Projects per year
Personal profile
Biography
Germ Cell Development and Epigenetics Research Group Head
Centre for Reproductive Health
Hudson Institute of Medical Research
Associate Professor Patrick Western’s research is focused on understanding the epigenetic processes underlying establishment of the germ cell lineage and the impact of transmitted epigenetic information on the next generation.
A/Prof Western completed his doctoral studies on temperature dependent sex determination in the American alligator. He then moved to Professor Azim Surani’s laboratory at the Wellcome Trust Gurdon Institute, Cambridge University, where he studied epigenetic reprogramming and the reacquisition of pluripotency in differentiated somatic cells, embryonic stem cells and germ cells. A/Prof Western then joined the ARC Centre of Excellence in Biotechnology and Development where he pursued an interest in sex-specific germ cell development with a focus on the regulation of pluripotency and differentiation in early germ cells.
A/Prof Western leads the Germ Cell Development and Epigenetics Group within the Centre for Reproductive Health at the Hudson Institute of Medical Research. Using genetic and pharmacological models, the Germ Cell Development and Epigenetics Group studies mechanisms regulating epigenetic programming in the germline and the impacts of germline epigenetic information on offspring development. Our work combines discovery science with translational research aimed at developing clinically relevant information required for understanding the impacts of epigenetic programming on disease inheritance, and the potential interactions between epigenomic drugs and the germline epigenome, and subsequent outcomes in offspring.
Education/Academic qualification
Genetics and Developmental Biology, Ph.D, La Trobe University
Award Date: 15 Sep 1999
Genetics, BSc Hons, La Trobe University
Award Date: 4 Nov 1993
Research area keywords
- epigenetics
- inheritance
- fetal origins of disease
- oocyte
- sperm
- developmental disease
Network
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Epigenetic regulation of genomic stability and inheritance
Western, P., Blewitt, M. & Ritchie, M. E.
1/10/21 → 30/09/24
Project: Research
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SCIREQ inExpose system
Winship, A., Carroll, J., Bourke, J., Simonds, S., Heng, T., Hutt, K., Stringer, J., Western, P., Coelho Marques, F. & Abud, H.
1/10/21 → 31/12/22
Project: Research
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Defining the epigenetic origins of maternally inherited disease.
Western, P., Gardner, D., Voss, A. K., van den Buuse, M., Adelson, D. L., Sims, N., Hutt, K., Dickinson, H., Stringer, J., Hill, R. & Gibson, W.
1/01/18 → 31/12/20
Project: Research
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Improving oocyte mitochondrial DNA copy number to enhance female reproductive capacity
St John, J., McKenzie, M., Western, P., Rombauts, L., McLachlan, P. R. & Carmody, D. R.
1/01/18 → 31/12/20
Project: Research
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Improving oocyte mitochondrial DNA copy number to enhance female reproductive capacity
St John, J., McKenzie, M., Western, P. & Rombauts, L.
1/01/18 → 31/12/20
Project: Research
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Activin A Determines Steroid Levels and Composition in the Fetal Testis
Whiley, P. A. F., O'Donnell, L., Moody, S. C., Handelsman, D. J., Young, J. C., Richards, E. A., Almstrup, K., Western, P. S. & Loveland, K. L., Jul 2020, In: Endocrinology. 161, 7, 16 p., bqaa058.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile2 Citations (Scopus) -
A novel approach to nonsurgical sterilization; application of menadione-modified gonocyte-targeting M13 bacteriophage for germ cell ablation in utero
Fraser, B. A., Miller, K., Trigg, N. A., Smith, N. D., Western, P. S., Nixon, B. & Aitken, R. J., 1 Oct 2020, In: Pharmacology Research & Perspectives. 8, 5, 13 p., e00654.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile -
Evidence that activin A directly modulates early human male germline differentiation status
Moody, S. C., Wakitani, S., Young, J. C., Western, P. S. & Loveland, K. L., 1 Jul 2020, In: Reproduction. 160, 1, p. 141-154 14 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
Identification of novel interacting partners of the NEDD4 ubiquitin ligase in mouse testis
Manning, J. A., Windley, S. P., Sandow, J. J., Shah, S. S., Western, P., Wilhelm, D. & Kumar, S., 15 Jul 2020, In: Journal of Proteomics. 223, 8 p., 103830.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
TIMP-2 regulates proliferation, invasion and STAT3-mediated cancer stem cell-dependent chemoresistance in ovarian cancer cells
Escalona, R., Bilandzic, M., Western, P., Kadife, E., Kannourakis, G., Findlay, J. K. & Ahmed, N., 6 Oct 2020, In: BMC Cancer. 20, 1, 24 p., 960.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile6 Citations (Scopus)