism of interaction between Mannose-binding lectin-associated serine protease-2 and complement C4

Drentin, N. C., Conroy, P., Gunzburg, M. J., Pike, R. N. & Wijeyewickrema, L. C., 2015, In : Molecular Immunology. 67, 2, p. 287 - 293 7 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes

Yagi, H., Conroy, P. J., Leung, E. W. W., Law, R. H. P., Trapani, J. A., Voskoboinik, I., Whisstock, J. & Norton, R. S., 2015, In : Journal of Biological Chemistry. 290, 42, p. 25213-25226 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2014
15 Citations (Scopus)

Reconciling the structural attributes of avian antibodies

Conroy, P., Law, R. H. P., Gilgunn, S., Hearty, S., Caradoc-Davies, T. T., Lloyd, G., O'Kennedy, R. & Whisstock, J., 2014, In : Journal of Biological Chemistry. 289, 22, p. 15384 - 15392 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2013
119 Citations (Scopus)

Aberrant PSA glycosylation-a sweet predictor of prostate cancer

Gilgunn, S., Conroy, P., Saldova, R., Rudd, P. M. & O'Kennedy, R., 2013, In : Nature Reviews Urology. 10, 2, p. 99 - 107 9 p.

Research output: Contribution to journalArticleResearchpeer-review

110 Citations (Scopus)

A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications

Byrne, H., Conroy, P., Whisstock, J. & O'Kennedy, R., 2013, In : Trends in Biotechnology. 31, 11, p. 621 - 632 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2012
19 Citations (Scopus)

Cardiac troponin I: a case study in rational antibody design for human diagnostics

Conroy, P., O'Kennedy, R. & Hearty, S., 2012, In : Protein Engineering, Design and Selection. 25, 6, p. 295 - 305 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2010
31 Citations (Scopus)

Surface plasmon resonance for vaccine design and efficacy studies: recent applications and future trends

Hearty, S., Conroy, P., Ayyar, B. V., Byrne, B. & O'Kennedy, R., 2010, In : Expert Review of Vaccines. 9, 6, p. 645 - 664 20 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
138 Citations (Scopus)

Antibody production, design and use for biosensor-based applications

Conroy, P., Hearty, S., Leonard, P. & O'Kennedy, R., 2009, In : Seminars in Cell and Developmental Biology. 20, 1, p. 10 - 26 17 p.

Research output: Contribution to journalArticleResearchpeer-review