1986 …2023
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2002

Molecular pharmacology of the calcitonin receptor

Purdue, B. W., Tilakaratne, N. & Sexton, P., 2002, In : Receptors and Channels. 8, 3 & 4, p. 243 - 255 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2001

REVIEW: Receptor activity modifying proteins

Sexton, P., Albiston, A. L., Morfis, M. & Tilakaratne, N., 2001, In : Cellular Signalling. 13, 2, p. 73 - 83 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2000

Amylin receptor phenotypes derived from human calcitonin receptor/RAMP coexpression exhibit pharmacological differences dependent on receptor isoform and host cell environment.

Tilakaratne, N., Christopoulos, G., Zumpe, E. T., Foord, S. M. & Sexton, P. M., Jul 2000, In : Journal of Pharmacology and Experimental Therapeutics. 294, 1, p. 61-72 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of key components in the irreversibility of salmon calcitonin binding to calcitonin receptors

Hilton, J. M., Dowton, M., Houssami, S. & Sexton, P. M., 1 Jan 2000, In : Journal of Endocrinology. 166, 1, p. 213-226 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Mouse receptor-activity-modifying proteins 1, -2 and -3: Amino acid sequence, expression and function

Husmann, K., Sexton, P. M., Fischer, J. A. & Born, W., 25 Apr 2000, In : Molecular and Cellular Endocrinology. 162, 1-2, p. 35-43 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Multiple ramp domains are required for generation of amylin receptor phenotype from the calcitonin receptor gene product.

Zumpe, E. T., Tilakaratne, N., Fraser, NJ., Christopoulos, G., Foord, S. M. & Sexton, P., 7 Jan 2000, In : Biochemical and Biophysical Research Communications. 267, 1, p. 368-372

Research output: Contribution to journalArticleResearchpeer-review

1999

Calcitonin

Sexton, P. M., Findlay, D. M. & Martin, T. J., 3 Nov 1999, In : Current Medicinal Chemistry. 6, 11, p. 1067-1093 27 p.

Research output: Contribution to journalArticleResearchpeer-review

Calcitonin receptor antibodies in the identification of osteoclasts

Quinn, J. M. W., Morfis, M., Lam, M. H. C., Elliott, J., Kartsogiannis, V., Williams, E. D., Gillespie, M. T., Martin, T. J. & Sexton, P. M., 1 Jan 1999, In : Bone. 25, 1, p. 1-8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product

Christopoulos, G., Perry, K. J., Morfis, M., Tilakaratne, N., Gao, Y., Fraser, N. J., Main, M. J., Foord, S. M. & Sexton, P. M., 1 Jan 1999, In : Molecular Pharmacology. 56, 1, p. 235-242 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1998

Characterization of binding sites for amylin, calcitonin, and CGRP in primate kidney

Chai, S. Y., Christopoulos, G., Cooper, M. E. & Sexton, P. M., 1 Jan 1998, In : American Journal of Physiology - Renal Physiology. 274, 1 43-1, p. F51-F62

Research output: Contribution to journalArticleResearchpeer-review

Function of the rat calcitonin receptors, C1a and C1b, expressed in Xenopus oocytes

Matsumoto, M., Kaibara, M., Uezono, Y., Izumi, F., Sumikawa, K., Sexton, P. M. & Taniyama, K., 26 Jan 1998, In : Biochemical and Biophysical Research Communications. 242, 3, p. 484-491 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Purification of calcitonin-like peptides from rat brain and pituitary

Hilton, J. M., Mitchelhill, K. I., Pozvek, G., Dowton, M., Quiza, M. & Sexton, P. M., 1 Jan 1998, In : Endocrinology. 139, 3, p. 982-992 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1997

Characterization of amylin and calcitonin receptor binding in the mouse α-thyroid-stimulating hormone thyrotroph cell line

Perry, K. J., Quiza, M., Myers, D. E., Morfis, M., Christopoulos, G. & Sexton, P. M., 1 Jan 1997, In : Endocrinology. 138, 8, p. 3486-3496 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Electrophoretic mobility and glycosylation characteristics of heterogeneously expressed calcitonin receptors

Quiza, M., Dowton, M., Perry, K. J. & Sexton, P. M., 1 Jan 1997, In : Endocrinology. 138, 2, p. 530-539 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Structure/function relationships of calcitonin analogues as agonists, antagonists, or inverse agonists in a constitutively activated receptor cell system

Pozvek, G., Hilton, J. M., Quiza, M., Houssami, S. & Sexton, P. M., 1 Jan 1997, In : Molecular Pharmacology. 51, 4, p. 658-665 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1996

Amylin binding in rat renal cortex, stimulation of adenylyl cyclase, and activation of plasma renin

Wookey, P. J., Tikellis, C., He-Cheng, D. U., Qin, H. F., Sexton, P. M. & Cooper, M. E., 1996, In : American Journal of Physiology. 270, 2 PART 2

Research output: Contribution to journalArticleResearchpeer-review

Homologous regulation of the rat C1a calcitonin receptor (CTR) in nonosteoclastic cells is independent of CTR messenger ribonucleic acid changes and cyclic adenosine 3',5'-monophosphate-dependent protein kinase activation

Findlay, D. M., Houssami, S., Christopoulos, G. & Sexton, P. M., 1 Jan 1996, In : Endocrinology. 137, 11, p. 4576-4585 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1995

Calcium inflow in cells transfected with cloned rat and porcine calcitonin receptors

Findlay, D. M., Houssami, S., Sexton, P. M., Brady, C. L., Martin, T. J. & Myers, D. E., 16 Mar 1995, In : BBA - Molecular Cell Research. 1265, 2-3, p. 213-219 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Comparative distribution of receptors for amylin and the related peptides calcitonin gene related peptide and calcitonin in rat and monkey brain

Christopoulos, G., Paxinos, G., Huang, X. F., Beaumont, K., Toga, A. W. & Sexton, P. M., 1 Jan 1995, In : Canadian Journal of Physiology and Pharmacology. 73, 7, p. 1037-1041 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Divergent structural requirements exist for calcitonin receptor binding specificity and adenylate cyclase activation

Houssami, S., Findlay, D. M., Brady, C. L., Martin, T. J., Epand, R. M., Moore, E. E., Murayama, E., Tamura, T., Orlowski, R. C. & Sexton, P. M., 1 Jan 1995, In : Molecular Pharmacology. 47, 4, p. 798-809 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Functionally different isoforms of the human calcitonin receptor result from alternative splicing of the gene transcript

Moore, E. E., Kuestner, R. E., Stroop, S. D., Grant, F. J., Matthewes, S. L., Brady, C. L., Sexton, P. M. & Findlay, D. M., 1 Aug 1995, In : Molecular Endocrinology. 9, 8, p. 959-968 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Heterogeneity of the calcitonin receptor: Functional aspects in osteoclasts and other sites

Martin, T. J., Findlay, D. M., Houssami, S., Ikegame, M., Rakopoulos, M., Moseley, J. M. & Sexton, P. M., 1 Jan 1995, In : Journal of Nutrition. 125, 7 SUPPL., p. 2009S-2014S

Research output: Contribution to journalArticleResearchpeer-review

In vitro autoradiographic localization of the calcitonin receptor isoforms, C1a and C1b, in rat brain

Hilton, J. M., Chai, S. Y. & Sexton, P. M., 1 Jan 1995, In : Neuroscience. 69, 4, p. 1223-1237 15 p.

Research output: Contribution to journalArticleResearchpeer-review

1994

Amylin and calcitonin gene-related peptide in the rat kidney: functional and autoradiographic studies.

Haynes, J. M., Wookey, P. J., Tikellis, C., Du, H-C., Sexton, P. & Cooper, M. E., 1994, In : Canadian Journal of Physiology and Pharmacology. 72, p. 566

Research output: Contribution to journalArticleResearchpeer-review

Amylin is an agonist of the renal porcine calcitonin receptor

Sextont, P. M., Houssami, S., Brady, C. L., Myers, D. E. & Findlays, D. M., 1 Jan 1994, In : Endocrinology. 134, 5, p. 2103-2107 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Cloning and characterization of an abundant subtype of the human calcitonin receptor

Kuestner, R. E., Elrod, R. D., Grant, F. J., Hagen, F. S., Kuijper, J. L., Matthewes, S. L., O'Hara, P. J., Sheppard, P. O., Stroop, S. D., Thompson, D. L., Whitmore, T. E., Findlay, D. M., Houssami, S., Sexton, P. M. & Moore, E. E., 1 Aug 1994, In : Molecular Pharmacology. 46, 2, p. 246-255 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Heterogeneity in ligand recognition of calcitonin receptors

Houssami, S., Findlay, D. M., Hilton, J. M., O'Keeffe, L. M., Martin, T. J. & Sexton, P. M., 1 Jan 1994, In : Endocrine. 2, 2, p. 127-134 8 p.

Research output: Contribution to journalArticleResearchpeer-review

In vitro autoradiographic localization of amylin binding sites in rat brain

Sexton, P. M., Paxinos, G., Kenney, M. A., Wookey, P. J. & Beaumont, K., 1 Jan 1994, In : Neuroscience. 62, 2, p. 553-567 15 p.

Research output: Contribution to journalArticleResearchpeer-review

In vitro autoradiographic localization of calcitonin binding sites in human medulla oblongata

Sexton, P. M., Paxinos, G., Huang, XF. F. & Mendelsohn, F. A. O., 1 Jan 1994, In : Journal of Comparative Neurology. 341, 4, p. 449-463 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Isoforms of the rat calcitonin receptor: Consequences for ligand binding and signal transduction

Houssami, S., Findlay, D. M., Brady, C. L., Myers, D. L., Martin, T. J. & Sexton, P. M., 1 Jan 1994, In : Endocrinology. 135, 1, p. 183-190 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The ontogeny of [ 125 i]rat-α-cgrp binding sites in the spinal cord of sheep: A prenatal and postnatal study

Nitsos, I., Sexton, P. M. & Rees, S., 1 Jan 1994, In : Neuroscience. 62, 1, p. 257-264 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Truncation of the porcine calcitonin receptor cytoplasmic tail inhibits internalization and signal transduction but increases receptor affinity

Findlay, D. M., Houssami, S., Lin, H. Y., Myers, D. E., Brady, C. L., Darcy, P. K., Ikeda, K., Martin, T. J. & Sexton, P. M., 1 Jan 1994, In : Molecular Endocrinology. 8, 12, p. 1691-1700 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1993

Identification of brain isoforms of the rat calcitonin receptor

Sexton, P. M., Houssami, S., Hilton, J. M., O'Keeffe, L. M., Center, R. J., Gillespie, M. T., Darcy, P. & Findlay, D. M., 1 Jan 1993, In : Molecular Endocrinology. 7, 6, p. 815-821 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1992

Biologically active salmon calcitonin-like peptide is present in rat brain

Sexton, P. M. & Hilton, J. M., 20 Nov 1992, In : Brain Research. 596, 1-2, p. 279-284 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Localization and Regulation of Renal Receptors for Angiotensin II and Atrial Natriuretic Peptide

Sexton, P. M., Zhuo, J. & Mendelsohn, F. A. O., 1 Jan 1992, In : Tohoku Journal of Experimental Medicine. 166, 1, p. 41-56 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1991

Central nervous system binding sites for calcitonin and calcitonin gene-related peptide

Sexton, P. M., 1 Jun 1991, In : Molecular Neurobiology. 5, 2-4, p. 251-273 23 p.

Research output: Contribution to journalArticleResearchpeer-review

Reversible calcitonin binding to solubilized sheep brain binding sites

Sexton, P. M., Schneider, H. G., D'Santos, C. S., Mendelsohn, F. A. O., Kemp, B. E., Moseley, J. M., Martin, T. J. & Findlay, D. M., 1 Jan 1991, In : Biochemical Journal. 273, 1, p. 179-184 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1990

Angiotensin ii receptors in the kidney: localization and physiological significance

Yamada, H., Sexton, P. M., Yeen Chai, S., Adam, W. R. & Mendelsohn, F. A. O., 1 Jan 1990, In : American Journal of Hypertension. 3, 3, p. 250-255 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1988

Decreased atrial natriuretic peptide binding in renal medulla in rats with chronic heart failure

Tsunoda, K., Mendelsohn, F. A. O., Sexton, P. M., Siew Yeen Chai, Y. C., Hodsman, G. P. & Johnston, C. I., 1 Jan 1988, In : Circulation Research. 62, 1, p. 155-161 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Evidence for a new subclass of calcitonin/ calcitonin gene-related peptide binding site in rat brain

Sexton, P. M., McKenzie, J. S. & Mendelsohn, F. A. O., 1 Jan 1988, In : Neurochemistry International. 12, 3, p. 323-335 13 p.

Research output: Contribution to journalArticleResearchpeer-review

1987

Angiotensin II receptors and angiotensin converting enzyme in the medulla oblongata

Allen, A. M., Chai, S. Y., Sexton, P. M., Lewis, S. J., Verberne, A. J. M., Jarrott, B., Louis, W. J., Clevers, J., McKinley, M. J., Paxinos, G. & Mendelsohn, F. A. O., 1 Jan 1987, In : Hypertension. 9, 6, Part 2, p. III-198-III-205 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Calcitonin receptors of human osteoclastoma

Nicholson, G. C., Horton, M. A., Sexton, P. M., D'Santos, C. S., Moseley, J. M., Kemp, B. E., Pringle, J. A. S. & Martin, T. J., 1 Jan 1987, In : Hormone and Metabolic Research. 19, 11, p. 585-589 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Chicken osteoclasts do not possess calcitonin receptors

Nicholson, G. C., Moseley, J. M., Sexton, P. M. & Martin, T. J., 1 Jan 1987, In : Journal of Bone and Mineral Research. 2, 1, p. 53-59 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Localization and characterizarion of renal calcitonin receptors by in vitro autoradiography

Sexton, P. M., Adam, W. R., Moseley, J. M., Martin, T. J. & Mendelsohn, F. A. O., 1 Jan 1987, In : Kidney International. 32, 6, p. 862-868 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Overlapping distributions of receptors for atrial natriuretic peptide and angiotensin II visualized by in vitro autoradiography: Morphological basis of physiological antagonism

Mendelsohn, F. A. O., Allen, A. M., Chai, S. Y., Sexton, P. M. & Figdor, R., 1 Jan 1987, In : Canadian Journal of Physiology and Pharmacology. 65, 8, p. 1517-1521 5 p.

Research output: Contribution to journalArticleResearchpeer-review

1986

Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization

Nicholson, G. C., Moseley, J. M., Sexton, P. M., Mendelsohn, F. A. & Martin, T. J., 1 Jan 1986, In : Journal of Clinical Investigation. 78, 2, p. 355-360 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

In vitro autoradiographic localization of ANP receptors in rat kidney and adrenal gland

Chai, S. Y., Sexton, P. M., Allen, A. M., Figdor, R. & Mendelsohn, F. A., 26 Nov 1986, In : American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 250, 4

Research output: Contribution to journalArticleResearchpeer-review

Localization of binding sites for calcitonin gene-related peptide in rat brain by in vitro autoradiography

Sexton, P. M., McKenzie, J. S., Mason, R. T., moseley, J. M., Martin, T. J. & Mendelsohn, F. A. O., 1 Jan 1986, In : Neuroscience. 19, 4, p. 1235-1245 11 p.

Research output: Contribution to journalArticleResearchpeer-review