1986 …2023
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Research Output 1986 2019

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2004
65 Citations (Scopus)

Amylin receptors: Molecular composition and pharmacology

Hay, D. L., Christopoulos, G., Christopoulos, A. & Sexton, P., 2004, In : Biochemical Society Transactions. 32, Pt 5, p. 865 - 867 3 p.

Research output: Contribution to journalArticleOther

Calcitonin

Findlay, D. M. & Sexton, P. M., 2004, In : Growth Factors. 22, 4, p. 217 - 224 8 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

G-protein-coupled receptor allosterism: the promise and the problem(s)

Christopoulos, A., May, L. T., Avlani, V. A. & Sexton, P. M., 2004, In : Biochemical Society Transactions. 32, Pt 5, p. 873 - 877 5 p.

Research output: Contribution to journalArticleOther

44 Citations (Scopus)

Hematological defects in the oc/oc mouse, a model of infantile malignant osteopetrosis

Blin-Wakkach, C., Blin-Wakkach, A., Sexton, P., Rochet, N. & Carle, G. F., 2004, In : Leukemia. 18, 9, p. 1505 - 1511 7 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

In vitro autoradiographic localization of calcitonin and amylin binding sites in monkey brain

Paxinos, G., Chai, S. Y., Christopoulos, G., Huang, X-F., Toga, A. W., Wang, H. Q. & Sexton, P. M., 2004, In : Journal of Chemical Neuroanatomy. 27, 4, p. 217 - 236 20 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Photoaffinity scanning in the mapping of the peptide receptor interface of class II G protein-coupled receptors

Pham, V. I. & Sexton, P. M., 2004, In : Journal of Peptide Science. 10, 4, p. 179 - 203 25 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Regulation of serotonin 5-HT{2C} receptors by chronic ligand exposure

Devlin, M. G., Smith, N. J., Ryan, O. M., Guida, E., Sexton, P. M. & Christopoulos, A., 2004, In : European Journal of Pharmacology. 498, 1-3, p. 59 - 69 11 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Spatial proximity between a photolabile residue in position 19 of salmon calcitonin and the amino terminus of the human calcitonin receptor

Pham, V., Wade, J. D., Purdue, B. W. & Sexton, P. M., 2004, In : Journal of Biological Chemistry. 279, 8, p. 6720 - 6729 10 p.

Research output: Contribution to journalArticleResearchpeer-review

68 Citations (Scopus)

The receptor activity modifying protein family of G protein coupled receptor accessory proteins

Udawela, M., Hay, D. L. & Sexton, P. M., 2004, In : Seminars in Cell and Developmental Biology. 15, 3, p. 299 - 308 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2003

Application of photoaffinity crosslinking in determining the interaction between calcitonin and its receptor

Pham, V., Wade, J. D. & Sexton, P. M., 1 Nov 2003, In : Letters in Peptide Science. 10, 5-6, p. 447-453 7 p.

Research output: Contribution to journalArticleResearchpeer-review

220 Citations (Scopus)

Novel receptor partners and function of receptor activity-modifying proteins

Christopoulos, A., Christopoulos, G., Morfis, M., Udawela, M., Laburthe, M., Couvineau, A., Kuwasako, K., Tilakaratne, N. & Sexton, P. M., 2003, In : Journal of Biological Chemistry. 278, 5, p. 3293 - 3297 5 p.

Research output: Contribution to journalArticleResearchpeer-review

82 Citations (Scopus)

RAMPs: 5 years on, where to now?

Morfis, M., Christopoulos, A. & Sexton, P., 2003, In : Trends in Pharmacological Sciences. 24, 11, p. 596 - 601 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2002
587 Citations (Scopus)

International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors

Poyner, D. R., Sexton, P. M., Marshall, I., Smith, D. M., Quirion, R., Born, W., Muff, R., Fischer, J. A. & Foord, S. M., 2002, In : Pharmacological Reviews. 54, 2, p. 233 - 246 14 p.

Research output: Contribution to journalArticleResearchpeer-review

90 Citations (Scopus)

Lipopolysaccharide supports survival and fusion of preosteoclasts independent of TNF-, IL-1 and RANKL

Suda, K., Woo, J-T., Takami, M., Sexton, P. M. & Nagai, K., 2002, In : Journal of Cellular Physiology. 190, p. 101 - 108 8 p.

Research output: Contribution to journalArticleResearchpeer-review

81 Citations (Scopus)

Molecular pharmacology of the calcitonin receptor

Purdue, B. W., Tilakaratne, N. & Sexton, P., 2002, In : Receptors and Channels. 8, 3 & 4, p. 243 - 255 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2001

REVIEW: Receptor activity modifying proteins

Sexton, P., Albiston, A. L., Morfis, M. & Tilakaratne, N., 2001, In : Cellular Signalling. 13, 2, p. 73 - 83 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2000
124 Citations (Scopus)

Amylin receptor phenotypes derived from human calcitonin receptor/RAMP coexpression exhibit pharmacological differences dependent on receptor isoform and host cell environment.

Tilakaratne, N., Christopoulos, G., Zumpe, E. T., Foord, S. M. & Sexton, P. M., Jul 2000, In : Journal of Pharmacology and Experimental Therapeutics. 294, 1, p. 61-72 12 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Identification of key components in the irreversibility of salmon calcitonin binding to calcitonin receptors

Hilton, J. M., Dowton, M., Houssami, S. & Sexton, P. M., 1 Jan 2000, In : Journal of Endocrinology. 166, 1, p. 213-226 14 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)

Mouse receptor-activity-modifying proteins 1, -2 and -3: Amino acid sequence, expression and function

Husmann, K., Sexton, P. M., Fischer, J. A. & Born, W., 25 Apr 2000, In : Molecular and Cellular Endocrinology. 162, 1-2, p. 35-43 9 p.

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)

Multiple ramp domains are required for generation of amylin receptor phenotype from the calcitonin receptor gene product.

Zumpe, E. T., Tilakaratne, N., Fraser, NJ., Christopoulos, G., Foord, S. M. & Sexton, P., 7 Jan 2000, In : Biochemical and Biophysical Research Communications. 267, 1, p. 368-372

Research output: Contribution to journalArticleResearchpeer-review

1999
160 Citations (Scopus)

Calcitonin

Sexton, P. M., Findlay, D. M. & Martin, T. J., 3 Nov 1999, In : Current Medicinal Chemistry. 6, 11, p. 1067-1093 27 p.

Research output: Contribution to journalArticleResearchpeer-review

67 Citations (Scopus)

Calcitonin receptor antibodies in the identification of osteoclasts

Quinn, J. M. W., Morfis, M., Lam, M. H. C., Elliott, J., Kartsogiannis, V., Williams, E. D., Gillespie, M. T., Martin, T. J. & Sexton, P. M., 1 Jan 1999, In : Bone. 25, 1, p. 1-8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

358 Citations (Scopus)

Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product

Christopoulos, G., Perry, K. J., Morfis, M., Tilakaratne, N., Gao, Y., Fraser, N. J., Main, M. J., Foord, S. M. & Sexton, P. M., 1 Jan 1999, In : Molecular Pharmacology. 56, 1, p. 235-242 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1998
24 Citations (Scopus)

Characterization of binding sites for amylin, calcitonin, and CGRP in primate kidney

Chai, S. Y., Christopoulos, G., Cooper, M. E. & Sexton, P. M., 1 Jan 1998, In : American Journal of Physiology - Renal Physiology. 274, 1 43-1, p. F51-F62

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Function of the rat calcitonin receptors, C1a and C1b, expressed in Xenopus oocytes

Matsumoto, M., Kaibara, M., Uezono, Y., Izumi, F., Sumikawa, K., Sexton, P. M. & Taniyama, K., 26 Jan 1998, In : Biochemical and Biophysical Research Communications. 242, 3, p. 484-491 8 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Purification of calcitonin-like peptides from rat brain and pituitary

Hilton, J. M., Mitchelhill, K. I., Pozvek, G., Dowton, M., Quiza, M. & Sexton, P. M., 1 Jan 1998, In : Endocrinology. 139, 3, p. 982-992 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1997
40 Citations (Scopus)

Characterization of amylin and calcitonin receptor binding in the mouse α-thyroid-stimulating hormone thyrotroph cell line

Perry, K. J., Quiza, M., Myers, D. E., Morfis, M., Christopoulos, G. & Sexton, P. M., 1 Jan 1997, In : Endocrinology. 138, 8, p. 3486-3496 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
15 Citations (Scopus)

Electrophoretic mobility and glycosylation characteristics of heterogeneously expressed calcitonin receptors

Quiza, M., Dowton, M., Perry, K. J. & Sexton, P. M., 1 Jan 1997, In : Endocrinology. 138, 2, p. 530-539 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
33 Citations (Scopus)

Structure/function relationships of calcitonin analogues as agonists, antagonists, or inverse agonists in a constitutively activated receptor cell system

Pozvek, G., Hilton, J. M., Quiza, M., Houssami, S. & Sexton, P. M., 1 Jan 1997, In : Molecular Pharmacology. 51, 4, p. 658-665 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1996
61 Citations (Scopus)

Amylin binding in rat renal cortex, stimulation of adenylyl cyclase, and activation of plasma renin

Wookey, P. J., Tikellis, C., He-Cheng, D. U., Qin, H. F., Sexton, P. M. & Cooper, M. E., 1996, In : American Journal of Physiology. 270, 2 PART 2

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Homologous regulation of the rat C1a calcitonin receptor (CTR) in nonosteoclastic cells is independent of CTR messenger ribonucleic acid changes and cyclic adenosine 3',5'-monophosphate-dependent protein kinase activation

Findlay, D. M., Houssami, S., Christopoulos, G. & Sexton, P. M., 1 Jan 1996, In : Endocrinology. 137, 11, p. 4576-4585 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1995
7 Citations (Scopus)

Calcium inflow in cells transfected with cloned rat and porcine calcitonin receptors

Findlay, D. M., Houssami, S., Sexton, P. M., Brady, C. L., Martin, T. J. & Myers, D. E., 16 Mar 1995, In : BBA - Molecular Cell Research. 1265, 2-3, p. 213-219 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
65 Citations (Scopus)

Comparative distribution of receptors for amylin and the related peptides calcitonin gene related peptide and calcitonin in rat and monkey brain

Christopoulos, G., Paxinos, G., Huang, X. F., Beaumont, K., Toga, A. W. & Sexton, P. M., 1 Jan 1995, In : Canadian Journal of Physiology and Pharmacology. 73, 7, p. 1037-1041 5 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Divergent structural requirements exist for calcitonin receptor binding specificity and adenylate cyclase activation

Houssami, S., Findlay, D. M., Brady, C. L., Martin, T. J., Epand, R. M., Moore, E. E., Murayama, E., Tamura, T., Orlowski, R. C. & Sexton, P. M., 1 Jan 1995, In : Molecular Pharmacology. 47, 4, p. 798-809 12 p.

Research output: Contribution to journalArticleResearchpeer-review

94 Citations (Scopus)

Functionally different isoforms of the human calcitonin receptor result from alternative splicing of the gene transcript

Moore, E. E., Kuestner, R. E., Stroop, S. D., Grant, F. J., Matthewes, S. L., Brady, C. L., Sexton, P. M. & Findlay, D. M., 1 Aug 1995, In : Molecular Endocrinology. 9, 8, p. 959-968 10 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Heterogeneity of the calcitonin receptor: Functional aspects in osteoclasts and other sites

Martin, T. J., Findlay, D. M., Houssami, S., Ikegame, M., Rakopoulos, M., Moseley, J. M. & Sexton, P. M., 1 Jan 1995, In : Journal of Nutrition. 125, 7 SUPPL., p. 2009S-2014S

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

In vitro autoradiographic localization of the calcitonin receptor isoforms, C1a and C1b, in rat brain

Hilton, J. M., Chai, S. Y. & Sexton, P. M., 1 Jan 1995, In : Neuroscience. 69, 4, p. 1223-1237 15 p.

Research output: Contribution to journalArticleResearchpeer-review

1994

Amylin and calcitonin gene-related peptide in the rat kidney: functional and autoradiographic studies.

Haynes, J. M., Wookey, P. J., Tikellis, C., Du, H-C., Sexton, P. & Cooper, M. E., 1994, In : Canadian Journal of Physiology and Pharmacology. 72, p. 566

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Amylin is an agonist of the renal porcine calcitonin receptor

Sextont, P. M., Houssami, S., Brady, C. L., Myers, D. E. & Findlays, D. M., 1 Jan 1994, In : Endocrinology. 134, 5, p. 2103-2107 5 p.

Research output: Contribution to journalArticleResearchpeer-review

143 Citations (Scopus)

Cloning and characterization of an abundant subtype of the human calcitonin receptor

Kuestner, R. E., Elrod, R. D., Grant, F. J., Hagen, F. S., Kuijper, J. L., Matthewes, S. L., O'Hara, P. J., Sheppard, P. O., Stroop, S. D., Thompson, D. L., Whitmore, T. E., Findlay, D. M., Houssami, S., Sexton, P. M. & Moore, E. E., 1 Aug 1994, In : Molecular Pharmacology. 46, 2, p. 246-255 10 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Heterogeneity in ligand recognition of calcitonin receptors

Houssami, S., Findlay, D. M., Hilton, J. M., O'Keeffe, L. M., Martin, T. J. & Sexton, P. M., 1 Jan 1994, In : Endocrine. 2, 2, p. 127-134 8 p.

Research output: Contribution to journalArticleResearchpeer-review

210 Citations (Scopus)

In vitro autoradiographic localization of amylin binding sites in rat brain

Sexton, P. M., Paxinos, G., Kenney, M. A., Wookey, P. J. & Beaumont, K., 1 Jan 1994, In : Neuroscience. 62, 2, p. 553-567 15 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

In vitro autoradiographic localization of calcitonin binding sites in human medulla oblongata

Sexton, P. M., Paxinos, G., Huang, XF. F. & Mendelsohn, F. A. O., 1 Jan 1994, In : Journal of Comparative Neurology. 341, 4, p. 449-463 15 p.

Research output: Contribution to journalArticleResearchpeer-review

85 Citations (Scopus)

Isoforms of the rat calcitonin receptor: Consequences for ligand binding and signal transduction

Houssami, S., Findlay, D. M., Brady, C. L., Myers, D. L., Martin, T. J. & Sexton, P. M., 1 Jan 1994, In : Endocrinology. 135, 1, p. 183-190 8 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

The ontogeny of [ 125 i]rat-α-cgrp binding sites in the spinal cord of sheep: A prenatal and postnatal study

Nitsos, I., Sexton, P. M. & Rees, S., 1 Jan 1994, In : Neuroscience. 62, 1, p. 257-264 8 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Truncation of the porcine calcitonin receptor cytoplasmic tail inhibits internalization and signal transduction but increases receptor affinity

Findlay, D. M., Houssami, S., Lin, H. Y., Myers, D. E., Brady, C. L., Darcy, P. K., Ikeda, K., Martin, T. J. & Sexton, P. M., 1 Jan 1994, In : Molecular Endocrinology. 8, 12, p. 1691-1700 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1993
130 Citations (Scopus)

Identification of brain isoforms of the rat calcitonin receptor

Sexton, P. M., Houssami, S., Hilton, J. M., O'Keeffe, L. M., Center, R. J., Gillespie, M. T., Darcy, P. & Findlay, D. M., 1 Jan 1993, In : Molecular Endocrinology. 7, 6, p. 815-821 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1992
56 Citations (Scopus)

Biologically active salmon calcitonin-like peptide is present in rat brain

Sexton, P. M. & Hilton, J. M., 20 Nov 1992, In : Brain Research. 596, 1-2, p. 279-284 6 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Localization and Regulation of Renal Receptors for Angiotensin II and Atrial Natriuretic Peptide

Sexton, P. M., Zhuo, J. & Mendelsohn, F. A. O., 1 Jan 1992, In : Tohoku Journal of Experimental Medicine. 166, 1, p. 41-56 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access