1994 …2022

Research output per year

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2020

Activin A determines steroid levels and composition in the fetal testis

Whiley, P. A. F., O'Donnell, L., Moody, S. C., Handelsman, D. J., Young, J. C., Richards, E. A., Almstrup, K., Western, P. S. & Loveland, K. L., 10 Apr 2020, (Accepted/In press) In : Endocrinology. 41 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Epigenomic drugs and the germline: Collateral damage in the home of heritability?

Western, P. S., 15 Jun 2018, In : Molecular and Cellular Endocrinology. 468, p. 121-133 13 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Esrp1 is a marker of mouse fetal germ cells and differentially expressed during spermatogenesis

Saeidi, S., Shapouri, F., De Iongh, R. U., Casagranda, F., Sutherland, J. M., Western, P. S., McLaughlin, E. A., Familari, M. & Hime, G. R., 1 Jan 2018, In : PLoS ONE. 13, 1, 15 p., e0190925.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Loss of maternal EED results in postnatal overgrowth

Prokopuk, L., Stringer, J. M., White, C. R., Vossen, R. H. A. M., White, S. J., Cohen, A. S. A., Gibson, W. T. & Western, P. S., 13 Jul 2018, In : Clinical Epigenetics. 10, 1, 14 p., 95.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)

Pharmacological inhibition of EZH2 disrupts the female germline epigenome

Prokopuk, L., Hogg, K. & Western, P. S., 5 Mar 2018, In : Clinical Epigenetics. 10, 1, 12 p., 33.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
8 Citations (Scopus)

Reduced PRC2 function alters male germline epigenetic programming and paternal inheritance

Stringer, J., Forster, S., Qu, Z., Prokopuk, L. A., O'Bryan, M. K., Gardner, D. K., White, S., Adelson, D. L. & Western, P. S., 20 Sep 2018, In : BMC Biology. 16, 20 p., 104.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)
2017

PRC2 is required for extensive reorganization of H3K27me3 during epigenetic reprogramming in mouse fetal germ cells

Prokopuk, L., Stringer, J. M., Hogg, K., Elgass, K. D. & Western, P. S., 20 Feb 2017, In : Epigenetics and Chromatin. 10, 1, 20 p., 7.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
16 Citations (Scopus)
2016

FGF9, activin and TGFβ promote testicular characteristics in an XX gonad organ culture model

Gustin, S. E., Stringer, J. M., Hogg, K., Sinclair, A. H. & Western, P. S., 1 Nov 2016, In : Reproduction. 152, 5, p. 529-543 15 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Tob1 is expressed in developing and adult gonads and is associated with the P-body marker, Dcp2

Shapouri, F., Saeidi, S., de Iongh, R. U., Casagranda, F., Western, P. S., McLaughlin, E. A., Sutherland, J. M., Hime, G. R. & Familari, M., 1 May 2016, In : Cell and Tissue Research. 364, 2, p. 443-451 9 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

WNT/β-catenin and p27/FOXL2 differentially regulate supporting cell proliferation in the developing ovary

Gustin, S. E., Hogg, K., Stringer, J. M., Rastetter, R. H., Pelosi, E., Miles, D. C., Sinclair, A. H., Wilhelm, D. & Western, P. S., 15 Apr 2016, In : Developmental Biology. 412, 2, p. 250-260 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
17 Citations (Scopus)
2015

Changing expression and subcellular distribution of karyopherins during murine oogenesis

Mihalas, B. P., Western, P. S., Loveland, K. A. L., McLaughlin, E. A. & Holt, J., 2015, In : Reproduction. 150, 6, p. 485 - 496 12 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Differentiation of fetal male germline and gonadal progenitor cells is disrupted in organ cultures containing knockout serum replacement

Hogg, K. & Western, P. S., 2015, In : Stem Cells and Development. 24, 24, p. 2899 - 2911 13 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Refurbishing the germline epigenome: out with the old, in with the new

Hogg, K. & Western, P. S., 2015, In : Seminars in Cell and Developmental Biology. 45, p. 104 - 113 10 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Transgenerational epigenetic inheritance: adaptation through the germline epigenome?

Prokopuk, L. A., Western, P. S. & Stringer, J., Aug 2015, In : Epigenomics. 7, 5, p. 829-846 18 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)
2014

Marker genes identify three somatic cell types in the fetal mouse ovary

Rastetter, R. H., Bernard, P. A., Palmer, J. S., Chassot, A-A., Chen, H., Western, P. S., Ramsay, R. G., Chaboissier, M-C. & Wilhelm, D., 15 Oct 2014, In : Developmental Biology. 394, 2, p. 242-252 11 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Technical considerations for genotyping multi-allelic copy number variation (CNV), in regions of segmental duplication

Cantsilieris, S., Western, P. S., Baird, P. N. & White, S., 2014, In : BMC Genomics. 15, Art. ID: 329, p. 1 - 8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
25 Citations (Scopus)
2013

Effects of TGFbeta2 on wild-type and Tgfbr3 knockout mouse fetal testis

Sarraj, M., Escalona, R. M., Western, P. S., Findlay, J. K. & Stenvers, K. L., 2013, In : Biology of Reproduction. 88, 3 (Art. No.: 66), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Fine-tuning evolution: germ-line epigenetics and inheritance

Stringer, J., Barrand, S. & Western, P. S., 2013, In : Reproduction. 146, 1, p. 37 - 48 12 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Identifying disruptors of male germ cell development by small molecule screening in ex vivo gonad cultures

Wakeling, S., Miles, D. C. & Western, P. S., 2013, In : BMC Research Notes. 6, 1 (Art # 68), p. 1 - 8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
11 Citations (Scopus)

Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development

Miles, D. C., Wakeling, S., Stringer, J., van den Bergen, J. A., Wilhelm, D., Sinclair, A. H. & Western, P. S., 2013, In : PLoS ONE. 8, 1, 16 p., e54606.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
55 Citations (Scopus)
2012

Germ cell sex and cell cycle

Miles, D. & Western, P., 2012, In : Histology and Histopathology. 27, 4, p. 445 - 457 13 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Redd1 is a novel marker of testis development but is not required for normal male reproduction

Notini, A. J., McClive, P., Meachem, S. J., van den Bergen, J. A., Western, P. S., Gustin, S. E., Harley, V. R., Koopman, P. A. & Sinclair, A. H., 2012, In : Sexual Development. 6, 5, p. 223 - 230 8 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

The proto-oncogene Ret is required for male foetal germ cell survival

Miles, D., van den Bergen, J., Wakeling, S., Anderson, R., Sinclair, A. & Western, P., 2012, In : Developmental Biology. 365, 1, p. 101 - 109 9 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)
2011

Copy number variation in patients with disorders of sex development due to 46,XY gonadal dysgenesis

White, S. J., Ohnesorg, T., Notini, A., Roeszler, K., Hewitt, J., Daggag, H., Smith, C., Turbitt, E., Gustin, S., van den Bergen, J., Miles, D., Western, P., Arboleda, V., Schumacher, V., Gordon, L., Bell, K., Bengtsson, H., Speed, T., Hutson, J., Warne, G. L. & 4 others, Harley, V., Koopman, P., Vilain, E. & Sinclair, A., 2011, In : PLoS ONE. 6, 3, 10 p., e17793.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
87 Citations (Scopus)

Mitotic arrest in teratoma susceptible fetal male germ cells

Western, P., Ralli, R., Wakeling, S., Lo, C., van den Bergen, J., Miles, D. & Sinclair, A., 2011, In : PLoS ONE. 6, 6, 11 p., e20736.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
20 Citations (Scopus)
2010

Male fetal germ cell differentiation involves complex repression of the regulatory network controlling pluripotency

Western, P., van den Bergen, J., Miles, D. & Sinclair, A., 2010, In : The FASEB Journal. 24, 8, p. 3026 - 3035 10 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)

Regulation of the female mouse germ cell cycle during entry into meiosis

Miles, D., van den Bergen, J., Sinclair, A. & Western, P., 2010, In : Cell Cycle. 9, 2, p. 408 - 418 11 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)
2009

Foetal germ cells: striking the balance between pluripotency and differentiation

Western, P., 2009, In : International Journal of Developmental Biology. 53, 2-3, p. 393 - 409 17 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Normalizing gene expression levels in mouse fetal germ cells

van den Bergen, J., Miles, D., Sinclair, A. & Western, P., 2009, In : Biology of Reproduction. 81, 2, p. 362 - 370 9 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Rapid and reliable determination of transgene zygosity in mice by multiplex ligation-dependent probe amplification

Notini, A., Li, R., Western, P., Sinclair, A. & White, S. J., 2009, In : Transgenic Research. 18, 6, p. 987 - 991 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)
2008

Dynamic regulation of mitotic arrest in fetal male germ cells

Western, P., Miles, D., van den Bergen, J., Burton, M. & Sinclair, A., 2008, In : Stem Cells. 26, 2, p. 339 - 347 9 p.

Research output: Contribution to journalArticleResearchpeer-review

170 Citations (Scopus)

Testis development, fertility, and survival in Ethanolamine kinase 2-deficient mice

Guston, S., Western, P., McClive, P., Harley, V., Koopman, P. & Sinclair, A., 2008, In : Endocrinology. 149, 12, p. 6176 - 6186 11 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

The migrating gubernaculum grows like a "limb bud"

Nightingale, S., Western, P. & Hutson, J., 2008, In : Journal of Pediatric Surgery. 43, 2, p. 387 - 390 4 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

The rhox homeobox gene family shows sexually dimorphic and dynamic expression during mouse embryonic gonad development

Daggag, H., Svingen, T., Western, P., van den Bergen, J., McClive, P., Harley, V., Koopman, P. & Sinclair, A., 2008, In : Biology of Reproduction. 79, 3, p. 468 - 474 7 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)
2007

Dppa2 and Dppa4 are closely linked SAP motif genes restricted to pluripotent cells and the germ line

Maldonado-Saldivia, J., van den Bergen, J., Krouskos, M., Gilchrist, M., Lee, C., Li, R., Sinclair, A., Surani, A. & Western, P., 2007, In : Stem Cells. 25, 1, p. 19 - 28 10 p.

Research output: Contribution to journalArticleResearchpeer-review

76 Citations (Scopus)
2005

Analysis of Esg1 expression in pluripotent cells and the germline reveals similarities with Oct4 and Sox2 and differences between human pluripotent cell lines

Western, P., Maldonado-Saldivia, J., van den Bergen, J., Hajkova, P., Saitou, M., Barton, S. & Surani, A., 2005, In : Stem Cells. 23, 10, p. 1436 - 1442 7 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)
2004

Mechanism of mouse germ cell specification: A genetic program regulating epigenetic reprogramming

Surani, M. A., Ancelin, K., Hajkova, P., Lange, U. C., Payer, B., Western, P. & Saitou, M., 1 Dec 2004, In : Cold Spring Harbor Symposia on Quantitative Biology. 69, p. 1-9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)
2003

Nuclei of adult mammalian somatic cells are directly reprogrammed to oct-4 stem cell gene expression by amphibian oocytes

Byrne, J., Simonsson, S., Western, P. & Gurdon, J., 2003, In : Current Biology. 13, 14, p. 1206 - 1213 8 p.

Research output: Contribution to journalArticleResearchpeer-review

185 Citations (Scopus)

The fragilis interferon-inducible gene family of transmembrane proteins is associated with germ cell specification in mice

Lange, U., Saitou, M., Western, P., Barton, S. & Surani, A., 2003, In : BMC Developmental Biology. 3, p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

105 Citations (Scopus)
2002

A comparative analysis of vertebrate sex determination

Sinclair, A., Smith, C., Western, P. & McClive, P., 1 Dec 2002, In : Novartis Foundation Symposium. 244, p. 102-114 13 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Nuclear reprogramming-alchemy or analysis?

Western, P. & Surani, A., 2002, In : Nature Biotechnology. 20, 5, p. 445 - 446 2 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)
2001

Sex, genes, and heat: Triggers of diversity

Western, P. S. & Sinclair, A. H., 1 Nov 2001, In : Journal of Experimental Zoology. 290, 6, p. 624-631 8 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)
2000

Cloning and expression of a DAX1 homologue in the chicken embryo

Smith, C. A., Clifford, V., Western, P. S., Wilcox, S. A., Bell, K. S. & Sinclair, A. H., 1 Jan 2000, In : Journal of Molecular Endocrinology. 24, 1, p. 23-32 10 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)

SOX8 expression during chick embryogenesis

Bell, K. M., Western, P. S. & Sinclair, A. H., 1 Jun 2000, In : Mechanisms of Development. 94, 1-2, p. 257-260 4 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Temperature-dependent sex determination in the American alligator: Expression of SF1, WT1 and DAX1 during gonadogenesis

Western, P. S., Harry, J. L., Graves, J. A. M. & Sinclair, A. H., 11 Jan 2000, In : Gene. 241, 2, p. 223-232 10 p.

Research output: Contribution to journalArticleResearchpeer-review

83 Citations (Scopus)
1999

Temperature-dependent sex determination: Upregulation of SOX9 expression after commitment to male development

Western, P. S., Harry, J. L., Graves, J. A. M. & Sinclair, A. H., 17 Mar 1999, In : Developmental Dynamics. 214, 3, p. 171-177 7 p.

Research output: Contribution to journalArticleResearchpeer-review

115 Citations (Scopus)

Temperature-dependent sex determination in the american alligator: AMH precedes SOX9 expression

Western, P. S., Harry, J. L., Graves, J. A. M. & Sinclair, A. H., 20 Dec 1999, In : Developmental Dynamics. 216, 4-5, p. 411-419 9 p.

Research output: Contribution to journalArticleResearchpeer-review

107 Citations (Scopus)
1996

Evolution of the mammalian mitochondrial control region - Comparisons of control region sequences between monotreme and therian mammals

Gemmell, N. J., Western, P. S., Watson, J. M. & A.-Marshall Graves, J., 1 Jan 1996, In : Molecular Biology and Evolution. 13, 6, p. 798-808 11 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)
1995

Determining platypus relationships

Gemmell, N. J., Grant, T. R., Western, P. S., Walmsley, J., Watson, J. M., Murray, N. D. & Graves, J. A. M., 1 Jan 1995, In : Australian Journal of Zoology. 43, 3, p. 283-291 9 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)
1994

Cloning and characterization of the platypus mitochondrial genome

Gemmell, N. J., Janke, A., Western, P. S., Watson, J. M., Pääbo, S. & Marshall Graves, J. A., 1 Jan 1994, In : Journal of Molecular Evolution. 39, 2, p. 200-205 6 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)